ABCB8

ATP-binding cassette, sub-family B (MDR/TAP), member 8
Identifiers
Symbols	ABCB8 ; EST328128; M-ABC1; MABC1
External IDs	OMIM: 605464 MGI: 1351667 HomoloGene: 5203 GeneCards: ABCB8 Gene
Gene ontology Molecular function • transporter activity • ATP binding • ATPase activity, coupled to transmembrane movement of substances Cellular component • nucleus • nucleolus • mitochondrion • mitochondrial envelope • mitochondrial inner membrane • membrane • integral component of membrane • ATP-binding cassette (ABC) transporter complex Biological process • transport • metabolic process • transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11194	74610
Ensembl	ENSG00000197150	ENSMUSG00000028973
UniProt	Q9NUT2	Q9CXJ4
RefSeq (mRNA)	NM_001282291	NM_029020
RefSeq (protein)	NP_001269220	NP_083296
Location (UCSC)	Chr 7: 151.03 – 151.05 Mb	Chr 5: 24.39 – 24.41 Mb
PubMed search	[1]	[2]

ATP-binding cassette sub-family B member 8, mitochondrial is a protein that in humans is encoded by the ABCB8 gene.

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes.

See also

• ATP-binding cassette transporter
• ABCB8 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

External links

• ABCB8 human gene location in the UCSC Genome Browser.
• ABCB8 human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.