4-Hydroxyamphetamine

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"Hydroxyamfetamine" redirects here. For other uses, see Hydroxyamphetamine.
4-Hydroxyamphetamine
P-Hydroxyamphetamine.svg
Systematic (IUPAC) name
4-(2-aminopropyl)phenol
Clinical data
Trade names Hydroxyamfetamine, Paredrine
Legal status
  • ℞ (Prescription only)
Routes of
administration		 Topical (ocular)
Identifiers
CAS Number 1518-86-1 YesY
ATC code None
PubChem CID: 3651
ChemSpider 3525 YesY
ChEMBL CHEMBL1546 YesY
Chemical data
Formula C9H13NO
Molecular mass 151.206 g/mol
  • Oc1ccc(cc1)CC(N)C
  • InChI=1S/C9H13NO/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,7,11H,6,10H2,1H3 YesY
  • Key:GIKNHHRFLCDOEU-UHFFFAOYSA-N YesY
  (verify)

4-Hydroxyamphetamine (4HA), also known as hydroxyamfetamine (INN and BAN), hydroxyamphetamine (USAN), oxamphetamine, norpholedrine, para-hydroxyamphetamine, and α-methyltyramine, is a sympathomimetic drug, that is, a drug that stimulates the sympathetic nervous system.

It is used medically in eye drops to dilate the pupil (a process called mydriasis), so that the back of the eye can be examined. It is also a major metabolite of amphetamine and certain substituted amphetamines.

Medical use

4-Hydroxyamphetamine is used in eye drops to dilate the pupil (a process called mydriasis) so that the back of the eye can be examined. This is a diagnostic test for Horner's Syndrome. Patients with Horner’s syndrome exhibit anisocoria brought about by lesions on the nerves that connect to the nasociliary branch of the ophthalmic nerve.[1] Application of 4-hydroxyamphetamine to the eye can indicate whether the lesion is preganglionic or postganglionic based on the pupil’s response. If the pupil dilates, the lesion is preganglionic. If the pupil does not dilate, the lesion is postganglionic.[1]

4-hydroxyamphetamine has some limitations to its use as a diagnostic tool. If it is intended as an immediate follow up to another mydriatic drug (cocaine or apraclonidine), then the patient must wait anywhere from a day to a week before 4-hydroxyamphetamine can be administered.[2][3] It also has the tendency to falsely localize lesions. False localization can arise in cases of acute onset; in cases where a postganglionic lesion is present, but the nerve still responds to residual norepinephrine; or in cases in which unrelated nerve damage masks the presence of a preganglionic lesion.[1][2]

Pharmacology

Like amphetamine, 4-hydroxyamphetamine is an agonist of human TAAR1.[4] 4-Hydroxyamphetamine acts as an indirect sympathomimetic and causes the release of norepinephrine from nerve synapses which leads to mydriasis (pupil dilation).[3][5]

It decreases metabolism of serotonin (5-hydroxytryptamine) and certain other monoamines by inhibiting the activity of a family of enzymes called monoamine oxidases (MAOs), particularly type A (MAO-A). The inhibition of MAO-A prevents metabolism of serotonin and catecholamines in the presynaptic terminal, and thus increases the amount of neurotransmitters available for release into the synaptic cleft.[6] 4-Hydroxyamphetamine is a major metabolite of amphetamine and a minor metabolite of methamphetamine. In humans, amphetamine is metabolized to 4-hydroxyamphetamine by CYP2D6, which is a member of the cytochrome P450 superfamily and is found in the liver.[7][8] 4-Hydroxyamphetamine is then metabolized by dopamine beta-hydroxylase into 4-hydroxynorephedrine or eliminated in the urine.[5]

Metabolic pathways of amphetamine in humans
Graphic of several routes of amphetamine metabolism
4-Hydroxyamphetamine
Para-
Hydroxylation
Para-
Hydroxylation
Para-
Hydroxylation
Beta-
Hydroxylation
Beta-
Hydroxylation
Oxidative
Deamination
Oxidation
Glycine
Conjugation
The image above contains clickable links
In humans, 4-hydroxyamphetamine is formed from CYP2D6 metabolism of amphetamine; 4-hydroxyamphetamine may subsequently be metabolized by dopamine β-hydroxylase into 4-hydroxynorephedrine.

Commercialization

Hydroxyamphetamine is a component of two controlled (prescription only), name-brand ophthalmic mydriatics: Paredrine and Paremyd. Paredrine consists of a 1% solution of hydroxyamphetamine hydrobromide[9]:543 while Paremyd consists of a combination of 1% hydroxyamphetamine hydrobromide and 0.25% tropicamide.[10] In the 1990s, the trade name rights, patents, and new drug applications (NDAs) for the two formulations were exchanged among a few different manufacturers after a shortage of the raw material required for their production, which caused both drugs to be indefinitely removed from the market.[11] Around 1997, Akorn, Inc., obtained the rights to both Paredrine and Paremyd,[12] and in 2002, the company reintroduced Paremyd to the market as a fast acting ophthalmic mydriatic agent.[10][13][14]

See also

References

  1. ↑ 1.0 1.1 1.2 Walton KA & Buono LM (2003). "Horner syndrome." Current opinion in ophthalmology. 14(6):357 PMID 14615640
  2. ↑ 2.0 2.1 Davagnanam I, Fraser CL, Miszkiel K, Daniel CS, & Plant GT (2013). "Adult Horner's syndrome: a combined clinical, pharmacological, and imaging algorithm." Eye (London, England). 27(3):291,294 PMID 23370415
  3. ↑ 3.0 3.1 Lepore FE (1985). "Diagnostic pharmacology of the pupil." Clinical neuropharmacology. 8(1):29 PMID 3884149
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ 5.0 5.1 Cho AK & Wright J (1978). "Pathways of metabolism of amphetamine and related compounds." Life sciences. 22(5):368 PMID 347211
  6. ↑ Nakagawasai O, et al. (2004). "Monoamine oxidase and head-twitch response in mice. Mechanisms of alpha-methylated substrate derivatives." Neurotoxicology. 25(1-2):223-232 PMID 14697897
  7. ↑ Markowitz JS & Patrick KS (2001). "Pharmacokinetic and pharmacodynamic drug interactions in the treatment of attention-deficit hyperactivity disorder." Clinical pharmacokinetics. 40(10):757-758 PMID 11707061
  8. ↑ Haefely W, Bartholini G, & Pletscher A (1976). "Monoaminergic drugs: general pharmacology." Pharmacology & therapeutics. Part B: General & systematic pharmacology. 2(1):197 PMID 817330
  9. ↑ Slamovits TL and JS Glaser. 'The Pupils and Accommodation." in Neuro-ophthamology, ed Glaser JS. Lippincott, Williams, & Wilkins; Philadelphia, PA, 1999. ISBN 978-0781717298
  10. ↑ 10.0 10.1 Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations
  11. ↑ Akorn press release. March 24, 1999. Akorn Acquires Paredrine - Specialty Ophthalmic Diagnostic Product From Pharmics, Inc.
  12. ↑ Akorn press release
  13. ↑ Akorn timeline Page accessed December 9, 2014
  14. ↑ Rebecca Lurcott for Ophthalmology Management. December 1, 2002 Unique Mydriatic Returns: The combination formula fosters patient flow efficiencies

External links

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