Benidipine

Benidipine

Systematic (IUPAC) name
O5-methyl O3-[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
Identifiers
CAS Number	105979-17-7 Y
ATC code	C08CA15 (WHO)
PubChem	CID: 656668
ChemSpider	571013 N
UNII	4G9T91JS7E Y
ChEMBL	CHEMBL2218858 N
Chemical data
Formula	C28H31N3O6
Molecular mass	505.57 g·mol−1
SMILES [O-][N+](=O)c1cccc(c1)[C@@H]4C(/C(=O)OC)=C(\N\C(=C4\C(=O)O[C@@H]3CCCN(Cc2ccccc2)C3)C)C
InChI InChI=1S/C28H31N3O6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3/t23-,26-/m1/s1 N Key:QZVNQOLPLYWLHQ-ZEQKJWHPSA-N N
NY (what is this?)  (verify)

Benidipine (INN), also known as Benidipinum or benidipine hydrochloride, is a dihydropyridine calcium channel blocker for the treatment of high blood pressure (hypertension). It is a triple L-, T-, and N- type calcium channel blocker. It is reno- and cardioprotective.

Dosing

Benidipine is dosed as 2–4 mg once daily.

Availability

Benidipine is sold as Coniel by Kyowa Hakko Kogyo.

Benidipine is only licensed for use in Japan and selected Southeast Asian countries, where it is sold as 4 mg tablets.