Calsenilin
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Calsenilin is a protein that in humans is encoded by the KCNIP3 gene.[1][2][3]
Function
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins.[4][5] Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.[3]
Interactions
Calsenilin has been shown to interact with PSEN1[1][6] and PSEN2.[1][7]
See also
References
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Further reading
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External links
- KCNIP3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- NCS proteins
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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