ITPR3

Inositol 1,4,5-trisphosphate receptor, type 3
Identifiers
Symbols	ITPR3 ; IP3R; IP3R3
External IDs	OMIM: 147267 MGI: 96624 HomoloGene: 1675 IUPHAR: 745 ChEMBL: 3904 GeneCards: ITPR3 Gene
Gene ontology Molecular function • inositol hexakisphosphate binding • intracellular ligand-gated calcium channel activity • inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity • protein binding • phosphatidylinositol binding • inositol 1,3,4,5 tetrakisphosphate binding • inositol 1,4,5 trisphosphate binding Cellular component • nuclear outer membrane • nucleoplasm • nucleolus • cytoplasm • endoplasmic reticulum • endoplasmic reticulum membrane • cytosol • plasma membrane • integral component of plasma membrane • brush border • membrane • platelet dense tubular network membrane • neuronal cell body • myelin sheath • receptor complex • apical part of cell Biological process • stimulatory C-type lectin receptor signaling pathway • energy reserve metabolic process • signal transduction • epidermal growth factor receptor signaling pathway • G-protein coupled receptor signaling pathway • activation of phospholipase C activity • positive regulation of cytosolic calcium ion concentration • blood coagulation • memory • fibroblast growth factor receptor signaling pathway • platelet activation • Fc-epsilon receptor signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • small molecule metabolic process • innate immune response • vascular endothelial growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • inositol phosphate-mediated signaling • regulation of insulin secretion • sensory perception of bitter taste • sensory perception of sweet taste • sensory perception of umami taste • protein homooligomerization • protein heterooligomerization • response to calcium ion • long-term synaptic potentiation • calcium ion transport into cytosol • calcium ion transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3710	16440
Ensembl	ENSG00000096433	ENSMUSG00000042644
UniProt	Q14573	P70227
RefSeq (mRNA)	NM_002224	NM_080553
RefSeq (protein)	NP_002215	NP_542120
Location (UCSC)	Chr 6: 33.62 – 33.7 Mb	Chr 17: 27.06 – 27.12 Mb
PubMed search	[1]	[2]

Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.

Function

ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.

See also

• Inositol trisphosphate receptor

External links

• ITPR3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)