GABRP

Gamma-aminobutyric acid (GABA) A receptor, pi
Identifiers
Symbols	GABRP ; MGC126386; MGC126387
External IDs	OMIM: 602729 MGI: 2387597 HomoloGene: 22798 IUPHAR: 419 ChEMBL: 3506 GeneCards: GABRP Gene
Gene ontology Molecular function • GABA-A receptor activity • extracellular ligand-gated ion channel activity • chloride channel activity Cellular component • integral component of plasma membrane • cell junction • chloride channel complex • neuron projection • synapse • postsynaptic membrane • GABA-A receptor complex Biological process • signal transduction • synaptic transmission • regulation of membrane potential • neurological system process • chloride transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2568	216643
Ensembl	ENSG00000094755	ENSMUSG00000020159
UniProt	O00591	Q8QZW7
RefSeq (mRNA)	NM_001291985	NM_146017
RefSeq (protein)	NP_001278914	NP_666129
Location (UCSC)	Chr 5: 170.76 – 170.81 Mb	Chr 11: 33.55 – 33.58 Mb
PubMed search	[1]	[2]

Gamma-aminobutyric acid receptor subunit pi is a protein that in humans is encoded by the GABRP gene.

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.

See also

• GABAA receptor

External links

• GABRP protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.