JM-1232

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JM-1232
JM-1232 structure.png
Systematic (IUPAC) name
(3R)-3-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-2-phenyl-3,5,6,7-tetrahydrocyclopenta[f]isoindol-1-one
Identifiers
PubChem CID: 17755150
ChemSpider 26231036 N
Chemical data
Formula C24H27N3O2
Molecular mass 389.489 g/mol
  • O=C1C2=CC3=C(C=C2[C@H](N1C4=CC=CC=C4)CC(N5CCN(CC5)C)=O)CCC3
  • InChI=1S/C24H27N3O2/c1-25-10-12-26(13-11-25)23(28)16-22-20-14-17-6-5-7-18(17)15-21(20)24(29)27(22)19-8-3-2-4-9-19/h2-4,8-9,14-15,22H,5-7,10-13,16H2,1H3/t22-/m1/s1 N
  • Key:MBGOHVUPIPFVMM-JOCHJYFZSA-N N
 NYesY (what is this?)  (verify)

JM-1232 is a sedative and hypnotic drug being researched as a potential anesthetic. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic.[1][2][3][4][5][6] It was developed by a team at Maruishi Pharmaceutica.[7]

A human study explored the sedation caused by infusions at a range of doses, finding a fair hemodynamic safety profile.[8]

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ EP Patent 1566378 Isoindoline Derivative
  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.


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