MAP3K7

Main article: MAP kinase kinase kinase

Mitogen-activated protein kinase kinase kinase 7 is an enzyme that in humans is encoded by the MAP3K7 gene.

Function

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Interactions

MAP3K7 has been shown to interact with:

• ASK1,
• CHUK,
• MAP2K6,
• MAP3K7IP1,
• MAP3K7IP2,
• MAP3K7IP3,
• Mothers against decapentaplegic homolog 6,
• PPM1B, and
• TRAF6.