Proteinase 3

Proteinase 3
Proteinase 3
	PDB rendering based on 1fuj.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1FUJ
Identifiers
Symbols	PRTN3 ; ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP-4; NP4; P29; PR-3; PR3
External IDs	OMIM: 177020 MGI: 893580 HomoloGene: 120934 ChEMBL: 3900 GeneCards: PRTN3 Gene
EC number	3.4.21.76
Gene ontology
Molecular function	• serine-type endopeptidase activity; • serine-type peptidase activity; • enzyme binding;
Cellular component	• extracellular space; • cytosol; • plasma membrane; • extracellular matrix; • extracellular exosome;
Biological process	• proteolysis; • blood coagulation; • positive regulation of cell proliferation; • collagen catabolic process; • negative regulation of phagocytosis; • mature conventional dendritic cell differentiation;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
Species	Human
Entrez	5657
Ensembl	ENSG00000196415
UniProt	P24158
RefSeq (mRNA)	NM_002777
RefSeq (protein)	NP_002768
Location (UCSC)	Chr 19:; 0.84 – 0.85 Mb
PubMed search	[1]
	v; t; e;

Proteinase 3 also known as PRTN3 is an enzyme that in humans is encoded by the PRTN3 gene.^[1]

Function

PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease granulomatosis with polyangiitis (formerly known as "Wegener's granulomatosis").^[2]

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Proteinase 3 at the US National Library of Medicine Medical Subject Headings (MeSH)