SKF-81,297

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SKF-81,297
SKF-81297 structure.png
Systematic (IUPAC) name
6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
Identifiers
CAS Number 253446-15-0
ATC code none
PubChem CID: 16219952
ChemSpider 1181
Chemical data
Formula C16H16ClNO2
Molecular mass 289.76 g/mol
  • Clc1c(O)c(O)cc2c1CCNCC2c3ccccc3

SKF-81,297 is a synthetic drug of the benzazepine chemical class that acts as a selective dopamine D1/D5 receptor full agonist, and produces a characteristic stimulant-like pattern of anorexia, hyperactivity and self-administration in animals.[1] This profile is shared with several related drugs such as 6-Br-APB and SKF-82,958,[2] but not with certain other D1 full agonists such as A-77,636, reflecting functional selectivity of D1 activation.[3][4][5] Newer findings reveal that SKF-81,297 additionally acts as a partial agonist at D1-D2 receptor heteromers.[6]

References

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