Bulbokapnin

Bulbokapnin
	(S)-6,7,7a,8-tetrahidro-11-metokdi-7-metil-5H- benzo[g]-1,3-benzodioksolo-[6,5,4-de]hinolin-2-ol
Identifikacija
CAS registarski broj	298-45-3
PubChem	12441
ChemSpider	11934
ChEMBL	CHEMBL157912
Jmol-3D slike	Slika 1
SMILES
	O1c4c(OC1)c3c2c(O)c(OC)ccc2C[C@H]5c3c(c4)CCN5C
InChI
	InChI=1S/C19H19NO4/c1-20-6-5-11-8-14-19(24-9-23-14)17-15(11)12(20)7-10-3-4-13(22-2)18(21)16(10)17/h3-4,8,12,21H,5-7,9H2,1-2H3/t12-/m0/s1 ; Kod: LODGIKWNLDQZBM-LBPRGKRZSA-N InChI=1/C19H19NO4/c1-20-6-5-11-8-14-19(24-9-23-14)17-15(11)12(20)7-10-3-4-13(22-2)18(21)16(10)17/h3-4,8,12,21H,5-7,9H2,1-2H3/t12-/m0/s1; Kod: LODGIKWNLDQZBM-LBPRGKRZBH
Svojstva
Molekulska formula	C19H19NO4
Molarna masa	325,36 g/mol
Tačka topljenja	201-203 °C, racemat 213-214 °C
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Bulbokapnin je alkaloid prisutan u Corydalis (Papaveraceae) i Dicentra, biljkama familije Fumariaceae, koji može da uzrokuje fatalno trovanje ovaca i goveda. On deluje kao inhibitor acetilholinesteraze,^[5] i inhibira biosintezu dopamina putem inhibicije enzima tirozinska hidroksilaza.^[6]^[7]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Adsersen, A.; Kjølbye, A.; Dall, O.; Jäger, A. K. (Aug 2007). „Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Corydalis cava Schweigg. & Kort.”. Journal of Ethnopharmacology 113 (1): 179–182. PMID 17574358.
↑ Zhang, Y. H.; Shin, J. S.; Lee, S. S.; Kim, S. H.; Lee, M. K. (Aug 1997). „Inhibition of Tyrosine Hydroxylase by Bulbocapnine”. Planta Medica 63 (4): 362–363. PMID 9270381.
↑ Shin, J. S.; Kim, K. T.; Lee, M. K. (Mar 1998). „Inhibitory Effects of Bulbocapnine on Dopamine Biosynthesis in PC12 Cells”. Neuroscience Letters 244 (3): 161–164. PMID 9593514.

Povezano

Spoljašnje veze

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] Adsersen, A.; Kjølbye, A.; Dall, O.; Jäger, A. K. (Aug 2007). „Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Corydalis cava Schweigg. & Kort.”. Journal of Ethnopharmacology 113 (1): 179–182. PMID 17574358.

[6] Zhang, Y. H.; Shin, J. S.; Lee, S. S.; Kim, S. H.; Lee, M. K. (Aug 1997). „Inhibition of Tyrosine Hydroxylase by Bulbocapnine”. Planta Medica 63 (4): 362–363. PMID 9270381.

[7] Shin, J. S.; Kim, K. T.; Lee, M. K. (Mar 1998). „Inhibitory Effects of Bulbocapnine on Dopamine Biosynthesis in PC12 Cells”. Neuroscience Letters 244 (3): 161–164. PMID 9593514.

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