Deramciklan

Deramciklan
(IUPAC) ime
	N,N-dimetil-2-([(1R,4R,6S)-1,7,7-trimetil-6-fenil-6-biciklo[2.2.1]heptanil]oksi)etanamin
Klinički podaci
Identifikatori
CAS broj	120444-72-6
ATC kod	nije dodeljen
PubChem	119590
UNII	O5KFK61E74
Hemijski podaci
Formula	C20H31NO
Mol. masa	301,466 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C20H31NO/c1-18(2)17-11-12-19(18,3)20(15-17,22-14-13-21(4)5)16-9-7-6-8-10-16/h6-10,17H,11-15H2,1-5H3/t17-,19-,20+/m1/s1 ; Key: QOBGWWQAMAPULA-RLLQIKCJSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Deramciklan (EGIS-3886) je lek koji deluje kao antagonist na 5-HT_2A receptoru,^[3] kao inverzni agonist na 5-HT_2C receptoru,^[4] i kao inhibitor GABA preuzimanja.^[5]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Kanerva, H.; Vilkman, H.; Någren, K.; Kilkku, O.; Kuoppamäki, M.; Syvälahti, E.; Hietala, J. (1999). „Brain 5-HT2A receptor occupancy of deramciclane in humans after a single oral administration--a positron emission tomography study”. Psychopharmacology 145 (1): 76–81. DOI:10.1007/s002130051034. PMID 10445375.
↑ Pälvimäki, E. P.; Majasuo, H.; Kuoppamäki, M.; Männistö, P. T.; Syvälahti, E.; Hietala, J. (1998). „Deramciclane, a putative anxiolytic drug, is a serotonin 5-HT2C receptor inverse agonist but fails to induce 5-HT2C receptor down-regulation”. Psychopharmacology 136 (2): 99–104. DOI:10.1007/s002130050544. PMID 9551765.
↑ Kovács, I.; Maksay, G.; Simonyi, M. (1989). „Inhibition of high-affinity synaptosomal uptake of gamma-aminobutyric acid by a bicyclo-heptane derivative”. Arzneimittel-Forschung 39 (3): 295–297. PMID 2502985.

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