Histonska deacetilaza
| Histonska deacetilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.5.1.98 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Histonska deacetilaza (EC 3.5.1.98, HDAC) je enzim sa sistematskim imenom histon amidohidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza N6-acetil-lizinskog ostatka histona čime se formira deacetilisani histon
Ova klasa enzima uklanja acetil grupe sa N6-acetil-lizinskih ostataka na histonu.
- ↑ Krieger, D.E., Levine, R., Merrifield, R.B., Vidali, G. and Allfrey, V.G. (1974). „Chemical studies of histone acetylation. Substrate specificity of a histone deacetylase from calf thymus nuclei”. J. Biol. Chem. 249: 332-334. PMID 4855628.
- ↑ Sanchez del Pino, M.M., Lopez-Rodas, G., Sendra, R. and Tordera, V. (1994). „Properties of the yeast nuclear histone deacetylase”. Biochem. J. 303: 723-729. PMID 7980438.
- ↑ Ouaissi, M. and Ouaissi, A. (2006). „Histone deacetylase enzymes as potential drug targets in cancer and parasitic diseases”. J. Biomed. Biotechnol. 2006: 13474-13474. PMID 16883049.
- ↑ Song, Y.M., Kim, Y.S., Kim, D., Lee, D.S. and Kwon, H.J. (2007). „Cloning, expression, and biochemical characterization of a new histone deacetylase-like protein from Thermus caldophilus GK24”. Biochem. Biophys. Res. Commun. 361: 55-61. PMID 17632079.
- ↑ Finnin, M.S., Donigian, J.R., Cohen, A., Richon, V.M., Rifkind, R.A., Marks, P.A., Breslow, R. and Pavletich, N.P. (1999). „Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors”. Nature 401: 188-193. PMID 10490031.
- ↑ Phiel, C.J., Zhang, F., Huang, E.Y., Guenther, M.G., Lazar, M.A. and Klein, P.S. (2001). „Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen”. J. Biol. Chem. 276: 36734-36741. PMID 11473107.
- ↑ de Ruijter, A.J., van Gennip, A.H., Caron, H.N., Kemp, S. and van Kuilenburg, A.B. (2003). „Histone deacetylases (HDACs): characterization of the classical HDAC family”. Biochem. J. 370: 737-749. PMID 12429021.
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