Áurea Gabriel

Universidade Nova de Lisboa, Instituto de Higiene e Medicina Tropical, Alumna

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PhD student researcher in Biomedical Sciences at the Institute of Hygiene and Tropical Medicine of the New University of Lisbon-Portugal, Graduated in Veterinary Medicine by the Federal University of Amazonia-Brazil, Master in Biology of Infectious and Parasitic Agents by the Federal University of Pará - Brazil (international CAPES 6). Member of the global health team of GHTM and Tropical Medicine associated to the Foundation for Science and Technology (FCT: UID / Multi / 04413/2013 ), member of the Ibero-American Network RedVLP by CYTED. Member of the Portuguese Society for Laboratory Animal Science (SPCAL). Professional experience in: Clinical Medicine, Microbiology, Zoonoses, Medical Parasitology, General Pathology, Clinical Pathology and Surgical Pathology, coaching, consulting, Zoo Design and technical management of Zoobotanical Parks, projects of commercial creation and conservation of wild animals, environmental management of fauna in situ and ex situ since 1999; Projects of Water Management and Wastewater Treatment Effluent Reuse Projects: Environmental and Landscaping Education; Environmental Monitoring and Control. External examiner, scientific evaluation, courses, supervision and Student Teacher.

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Washington L U I Z A S S U N Ç Ã O Pereira

Edilene Oliveira da Silva

Marie Lipoldova

Institute of Molecular Genetics

Carlos Roberto Alves

Sueli de Oliveira Silva

Hadida Yasmin

Anabela Cordeiro-da-silva

Universidade do Porto

Rachel BRAS-GONCALVES

Mihaela Anca DASCALU

Isis Bugia Santana

Universidade Estadual de Feira de Sanana

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Pathogenesis of canine leishmaniasis: diagnostic accuracy and experimental models targeting Leishmania lipid-bound vesicles

Academia Biology, Jan 28, 2025

Leishmania parasites often infect different host types over the course of their complex life cycl... more Leishmania parasites often infect different host types over the course of their complex life cycle, and the interspecific correlations exist between traits expressed in natural reservoirs and potential new hosts or vectors. Comparable to other eukaryotes, Leishmania release extracellular vesicles that promote crucial interactions, modulating the subsequent systemic immune response to establish host infection, which seriously affects the health of humans and pets (dogs or cats). Recent studies in endemic areas of Brazil concluded that canine leishmaniases were predominantly due to Leishmania amazonensis and not restricted to Leishmania infantum (syn. Leishmania chagasi). Under these premises, the diagnosis of canine leishmaniasis needs improvement, including the identification of the current etiological agent, clinical differential diagnosis, and histopathologic features. The study aims to achieve two main objectives: to present findings on natural canine infections and to highlight the importance of differential diagnosis in companion animals. It also seeks to investigate the role of lipids in Leishmania extracellular vesicles (LEVs) in vitro, focusing on the emerging research area that explores the mechanisms and biological aspects of parasite–host interactions. In essence, the study aims to bridge gaps in our understanding of how lipids in LEVs influence parasite–host interactions, while emphasizing the significance of accurate diagnosis in companion animals. Therefore, future studies of parasitology research for both fields are important for advancing diagnostics, prognostics, and treatments, as well as addressing the ongoing global need for prevention, control, elimination, and eradication.

Áurea Gabriel

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