Adaptive Response

Acute stress is a fundamental adaptive response which enables an organism to cope with daily threatening environmental stimuli. If prolonged and uncontrollable, the stress response may become inadequate and ultimately result in health damage. Animal models of stress in rodents indicate that both acute and chronic stressors have pronounced effects on sleep architecture and circadian rhythms. One major physiological response elicited by stress is activation of the hypothalamo-pituitary-adrenal axis. In both animals and humans, the hypothalamo-pituitary-adrenal axis plays an important role in sleep-wake regulation and in alterations of the sleep-wake cycle secondary to exposure to acute or chronic stressors. In humans, dysfunction of the neuroendocrine regulation of sleep can lead to severe sleep disturbances. The progressive decay of the hypothalamo-pituitary-adrenal axis in elderly people, which mimics chronic exposure to stress, may contribute to fragmented and unstable sleep in ageing. Shift workers, chronic insomniacs or patients suffering from mental disorders show abnormal hypothalamo-pituitary-adrenal secretory activity and concomitant sleep disturbances. Those sleep disorders and possible underlying mechanisms are briefly reviewed.

tion signals, hormones, cytokines, other mediators) that arrive through distinct pathways. Activation of the stress system leads to a cluster of time-limited behavioral and physical changes that are remarkably consistent in their qualitative presentation and collectively called the general adaptation or stress syndrome . These changes are normally adaptive and improve the chances of the individual for survival. Components of the stress syndrome are stimulated in a stressor-specific fashion; however, as the potency of the stressor increases, the specificity of the response decreases to eventually produce the relatively "nonspecific" stress syndrome.

The stress system coordinates the adaptive responses of the organism to stressors of any kind. The main components of the stress system are the corticotropin-releasing hormone (CRH) and locus ceruleus -norepinephrine (LC/NE)-autonomic systems and their peripheral effectors, the pituitary -adrenal axis, and the limbs of the autonomic system. Activation of the stress system leads to behavioral and peripheral changes that improve the ability of the organism to adjust homeostasis and increase its chances for survival. The CRH and LC/NE systems stimulate arousal and attention, as well as the mesocorticolimbic dopaminergic system, which is involved in anticipatory and reward phenomena, and the hypothalamic b-endorphin system, which suppresses pain sensation and, hence, increases analgesia. CRH inhibits appetite and activates thermogenesis via the catecholaminergic system. Also, reciprocal interactions exist between the amygdala and the hippocampus and the stress system, which stimulates these elements and is regulated by them. CRH plays an important role in inhibiting GnRH secretion during stress, while, via somatostatin, it also inhibits GH, TRH and TSH secretion, suppressing, thus, the reproductive, growth and thyroid functions. Interestingly, all three of these functions receive and depend on positive catecholaminergic input. The end-hormones of the hypothalamic -pituitary -adrenal (HPA) axis, glucocorticoids, on the other hand, have multiple roles. They simultaneously inhibit the CRH, LC/NE and b-endorphin systems and stimulate the mesocortico-limbic dopaminergic system and the CRH peptidergic central nucleus of the amygdala. In addition, they directly inhibit pituitary gonadotropin, GH and TSH secretion, render the target tissues of sex steroids and growth factors resistant to these substances and suppress the 5 0 deiodinase, which converts the relatively inactive tetraiodothyronine (T 4 ) to triiodothyronine (T 3 ), contributing further to the suppression of reproductive, growth and thyroid functions. They also have direct as well as insulin-mediated effects on adipose tissue, ultimately promoting visceral adiposity, insulin resistance, dyslipidemia and hypertension (metabolic syndrome X) and direct effects on the bone, causing ''low turnover'' osteoporosis. Central CRH, via glucocorticoids and catecholamines, inhibits the inflammatory reaction, while directly secreted by peripheral nerves CRH stimulates local inflammation (immune CRH). CRH antagonists may be useful in human pathologic states, such as melancholic depression and chronic anxiety, associated with chronic hyperactivity of the stress system, along with predictable behavioral, neuroendocrine, metabolic and immune changes, based on the interrelations outlined above. Conversely, potentiators of CRH secretion/action may be useful to treat atypical depression, postpartum depression and the fibromyalgia/chronic fatigue syndromes, all characterized by low HPA axis and LC/NE activity, fatigue, depressive symptomatology, hyperalgesia and increased immune/inflammatory responses to stimuli. D

Acute stress is a fundamental adaptive response which enables an organism to cope with daily threatening environmental stimuli. If prolonged and uncontrollable, the stress response may become inadequate and ultimately result in health damage. Animal models of stress in rodents indicate that both acute and chronic stressors have pronounced effects on sleep architecture and circadian rhythms. One major physiological response elicited by stress is activation of the hypothalamo-pituitary-adrenal axis. In both animals and humans, the hypothalamo-pituitary-adrenal axis plays an important role in sleep–wake regulation and in alterations of the sleep–wake cycle secondary to exposure to acute or chronic stressors. In humans, dysfunction of the neuroendocrine regulation of sleep can lead to severe sleep disturbances. The progressive decay of the hypothalamo-pituitary-adrenal axis in elderly people, which mimics chronic exposure to stress, may contribute to fragmented and unstable sleep in age...

Vertebrates have developed systems of immune defence enabling them to cope with the constant threat posed by environmental pathogens. The mammalian immune system represents a multilayered defence system comprising both innate and adaptive immune responses, characterized by the increasing complexity of their antigen-recognition systems. The discovery of the intimate relationship between innate and adaptive responses has paved the way to a novel understanding of the basic mechanisms governing the regulation of an immune response. The purpose of the present review is to briefly describe the basic immunological concepts that constitute the founding principles of modern vaccinology in humans.

All books in this series illustrate point-of-care testing and critically evaluate the potential of antioxidant supplementation in various medical disorders associated with oxidative stress. Future volumes will be updated as warranted by emerging new technology, or from studies reporting clinical trials.

About 150 studies exist in print, examining the use of self modeling (mostly in the video medium) in a variety of training and therapeutic applications. Evidently, two lines of thoughts have driven the development of these applications: (a) an extension of peer modeling or (b) a description of personal success. Studies report self-modeling interventions for physical skills (rehabilitation, sports), academic and vocational issues, communication, and personal and social adjustment. A wide range of ages (toddler to grandparent) and diverse developmental conditions have been addressed. The most fruitful applications may be those that emphasize the image of future success--sldlls not previously attained and adaptive responses to a challenging context. Rather than examine efficacy related to target "problems," this review identifies categories of application made possible by current knowledge and technology (e.g., use of hidden supports, selectively editing low-frequency behaviors). Seven such categories are identified and illustrated with descriptions of interventions. The evidence is used to argue for the recognition of learning from the observation of one's own successful or adaptive behavior (or images of it) as a mechanism in its own right.

Natural resource-dependent societies in developing countries are facing increased pressures linked to global climate change. While social-ecological systems evolve to accommodate variability, there is growing evidence that changes in drought, storm and flood extremes are increasing exposure of currently vulnerable populations. In many countries in Africa, these pressures are compounded by disruption to institutions and variability in livelihoods and income. The interactions of both rapid and slow onset livelihood disturbance contribute to enduring poverty and slow processes of rural livelihood renewal across a complex landscape. We explore cross-scale dynamics in coping and adaptation response, drawing on qualitative data from a case study in Mozambique. The research characterises the engagements across multiple institutional scales and the types of agents involved, providing insight into emergent conditions for adaptation to climate change in rural economies. The analysis explores local responses to climate shocks, food security and poverty reduction, through informal institutions, forms of livelihood diversification and collective land-use systems that allow reciprocity, flexibility and the ability to buffer shocks. However, the analysis shows that agricultural initiatives have helped to facilitate effective livelihood renewal, through the reorganisation of social institutions and opportunities for communication, innovation and micro-credit. Although there are challenges to mainstreaming adaptation at different scales, this research shows why it is critical to assess how policies can protect conditions for emergence of livelihood transformation.

Formal planning for climate change adaptation is emerging rapidly at a range of geo-political scales. This first generation of adaptation plans provides useful information regarding how institutions are framing the issue of adaptation and the range of processes that are recognized as being part of an adaptation response. To better understand adaptation planning among developed nations, a set of 57 adaptation plans from Australia, the United Kingdom and the United States was evaluated against a suite of 19 planning processes identified from existing guidance instruments for adaptation planning. Total scores among evaluated plans ranged from 16% of the maximum possible score to 61%, with an average of 37%. These results suggest adaptation plans are largely under-developed. Critical weaknesses in adaptation planning are related to limited consideration for non-climatic factors as well as neglect for issues of adaptive capacity including entitlements to various forms of capital needed for effective adaptation. Such gaps in planning suggest there are opportunities for institutions to make better use of existing guidance for adaptation planning and the need to consider the broader governance context in which adaptation will occur. In addition, the adaptation options prescribed by adaptation plans reflect a preferential bias toward low-risk capacity-building (72% of identified options) over the delivery of specific actions to reduce vulnerability. To the extent these findings are representative of the state of developed nation adaptation planning, there appear to be significant deficiencies in climate change preparedness, even among those nations often assumed to have the greatest adaptive capacity.

Formal planning for climate change adaptation is emerging rapidly at a range of geo-political scales. This first generation of adaptation plans provides useful information regarding how institutions are framing the issue of adaptation and the range of processes that are recognized as being part of an adaptation response. To better understand adaptation planning among developed nations, a set of 57 adaptation plans from Australia, the United Kingdom and the United States was evaluated against a suite of 19 planning processes identified from existing guidance instruments for adaptation planning. Total scores among evaluated plans ranged from 16% of the maximum possible score to 61%, with an average of 37%. These results suggest adaptation plans are largely under-developed. Critical weaknesses in adaptation planning are related to limited consideration for non-climatic factors as well as neglect for issues of adaptive capacity including entitlements to various forms of capital needed for effective adaptation. Such gaps in planning suggest there are opportunities for institutions to make better use of existing guidance for adaptation planning and the need to consider the broader governance context in which adaptation will occur. In addition, the adaptation options prescribed by adaptation plans reflect a preferential bias toward low-risk capacity-building (72% of identified options) over the delivery of specific actions to reduce vulnerability. To the extent these findings are representative of the state of developed nation adaptation planning, there appear to be significant deficiencies in climate change preparedness, even among those nations often assumed to have the greatest adaptive capacity.

Introduction. The revised version of the Temperament and Character Inventory (TCI-R), a tool designed by C. R. Cloninger for the evaluation of the seven dimensions defined in his psychobiological model of personality, was translated and adapted to Spanish. The aim of the study was to obtain normative data and scales with T-scores in a incidental sample of the general Spanish population.

This study examines adaptive responses that mental health professionals of color use to cope with racial microaggressions in their professional lives. Twenty-four mental health professionals from diverse ethnic backgrounds in the United States and Canada participated in focus groups discussing their experiences with racial microagressions and how they cope with them. Results of the analysis indicated that 8 primary coping themes illustrated strategies used by the participants. These include: identifying key issues in responding to racial microaggressions, self-care, spirituality, confrontation, support, documentation, mentoring, and collective organizing. Suggestions for mentoring professionals of color are offered.

For design problems involving computation-intensive analysis or simulation processes, approximation models are usually introduced to reduce computation time. Most approximation-based optimization methods make step-by-step improvements to the approximation model by adjusting the limits of the design variables. In this work, a new approximation-based optimization method for computation-intensive design problems * Corresponding Author Engineering Optimization, 2001, Vol. 33, pp. 707-733 2 -the adaptive response surface method (ARSM), is presented. The ARSM creates quadratic approximation models for the computation-intensive design objective function in a gradually reduced design space. The ARSM was designed to avoid being trapped by local optimum and to identify the global design optimum with a modest number of objective function evaluations. Extensive tests on the ARSM as a global optimization scheme using benchmark problems, as well as an industrial design application of the method, are presented. Advantages and limitations of the approach are also discussed.

The skin, the body's largest organ, helps to secure the integrity of the host and, at the same time, allows the individual to communicate with the outside world. This finely tuned balance between protection from harmful pathogens (mostly microorganisms) and bidirectional signal exchange is provided by a network of structural, cellular, and molecular elements that are collectively referred to as the skin barrier. This "gateway" has a physical, chemical, and immunologic component. The role of the latter is to elicit a powerful defense reaction in the case of danger and, at the same time, to prevent such a reaction against innocuous substances. Immune responses originating in the skin are mounted and executed by cells and molecules of the innate or the adaptive immune system. Innate reactions are typically rapid, poorly discriminating, and do not exhibit memory. Adaptive responses, in contrast, show a high degree of specificity as well as memory but need a protracted time for their development. As a consequence, innate and adaptive responses are consecutive events influencing each other. In fact, we now know that the type and magnitude of the innate reactions govern and often determine the quality and quantity of adaptive responses.

Lactic acid bacteria (LAB) constitute a heterogeneous group of bacteria that are traditionally used to produce fermented foods. The industrialization of food bio-transformations increased the economical importance of LAB, as they play a crucial role in the development of the organoleptique and hygienic quality of fermented products. Therefore, the reliability of starter strains in terms of quality and functional properties (important for the development of aroma and texture), but also in terms of growth performance and robustness has become essential. These strains should resist to adverse conditions encountered in industrial processes, for example during starter handling and storage (freeze-drying, freezing or spray-drying). The development of new applications such as life vaccines and probiotic foods reinforces the need for robust LAB since they may have to survive in the digestive tract, resist the intestinal flora, maybe colonize the digestive or uro-genital mucosa and express s...

The brain noradrenergic system is activated by acute stress. The post-synaptic effects of norepinephrine (NE), exerted at a cellular or neural circuit level, have been described as modulatory in nature, as NE facilitates responses evoked in target cells by both excitatory and inhibitory afferent input. Over the past few years, we have undertaken a series of studies to understand how these cellular modulatory effects of NE, elicited by acute stress, might translate into modulation of the behavioral -affective components of the whole-animal response to stress. Using microdialysis, we have demonstrated that acute immobilization stress activates NE release in a number of stress-related limbic forebrain target regions, such as the central and medial amygdala, lateral bed nucleus of the stria terminalis, medial prefrontal cortex, and lateral septum. Using microinjections of adrenergic antagonist drugs directly into these regions, we have shown that this stress-induced release of NE facilitates a number of anxiety-like behavioral responses that are mediated in these regions, including stress-induced reduction of openarm exploration on the elevated plus-maze, stress-induced reduction of social interaction behavior, and activation of defensive burying behavior by contact with an electrified probe. Dysregulation of the brain noradrenergic system may be a factor in determining vulnerability to stress-related pathology, or in the interaction of genetic vulnerability and environmental sensitization. Compared to outbred Sprague -Dawley rats, we have shown that the modulatory effect of NE is deficient in Wistar -Kyoto rats, which also exhibit attenuated behavioral reactivity to acute stress, as well as increased vulnerability to stress-induced gastric ulcers and exaggerated activation of the hypothalamic -pituitaryadrenal (HPA) stress axis. Further, repeated exposure to mild intermittent cold stress resulted in a much greater sensitization of both the brain noradrenergic system and the HPA axis in Wistar -Kyoto rats compared to Sprague -Dawley rats. The recruitment of a robust noradrenergic facilitatory influence following repeated cold exposure in this previously deficient strain resulted in an aberrant HPA response, which may be illustrative of the kinds of neurobiological changes that may contribute to the development of stress-related neuropsychiatric disorders such as depression, post-traumatic stress disorder, or other anxiety disorders in predisposed or susceptible individuals. On the other side of the same issue, regulatory alterations in noradrenergic neurotransmission, or in the stress-modulatory functions of NE, may be important in the behavioral effects of chronic antidepressant drug treatment. We present recent preliminary results addressing the effects of chronic treatment with the selective NE reuptake inhibitor, desipramine, on acute behavioral reactivity to stress. A better understanding of the role of NE in adaptive responses to acute stress, the pathological consequences of prolonged, repeated or severe stress, and the mechanisms of action of drugs used to treat stress-related diseases, may contribute to the future development of more effective strategies for the treatment or even prevention of such disorders. D

Training and nutrition are highly interrelated in that optimal adaptation to the demands of repeated training sessions typically requires a diet that can sustain muscle energy reserves. As nutrient stores (i.e. muscle and liver glycogen) play a predominant role in the performance of prolonged, intense, intermittent exercise typical of the patterns of soccer match-play, and in the replenishment of energy reserves for subsequent training sessions, the extent to which acutely altering substrate availability might modify the training impulse has been a key research area among exercise physiologists and sport nutritionists for several decades. Although the major perturbations to cellular homeostasis and muscle substrate stores occur during exercise, the activation of several major signalling pathways important for chronic training adaptations take place during the first few hours of recovery, returning to baseline values within 24 h after exercise. This has led to the paradigm that many chronic training adaptations are generated by the cumulative effects of the transient events that occur during recovery from each (acute) exercise bout. Evidence is accumulating that nutrient supplementation can serve as a potent modulator of many of the acute responses to both endurance and resistance training. In this article, we review the molecular and cellular events that occur in skeletal muscle during exercise and subsequent recovery, and the potential for nutrient supplementation (e.g. carbohydrate, fat, protein) to affect many of the adaptive responses to training.

of high resolution elevational climate models has greatly improved our capacity to characterize plant habitats and species' adaptive responses to stresses. Evidence suggests that there has been increased use of wild relatives as well as new resources resulting from mutagenesis to enhance the genetic base of legume cultigens.

A number of studies have provided quantitative assessments of the potential climate change impacts on crop production in Asia. Estimates take into account (a) uncertainty in the level of climate change expected, using a range of climate change scenarios; (b) physiological effects of carbon dioxide on the crops; and (c) different adaptive responses. In all cases, the effects of climate change induced by increased atmospheric carbon dioxide depended on the counteracting effects among higher daily evapotranspiration rates, shortening of crop growth duration, and changes in precipitation patterns, as well as the effects of carbon dioxide on crop growth and water-use efficiency. Although results varied depending on the geographical locations of the regions tested, the production of rice (the main food crop in the region) generally did not benefit from climate change. In South and Southeast Asia, there is concern about how climate change may affect El Nifio/Southern Oscillation events, since these play a key role in determining agricultural production. Furthermore, problems arising from variability of water availability and soil degradation are currently major challenges to agriculture in the region. These problems may be exacerbated in the future if global climate change projections are realized. Many studies have considered strategies for improving agricultural management, based on the optimization of crop management decisions. Climate change analyses could be further strengthened by economic studies that integrate the potential use of natural resources across sectors.

Like most of their counterparts in other social sciences, tourism researchers have traditionally focused on aspects of tourism phenomena that exhibit order, linearity and equilibrium, while eschewing situations where disorder, non-linearity and disequilibrium are more apparent. Although constructs such as the Destination Life Cycle Model demonstrate the heuristic value of this approach, it results in aspects of tourism development that are intrinsically chaotic, being overlooked. Thus, for instance, the fundamental role of entrepreneurs in destination development has received scant attention, largely because their behaviour is not readily understood in terms of the conventional analytical framework. This paper argues that the Chaos/Complexity perspective provides a potentially useful alternative framework for providing insights into the underlying dynamics of tourism development and a case study involving the examination of entrepreneurial activity on the Gold Coast in Australia is used for illustrative purposes. In this context, chaos is presented as essentially a creative process and entrepreneurs play a primary role both as chaos-makers and as initiators of adaptive responses to chaos induced by external events.

Non-prescriptional use of medicinal herbs among cancer patients is common around the world. The alleged anti-cancer effects of most herbal extracts are mainly based on studies derived from in vitro or in vivo animal experiments. The current information suggests that these herbal extracts exert their biological effect either through cytotoxic or immunomodulatory mechanisms. One of the active compounds responsible for the immune effects of herbal products is in the form of complex polysaccharides known as β-glucans. β-glucans are ubiquitously found in both bacterial or fungal cell walls and have been implicated in the initiation of anti-microbial immune response. Based on in vitro studies, β-glucans act on several immune receptors including Dectin-1, complement receptor (CR3) and TLR-2/6 and trigger a group of immune cells including macrophages, neutrophils, monocytes, natural killer cells and dendritic cells. As a consequence, both innate and adaptive response can be modulated by β-glucans and they can also enhance opsonic and non-opsonic phagocytosis. In animal studies, after oral administration, the specific backbone 1→3 linear β-glycosidic chain of β-glucans cannot be digested. Most β-glucans enter the proximal small intestine and some are captured by the macrophages. They are internalized and fragmented within the cells, then transported by the macrophages to the marrow and endothelial reticular system. The small β-glucans fragments are eventually released by the macrophages and taken up by other immune cells leading to various immune responses. However, β-glucans of different sizes and branching patterns may have significantly variable immune potency. Careful selection of appropriate β-glucans is essential if we wish to investigate the effects of β-glucans clinically. So far, no good quality clinical trial data is available on assessing the effectiveness of purified β-glucans among cancer patients. Future effort should direct at performing well-designed clinical trials to verify the actual clinical efficacy of β-glucans or β-glucans containing compounds.

To develop improved estimates of (1) #ooding due to storm surges, and (2) wetland losses due to accelerated sea-level rise, the work of is extended to a dynamic analysis. It considers the e!ects of several simultaneously changing factors, including: (1) global sea-level rise and subsidence; (2) increasing coastal population; and (3) improving standards of #ood defence (using GNP/capita as an`ability-to-paya parameter). The global sea-level rise scenarios are derived from two General Circulation Model (GCM) experiments of the Hadley Centre: (1) the HadCM2 greenhouse gas only ensemble experiment and (2) the more recent HadCM3 greenhouse gas only experiment. In all cases there is a global rise in sea level of about 38 cm from 1990 to the 2080s. No other climate change is considered. Relative to an evolving reference scenario without sea-level rise, this analysis suggests that the number of people #ooded by storm surge in a typical year will be more than "ve times higher due to sea-level rise by the 2080s. Many of these people will experience annual or more frequent #ooding, suggesting that the increase in #ood frequency will be more than nuisance level and some response (increased protection, migration, etc.) will be required. In absolute terms, the areas most vulnerable to #ooding are the southern Mediterranean, Africa, and most particularly, South and South-east Asia where there is a concentration of low-lying populated deltas. However, the Caribbean, the Indian Ocean islands and the Paci"c Ocean small islands may experience the largest relative increase in #ood risk. By the 2080s, sea-level rise could cause the loss of up to 22% of the world's coastal wetlands. When combined with other losses due to direct human action, up to 70% of the world's coastal wetlands could be lost by the 2080s, although there is considerable uncertainty. Therefore, sea-level rise would reinforce other adverse trends of wetland loss. The largest losses due to sea-level rise will be around the Mediterranean and Baltic and to a lesser extent on the Atlantic coast of Central and North America and the smaller islands of the Caribbean. Collectively, these results show that a relatively small global rise in sea level could have signi"cant adverse impacts if there is no adaptive response. Given the`commitment to sea-level risea irrespective of any realistic future emissions policy, there is a need to start strategic planning of appropriate responses now. Given that coastal #ooding and wetland loss are already important problems, such planning could have immediate bene"ts.

Radiobiologists have been struggling to estimate the health risks from low doses of radiation in humans for decades. Health risks involve not only neoplastic diseases but also somatic mutations that may contribute to other illnesses (including birth defects and ocular maladies) and heritable mutations that may increase the risk of diseases in future generations. Low dose radiation-induced cancer in humans depends on several variables, and most of these variables are not possible to correct for in any epidemiologic study. Some of the confounding factors include (i) interaction of radiation with other physical (UV light), chemical, and biological mutagens and carcinogens in a synergistic manner; (ii) variation in repair mechanisms that depend on dose; (iii) variation in sensitivity of bystander cells to subsequent radiation exposure that depends on whether they have been pre- or postirradiated; and (iv) variation in adaptive response that depends on radiation doses and protective subs...

The frontostriatal system (dorsolateral prefrontal cortex, lateral orbitofrontal cortex, anterior cingulate, supplementary motor area, and associated basal-ganglia structures) is subject to a range of neurodevelopmental disorders: Tourette's syndrome (TS), obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), schizophrenia (SCZ), autism, and probably depression. The system is responsible for our adaptive responses (initiation, execution, or withholding) to environmental situations, and the above disorders, involving effectively excessive release or withholding of various types of response, are all a consequence of changes in specific frontostriatal regions. The disorders all have a genetic component, and their persistence in the genome indicates that their clinical manifestations may also be associated, perhaps in low levels in close relatives, with certain adaptive advantages in given situations. Thus autism is associated with computational careers, depression with literary creativity, SCZ with lateral thinking and the Odyssean personality, ADHD with an Ice-Age readiness to respond, OCD with a focused range of interests, and TS with competitive sports and jazz improvisation. The disorders are all highly comorbid, and which one predominantly manifests may depend on how the frontostriatal system happens to be compromised as a result of inherited genetic predispositions and environmental contingency. We review the adaptive nature of the various subclinical manifestations and the evidence for concomitant phenomena (possibly epiphenomena): alterations in structural, functional, and behavioral lateralization in each syndrome. Indeed it is not clear that altered lateralization in frontostriatal disorders of a neurodevelopmental origin generally has any adaptive significance; it may often simply serve as a marker for altered regulatory function of the frontostriatal system, alterations which in low genetic dosage or penetrance continue to play an adaptive role in clinically unaffected close relatives of probands, but which, in high dosage or penetrance in the probands themselves, are generally deleterious.

India has reasons to be concerned about climate change. Over 650 million people depend on climate-sensitive sectors, such as rain-fed agriculture and forestry, for livelihood and over 973 million people are exposed to vector borne malarial parasites. Projection of climatic factors indicates a wider exposure to malaria for the Indian population in the future. If precautionary measures are not taken and development processes are not managed properly some developmental activities, such as hydro-electric dams and irrigation canal systems, may also exacerbate breeding grounds for malaria. This article integrates climate change and developmental variables in articulating a framework for integrated impact assessment and adaptation responses, with malaria incidence in India as a case study. The climate change variables include temperature, rainfall, humidity, extreme events, and other secondary variables. Development variables are income levels, institutional mechanisms to implement preventive measures, infrastructure development that could promote malarial breeding grounds, and other policies. The case study indicates that sustainable development variables may sometimes reduce the adverse impacts on the system due to climate change alone, while it may sometimes also exacerbate these impacts if the development variables are not managed well and therefore they produce a negative impact on the system. The study concludes that well crafted and well managed developmental policies could result in enhanced resilience of communities and systems, and lower health impacts due to climate change.

Aim. Vibration exercise is a novel exercise intervention, which is applied in athletes and general populations with the aim of improving strength and power performance. The present study was aimed to analyse the adaptive responses to different whole body vibration frequencies.

A year-long field study of the thermal environment in university classrooms was conducted from March 2005 to May 2006 in Chongqing, China. This paper presents the occupants' thermal sensation votes and discusses the occupants' adaptive response and perception of the thermal environment in a naturally conditioned space. Comparisons between the Actual Mean Vote (AMV) and Predicted Mean Vote (PMV) have been made as well as between the Actual Percentage of Dissatisfied (APD) and Predicted Percentage of Dissatisfied (PPD). The adaptive thermal comfort zone for the naturally conditioned space for Chongqing, which has hot summer and cold winter climatic characteristics, has been proposed based on the field study results. The Chongqing adaptive comfort range is broader than that of the ASHRAE Standard 55-2004 in general, but in the extreme cold and hot months, it is narrower. The thermal conditions in classrooms in Chongqing in summer and winter are severe. Behavioural adaptation such as changing clothing, adjusting indoor air velocity, taking hot/cold drinks, etc., as well as psychological adaptation, has played a role in adapting to the thermal environment.

The intimate connection, both physical and biochemical, between blood vessels and bone cells has long been recognized. Genetic, biochemical, and pharmacological studies have identified and characterized factors involved in the conversation between endothelial cells (EC) and osteoblasts (OB) during both bone formation and repair. The longawaited FDA approval of two growth factors, BMP-2 and OP-1, with angiogenic and osteogenic activity confirms the importance of these two processes in human skeletal healing. In this review, the role of osteogenic factors in the adaptive response and interactive function of OB and EC during the multi-step process of bone repair will be discussed.

Endurance exercise induces increases in mitochondria and the GLUT4 isoform of the glucose transporter in muscle. Although little is known about the mechanisms underlying these adaptations, new information has accumulated regarding how mitochondrial biogenesis and GLUT4 expression are regulated. This includes the findings that the transcriptional coactivator PGC-1 promotes mitochondrial biogenesis and that NRF-1 and NRF-2 act as transcriptional activators of genes encoding mitochondrial enzymes. We tested the hypothesis that increases in PGC-1, NRF-1, and NRF-2 are involved in the initial adaptive response of muscle to exercise. Five daily bouts of swimming induced increases in mitochondrial enzymes and GLUT4 in skeletal muscle in rats. One exercise bout resulted in ϳ twofold increases in full-length muscle PGC-1 mRNA and PGC-1 protein, which were evident 18 h after exercise. A smaller form of PGC-1 increased after exercise. The exercise induced increases in muscle NRF-1 and NRF-2 that were evident 12 to 18 h after one exercise bout. These findings suggest that increases in PGC-1, NRF-1, and NRF-2 represent key regulatory components of the stimulation of mitochondrial biogenesis by exercise and that PGC-1 mediates the coordinated increases in GLUT4 and mitochondriations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J. 16, 1879 -1886 (2002)

Contemplation of death increases support of ingroup ideologies, a result explained by proponents of terror management theory (TMT) as an attempt to buffer existential anxiety. While TMT claims that only death-salient stimuli yield such effects, an evolutionary perspective suggests that increased intergroup bias may occur in response to a wide variety of situations that, in ancestral environments, posed adaptive problems for which marshaling social support was a reliably adaptive response. Four experiments from two cultures produced results consistent with this latter perspective but contrary to TMT. Studies 1 and 2 demonstrated that, among UCLA undergraduates, participants asked to contemplate aversive scenarios unrelated to death displayed increased support of ingroup ideology. Studies 3 and 4 replicated elements of these results, exploring the moderating effects of self-esteem and collectivism on intergroup bias in two Costa Rican samples. These results indicate that worldview defense effects occur even when death is not salient.

The Cambrian explosion is probably the most spectacular diversification in evolutionary history, and understanding it has been a challenge for biologists since the time of Darwin. We propose that one of the key factors that drove this great diversification was associative learning. Although the evolutionary emergence of associative learning required only small modifications in already existing memory mechanisms and may have occurred in parallel in several groups, once this type of learning appeared on the evolutionary scene, it led to extreme diversifying selection at the ecological level: it enabled animals to exploit new niches, promoted new types of relations and arms races, and led to adaptive responses that became fixed through genetic accommodation processes. This learning-based diversification was accompanied by neurohormonal stress, which led to an ongoing destabilization and re-patterning of the epigenome, which, in turn, enabled further morphological, physiological, and behavioral diversification. Our hypothesis combines several previous ideas about the dynamics of the Cambrian explosion and provides a unifying framework that includes both ecological and genomic factors. We conclude by suggesting research directions that would clarify the timing and manner in which associative learning evolved, and the effects it had on the evolution of nervous systems, genomes, and animal morphology.

Ischemia has been an inevitable event accompanying the procedure of kidney transplantation. Ischemic changes start with brain death which is associated with severe homodynamic disturbances: increasing intracranial pressure results in bradycardia and decrease in cardiac output; Cushing reflex causes tachycardia and increase of blood pressure, and after short period of stabilization, systemic vascular resistance declines with hypotension leading to cardiac arrest. Free radical mediated injury occurs and release of pro-inflammatory cytokines and activation of the innate immunity develops. It has been is suggested that all of these changes -the early innate response and the ischemic tissue damage play a role in development of adaptive response which in turn may lead to acute kidney rejection, Hypothermic kidney storage of various duration before transplantation adds to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion. Reperfusion injury, as an effector phase of ischemic injury, develops hours or days after initial insult. Repair and regeneration process occur along with cellular apoptosis, autophagy and necrosis, and the fate of the organ depends on whether cell death or regeneration prevails. The whole process has been described as the ischemia/reperfusion injury. It has profound influence not only on the early, but also late function of the transplanted kidney. Prevention of I/R injury should be started before recovery of the organs (donor pretreatment).

Developing appropriate responses to address and prevent surface water flooding requires an analysis of interactions between elements of a risk framework encompassing hazard, vulnerability and exposure. This paper explores the spatial distribution of surface water flooding, the vulnerability of communities to flooding, and the characteristics of physical environment and land use that affect people's exposure to flooding, particularly concerning green cover in Greater Manchester, UK. A set of 26 indicators known to influence the vulnerability of people to flooding was identified for spatial census units in Greater Manchester, and simplified with Principal Component Analysis to four underlying factors relating to material situation, diversity of communities and high proportion of children or elderly in the population. This was followed by an analysis of the presence and spatial distribution of surface water flooding areas, land use types, green cover and housing. Finally, the spatial associations between hazard, vulnerability and exposure were analysed. The results indicate that some of the most vulnerable people in Greater Manchester, namely the culturally diverse and materially deprived communities, are at high risk of flooding due to a convergence of factors related to socio-economic characteristics of the population, spatial distribution of the hazard, and the land use and housing types present in the area. Some adaptation responses tailored to the characteristics of the community and the environment they live in are discussed.