Hyperinsulinemia

Animal source foods (ASF) are essential for proper human development and function. Livestock in general, and ruminants in particular, are essential components of our sustainable global food systems. Of significant worldwide impact, diets with higher-than-recommended levels of ASF can correct the symptoms of metabolic illnesses, offering hope in arresting the current worldwide epidemic of diabetes and other metabolic diseases. Most dietary policy and recommendations are based on the ill-founded belief that plant-based, high-carbohydrate diets are “healthy.” High-quality scientific evidence does not support the belief that vegetarian diets are healthier than omnivorous or animal-based diets. A Therapeutic Carbohydrate Reduction (TCR) lifestyle approach has demonstrated its efficacy in reversing Insulin Resistance (IR) and the non-communicable diseases associated with, or caused, by it. True sustainability is a multifaceted topic consisting of societal, economic, and ecological aspects...

Compensatory hyperinsulinemia stemming from peripheral insulin resistance is a well-recognized metabolic disturbance that is at the root cause of diseases and maladies of Syndrome X (hypertension, type 2 diabetes, dyslipidemia, coronary artery disease, obesity, abnormal glucose tolerance). Abnormalities of fibrinolysis and hyperuricemia also appear to be members of the cluster of illnesses comprising Syndrome X. Insulin is a well-established growth-promoting hormone, and recent evidence indicates that hyperinsulinemia causes a shift in a number of endocrine pathways that may favor unregulated tissue growth leading to additional illnesses. Specifically, hyperinsulinemia elevates serum concentrations of free insulin-like growth factor-1 (IGF-1) and androgens, while simultaneously reducing insulin-like growth factor-binding protein 3 (IGFBP-3) and sex hormone-binding globulin (SHBG). Since IGFBP-3 is a ligand for the nuclear retinoid X receptor a, insulin-mediated reductions in IGFBP-3 may also influence transcription of anti-proliferative genes normally activated by the body's endogenous retinoids. These endocrine shifts alter cellular proliferation and growth in a variety of tissues, the clinical course of which may promote acne, early menarche, certain epithelial cell carcinomas, increased stature, myopia, cutaneous papillomas (skin tags), acanthosis nigricans, polycystic ovary syndrome (PCOS) and male vertex balding. Consequently, these illnesses and conditions may, in part, have hyperinsulinemia at their root cause and therefore should be classified among the diseases of Syndrome X. ᮊ

Animal source foods (ASF) are essential for proper human development and function. Livestock in general, and ruminants in particular, are essential components of our sustainable global food systems. Of significant worldwide impact, diets with higher-than-recommended levels of ASF can correct the symptoms of metabolic illnesses, offering hope in arresting the current worldwide epidemic of diabetes and other metabolic diseases. Most dietary policy and recommendations are based on the ill-founded belief that plant-based, highcarbohydrate diets are "healthy." High-quality scientific evidence does not support the belief that vegetarian diets are healthier than omnivorous or animal-based diets. A Therapeutic Carbohydrate Reduction (TCR) lifestyle approach has demonstrated its efficacy in reversing Insulin Resistance (IR) and the noncommunicable diseases associated with, or caused, by it. True sustainability is a multifaceted topic consisting of societal, economic, and ecological aspects. The enormous suffering and financial costs of chronic illness must be acknowledged. The production of high-quality animal protein and animal fat by ruminants from feed resources humans cannot directly utilize will be fundamental to feeding a growing population. This essential food production can preserve and enhance the diverse environments where it takes place. We need a revolution in our thinking of what constitutes a healthy diet, of what causes chronic illness, of the vital role that animal product play in the human diet, and the essential nature of ruminant animal agriculture in meeting humanity's needs. This will mean overthrowing established policies and institutions, and confronting vested belief systems. We'll need an effort, analogous to the Green Revolution, to develop and deploy the knowledge and technology necessary to meet the needs of the mid-21st Century world.

Numerous studies have documented a strong association between diabetes and Alzheimer's disease (AD). The nature of the relationship, however, has remained a puzzle, in part because of seemingly incongruent findings. For example, some studies have concluded that insulin deficiency is primarily at fault, suggesting that intranasal insulin or inhibiting the insulin-degrading enzyme (IDE) could be beneficial. Other research has concluded that hyperinsulinemia is to blame, which implies that intranasal insulin or the inhibition of IDE would exacerbate the disease. Such antithetical conclusions pose a serious obstacle to making progress on treatments. However, careful integration of multiple strands of research, with attention to the methods used in different studies, makes it possible to disentangle the research on AD. This integration suggests that there is an important relationship between insulin, IDE, and AD that yields multiple pathways to AD depending on the where deficiency or excess in the cycle occurs. I review evidence for each of these pathways here. The results suggest that avoiding excess insulin, and supporting robust IDE levels, could be important ways of preventing and lessening the impact of AD. I also describe what further tests need to be conducted to verify the arguments made in the paper, and their implications for treating AD. Alzheimer's disease (AD) is a devastating, fatal disease that affects an estimated 5.2 million Ameri-cans, and 44 million people worldwide. It is a disease that is often harder on the families and caregivers of the patient than on the patient themselves. The direct costs to the US of AD in 2014 were estimated to total $214 billion [1]. Adding in the informal costs (the costs of family members and friends providing

Insulin resistance (IR) is a complex trait with multiple genetic and environmental components. Confounded by large differences between the sexes, environment, and disease pathology, the genetic basis of IR has been difficult to dissect. Here we examine IR and related traits in a diverse population of more than 100 unique male and female inbred mouse strains after feeding a diet rich in fat and refined carbohydrates.
Our results show dramatic variation in IR among strains of mice and widespread differences between sexes that are dependent on genotype. We uncover more than 15 genome-wide significant loci and validate a gene, Agpat5, associated with IR. We also integrate plasma metabolite levels and global gene
expression from liver and adipose tissue to identify metabolite quantitative trait loci (mQTL) and expression QTL (eQTL), respectively. Our results provide a resource for analysis of interactions between diet, sex, and genetic background in IR.

It is time we realize that food is a form of healthcare and promote a proper human dietary lifestyle. What is normal for one person may be poison for another. Being and getting healthy should not be predicated by any disease or infection that is out there. We human beings, who have been living with microbes in and on us, should not be afraid of the bug of the day. Whatever we do to survive as a human, depends on complex interactions of each one's immune system with their own environment and how their unique genetic system interacts with epigenetic mechanisms with food, being the biggest influence. The interaction between multiple factors (environment, lifestyle, genetic/epigenetics, microbiome, lipidology, and immunology) predispose or protect one from acute or chronic disease processes and nutrition is the most important stimulation human genes get influenced by. (Figure 1) The current mass medicine mindset helps with population-based theory generation, but the real solutions must be based on the N=1 personalized approach-if we have to fight the bug of the day. The dietary lifestyle one follows has a lot to do with the outcome of a disease process. We have known for many years that people with metabolic syndrome and chronic diseases are the ones who suffer from complications of infections. This is observed when patients with different age groups get a viral infection. Patients affected by influenza

Adrenal incidentalomas are incidentally discovered adrenal masses greater than one centimeter in diameter. An association between insulin resistance and adrenal incidentalomas has been established. However, the pathophysiological link between these two conditions remains incompletely characterized. This review examines the literature on the interrelationship between insulin resistance and adrenal masses, their subtypes, and related pathophysiology. Some studies show that functional and non-functional adrenal masses elicit systemic insulin resistance, whereas others conclude the inverse. Insulin resistance, hyperinsulinemia, and the anabolic effects on adrenal gland tissue, which have insulin and insulin-like growth factor-1 receptors, offer possible pathophysiological links. Conversely, autonomous adrenal cortisol secretion generates visceral fat accumulation and insulin resistance. Further investigation into the mechanisms and timing of these two pathologies as they relate to one a...