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Origin and history of vain
vain(adj.)
c. 1300, vein, "having no value or importance;" also "idle, unprofitable, fruitless, producing no good result;" from Old French vain, vein "worthless, void, invalid, feeble; conceited" (12c.), from Latin vanus "empty, void," figuratively "idle, fruitless" (from suffixed form of PIE root *eue- "to leave, abandon, give out").
By late 14c. in reference to persons, "silly, idle, foolish;" the meaning "conceited, proud of petty things or trifling attainments" is recorded by 1690s. The phrase in vain "to no effect" (c. 1300, after Latin in vanum) preserves the older sense. Related: Vainly; vainness. Compare also vainglory.
In Middle English also sometimes with the classical literal sense "empty, vacant;" Wycliffe (1382) in Genesis has Þe erþ was veyn withinne and voyde.
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