Alpha-5 beta-1
α5β1 is an integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis.[1] It is composed of α5 (ITGA5/CD49e) and β1 (ITGB1/CD29) subunits. It is the primary receptor for fibronectin. The interaction of VLA-5 with fibronectin plays an important role in regulating inflammatory cytokine production by human articular chondrocytes (From the Cell Migration Gateway ITGA5 ITGB1).
α5β1-integrin is transported inside the cell by the kinesin KIF1C,[2] a kinesin-3 organelle transporter that walks along microtubules.
References
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<references />, or <references group="..." />External links
- Integrin alpha5beta1 at the US National Library of Medicine Medical Subject Headings (MeSH)
- ITGA5 ITGB1 Info with links in the Cell Migration Gateway
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