ITGA5

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.[1]

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[2]

Interactions

ITGA5 has been shown to interact with GIPC1.[3]

See also

References

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Further reading

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External links


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