Doravirine
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File:Doravirine structure.svg | |
Systematic (IUPAC) name | |
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3-Chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydro-3-pyridinyl}oxy)benzonitrile
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Clinical data | |
Legal status |
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Routes of administration |
Oral[1] |
Identifiers | |
CAS Number | 1338225-97-0 |
ATC code | none |
PubChem | CID: 58460047 |
ChemSpider | 28424197 |
UNII | 913P6LK81M |
KEGG | D10624 |
ChEMBL | CHEMBL2364608 |
Synonyms | MK-1439 |
PDB ligand ID | 2KW (PDBe, RCSB PDB) |
Chemical data | |
Formula | C17H11ClF3N5O3 |
Molecular mass | 425.75 g/mol |
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Doravirine (MK-1439) is a non-nucleoside reverse transcriptase inhibitor under development by Merck & Co. for use in the treatment of HIV/AIDS. Doravirine demonstrated robust antiviral activity and good tolerability in a small clinical study of 7-day monotherapy reported at the 20th Conference on Retroviruses and Opportunistic Infections in March 2013. Doravirine appeared safe and generally well-tolerated with most adverse events being mild-to-moderate.[2][3]
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Safety and Antiviral Activity of MK-1439, a Novel NNRTI, in Treatment-naïve HIV+ Patients. Gathe, Joseph et al. 20th Conference on Retroviruses and Opportunistic Infections. 3–6 March 2013. Abstract 100.
- ↑ CROI 2013: MK-1439, a Novel HIV NNRTI, Shows Promise in Early Clinical Trials. Highleyman, Liz. HIVandHepatitis.com. 6 March 2013.
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