Fluvastatin
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Systematic (IUPAC) name | |
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(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
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Clinical data | |
Trade names | Lescol |
AHFS/Drugs.com | monograph |
MedlinePlus | a694010 |
Pregnancy category |
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Legal status | |
Routes of administration |
Oral |
Pharmacokinetic data | |
Bioavailability | 30%[1] |
Protein binding | >98%[1] |
Metabolism | Hepatic (CYP2C9 (75%), CYP2C8 (5%), CYP3A4 (20%))[1][2] |
Biological half-life | 1-3 hours (capsule), 9 hours (XR)[1][2] |
Excretion | Faeces (95%), urine (5%)[1] |
Identifiers | |
CAS Number | 93957-54-1 |
ATC code | C10AA04 (WHO) |
PubChem | CID: 446155 |
IUPHAR/BPS | 2951 |
DrugBank | DB01095 |
ChemSpider | 393587 |
UNII | 4L066368AS |
KEGG | D07983 |
ChEBI | CHEBI:38565 |
ChEMBL | CHEMBL1078 |
Chemical data | |
Formula | C24H26FNO4 |
Molecular mass | 411.466 g/mol |
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Fluvastatin (trade names Lescol, Canef, Vastin) is a member of the drug class of statins, used to treat hypercholesterolemia and to prevent cardiovascular disease.
It has also been shown to exhibit antiviral activity against hepatitis C in a study with 31 patients. This effect has been described as modest, variable, and often short-lived by the authors.[3]
References
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