Haloacetate dehalogenase

haloacetate dehalogenase
Identifiers
EC number	3.8.1.3
CAS number	Template:CAS
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a haloacetate dehalogenase (EC 3.8.1.3) is an enzyme that catalyzes the chemical reaction

haloacetate + H₂O $\rightleftharpoons$ glycolate + halide

Thus, the two substrates of this enzyme are haloacetate and H₂O, whereas its two products are glycolate and halide.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is haloacetate halidohydrolase. This enzyme is also called monohaloacetate dehalogenase. This enzyme participates in gamma-hexachlorocyclohexane degradation and 1,2-dichloroethane degradation.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1Y37.