Interleukin 29

Interferon, lambda 1
250px Rendering based on PDB 3OG4.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3OG4, 3OG6
Identifiers
Symbols	IFNL1 ; IL-29; IL29
External IDs	OMIM: 607403 HomoloGene: 131189 GeneCards: IFNL1 Gene
Gene ontology Molecular function • receptor binding • cytokine activity • interleukin-28 receptor binding Cellular component • extracellular region • extracellular space • intracellular • interleukin-28 receptor complex Biological process • negative regulation of type 2 immune response • JAK-STAT cascade • negative regulation of cell proliferation • negative regulation of interleukin-13 production • negative regulation of interleukin-5 production • positive regulation of interferon-gamma production • positive regulation of tyrosine phosphorylation of STAT protein • negative regulation of memory T cell differentiation • innate immune response • positive regulation of MHC class I biosynthetic process • negative regulation of T cell differentiation • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of JAK-STAT cascade • positive regulation of immune response • defense response to virus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	282618	n/a
Ensembl	ENSG00000182393	n/a
UniProt	Q8IU54	n/a
RefSeq (mRNA)	NM_172140	n/a
RefSeq (protein)	NP_742152	n/a
Location (UCSC)	Chr 19: 39.3 – 39.3 Mb	n/a
PubMed search	[1]	n/a

Interleukin-29 (IL-29) is a protein that in humans is encoded by the IL29 gene that resides on chromosome 19.

IL-29 is a member of the helical cytokine family and is a type III interferon. It is also known as IFNλ1 and is highly similar in amino acid sequence to the IL-28, the other type III interferon. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL29 is not present in the mouse genome.