XCL1
From Infogalactic: the planetary knowledge core
| chemokine (C motif) ligand 1, lymphotactin | |
|---|---|
| Identifiers | |
| Symbol | XCL1 |
| Alt. symbols | SCYC1, LTN, LPTN, ATAC, SCM-1a, SCM-1 |
| Entrez | 6375 |
| HUGO | 10645 |
| OMIM | 600250 |
| RefSeq | NM_002995 |
| UniProt | P47992 |
| Other data | |
| Locus | Chr. 1 q24.2 |
Chemokine (C motif) ligand (XCL1) is a small cytokine belonging to the XC chemokine family that is also known as lymphotactin. It is found in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary. Cellular sources for XCL1 include activated thymic and peripheral blood CD8+ T cells.[1][2][3] This chemokine attracts T cells. In humans, XCL1 is closely related to another chemokine called XCL2, whose gene is found at the same locus on chromosome 1.[3] XCL1 induces it chemotactic function by binding to a chemokine receptor called XCR1.[4]
Lymphotactin, LTN, is found in two states: a monomer at 10 °C, LTN10, and a dimer at 40 °C, LTN40.[5]
References
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