Naltalimide
Systematic (IUPAC) name | |
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2-[(5α,6β)-17-(Cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-yl]-1H-isoindole-1,3(2H)-dione
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Identifiers | |
CAS Number | 160359-68-2 |
ATC code | None |
PubChem | CID: 16066809 |
ChemSpider | 17226389 |
Chemical data | |
Formula | C28H28N2O5 |
Molecular mass | 472.532 g/mol |
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Naltalimide (INN) (code name TRK-130, formerly TAK 363) is a novel, centrally-acting opioid drug which is under development by Takeda and Toray for the treatment of overactive bladder/urinary incontinence.[1][2] It acts as a potent and selective partial agonist of the μ-opioid receptor (Ki = 0.268 nM, EC50 = 2.39 nM, Emax = 66.1%) over the δ-opioid (Ki = 121 nM, EC50 = 26.1 nM, Emax = 71.0%) and κ-opioid receptors (Ki = 8.97 nM, EC50 = 9.51 nM, Emax = 62.6%).[1] Notably, naltalimide somehow appears to lack certain undesirable side effects such as constipation seen with other μ-opioid receptor agonists such as morphine.[1] It enhances bladder storage via suppression of the afferent limb of the micturition reflex pathway.[1]
References
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- Isoindoles
- Morphinans
- Mu-opioid agonists
- Phthalimides
- Takeda Pharmaceutical Company
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