Zenazocine

Zenazocine
Systematic (IUPAC) name
	1-[(1S,9R)-4-hydroxy-1,10,13-trimethyl-10-azatricyclo[7.3.1.02,7]trideca-2,4,6-trien-13-yl]-6-methyl-3-heptanone
Clinical data
Legal status	Non-regulated;
Identifiers
CAS Number	74559-85-6
ATC code	None
PubChem	CID: 9885108
ChemSpider	8060782
Chemical data
Formula	C23H35NO2
Molecular mass	357.530 g/mol
	SMILES O=C(CCC(C)C)CCC3([C@@H]2N(CC[C@]3(c1c(ccc(O)c1)C2)C)C)C ;
	InChI InChI=1S/C23H35NO2/c1-16(2)6-8-18(25)10-11-23(4)21-14-17-7-9-19(26)15-20(17)22(23,3)12-13-24(21)5/h7,9,15-16,21,26H,6,8,10-14H2,1-5H3/t21-,22+,23?/m1/s1 ; Key:JZFZEWWOIOYBTQ-AXWGZAFASA-N ;

Zenazocine (INN; WIN-42,964) is an opioid analgesic of the benzomorphan family which made it to phase II clinical trials before development was ultimately halted and it was never marketed.^[1]^[2] It acts as a partial agonist of the μ- and δ-opioid receptors, with less intrinsic activity at the former receptor and more at the latter receptor (hence, it behaves more antagonistically at the former and more agonistically at the latter), and produces antinociceptive effects in animal studies.^[1]

References