Nitric oxide synthase 2 (inducible)

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene.[1]

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in the liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[2]

Interactions

Nitric oxide synthase 2A has been shown to interact with Caveolin 1[3] and Rac2.[4]

References

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