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Understanding vertebrate immunity through comparative immunology

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Volume 25 Issue 2
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  • Poster

    This poster from Nature Reviews Immunology and Nature Reviews Cancer illustrates approaches in four main categories — targeting effector T cells, innate immune and regulatory cells, the tumour microenvironment and stromal cells, and cancer cells — that could be combined with PD1 axis blockade to provide cooperative or synergistic clinical benefit.

  • Are you an early career researcher (ECR) who is working with a cool tool or method? Would you like others to learn about it? Let us know! We recently introduced Tools of the Trade articles to showcase the role of ECRs in driving technological advancements in immunology. Email us at nri@nature.com the method/tool you'd like to write about and why it's important.

  • A regularly updated list of upcoming immunology conferences, including virtual meetings

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Latest Reviews & Analysis

    • HIV infection persists under antiretroviral therapy due to a reservoir of latently infected cells. This Perspective discusses how host immune responses might affect the establishment and persistence of the viral reservoir, an understanding of which supports the development of immune-based approaches to ‘cure’ HIV infection by disrupting the reservoir.

      • Deanna A. Kulpa
      • Mirko Paiardini
      • Guido Silvestri
      Perspective

    • B cells are major drivers of systemic immunity, but they also act locally in non-lymphoid organs. This Review highlights new insights into mechanisms of tissue B cell function as well as efforts to leverage this biology for immunotherapy.

      • Abrar Samiea
      • George Celis
      • Joshua M. Moreau
      Review Article

    • The peripheral immune system communicates with the brain through diverse anatomical routes to shape brain physiology. Here we discuss why such diversity is needed and explore how these routes are leveraged during development and hijacked in ageing.

      • Mariángeles Kovacs
      • Amaia Dominguez-Belloso
      • Aleksandra Deczkowska
      Perspective

    • Besides its beneficial effects against infection, trained immunity has recently been implicated in inflammation-related disorders and is being exploited in cancer immunotherapy. These advances may enable the development of therapeutic interventions to modulate trained immunity towards promoting human health.

      • George Hajishengallis
      • Mihai G. Netea
      • Triantafyllos Chavakis
      Review Article

    • Kidney diseases affect millions globally. Advances in understanding immunological mechanisms and disease endotypes have enhanced diagnostic accuracy and treatment strategies. Here, the authors review our current understanding of immune mechanisms of kidney disease and highlight the interplay between renal and systemic immunity.

      • Christian Kurts
      • Sibylle von Vietinghoff
      • Ulf Panzer
      Review Article

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Neuroimmune connections

Neuroimmunology

A Series of articles published in Nature Reviews Immunology focusing on connections between the immune system and nervous system.
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