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Autoimmune diseases are a pathophysiological state wherein immune responses are directed against, and damage, the body's own tissues (autoimmunity). Common examples of autoimmune disease include type 1 diabetes, rheumatoid arthritis, multiple sclerosis and psoriasis.
The induction of autoimmune symptoms may require both endogenous and exogenous cues. Here the authors show that a single nucleotide polymorphism in the NCF1 gene, NCF1R90H, known to be associated with systemic lupus erythematosus synergizes with mouse norovirus virus infection to promote interferon and toll-like receptor signaling to cause lupus symptoms in mice.
The authors show that terminally differentiated colonic Treg cells are required for maintaining colonic health and, although these cells are major producers of this cytokine, IL-10 is dispensable for their suppressive function.
Systemic lupus erythematosus (SLE) is an autoimmune disease with considerable clinical heterogeneity and diverse treatment options. A study now shows that heightened extrafollicular B cells and anti-BAFF therapy are linked to inferior responses to COVID-19 vaccines.
Synovial dendritic cell profiles and localization patterns provide insights about the roles of dendritic cell subsets in the initiation, remission and relapse of rheumatoid arthritis.
The release of TGFβ by a subset of ITGA5+ synovial fibroblasts can promote the differentiation of pathogenic PD-1hiCXCL13+ T cells in RA, altering the inflammatory niche.
A preprint by Villar-Vesga et al. shows that monocyte-derived cells in the central nervous system produce mitochondrial reactive oxygen species to promote neuroinflammation.
