Histologi Pleura

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PLEURA The lung's outer surface and the internal wall of the thoracic cavity are covered by a serous

membrane called the pleura The two layers are continuous at the hilum and are both composed of simple squamous mesothelial cells on a thin connective tissue layer containing collagen and elastic fibers. Mesothelial cell contain microvilli on their surface. Th e microvilli are present over the entire pleural surface Function of the microvilli is not completely certain, it appears that they enmesh glycoproteins (such as hyaluronic acid) to reduce friction between the parietal and visceral surfaces The elastic fibers of the visceral pleura are continuous with those of the pulmonary parenchyma. The narrow pleural cavity (Figure 1718) between the parietal and visceral layers is entirely lined with mesothelial cells that normally produce a thin film of serous fluid (pleural fluid) that acts as a lubricant, facilitating the smooth sliding of one surface over the other during respiratory movements. It is estimated that 0.10.2 mL/kg of low protein fluid is normally present between layers. Th e cells present in normal pleural fluid are mainly macrophages, monocytes, and mesothelial cells, although lymphocytes and neutrophils may also be present. Pleural fluid typically contains fewer than 1000 cells/mL. In certain pathologic states, the pleural cavity may contain liquid or air. Like the walls of the peritoneal and pericardial cavities, the serosa of the pleural cavity is quite permeable to water and fluid exuded from blood plasma commonly accumulates (as a pleural effusion) in this cavity under abnormal conditions.

simple squamous mesothelium (M) on a thin layer of connective tissue, as shown here for visceral pleura covering alveoli (A). The connective tissue is rich in both collagen and elastic fibers and contains both blood vessels (V) and lymphatics (L), nerve Blood vessels and lymphatic vessels course throughout the connective tissue and are important in the dynamics of liquid formation and resorption in the pleural space.

On the parietal but not the visceral pleural surface, openings called stomata are located between the mesothelial cells. Each stoma leads to lymphatic channels, allowing a passageway for liquid from the pleural space to the lymphatic system

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