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    Aim: Requirement: Reference: Formula:: Ingrediants Formula For One Tablet Formula For 20 Tablets

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    kjghlkdfjg
    This document provides the formula and procedure for making metformin tablets through wet granulation. It lists the ingredients needed to make one tablet or 20 tablets including metformin, lactose, starch, isopropyl alcohol, talc, magnesium stearate and aerosil. The procedure involves accurately weighing ingredients, mixing metformin and lactose, adding isopropyl alcohol to form granules, drying the granules, adding additional ingredients and compressing into tablets. The tablets are then evaluated based on weight variation, hardness, friability and dissolution over 60 minutes.

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    Aim: Requirement: Reference: Formula:: Ingrediants Formula For One Tablet Formula For 20 Tablets

    Uploaded by

    kjghlkdfjg
    40 views3 pages
    This document provides the formula and procedure for making metformin tablets through wet granulation. It lists the ingredients needed to make one tablet or 20 tablets including metformin, lactose, starch, isopropyl alcohol, talc, magnesium stearate and aerosil. The procedure involves accurately weighing ingredients, mixing metformin and lactose, adding isopropyl alcohol to form granules, drying the granules, adding additional ingredients and compressing into tablets. The tablets are then evaluated based on weight variation, hardness, friability and dissolution over 60 minutes.

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    This document provides the formula and procedure for making metformin tablets through wet granulation. It lists the ingredients needed to make one tablet or 20 tablets including metformin, lactose, starch, isopropyl alcohol, talc, magnesium stearate and aerosil. The procedure involves accurately weighing ingredients, mixing metformin and lactose, adding isopropyl alcohol to form granules, drying the granules, adding additional ingredients and compressing into tablets. The tablets are then evaluated based on weight variation, hardness, friability and dissolution over 60 minutes.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    40 views3 pages

    Aim: Requirement: Reference: Formula:: Ingrediants Formula For One Tablet Formula For 20 Tablets

    Uploaded by

    kjghlkdfjg
    This document provides the formula and procedure for making metformin tablets through wet granulation. It lists the ingredients needed to make one tablet or 20 tablets including metformin, lactose, starch, isopropyl alcohol, talc, magnesium stearate and aerosil. The procedure involves accurately weighing ingredients, mixing metformin and lactose, adding isopropyl alcohol to form granules, drying the granules, adding additional ingredients and compressing into tablets. The tablets are then evaluated based on weight variation, hardness, friability and dissolution over 60 minutes.

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    Aim:

    Requirement:
    Reference:
    Formula:
    Ingrediants
    Metformin
    Lactose
    Starch
    Isopropyl alcohol
    (IPA)
    Talc
    Magnesium
    Stearate
    Aerosil

    Formula for one


    tablet
    500 mg
    4.7 mg
    4.5 mg
    10 ml

    Formula for 20
    tablets
    10 gm
    0.094 gm
    0.090 gm
    0.2 gm

    0.8 mg
    5 mg

    0.016 gm
    0.1 gm

    5 mg

    0.1 gm

    Procedure (wet granulation):


    All the ingredients were weighed accurately.
    Metformin and lactose were taken in mortar and pestle
    and grinded together to have uniform mixing and obtain
    fine powder.
    10% of PVP solution of IPA was prepared and q.s was
    added to the fine powder to obtain the lump mass.
    Pass this lump mass through 10# sieve and collect
    granules obtained.
    The granules were collected on the paper and allowed to
    dry in oven at 45C.
    After drying the mass was passed through 20# sieve and
    granules were retained on 40# sieve.
    Talc, magnesium stearate and aerosil were mixed with
    granule geometrically.
    Fines obtained were weighed.
    15% of fines were added to the dried granules and pack
    edt in zip lock bag and punched into tablets using tablet
    punching machine.
    Tablets were then evaluated.

    Evaluation parameters:
    1.
    2.
    3.
    4.

    Weight variation
    Hardness
    Friability
    Dissolution

    1 .Observation table of weight variation


    Sr.n
    o.
    1
    2
    3
    4
    5
    6
    7
    8
    9
    10
    11
    12
    13
    14
    15
    16
    17
    18
    19
    20
    Avg.

    Weight of
    tablets(x)
    519
    520
    520
    521
    521
    520
    522
    520
    518
    519
    520
    523
    522
    521
    520
    518
    519
    520
    520
    521

    x-x

    avg

    2. Hardness of tablet:
    3. Observation table of Friability
    Initial weight of tablet (a):

    x-x avg /x avg


    *100

    Final weight of tablet (b):


    Weight loss: a-b
    % weight loss: a-b/a*100
    4. Observation table of Dissolution

    Sr.n
    o.

    Time(mi
    n.)

    1
    2
    3
    4
    5
    6
    7

    0
    10
    20
    30
    40
    50
    60

    absorban Conc.p
    ce
    er ml.

    Conc.i
    n 900
    ml

    Cumulati %
    ve conc. drug
    releas
    e

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