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    Lubrication Time

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    This document describes a study on the effect of lubrication time on oral tablets prepared with paracetamol as the model drug. Granules were prepared through wet granulation and then lubricated by mixing with talc, magnesium stearate and Aerosil for varying times between 5-30 minutes. The lubricated granules were used to produce tablets which were evaluated for hardness, disintegration time and dissolution. The results showed that excessive lubrication, through either higher concentrations or longer lubrication times, can impart hydrophobicity to the granules. This hydrophobicity affects the disintegration, deaggregation and dissolution times of the tablets by potentially extending these times, which is not desirable.

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    Lubrication Time

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    kjghlkdfjg
    73 views5 pages
    This document describes a study on the effect of lubrication time on oral tablets prepared with paracetamol as the model drug. Granules were prepared through wet granulation and then lubricated by mixing with talc, magnesium stearate and Aerosil for varying times between 5-30 minutes. The lubricated granules were used to produce tablets which were evaluated for hardness, disintegration time and dissolution. The results showed that excessive lubrication, through either higher concentrations or longer lubrication times, can impart hydrophobicity to the granules. This hydrophobicity affects the disintegration, deaggregation and dissolution times of the tablets by potentially extending these times, which is not desirable.

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    This document describes a study on the effect of lubrication time on oral tablets prepared with paracetamol as the model drug. Granules were prepared through wet granulation and then lubricated by mixing with talc, magnesium stearate and Aerosil for varying times between 5-30 minutes. The lubricated granules were used to produce tablets which were evaluated for hardness, disintegration time and dissolution. The results showed that excessive lubrication, through either higher concentrations or longer lubrication times, can impart hydrophobicity to the granules. This hydrophobicity affects the disintegration, deaggregation and dissolution times of the tablets by potentially extending these times, which is not desirable.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    73 views5 pages

    Lubrication Time

    Uploaded by

    kjghlkdfjg
    This document describes a study on the effect of lubrication time on oral tablets prepared with paracetamol as the model drug. Granules were prepared through wet granulation and then lubricated by mixing with talc, magnesium stearate and Aerosil for varying times between 5-30 minutes. The lubricated granules were used to produce tablets which were evaluated for hardness, disintegration time and dissolution. The results showed that excessive lubrication, through either higher concentrations or longer lubrication times, can impart hydrophobicity to the granules. This hydrophobicity affects the disintegration, deaggregation and dissolution times of the tablets by potentially extending these times, which is not desirable.

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    PRACTICALAIM: To study effect of lubrication time in formulation of oral tablet

    prepared by wet granulation, using Paracetamol as model drug.


    Formula: Each tablet contains

    Paracetamol IP, 300mg.

    Excipients
    Batch size:

    q.s.

    50 tablets

    Packaging: Aluminium foil . strip of 10 tablets.

    FORMULATION:
    INGREDIENTS

    Paracetamol
    Microcrystalline
    cellulose
    Starch paste
    (10%w/v)
    Sodium starch
    glycolate
    Talc
    Magnesium stearate
    Aerosil

    QUANTITY
    / TABLET)

    QUANTITY
    TAKEN

    300mg
    60 mg

    15g
    3g

    q.s.

    q.s.

    24mg

    1.2g

    2mg
    8mg
    3mg

    0.1g
    0.4g
    0.15g

    Roll of
    each
    ingredien
    ts

    PROCEDURE:
    I.
    Wet granulation of Paracetamol IP.
    Paracetamol , sodium starch glycolate and microcrystalline cellulose
    were mixed thoroughly and sifted through 40 # sieve.
    A 10%w/v starch paste was prepared and weighed quantity was added
    to dry mixture, gradually to prepare desired wet mass, which was
    granulated through 10 # sieve and granules were dried in tray drier.
    The dried granules were sized through 20# sieve and checked for
    yield, appearance and quantity of fines. The results were reported.
    II.
    Lubrication of granules:
    Talc, magnesium stearate and Aerosil were weighed accurately in
    quantity required, and mixed properly by tumbling method. (in dry glss
    beaker or in plastic bag).

    The granules were tapped on 40# sieve to collect fines.


    The fines were mixed with lubricant mixture by same tumbling method,
    varying mixing time 5min,10 min, 15,20 and 30 min.
    The lubricated fines were mixed with remaining granules by tumbling,
    ensuring complete mixing. (Gentle mixing).
    The tablets were compressed from each batch of granules, with target
    hardness 3-4 kg and target weight of-------------mg. and evaluated for
    key parameters like disintegration and dissolution tests.
    The results were compiled and commented upon. Graph: Dissolution
    profiles.

    Observation tables:
    Table 1 Granules characteristics
    B.no

    Appearance

    Yield

    Wt of fines

    Moisture
    content

    Table 2 Evaluation of compressed tablets of Paracetamol

    PARAMETER
    Hardness
    (kg/cm2)
    Disintegration
    Time (sec)
    Disintegration
    pattern
    Cumulative
    drug release
    in 30 mins

    B1 (5 mins)

    B2 (10 mins)

    B3 (15 mins)

    B4 (20 min)

    DISSOLUTION STUDY:
    BATC
    H

    TIME
    (mins
    )

    B-1

    0
    10
    20
    30
    0
    10
    20
    30
    0
    10
    20
    30
    0
    10
    20
    30

    B-2

    B-3

    B-4

    ABSO
    RBAN
    CE

    CONCE
    NTRATI
    ON
    (g/ml)

    CONCE
    NTRATI
    ON
    (mg/5
    ml)

    CONCENT
    RATION
    (mg/900
    ml)

    Cumulative
    concentrati
    on

    %D
    R

    CPR

    Comments:
    Paracetamol is sparingly soluble drug having slight hydrophobic nature. This
    characteristic may hinder the rate of de-aggregation after disintegration of tablets.
    The function of lubricants in tablet are:

    To decrease friction between tablet and the die wall.


    To coat each granule properly to facilitate the distribution of compression
    force evenly.
    To impart bonding between the particles upon compression.

    But excessive lubrication (either higher concentration or prolonged lubrication )


    impart hydrophobicity to the granules which affects disintegration , de-aggregation
    and consequently dissolution time of the tablets, the time may be extended, which

    is not desired. The present experiment evaluates the effect of lubrication time on
    disintegration and dissolution time of compressed tablets.
    The results show that------------------

    REFERENCE :Pharmaceutical dosage forms: Tablet volume 1,


    edited by Herbert A Liebermann and Leon Lachmann, pg no. 136.

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