Supplement Reference Guide: 1 Edition 2009
Supplement Reference Guide: 1 Edition 2009
Supplement Reference Guide: 1 Edition 2009
Edition 2009
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First Edition
2009
Statements found in this guide have not been evaluated by the FDA. dotFIT
products are not intended to treat, cure or prevent any disease.
2009 dotFIT, LLC.
250 N. Westlake Blvd. Ste. 220
Westlake Village, CA 91362
877.4dotFIT (877.436.8348)
www.dotFIT.com
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Table of Contents
Introduction ........................................................................................................................................ 5
About dotFIT ........................................................................................................................ 5
dotFIT Worldwide Faculty & Advisory Board ......................................................................... 6
Position on Use, Recommendation & Manufacture of Dietary Supplements ....................... 6
Position on Overall Dietary Supplement Use & Recommendations ...................................... 6
Position on Use of Supplements for Health ........................................................................... 7
Position on Use of Supplements in Support of Weight Control ............................................ 7
Position on Use of Supplements for Enhancing Performance ............................................... 8
Position on Final Individual Recommendations ..................................................................... 8
Position on Manufacturing and Facts Regarding dotFIT Products ......................................... 8
Product Testing Documentation ............................................................................................ 10
Product Evaluation Guidelines and Scoring ........................................................................... 10
The Products ....................................................................................................................................... 13
Definitions .............................................................................................................................. 13
Dietary Supplements for Health ........................................................................................................ 15
health dotFIT ...................................................................................................................................... 15
Multivitamin & Mineral Formulas .......................................................................................... 15
ActiveMV Formula .................................................................................................................. 20
WomensMV Formula ............................................................................................................ 20
Over50MV Formula ................................................................................................................ 21
VegetarianMV Formula .......................................................................................................... 21
PrenatalMV Formula .............................................................................................................. 24
KidsMV Formula ..................................................................................................................... 28
SuperCalcium+ ........................................................................................................................ 31
SuperiorAntioxidant ............................................................................................................... 35
Joint Flexibility Plus ................................................................................................................ 40
SuperOmega-3 ........................................................................................................................ 44
Advanced Brain Health ........................................................................................................... 49
Fitness & Performance-Enhancing Dietary Supplements ................................................................ 54
weight loss dotFIT ............................................................................................................................... 54
FatReleaser FatRelease .......................................................................................................... 55
CarbKiller/CarbRepel ............................................................................................................... 59
ThermoShock/ThermAccel ...................................................................................................... 62
LeanMR Drink Mix .................................................................................................................. 70
performance dotFIT ............................................................................................................................ 68
CreatineMonohydrate ............................................................................................................ 69
CreatineXXL ............................................................................................................................ 79
NO7Rage ................................................................................................................................. 84
WorkoutExtreme ..................................................................................................................... 91
Recover&Build ........................................................................................................................ 96
AminoBoostXXL ...................................................................................................................... 100
MuscleDefender ..................................................................................................................... 108
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Figure References
Figure 1 - Glucosomine for Pain Control Study ................................................................................... 40
Figure 2 - Adverse Event Data, Pain Control Study ............................................................................. 41
Figure 3 - Rhododendron Weight Loss Study ...................................................................................... 56
Figure 4 - Phase 2 Weight Loss Study ............................................................................................... 59
Figure 5 - Caffiene/EGCG Study .......................................................................................................... 63
Figure 6 - Fat Oxidization in Caffiene/EGCG Study ............................................................................. 63
Figure 7 - Loleptin Weight Loss Study ................................................................................................. 64
Figure 8 - Meal Replacements & Weight Maintenance
Figure 9 - Meal Replacements & Weight Loss
Figure 10 - Creatine & High Intensity Exercise .................................................................................... 70
Figure 11 - Creatine Performance Study ............................................................................................. 72
Figure 12 - Creatine/LBM Study .......................................................................................................... 73
Figure 13 - Creatine/Muscle Hypertrophy Study ................................................................................ 74
Figure 14 - Metabolic Pathway for NO Production ............................................................................. 85
Figure 15 A & B - Caffiene and Performance ....................................................................................... 92
Figure 16 - Plasma Creatine Kinase ...................................................................................................... 109
Figure 17 - Plasma Glutamine Levels ................................................................................................... 109
Figure 18 - Meal Replacements & Weight Loss .................................................................................. 112
Figure 19 - Meal Replacements & Weight Maintenance .................................................................... 112
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Table References
Table 1Product Evaluation Score ..................................................................................................... 12
Table 2Multivitamin & Mineral Formulas ....................................................................................... 18
Table 3dotFIT Multivitamin & Mineral Recommendations .......................................................... 19
Table 4Safe and Probable Optimal Range ....................................................................................... 23
Table 5CreatineXXL Intake Recommendations ............................................................................ 81
Table 6Toxicity in Animals ............................................................................................................... 105
Table 7Safe and Probable Optimal Range ....................................................................................... 150
Table 8-- Sample Anabolic Diet Plan ................................................................................................... 163
Table 9Maximal Protein Synthsis Periodization .............................................................................. 165
Table 10CreatineXXL Strategy ...................................................................................................... 166
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dotFIT Worldwide
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Introduction
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Introduction
About dotFIT Worldwide
The group of individuals and organizations that make up dotFIT Worldwide www.dotfitww.com created
the first and most successful complete nutrition/weight control and exercise program used by fitness
professionals around the world. dotFIT Worldwide offers
Education and certification from The National Academy of Sports Medicine (NASM)
o The market leader in Fitness, Sports Medicine and Sports Performance credentials
o NASM activates over 25,000 credentials annually with over 100,000 professionals
worldwide
o Works with over 6,000 health clubs and all professional sports organizations
Unlimited education: For consumers and professionals via website, live webinars, certifications,
and direct access to R&D team via our toll-free phone number (877.436.8348)
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dotFIT Worldwide
Faculty
& Advisory Board
dotFIT Worldwide Faculty and Advisory Board
NUTRITION, DIETETICS AND WEIGHT CONTROL
Jill Fairweather, MS, RD
Gay Riley,
MS, RD,AND
CCNWEIGHT CONTROL
NUTRITION
NUTRITION,
DIETETICS
JillTitchenal,
Fairweather,
MS, RD
Alan
PhD
Gay Riley, MS, RD, CCN
Kathleen
Barefield,
MS, RD, PES, NASM- CPT
Alan Titchenal,
PhD
Kat Barefield, MS, RD, NASM-CPT & PES,
ACSM-HFS
University of Hawaii
NATIONAL
ACADEMY
OF SPORTS MEDICINE
COMMAND
NUTRITIONALS
Dr. Micheal A. Clark, DPT, MS, PT, PES
http://www.commandnutritionals.com/
Dr. Darin Padua, PhD, ATC
Dr. Kevin Guskiewicz, PhD, ATC
Dr. Steve Marshall, PhD
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Preserving health
o Objective: potentially stave off chronic or age-related disease by improving the daily
nutrient intake achieved through diet alone
Safely enhance sport and fitness outcomes
o Objective: hasten and support fitness/weight control goals
o Objective: improve training-induced performance results
Help create and maintain a calorie deficit by increasing daily calorie expenditure when
compared to a non-supplemented state
Raise energy levels that may make one more active throughout the day
Reduce the drive to consume food
Decrease calorie absorption
The dieter would cease supplementation once the weight goal is reached or when they have their daily
routines under control to continue making progress without supplements.
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Products are designed with customized controlled-release delivery systems established by each
products ingredients, desired target tissues, and the amounts required in specific time periods to
deliver on the product claims. In other words, validate that the right ingredients and amounts get to the
right places at the right times.
Finished products are tested in a simulated human digestive system to validate whether release
patterns match their respective designed criteria in order to assure the desired results
Ingredient testing for purity, potency and delivery from raw materials to finished product
Final product rigorous testing, both in-house and through third-party, FDA-approved
laboratories, assures users that all nutritional claims meet or surpass FDA guidelines, USDA
guidelines, and industry norms
All formulas must be able to work in synergy with other dotFIT products in order to avoid
nutrient overages, which are common with typical, indiscriminate supplement use
dotFIT programs consider diet, medications, and other dotFIT products before a personalized dietary
supplement recommendation is generated. This assures the user remains in a safe and optimal nutrient
range throughout the day.
dotFIT foods cannot be spiked with unnecessary nutrients. Most other products in this space (e.g.
bars, shakes, ready-to-drinks, etc.) are heavily spiked with many nutrients that can lead to undesirable
levels within the body when combining multiple manufacturers, products and normal food intake. When
consuming only dotFIT products, as directed with ones normal daily food intake, the recipient can be
assured of keeping the body at a safe and optimal nutrient level.
dotFIT must provide complete customer product/program education and support, including full
disclosure regarding product ingredients and manufacturing.
Tests that include disintegration, dissolution, stability, purity (no contaminants) and potency,
which includes the finished products certificate of analysis
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In-house product validation and testing methods based on all available certified protocols
including applicable USPs
and other international compendia
Appropriate peer-review research that supports the dosage and purpose of the compound
Proof of equivalence or evidence that a given dose of a product must contain a certain amount
of key ingredients in order to produce a known effect
Assurance that the substance is nontoxic, along with list of any known potential side effects and
drug interactions
Qualified personnel and support documents available to all consumers via www.dotFIT.com or
877.436.8348
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2. Individual ingredients
D. Research supporting either a biochemical or physiological rationale
Research documenting claims, performed on animals
All same as above
Safety Studies
A. Animal toxicology studies
B. In vitro toxicology studies
C. Human clinical evaluations
1. Dosage and route of administration
2. Toxicity
D. Human anecdotal/empirical reports
1. Dosage and route of administration
2. Toxicity
Adverse Event Reports
A.
B.
C.
D.
E.
* DSHEA is the Dietary Supplement Health Education Act of 1994. The DSHEA established a formal definition of
"dietary supplement" using several criteria. A dietary supplement
is a product (other than tobacco) that is intended to supplement the diet that bears or contains one or
more of the following dietary ingredients: a vitamin, a mineral, an herb or other botanical, an amino acid,
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a dietary substance for use by man to supplement the diet by increasing the total daily intake, or a
concentrate, metabolite, constituent, extract, or combinations of these ingredients
is intended for ingestion in pill, capsule, tablet, or liquid form
is not represented for use as a conventional food or as the sole item of a meal or diet
is labeled as a "dietary supplement"
includes products such as an approved new drug, certified antibiotic, or licensed biologic that was
marketed as a dietary supplement or food before approval, certification, or license (unless the Secretary
of Health and Human Services waives this provision)
SCORE
RATING
Excellent
(>90% Probability)
Very Good
(>70%<90% Probability)
(High Probability)
Good
(<70%>30% Probability)
(Medium Probability)
Fair
(>10%<30% Probability)
(Low Probability)
Poor
<10% Probability)
(Questionable Probability)
Fails
(Zero Probability Hype)
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2
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The Products
Included in this guide are the following for each dotFIT product:
Goal
Rationale
Typical Use
Dosage
Definitions
Precautions
Contraindications
Adverse Reactions
Upper Limits/Toxicity
Definitions
Goal
Describes the purpose of the formulation, including each products intended outcome.
Rationale
Lists the ingredients basic mechanisms of action and their respective function in participating in the
products intended outcome or goal.
Typical Use
Describes the known group of users that may experience the products potential listed benefits.
Dosage
Lists the dosages used in studies and historically with the greatest potential for safety and efficacy.
Precautions
The compounds in this Supplement Reference Guide (SRG) are considered safe for the general
population at the proper dosage. Under this heading and the subheadings below, a summary of safety
considerations will be called out for potential vulnerable subpopulations.
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Contraindications
Describes conditions in which the compound might be avoided or signal caution, including people with
unique genetic predispositions, certain pre-existing disease states or persons taking specific prescription
medications.
Adverse Reactions
Lists possible side effects and/or explains commonly reported reactions that may not be clinically
supported or causally related to the compound. Case reports may be used to explain theoretical risk
when clinical trials or specific studies are not available. Case reports are not considered scientifically
valid for proving efficacy or documenting risks, but may be used to highlight an unlikely but potential
safety issue.
Upper Limit/Toxicity
Gives the highest known dose that still maintains a large margin of safety and any known toxicity data.
When available the Recommended Daily Allowance (RDA), No Observed Adverse Effect Level (NOAEL),
Lowest Observed Adverse Effect Level (LOAEL) and the lethal dose 50 (LD50) values will be given. The LD
is the dose at which 50% of the test animals (rats or mice) died and is usually only used as a reference
for the relative toxicity of a substance.
The Tolerable Upper Intake Level or Upper Limit (UL) is the maximum level of total chronic (long-term)
daily intake judged unlikely to pose a risk of adverse health effects to most of the healthy population,
including sensitive individuals, throughout their life stages. The UL is intended to provide a safety
standard for dietary supplements such that no significant or unreasonable risk of illness or injury would
arise at or below this intake level.
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The Products
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Rationale
Defining the perfect diet has been a laborious task for the nutritional sciences for decades.3 Likewise,
specifying the optimal intake of vitamins and minerals is difficult in the face of continuing nutrient
research. This makes giving concrete nutrient recommendations challenging. For most nutrients, there
is a large therapeutic range within which the average person will receive benefit and simultaneously
remain below the threshold that can yield adverse events. It is one matter to define nutrient
recommendations, but another entirely more frustrating endeavor to actually consume the
recommended dosages through the course of a normal day with typical foods. 2,4,5,6,7 The notion that
food alone will satisfy all physiological needs of the body for proper and ideal nutrient intake is
outdated.8 Obstacles to proper eating and ideal nutrient intake include
Insufficient food intake9,10
Increased needs that are not met by diet alone11,12,13,14,15,16,17,18
Lack of interest in or avoidance of essential food groups19,20,21,22,23,24
Low body fat maintenance1,25,26,27
Variables of actual nutrient content of food28,29,30,31
Cant/dont move enough to eat enough32,33
In the modern world, where many people maintain a sedentary lifestyle, maintaining a healthy
o weight often requires eating too few calories to get proper nutrition through food alone24,25
Low sun exposure34,35,36,37,38,39
Inability to define the perfect diet1,3,40,41
It is in the context of all the above that dotFIT multivitamin and mineral formulas are made, including
the nutrient values contained in todays typical diet and the different overall nutrient needs based on
age, gender and activity, each for a specific user.2,4,6 The dotFIT multivitamin and mineral formulas are
used at the specified times throughout ones lifetime. In addition, they include the coverage of an active
persons basic antioxidant needs.
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dotFIT formulas are engineered with ideal health and functioning as the goal, not the media driven need
to see a lot of popular ingredients in a pill. An example is the decision to remove calcium from dotFIT
MVM formulas. Due to the variety of nutrients in a MVM, a decision has to be made if something goes in
because it is needed (in the proper dosage) or if it is just window dressing ( included but in an
ineffective amount just so it can appear on the label). If one is failing at meeting their calcium needs
through the diet, then a calcium supplement is warranted.16,42 This required dose will far exceed that
included in any effective MVM formula because it would make the MVM far too large to comfortably
ingest. The dotFIT approach includes a specific calcium supplement to address that need. Also, calcium
supplementation concurrent with iron supplementation can interfere with the absorption of iron. 43
Another example of the dotFIT difference is that most experts believe the current recommendation for
vitamin D is far too low, so dotFIT is taking the lead on ensuring optimal vitamin D intake. More and
more research is emerging linking low vitamin D status with numerous chronic health issues, 44,45 not just
its relationship with calcium absorption. Population studies show that those with the lowest vitamin D
intakes have a higher rate of mortality from all factors, especially cardiovascular disease and cancer.46
Typical dosing with dotFIT MVM formulas will give the user a full 1000 IU.
All dotFIT multivitamin and mineral formulas are prepared in a proprietary delivery system to accurately
control the release of their contents to match the bodys ability to properly utilize the nutrients and thus
maintain the ideal tissue levels (see Table 4).
The human digestive tract is a unique, amazing and dynamic environment. Due to varying pH levels and
availability of receptors, certain vitamins and minerals are best absorbed over time throughout many
areas of the digestive tract. A controlled-release delivery system not only ensures that nutrients make it
through the harsh acid environment of the stomach (which is a digestive organ, not an absorptive one)
but that that they are released in the proper place/time, in the proper forms and at the proper doses.
The goal is total tissue saturation with the nutrients needed to optimally perform all cellular activities,
thus ensuring the cells have the potential to function at full capacity, 24 hours a day.
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Unit
Over50
Kids
1000
1000
5000
400
8
50
6
6
20
10
400
100
100
10
75
100
15
70
1
100
50
500
250
2000
50
5
20
1
1
6
1
100
3
10
2
50
20
5
20
0
0
30
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ActiveMV
ActiveMV
(1 tablet)
(2 tablets)
Women'sMV
PrenatalMV
Over50MV
VegetarianMV
KidsMV
1
chewable
2
chewables
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
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ActiveMV Formula
The ActiveMV formula is a multipurpose multivitamin and mineral formula. At one pill daily, it is the
basic multivitamin for everyone over 12 years of age. At two pills daily, it is designed for athletes and all
others with an active lifestyle aged 18 to 65 (general population over age 50, see the Over50MV formula
and women 18 to 50 years of age, see the WomensMV formula) who consume the general variety of
todays typically available foods.
Rationale
Studies suggest that athletes require additional vitamins due to increased energy demands.47,48,49,50,51
Some, but not all, athletes consume more nutrients simply by eating more food. This assumes the
athlete is on a relatively high-calorie, balanced diet thus able to consume enough nutritious food to
match their energy expenditure. Athletes trying to lose weight/body fat or maintain low weight/fat
represent a different category since they have increased requirements and a lower caloric intake.8,9 As
such, the B vitamins are higher in this formula. Additionally, the ActiveMV formula contains doses of
antioxidants at the higher end of the optimal range. The ActiveMV dose for athletes is two pills daily,
one in the morning with a meal and the other at night with a meal, to maintain the ideal nutrient levels
in all tissues all day, every day.
Typical Use
For all persons with an active lifestyle, 12-65 years of age, except those who are pregnant, trying
to conceive, lactating or following a vegetarian/high carbohydrate diet
o One tablet per day before or after main meal with a favorite beverage
Active athletes and exercisers, two tablets per day before or after main meal with a favorite
beverage
Supplement Fac ts
Serving Size: 1 Tablet
% Daily Value
4,500 IU 90%
450 mg
600 IU
150 IU
50 mcg
5 mg
5 mg
15 mg
6 mg
100 mcg
15 mcg
150 mcg
750%
150%
500%
63%
333%
294%
75%
300%
25%
250%
50%
Contains No: Dairy, Fish, Crustacean shellfish, Tree nuts, Peanuts, Soy or Gluten.
No Sugar, Salt, Starch, Yeast, Artificial flavors, Coloring or Preservatives added.
Components in this product are derived from natural sources.
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WomensMV Formula
The WomensMV formula was created for women younger than 50 years of age who are not pregnant or
trying to conceive.
Rationale
This formula was designed with the specific needs of females52 in mind by including slightly higher levels
of magnesium, iron and folic acid and the proper extra nutrients for lactating women not needing the
higher iron found in the PrenatalMV formula.
Typical Use
For use by women 13-50 years of age not using the ActiveMV Formula
Non-pregnant females not trying to conceive
One tablet per day before or after main meal with a favorite beverage
Supplement Fac ts
Serving Size: 1 Tablet
Contains No: Dairy, Fish, Crustacean shellfish, Tree nuts, Peanuts, Soy or Gluten.
No Sugar, Salt, Starch, Yeast, Artificial flavors, Coloring or Preservatives added.
Components in this product are derived from natural sources.
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Over50MV Formula
The Over50MV formula is for the general population over 50 years of age, and for athletes and intense
exercisers over 65 years of age.
Rationale
This formula considers the requirements of older individuals in helping to combat preventable diseases
such as osteoporosis and heart disease. 53,54 It contains optimal doses of folate, B6 and B12 along with
bone-building nutrients such as vitamin D, vitamin A (also beta carotene) and even vitamin K. This
formula should be used with 1000 mg of calcium from food or supplements.
Typical Use
Supplement Fac ts
Serving Size: 1 Tablet
Contains No: Dairy, Fish, Crustacean shellfish, Tree nuts, Peanuts, Soy or Gluten.
No Sugar, Salt, Starch, Yeast, Artificial flavors, Coloring or Preservatives added.
Components in this product are derived from natural sources.
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VegetarianMV Formula
The VegetarianMV formula is designed for those who avoid animal products or who eat a diet high in
carbohydrates and/or who want nutrients not supplied from animal forms.
Rationale
The nutrients typically lacking in vegetarian or high carbohydrate diets such as zinc, iron and B12 are
boosted in this formula.55,56 Folic acid is reduced in this formula because the fortification of folic acid in
the food supply has resulted in a much greater intake in the US. Without Calcium in the formula, iron
absorption is maximized. The dotFIT SuperCalcium+ formula is available for those who lack it in their
diets."
Typical Use
For any male over 18 or non-pregnant female over 18 who is a vegetarian or who prefers a diet
very high in carbohydrates
One tablet per day before or after main meal with a favorite beverage
Supplement Fac ts
Serving Size: 1 Tablet
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Precautions
dotFIT multivitamin and mineral formulas are considered safe for the general population at the proper
dosage. Given the risk to benefit ratio, the long-term use of dotFIT multivitamin and mineral formulas is
much safer than consuming the typical American diet without nutrient augmentation. 2,4,5,6
Contraindications
dotFIT multivitamin and mineral formulas are contraindicated in pregnancy and lactation. Pregnant
women should use the dotFIT PrenatalMV formula. Lactating women should use the WomensMV
formula unless advised otherwise by a physician. The dotFIT multivitamin and mineral formulas are
contraindicated for those with hemochromatosis (an inherited disease that leads to iron-overload,
affecting 0.5 percent of the population) because of the iron content, and for anyone suffering adverse
reactions to any of the supplements ingredients. The vitamin E content in two tablets per day may be
contraindicated for those individuals taking blood-thinning medication. 57 In all cases, consult with a
physician. Smokers should stay below 66,000 IU of beta-carotene daily (the multivitamin formula
contains less than 15,000 IU) until a dose can be established for them.
Adverse Reactions
At the recommended doses adverse effects are highly unlikely.
Upper Limit/Toxicity
See Table 4 for a list of known ULs and LOAELs for nutrients in the dotFIT multivitamin and mineral formulas.
No nutrient in these formulas is above the UL or LOAEL.
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Low High
1
Pre-formed Vitamin A
2
0 IU - 10,000 IU
LOAEL
21,645 IU
Beta Carotene
10,000 IU - 25,000 IU
Vitamin D (D3)
400 IU 1500 IU
2000 IU
3800 IU*
Vitamin E
100 IU 800 IU
Vitamin K
60-120 mcg
Vitamin C
200 mg 1000 mg
2,000 mg
3,000 mg
Vitamin B1
2 mg 30 mg
Vitamin B2
5 mg 30 mg
Vitamin B3 (Niacinamide)
30 mg 50 mg
35 mg
1000 mg
Vitamin B6
6 mg 50 mg
100 mg
500 mg
Folic acid
1,000 mcg
5,000 mcg
Vitamin B12
6 mcg 50 mcg
1200 mg 2000 mg
2,500 mg
5,000 mg
420 mg 600 mg
350 mg4
350 mg
Iodine
150 mcg - ?
1,100 mcg
1,700 mcg
Iron5
15 mg 25 mg
45 mg
70 mg
15 mg 30 mg
40 mg
60 mg
Copper
2 mg 4 mg
10 mg
Manganese
2 mg 5 mg
11 mg
15 mg
Calcium
Magnesium5
Zinc
Potassium
2000 mg -?
Selenium3
400 mcg
910 mcg
Chromium
Supplemental amount can be zero if daily intake of beta carotene is within the safe and optimal range.
Smokers, those likely to develop, or those that already have lung cancer, should avoid beta carotene supplementation.
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Summary
Purpose
dotFIT formulas can be used by EVERYONE unless instructed otherwise for medical reasons
Based on the sophisticated controlled delivery systems and progressive formulations, dotFIT
multivitamin and mineral formulas would be considered todays ideal formulation, especially
when compared to popular common multivitamin products that must compete on price rather
than efficacy
Unique Features
All products are regularly updated with the most recent recommendations from the Institute of
Medicine (IOM) and the industrys leading experts i.e. progressive evidence-based formulations
All formulas are part of the dotFIT program for safe and ideal compatibility with all products
when following program supplement recommendations
Different formulas to meet the unique needs of different populations
Formula and use follow strict scientific research criteria
The nutrients are in their proper forms, ratios and strengths to help maintain a safe and optimal
range 24 hours/day
Uses the most sophisticated controlled-release delivery systems to ensure ideal nutrient levels
and prevent tissue over-saturation and losses
Manufactured in a FDA-registered facility, in compliance with Good Manufacturing Practices
(GMPs) exclusively for dotFIT, LLC
27
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PrenatalMV
Goal
The PrenatalMV formula is designed for women who are pregnant or trying to conceive. It has been
updated to include the latest recommendations of the National Academy of Sciences for pregnant
women. After childbirth, many women no longer need the high iron of a prenatal formula and can
switch back to the dotFIT WomensMV formula or ActiveMV formula.
Proper nutrition is vital to a healthy pregnancy and often poor diet is the main cause of multiple
micronutrient deficiencies. Not only does it affect the status of the fetus, but the mother as well.
Inadequate nutrient intake can cause complications, deformities in the child, and even death.1,2 The
nutritional status of the mother must be sufficient to fulfill the needs of her baby and to maintain her
own health. Iron, folic acid and calcium are three of the key nutrients often deficient in womens
diets.3,4,5,6,7,8 This formula is specially designed to meet the increased needs of a woman who plans to
conceive and give birth.
Rationale
Iron is needed during pregnancy because of the significant increase in the mothers blood supply.
Women of childbearing age are at great risk for iron deficiency even before conception, due to an
inadequate diet and menstruation. Several studies show that low iron stores at conception are a strong
predictor of maternal iron status and risk of anemia later in pregnancy.9,10, 11 Once pregnancy is in
progress, it is difficult to replenish depleted iron stores, making prenatal micronutrient supplementation
critical before conception. Low maternal iron stores are directly correlated with pre-term delivery, low
birth weight, maternal infection and anemia in the child later on in life.9,12
During the last trimester of pregnancy, iron demand from mother and fetus is the greatest.13 The fetus
draws iron from the mother to create its own stores for times when milk, a low-iron food, will be its sole
form of nourishment.12 Furthermore, adequate iron stores are crucial due to the loss of blood during
delivery. The RDA recommendation for iron during pregnancy increases from 18 mg to 27 mg per day,
which normally cannot be obtained from food alone.
Folic acid (folate) is a B vitamin required for the manufacture of blood cells, the genetic material DNA
and RNA, and proper cell division.14,15 This nutrient is especially important during the first trimester as a
deficiency in this vitamin is associated with an increase in neural tube defects and other malformations,
which form early in the fetus.15 Extensive research has found that adequate intake of folic acid leads to
fewer malformations, especially neural tube defects (approximately an 80% reduction16).15,17,18
According to the CDC, folate and folic acid supplementation among women of reproductive age is still
lacking, especially in specific ethnic groups.19,20
28
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The RDA for folate increases from 400 to 600 mcg per day during pregnancy. Note that this
recommendation is based on folic acid from supplements and fortified foods and assumes that a female
is consuming at least 400 mcg per day prior to confirmation of pregnancy.
Calcium is a mineral that is crucial for all women, but especially for pregnant and lactating women.
During pregnancy, calcium stores are greatly mobilized and the fetus uses calcium for skeletal bone
mineralization.15 Low calcium consumption during this time may lead to osteoporosis later in life.
Adequate calcium intake has been related to a reduced risk for pre-term delivery, low birth weight, and
hypertensive disorders during pregnancy.21,22,23,24 Women who are not meeting their calcium needs
through diet should use the dotFIT SuperCalcium+ in conjunction with the PrenatalMV.
The RDA for calcium is 1000 mg per day, which does not increase during pregnancy because absorption
increases during this time. However, most individuals consume less than the RDA.22,23
Vitamin A is a nutrient that is of much concern during pregnancy.24,25 Too much has been linked to
malformations in the fetus.26 Beta-carotene supplements have not been reported to increase the risk of
birth defects27 and therefore this formula uses a safe amount in the beta-carotene form. Beta-carotene
is converted to Vitamin A only as needed by the body, ensuring that toxicity is not a factor.
The RDA for Vitamin A is 700 mcg (2310 IU) per day and increases to 770 (2541 IU) and 1,300 mcg (4250
IU) per day during pregnancy and lactation respectively.
Other nutrients are provided for adequate nutrition, taking into consideration a womans increased
needs. Women may need more vitamin D to better absorb calcium. B vitamins are also important for
their role in energy production and controlling homocysteine levels which are associated with adverse
pregnancy outcomes.27
Supplement Fac ts
Serving Size: 1 Tablet
% Daily Value
5,000IU
250mg
600IU
100IU
50mcg
4mg
4mg
20mg
8mg
600mcg
12mcg
50mcg
15mg
27mg
150mcg
100mg
10mg
100mcg
0.5mg
50mcg
100%
417%
150%
333%
63%
267%
235%
100%
400%
150%
200%
17%
150%
150%
100%
25%
67%
143%
25%
42%
29
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Typical Use
Precautions
The dotFIT PrenatalMV is considered safe for the healthy pregnant woman at the proper dosage.
Given the risk to benefit, the long-term use of this formula is much safer for the baby and mother than
consuming the typical American diet without nutrient augmentation especially during pregnancy (see
Appendix 1 for further discussion).28,29,30
Contraindications
Pregnant or females trying to conceive should use the dotFIT PrenatalMV formula. dotFIT multivitamin
and mineral formulas are contraindicated in those with hemochromatosis, iron-loading anemias,
thalassemia and sideroblastic anemia due to the iron content and for anyone suffering adverse reactions
to any of the ingredients. The NOAEL for iron is 65 mg per day, which is considered safe for most
individuals. (UL is 45 mg during pregnancy.)
Adverse Reactions
There should be few side effects in healthy users at the recommended doses.
Upper Limit/Toxicity
No nutrient in this formula is above the UL or LOAEL.
Summary
Purpose
Unique Features
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KidsMV
Goal
The goal of the KidsMV formula is to provide the nutrients a growing child needs and often does not get
in sufficient amounts due to myriad factors such as poor food choices, lack of interest in certain foods or
food groups and picky eating behavior. There are windows of opportunity for intellectual and physical
growth from infancy through adolescence. A child whose diet is not nutritionally complete during these
critical periods will not be able to compensate for the loss at another time.
Rationale
Children generally need more nutrient-dense foods in their diets due to smaller amounts of food
consumed at meals.31,32 A child's diet may lack essential nutrients for a number of reasons. For example
there are very few dietary sources of Vitamin D other than fatty fish and liver, which are uncommon in a
young childs diet.33 Not surprisingly, children tend to avoid nutritious foods.34,35,36,37,38,39,40,41 They
commonly gravitate towards empty-calorie foods, such as cookies, crackers and candies.42,43 Eating this
type of food generally depresses a child's appetite for healthier foods. Pediatricians may advise parents
of poor eaters that their children will eat when they're hungry. This advice may alleviate a parent's
concern, but it could result in an undernourished child. Children who do not receive proper levels of all
nutrients do not have the potential to develop and function optimally. Although vitamin deficiency is
uncommon in the United States, insufficiency or marginal deficiency is widespread44 which could have
profound health consequences later in life.45
Children with substandard daily diets find it difficult to produce academic performance equal to their
counterparts who consume diets that come closer to the suggested RDAs. In a well-designed study by
Schoenthaler et al., children using a multivitamin and mineral supplement (MVM) who raised their
nutrient intake to the equivalent of a well-balanced diet increased their I.Q. compared to the placebo
group by an average of two-point-five points. In one-fifth of the participants, the MVM raised their I.Q.
16 points, presumably because this group of children ate a poorer diet. 46 More recently, research
suggests that MVM supplementation improves brain function (spatial working memory) in
children.33,47,48
A daily multivitamin and mineral formula helps children receive the nutrients their diet may lack. Giving
a child a multivitamin does not decrease the importance of eating healthy foods and establishing good
eating patterns, nor can a multivitamin and mineral formula replace the nutritional value of food, but it
can supplement a diet lacking essential nutrients.
The American Academy of Pediatrics now recommends that infants, children and adolescents obtain 400
international units (IU) of vitamin D every day, which is double the previous recommendation.45 This
guideline is based on recent evidence that children and adolescents may not be getting enough of this
vitamin, and the occurrence of extreme vitamin D deficiency (rickets) among infants and adolescents in
the United States is of particular concern. The safety of giving infants and children 400 IU of vitamin D
per day has also been established, and research indicates that getting enough calcium and vitamin D
throughout childhood reduces the risk of osteoporosis and other diseases later in life.
31
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Supplement Fac ts
Serving Size: 1 Tablet
Contains No: Dairy, Fish, Crustacean shellfish, Tree nuts, Peanuts, Soy or Gluten.
No Salt, Starch, Artificial coloring, Flavoring or Preservatives added.
Components in this product are derived from natural sources.
Typical Use
All children ages two to 11 unless a specific medical condition prohibits the proper intake of any
nutrient contained in the formula
Ages two to four take one daily
Ages five to 11 take two daily
Ages 12 to 17 use one adult ActiveMV multivitamin and mineral tablet
Precautions
The dotFIT KidsMV is considered safe for healthy users at the proper dosage. Given the ratio of risk to
benefit, the long-term use of this formula is much safer than consuming the typical American diet
without nutrient augmentation.49,50
Contraindications
The dotFIT KidsMV is contraindicated for those with hemochromatosis because of the iron content. The
KidsMV is also contraindicated for anyone suffering adverse reactions to any of its ingredients. Consult
with a physician for drug/nutrient interactions.
32
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Adverse Reactions
At the recommended dosages side effects would be highly unlikely.
Upper Limit/Toxicity
No nutrient in these formulas is above the UL or LOAEL for children.
Summary
Purpose
Unique Features
Formula and use follow strict and updated scientific research criteria for all youth ages
Uniquely formulated to maintain a safe and optimal range of nutrients when combined with
other dotFIT products
The nutrients are in their proper forms, ratios and strengths to complement food intake and
help maintain a safe and optimal range for 24 hours per day
Manufactured in a FDA-registered facility, in compliance with Good Manufacturing Practices
(GMPs) exclusively for dotFIT, LLC
33
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dotFIT SuperCalcium+
Goal
According to the National Center for Health Statistics (NCHS), most Americans do not meet the
Adequate Intake Values of calcium1 or the current higher recommendation of vitamin D.2 Female
adolescents have the lowest intake overall.2 Natural food sources of Vitamin D are scarce, and
dependence on the suns rays present several problems e.g. skin color, fears of skin cancer, sunburns,
etc.3,4,5,6,7,8 Less than adequate intake of these essential micronutrients may lead to osteoporosis,9,10 hip
fractures, falls in the elderly11 and specific cancers.12,13 Supplementation of calcium in combination with
vitamin D can supply the proper amounts of these essential nutrients to help prevent and/or slow the
progression of these conditions.14,15 The objective of Super Calcium+ is to supply the body with specific
amounts of calcium in various salt forms for maximum absorption along with vitamin D and magnesium
for improved utilization in order to meet the bodys established needs that are generally not met
through diet alone.
Rationale
Calcium: The skeletal system accounts for 20 percent of the adult human bodys weight and serves as a
major reservoir for calcium. As we age, the calcium content of bone begins to decline, increasing the
likelihood of fractures. When this critical breaking point is reached, the condition is known as
osteoporosis. This disease affects millions of Americans each year, causing approximately one-point-five
million bone fractures (over 250,000 involve the hip) at a cost of $12-18 billion.10 Fall-related injuries are
a leading cause of morbidity and mortality in older adults.9 Supplying adequate amounts of calcium as
we age may minimize the loss of this important mineral and prevent loss of bone mass.9,10,15 Besides its
function in bone, calcium is required for such essential functions as nerve conduction, muscle
contraction and blood clotting.16
Vitamin D: Recently there has been a steady stream of research on the benefits of vitamin D. Solid
evidence shows that it is just as important as calcium in building and maintaining strong bones by
increasing the absorption of calcium.6,17 Many other tissues in the body have receptor sites for vitamin
D, providing proof that it confers other important health benefits. 6 It plays a role in building muscle
strength which may protect elderly people from falling and bone fractures.18,19,20,21,22,23 In 2005, it was
concluded in the American Journal of Public Health that vitamin D substantially reduced the risk of for
breast, colon, prostate, and ovarian cancer.24
Calcium and Vitamin D: Scientific research has found an inverse relationship between calcium and
vitamin D intake and breast cancer in women.25,26,27,28 Calcium by itself may have a protective effect
against colon cancer.29,30 Although the exact mechanism behind calcium and vitamin Ds cancer-fighting
35
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properties has yet to be discovered, it would be beneficial to maintain adequate levels of these two
micronutrients.
The significant departure in adulthood from the use of dairy products (especially milk) and the warnings
on sun exposure to all have significantly reduced the ability of the U.S. population to acquire adequate
levels of calcium and vitamin D without supplementation.
Magnesium is necessary for the secretion of parathyroid hormone (PTH).31 This hormone aids in calcium
utilization.31 The average American diet lacks magnesium; magnesium is therefore included in this
formula.32
Given the overall positive findings, including the dramatically increased recommendations of vitamin D,
maintaining adequate intakes of calcium and vitamin D throughout life may be a useful strategy for the
prevention and management of osteoporosis, bone fractures, falls in the elderly and specific cancers.
Supplement Fac ts
Serving Size: 2 Tablets
% Daily Value
400 IU
100%
1,000 mg
100%
500 mg
125%
Contains No: Dairy, Fish, Crustacean shellfish, Tree nuts, Peanuts, Soy or Gluten.
No Sugar, Salt, Starch, Artificial flavors, Coloring or Preservatives added.
Components in this product are derived from natural sources.
Typical Use
Anyone not meeting the recommended intakes of calcium and vitamin D through diet or
adequate sun exposure
As a dietary supplement, take one or two tablets daily with meals to meet calcium and vitamin D
requirements as previously stated
36
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Summary
Purpose
Summary
Summary
Based on the current scientific data and the use of various salt forms of calcium found in the
Purpose
Purposeformula, dotFIT Super Calcium+ would be considered an ideal choice, especially when
compared
to other
common
calcium
products
must compete
on of
price
rather
than in
efficacy
Based on the
current
scientific
data and
the usethat
of various
salt forms
calcium
found
the
Based Calcium+
on the current
scientific
datainand
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use longevity
of variousprogram,
salt formswhich
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in theto all
Super
is
one
component
the
dotFIT
is
made
available
formula, dotFIT Super Calcium+ would be considered an ideal choice, especially when
formula, dotFIT
Calcium+
would
be considered an ideal choice, especially when
program
andSuper
will
appear
on the
website
comparedusers
to other
common
calcium
products
that must compete on price rather than efficacy
compared to other common calcium products that must compete on price rather than efficacy
Super Calcium+ is one component in the dotFIT longevity program, which is made available to all
Super Calcium+ is one component in the dotFIT longevity program, which is made available to all
Unique
Featuresusers and will appear on the website
program
program users and will appear on the website
Contains calcium, magnesium and vitamin D, which have been shown to be crucial for proper
calcium utilization
Calcium and magnesium are prepared in mineral transporters including various salt forms
designed to optimize delivery and utilization
This formula considers use of other dotFIT products in order to allow the user to maintain a safe
37
and optimal range of total nutrient intake
Manufactured in a FDA-registered facility, in compliance with Good Manufacturing Practices
(GMPs) exclusively for dotFIT, LLC
37
37
35
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dotFIT SuperiorAntioxidant
Goal
Excess free radicals are caused by normal biological processes, exercise, and the environment and have
been linked to the aging process. This formula is used to increase the intake of nutrients that have been
shown to help contain free radical production. The goal of reducing free radicals is to stave off the
cellular damage they cause and potentially reduce the risk of chronic or age-related diseases. This
includes improving the maintenance of eye health, protecting against heart disease, cognitive decline
and certain cancers.
Rationale
Carotenes: Four of the antioxidants in this formula belong to a class of compounds called carotenes.
Carotenes are plant pigments that result in the yellow, orange and red colors of fruits and vegetables.
Only 34 of the 600 known carotenoids have been found in human serum. Several carotenoids can be
converted by the body to vitamin A. These carotenoids; -carotene, -carotene and -cryptoxanthin are
called provitamin A carotenoids. Carotenoids that do not convert to vitamin A, such as lutein, lycopene
and zeaxanthin, are called non-provitamin A carotenoids. These six carotenoids are the most abundant
in the American diet. Carotenoid absorption requires the presence of fat in a meal. As little as three to
five grams of fat in a meal appears sufficient to ensure carotenoid absorption.1 Because they do not
need to be released from the plant matrix, carotenoids supplements are more efficiently absorbed than
carotenoids in foods. Carotenoids facilitate intercellular communication by increasing the expression of
the gene encoding a connexin protein.2 This type of intercellular communication is important for
maintaining cells in a differentiated state and is often lost in cancer cells.
Alpha () Carotene: -carotene is a fat-soluble compound present in cell membranes. It has the ability
to quench singlet oxygen and other free radicals. Recently, the intake of -carotene has been associated
with a lower risk for lung cancer3 and may offer protection against colorectal and prostate cancers4,5
coronary artery disease6,7,8 and ischemic stroke. Alpha carotene can also inhibit the oxidation of fats
(lipid peroxidation) under certain conditions.9
Lutein/Zeaxanthin: Lutein and Zeaxanthin are similar structures. The difference lies in the orientation of
a single bond, making them geometric isomers. They are the only carotenoids found in the human eye,
predominately in the macula of the retina.10 The macula is responsible for central vision and acuity. Both
compounds serve as blue light and near-ultraviolet radiation filters, protecting underlying ocular tissues
from damage. Both lutein and zeaxanthin effectively quench free radicals.11,12
Clinical trials clearly show that supplementation with lutein and/or zeaxanthin increases macular
pigmentation.10,13,14,15,16,17 Lutein and zeaxanthin may protect against eye diseases such as cataract
formation and age-related macular degeneration (AMD),13,17,18,19,20 the leading cause of vision loss in the
United States.20
39
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Lycopene: Lycopene is the most effective carotenoid at quenching the free radical singlet oxygen.
Lycopene gives tomatoes their red color. Lycopene is more bioavailable from processed tomato
products such as ketchup, tomato juice and pizza sauce than the fresh, whole food. The intake of
lycopene is associated with a significantly lower risk for prostate cancer, a leading cause of cancer death
in the United States.21,22 Lycopene may also protect against heart disease23,24,25,26,27 and other
cancers.28,29 The intake of lycopene from supplements increases the level of lycopene in humans.30
Conclusions from a growing collection of placebo-controlled trials suggest that consumption of lycopene
(either as a dietary supplement or in the form of processed tomatoes) can reduce DNA damage and may
have beneficial effects on prostate cancer.31,32
Coenzyme Q-10: Coenzyme Q-10 (CoQ-10) is part of the ubiquinone family and is involved in energy
production in the electron transport chain. It is a fat-soluble substance, providing protection for cell
membranes against oxidation. CoQ-10 also prevents the oxidation of LDL cholesterol, 33,34,35,36 which is
thought to contribute to the formation of atherosclerosis.37 Therefore, CoQ-10 may support
cardiovascular health.38,39 In humans, CoQ-10 levels decrease with age. Recent research shows that CoQ10 has the ability to reduce fatigue in endurance activity as well as reduce markers of muscle damage
from intense exercise.
-Lipoic acid: D-Lipoic acid is a part of energy producing cycles (enzyme systems) in the body and is a
universal antioxidant. It scavenges the major free radicals: hydrogen peroxide, singlet oxygen,
hydroxyl radical, nitric oxide radical, hypochlorous acid, and peroxynitrite. It can also regenerate other
antioxidants (vitamins C and E) in the body. It is therefore protective against oxidative damage40,41 and
may play a role in disease prevention.42 D-lipoic acid is being extensively researched for several disease
states including diabetic peripheral neuropathy, heart disease and memory loss reduction.
Optiberry Mix: OptiBerry is a standardized, multiple berry anthocyanin extract formulated and tested
for optimum safety, bioavailability, antioxidant and anti-angiogenic (the ability to reduce unwanted
growth of blood vessels, which may lead to varicose veins and tumor formation) activity. OptiBerry
contains a unique, proprietary blend of wild blueberry, strawberry, cranberry, wild bilberry, elderberry
and raspberry extracts (patent-pending), which are known for their health-promoting properties due to
their high content of anthocyanins.43 Anthocyanins also help maintain DNA integrity, serve as antiinflammatory and antimutagenic agents,44 and provide cardioprotection by maintaining vascular
permeability.45 OptiBerry is the result of extensive scientific research, which methodically evaluated
key functional parameters, including ORAC (antioxidant activity), VEGF (anti-angiogenic activity),
bioavailability and safety of numerous individual berry extracts.
40
37
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Supplement Fac ts
Serving Size: 1 Tablet
Typical Use
Everyone, exercisers and non-exercisers, interested in reducing the ravages of free radical
damage and optimal health and functioning and reducing the risk of chronic disease such as
cancers and heart disease
Intense exercisers to reduce the increased free radical production and damage associated with
intense and prolonged training bouts
One tablet per day before or after main meal with a favorite beverage
Can be combined with a dotFIT multivitamin
Precautions
The dotFIT SuperiorAntioxidant is considered safe for the general population at the proper dosage in
healthy users. Given the ratio of risk to benefit, the long-term use of a dotFIT multivitamin with the
SuperiorAntioxidant is much safer than consuming the typical American diet without nutrient
augmentation.46,47 ,48,49,50
CoQ10: Consult a physician if taking warfarin and/or other blood thinning medications. Individuals with
cancer should consult their physician before taking the dotFIT antioxidant formula as high dosages of
CoQ-10 decrease the effectiveness of radiation therapy in mice.51 CoQ-10 has been thought to alter
glycemic control and insulin requirements in diabetic individuals; however, CoQ-10 supplementation
does not appear to alter glycemic control or insulin requirements.52,53 In either case, diabetics should
consult their physician before using the SuperiorAntioxidant.
-lipoic acid: Has been well-tolerated in clinical studies lasting from four months to two years at the
suggested dose of one to three tablets per day (200 to 600 mg/day).54,55,56 Studies of lipoic acid
supplementation in people with conditions like Type II diabetes and peripheral arterial disease have
reported potential minor side effects such as tingling in legs and feet and mild stomach queasiness.
However, it was difficult to know if this was caused by the supplement or the condition.57
41
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Contraindications
The dotFIT SuperiorAntioxidant formula is contraindicated in pregnancy and lactation and for anyone
suffering adverse reactions to any of the ingredients. Pregnant or lactating females should use only the
dotFIT PrenatalMV.
Adverse Reactions
There should be no serious side effects in healthy users at the recommended doses.
-lipoic acid: Side effects are usually not seen unless dosage exceeds 600 mg/day. Reported reactions
include headache, skin rash and stomach upset.58,59
Lutein/zeaxanthin : None reported.
Lycopene: None reported.
CoQ-10: Symptoms of gastrointestinal distress have been reported with dosages of 200 mg or more,
which is unlikely to occur at the present dose of 30 mg/day.
Upper Limit/Toxicity
The National Academy of Sciences has not set an upper limit (UL) for any of the ingredients contained in
the dotFIT SuperiorAntioxidant formula.
-lipoic acid: No upper limit has been established for human use. A two-year study of laboratory rats
reported a no-observed-adverse-effect level (NOAEL) of 60 mg per kilogram body weight.60 The dose in
the dotFIT SuperiorAntioxidant is less than one-tenth of this dose.
Lutein/zeaxanthin : UL data is not available at this time. Human clinical trials have used doses up to 40
mg/day without any adverse or toxicological effects.50 An upper limit has yet to be established.
Lycopene: There have been no reports of adverse or toxicological effects with doses as high as 150
mg/day.50 An upper limit has yet to be established.
CoQ-10: Evidence from randomized human clinical trials indicates that the UL for CoQ-10 is 1200 mg.
There have been no reports of toxicity in studies lasting up to 30 months.61
OptiBerry: Acute oral LD (50) of OptiBerry was greater than 5 g/kg in rats. No human data is available
at this time.44
42
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Summary
Purpose
Intense, prolonged exercise, normal biological processes, etc., can increase free radical
production and damage. The goal of the dotFIT SuperiorAntioxidant is to reduce free radical
damage and optimize health and functioning while reducing the risk of chronic disease such as
cancers and heart disease
A complement to the dotFIT multivitamin and mineral formulas
The dotFIT SuperiorAntioxidant is one component of the dotFIT longevity program which is
made available to all program users and appears on the website
Unique Features
Contains only the most effective researched antioxidants in their proper amounts
Accurately complements the dotFIT multivitamin formulas
Ingredients are prepared in a controlled-release delivery system
Uses the OptiBerry blend which is clinically proven to have superior antioxidant activity
This formula considers use of other dotFIT products to help maintain a safe and optimal range of
total nutrient intake
Manufactured in a FDA-registered facility, in compliance with Good Manufacturing Practices
(GMPs) exclusively for dotFIT, LLC
43
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dotFIT
Joint Flexxibility Pluss
Goal
Cartilage in joints is slo
owly lost with
h age (most noticeably in our
o 50s and 60s) or injury. Because carttilage
is used as a cushion be
etween bone joints, its losss causes frictiion, pain and stiffness. Glucosamine an
nd
chondroittin are naturaal substrates found
f
in and around the cells of cartilagge that provid
de lubrication
n,
retain watter around th
he joint and delay structural degeneratiion of joint tisssue. Joint Fleexibility Plus (JJFP) is
designed to supply glucosamine and
d chondroitin
n sulfate in the forms and amounts
a
used in published
d
1,2,3,4,5,6,7
7,8,9
research to
t support he
ealthy joint tisssue and funcction.
Rationale
e
Recently, the Glucosam
mine/Chondro
oitin Arthritiss Intervention
n Trial (GAIT) study has sho
own that a
w moderate to severe osteoarthritis (OA) found siignificant pain
n relief with the
t
subgroup of patients with
d compounds.10
combined
mine is a necessary substan
nce in the maaintenance of healthy jointts. Glucosamine is required
d for
Glucosam
the synthesis of glycop
proteins, glyco
olipids, and glycosaminogl
g
lycans (also known
k
as
mucopolyysaccharides). These carbo
ohydrate-con
ntaining comp
pounds are fo
ound in tendo
ons, ligamentss,
cartilage, and synovial fluid. Glucosamine stimulates metabolism of chond
drocytes in the articular
cartilage and
a synovial cells
c
in the syynovial tissues. Glucosamin
ne is also useed in the synth
hesis of
proteoglyycans in the jo
oints. Proteogglycans attracct water to the joint and provide essenttial lubrication.11
Several sttudies have sh
hown that glu
ucosamine lesssens sympto
oms of joint pain with no side effects (Figure
1).
Figure 1: The
T basic resultts from several clinical trials comparing
c
NSA
AIDs, placebo and
a glucosamine sulfate for pain
control.9
15
13
11
Before Trials
T
9
7
GS
Placebo
o
NSAIDS
S
1
-1
Pa
ain Level
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dies compare
e glucosaminee to ibuprofen, a non-stero
oidal anti-infllammatory (N
NSAID) which is
Many stud
commonlyy used to treaat pain.5,9,12,133 It was found
d that subjectts symptoms were alleviatted by both
treatmentts equally, bu
ut that the glu
ucosamine group had feweer complaintss of gastrointeestinal distress
(see Figurre 2). In addition, glucosam
mine sulfate will
w not hasten the degradaation of cartilage like NSAIDs
and may delay
d
its degrradation. The exact mechaanism of how it delays the breakdown of
o cartilage tisssue
is unknow
wn at this time
e.
Figure 2: Adverse
A
event data
d
from threee clinical trialss comparing NSSAIDs to glucossamine sulfatee. 9
40
35
30
25
GS
20
Placeb
bo
15
NSAIDS
10
5
0
% of Participa
ants Reporting Adve
erse Events
Supplement Fac ts
Serving Size: 1 Tablet
% Daily Value**
500 mg
400 mg
*
*
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Typical Use
Precautions
Glucosamine and chondroitin are generally considered safe at the recommended doses.15,16
Contraindications
The use of any glucosamine/chondroitin sulfate formula is contraindicated during pregnancy and
lactation because of a lack of data for this population. Supraphysiological amounts of glucosamine have
been shown to reduce the insulin response to glucose in rat studies. This has raised concern regarding
glucosamine use with diabetics. Such concern may be minimized if one considers the recommended
dose is only 1500 mg daily while the dose used in the rat studies would be equivalent to a 154 lb person
taking 132,000 mg in a 3.5 hour period.17 A recent study of oral glucosamine showed no major alteration
in glucose metabolism in patients with Type II diabetes mellitus.7,18,19 Diabetics may wish to discuss
glucosamine use with their physician.
Adverse Reactions
There are few reported side effects from studies on glucosamine or chondroitin. Side effects in clinical
studies have generally been comparable to placebo.20
Upper Limit/Toxicity
There are no known overdoses from glucosamine or chondroitin even in rodent studies at doses up to
5000 mg/kg. Evidence strongly supports safety at intakes of 2000 mg/day for glucosamine and 1200
mg/day for chondroitin sulfate. These values represent the highest levels tested in humans.21
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Summary
Purpose
Joint Flexibility Plus is a safe alternative to the more dangerous NSAIDs for the treatment of mild
osteoarthritis and should be a strong consideration for OA sufferers. JFP would be targeted to those
older adults who experience mild to severe joint pain due to the loss of cartilage that leads to
osteoarthritis.
Joint Flexibility Plus is one component of the dotFIT longevity program which is made available
to all program users and appears on the dotFIT website
Studies have shown glucosamine supplementation to work as well as NSAIDs for relief of mild
joint discomfort with far fewer side effects
Unique Features
Joint Flexibility Plus has no other added ingredients, allowing users to take other supplements
(multivitamin and mineral formula, antioxidant, etc.) without worrying about reaching excessive
levels that may become detrimental over time a common occurrence with other brands
The dotFIT multivitamin acts as a cofactor for this product
This formula considers use of other dotFIT products to help the user maintain a safe and optimal
range of total nutrient intake
The dosage and components are in the precise amounts consistently used in research that has
shown improved mobility, joint comfort, and knee-joint strength
Manufactured in a FDA-registered facility, in compliance with Good Manufacturing Practices
(GMPs) exclusively for dotFIT, LLC
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dotFIT SuperOmega-3
Goal
Fish oils are fats found in fish (e.g. mackerel, lake trout, herring, sardines, albacore tuna and salmon),
which are a rich source of long-chain polyunsaturated fatty acids (LCPUFA), better known as omega-3 (n3 or -3) fatty acids (FA). The two most studied n-3 fatty acids are the 20-carbon eicosapentaenoic acid
(EPA) and the 22-carbon docosahexaenoic acid (DHA).
Due to current dietary habits, the median intake of n-3 fatty acids EPA and DHA for Americans is
approximately 128 mg/day ,well below any level of benefit.1,2 National Health and Nutrition Examination
Survey (NHANES) data from 1999-2000 reveals that fish intake is approximately three ounces per week
and, moreover, from seafood not high in n-3 fatty acids. 3 The goal of this product is to provide a source
of these important fatty acids in a mercury-free, easy-to-ingest form. The formula will also supply the
appropriate amounts that have demonstrated myriad health benefits related to heart and brain function
for those who do not or cannot consume diets containing these heart healthy nutrients e.g. specific oily
fishes and certain plant foods.
Rationale
Heart Disease (high blood pressure, hyperlipidemia and cardiac arrhythmias)
These fatty acids have been shown in numerous studies to lower elevated triglyceride levels .4,5 ,6 ,7,8 The
triglyceride-lowering effect of EPA and DHA appears to result from the combined effects 9 of inhibition of
lipogenesis,10 faster clearance of chylomicrons11 and stimulation of fatty acid oxidation in liver. 12,13
Eicosanoids are bioactive molecules that have various roles in inflammation, regulation of blood
pressure, blood clotting, and immune system modulation. They are derived mostly from the -6 fatty
acids, arachidonic acid.
A diet high in n-6 fatty acids leads to an increase in prothrombotic and proinflammatory prostaglandins
thus increasing the risk of hyperlipidemia, cardiovascular disease and Type II diabetes. 14,15,16,17,18,19
Ingestion of DHA and EPA partially replace the n-6 fatty in the cell membranes (i.e. red blood cells, liver
cells and specific leukocytes), thus reducing prostaglandin E2, thromboxane A2 (potent platelet
aggregator and vasoconstrictor),and formation of leukotriene B4, an inducer of inflammation and a
powerful inducer of leukocyte chemotaxis and adherence. Concurrently there is an increased
concentration of prostacyclin PGI3 without decreasing PGI2. Both PGI2 and PGI3 are active vasodilators
and inhibitors of platelet aggregation.14,15,16 This may explain EPA and DHAs positive effects on
hyperlipidemia, coronary artery disease progression and blood pressure. 20
Although scientific studies have produced mixed results regarding higher intakes of n-3 FA and
reductions in non-fatal myocardial infarction, the anti-arrhythmic effect is well-established.21,22,23,24,25,26
Based on animal models and in vitro studies, EPA and DHA exert their effects on heart cells by inhibiting
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fast, voltage-dependent sodium and calcium currents. This is especially promising in possibly reducing
arrhythmias and fibrillation (e.g. sudden cardiac death) in those who have suffered a myocardial
infarction (such as a heart attack).23,25
Inflammation
As stated earlier, inflammatory and immune cells are sensitive to change according to the ratio of n-3
and n-6 fatty acids in ones diet.17 Several other anti-inflammatory effects of DHA and EPA might be
explained by competitively inhibiting cyclooxygenase-2 (COX-2), lipoxygenase-5 (LOX-5), interleukin (IL)1 and tumor necrosis factor-alpha (TNF-), enzymes involved in inflammation and cartilage
degradation.27,28,29 Therefore, the n-3 fatty acids, EPA and DHA, may possess anti-inflammatory activity,
reducing rheumatoid arthritis17 and other arthritic conditions. Unlike non-steroidal anti-inflammatory
drugs (NSAIDs) which can reduce inflammation on-demand, fish oil supplementation is not associated
with gastrointestinal distress and does not increase cardiovascular risk.28
Age-related Macular Degeneration (AMD)
AMD is the leading cause of blindness.30 DHA is a key essential fatty acid found in the retina 31,32,33 and is
involved in visual development.34 Photoreceptor outer segments in the eyes are constantly being
renewed which may require a steady supply of DHA to maintain proper functioning.33 Blockage of the
blood vessels that supply the retina contributes to AMD. The beneficial effects of n-3 fatty acids on the
retina may be due to DHA and EPAs antithrombotic and hypolipidemic effects.33,35 Epidemiological
studies have suggested that the n-3 fatty acids, DHA and EPA, may be protective against AMD.33,35,36
Cognitive Function
Finally, because DHA is integral to the maintenance of the cell membranes in the brain and important to
the overall central nervous system function, regular consumption of n-3 FA is believed to dramatically
reduce the risk of dementia, thus preserving cognitive function in the aging population and contributing
to mood improvement.37,38,39,40,41
When diet lacks the DHA and EPA content that has demonstrated the above protective qualities, an n-3
FA supplement would be prudent in order to help preserve overall health.
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Supplement Fac ts
Serving Size: 1 Softgel
Servings Per Container: 30
Calories 13
Calories from Fat 11
% Daily Value
1.2 g
2%
0.1 g <1%
0g
0%
1.1 g
*
0.2 g
*
1 mg <1%
2 IU
7%
600 mg
*
360 mg
*
240 mg
*
Typical Use
To maintain cardiac and brain health, take one or two softgels with any meal.
Precautions
Fish oil supplements should be used by children, pregnant women and nursing mothers only if
recommended and monitored by a physician. Because of the possible anti-thrombotic effect of fish oil
supplements, hemophiliacs and those taking warfarin (Coumadin) should exercise caution in their
use.42,43 Fish oil supplements should be stopped before any surgical procedure. Conflicting results have
been reported regarding the effects of fish oil supplements on glycemic control in those with glucose
intolerance including Type II diabetics.20,44 Some early studies indicated that fish oil supplements might
have detrimental effects in those groups. Recently, better designed studies have not reported these
adverse effects. There is no evidence that fish oil supplements have detrimental effects on glucose
tolerance, insulin secretion or insulin resistance in non-diabetic subjects. Diabetics should discuss the
use of these supplements with their physicians and note if the supplements affect their glycemic
control. Diabetics who take fish oil supplements should be monitored by their physicians.
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Contraindications
Anyone taking greater than three grams per day should do so only under the care of their
physician due to risk of excessive bleeding at higher doses 20
Should not be used if user is on anticoagulants or has uncontrolled hypertension42,43
May raise blood sugar and LDL in people with diabetes20
Adverse Reactions
Fish oil supplementation is usually well-tolerated at three to four grams per day. Those side effects that
have been reported include mild gastrointestinal upsets such as nausea and diarrhea, halitosis,
eructation (belching) and "fishy" smelling breath, skin and even urine.20 Taking greater than three grams
per day of n-3 fatty acids can cause excessive bleeding.20
Upper Limit/Toxicity
The US Food and Drug Administration has set the Generally Regarded as Safe (GRAS) level for n-3 fatty
acids at three grams per day.45
Summary
Purpose
Omega-3 FAs are uncommon in the American diet yet are shown to have greater potential than most
other nutrients in maintaining good health. Additionally, it is well known that there is an increasing
shortage of the fish that are the best sources of these omega-3 FA, making supplements an important
consideration.
Cardiovascular (CV) disease is the number one killer in the US and regular consumption of
omega-3 FAs has the ability to reduce negative CV incidences
Omega-3 FA supplementation would be targeted to all adults (over 18) who do not receive one
to two grams per day of the omega-3 FAs EPA & DHA (equivalent to two to four servings of fatty
fish/weekly) as a potential natural preventative aid in age-related cognitive decline and
prevention of CV disease
Recommended as part of the dotFIT longevity program
It has been demonstrated that supplemental fish oil can deliver the same benefits as the oil in
fish46,47,48
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Unique Features
dotFITs SuperOmega-3 fish oil complex provides maximum potencies of two key essential fatty
acids, EPA and DHA
Each dotFIT Omega- 3 softgel delivers 60 percent EPA and 40% DHAdouble the potency of
typical fish oil products
To maximize the body's absorption of Omega-3 essential fatty acids, each softgel is uniquely
enteric-coated to withstand stomach acid and dissolve in the small intestine. The result is
maximum absorption and no "fishy repeat or fish burps
dotFITs SuperOmega-3 fish oil complex is mercury-free and contains no PCBs
This formula considers use of other dotFIT products to help the user maintain a safe and optimal
range of total nutrient intake
Manufactured in a FDA-registered facility, in compliance with Good Manufacturing Practices
(GMPs) exclusively for dotFIT, LLC
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Rationale
Phosphatidylserine (PS): PS is a natural compound produced in the body and obtained in small amounts
in some foods. PS is a special fat-like molecule that is called a phospholipid. It functions as a major
component of cell and mitochondrial membranes. PS is thought to be especially important for the
normal function of nerve and brain cells.4,5 PS is the major type of phospholipid in the brain and is known
to contribute to several essential components of brain cell function.6,7 Many animal studies have
demonstrated enhanced mental function from providing supplemental PS to older animals. Similarly,
several human studies have found that PS supplementation benefited mental functions in older people
suffering from various degrees and types of dementia.4 Since PS is present in virtually all cells in the
body, it is not surprising that PS supplementation is being studied for its likely benefits to many
functions of the body.8
Acetyl-L-Carnitine (ALC): ALC is a specific form of carnitine that is used for a variety of functions in many
types of cells, including brain cells.9 ALC is synthesized naturally in the body; however, ALC levels may
decline in older adults.10 Common foods such as red meats and milk products contain natural L-carnitine
in modest amounts, but these amounts may not make up for the decline observed with aging. One
theory of brain aging is based on observations that the energy generating components (mitochondria) in
brain cells suffer increased amounts of oxidative damage with age. 11 The acetyl form of L-carnitine has
been found to enhance mitochondrial function and to prevent brain mitochondrial decay and decline in
mental function in aging animals.12,13 Several human studies have demonstrated a wide variety of
potential benefits to brain and nerve function.14,15,16,17 Clinical trials have tested ALC supplementation in
older people, showing benefits in the treatment of a variety of mental problems.16,18,19,20 Several studies
have combined supplementation of ALC with alpha lipoic acid, resulting in a potentially enhanced
beneficial effect on aging brain mitochondrial function (see next section).
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Alpha Lipoic Acid (ALA): Due to its essential functions, lipoic acid was initially thought to be a B-vitamin.
It was soon realized that it is not a vitamin since the body can synthesize it. Despite its non-vitamin
status, lipoic acid continues to be the subject of extensive research more than 50 years after its
discovery.16,21,22,23,24 Much of the interest focuses on lipoic acids central role in energy metabolism and
in its ability to function as an antioxidant and free radical scavenger in mitochondria.25 Although ALA is
produced naturally in the cells of humans and animals, there is evidence that boosting ALA levels
through supplementation can benefit nerve and brain function in older animals.26,27,28,29,30,31 Human
studies of supplementation with ALA have focused primarily on its possible role in the treatment of
those with age-related problems in brain function.22 Studies are needed to confirm that similar
supplementation can slow age-related cognitive decline, but animal studies show that benefits are
promising.13,32,33 Lipoic acid supplementation also is being studied for its potential role in the treatment
or prevention of a variety of nerve diseases, Type II diabetes, age-related eye conditions, liver disease,
cancer, cardiovascular disease, etc.13
Vitamin B-12: Among other functions, vitamin B-12 provides essential support for the maintenance of
neural tissues, including neural tissues of the brain. Some studies have reported that as many as one out
of seven people over the age of 65 develop B12 deficiency due to a declining capacity to absorb the
vitamin from foods.34,35 A deficiency may take years to develop, but a long-standing deficiency can result
in permanent damage to neural tissues if diagnosis and treatment are delayed.36,37 Consequently,
prophylactic supplementation with vitamin B12 has been suggested as a reasonable precaution to
protect vitamin B12 status in older adults with a suggested dose ranging from six to 300 mcg/day.34
Supplement Fac ts
Serving Size: 1 Tablet
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Typical Use
Suitable for adults age 45 and older interested in supporting brain and nerve function during aging.
Precautions
The dotFIT Advanced Brain Health is considered safe for the general population at the proper dosage
in healthy users. Advanced Brain Health is designed to be safe to use along with any other dotFIT
supplements taken in their suggested dosages. The Advanced Brain Health Formula is designed to provide
additional brain support elements that complement those already present in the dotFIT multivitamin
formulas as well as the SuperiorAntioxidant and SuperOmega-3 formulas.
Like any dietary supplement, users should consult with their physician and/or pharmacist before taking
this supplement, especially if they are also taking any drugs for medical purposes.
Phosphatidylserine is generally well-tolerated38 when taken at the suggested levels of one to three
tablets per day (100 to 300 mg/day). Phosphatidylserine in dotFIT Advanced Brain Health comes from
soybean sources, removing concerns about any risk associated with bovine sources that were commonly
used in the early research on the substance. Uncommon side effects of phosphatidylserine include
gastrointestinal upset and insomnia.39,40
Acetyl-L-carnitine is typically well-tolerated38 when taken at the suggested dose of one to three tablets
per day (350 to 1050 mg/day). Rare side effects have included nausea, gastrointestinal upset, and
restlessness.41,42
Alpha lipoic acid has been well-tolerated in clinical studies lasting from four months to two years at the
suggested dose of one to three tablets per day (200 to 600 mg/day).43,44,45 Studies of lipoic acid
supplementation in people with conditions like Type II diabetes and peripheral arterial disease have
reported potential minor side effects such as tingling in legs and feet and mild stomach queasiness.
However, it was difficult to know if this was caused by the supplement or the condition.46
Vitamin B-12 is very safe when taken at the dosage in this formula. Since toxicity from vitamin B12 is
virtually unknown, no tolerable upper intake level has been established for vitamin B12 by the Institute
of Medicine.47
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Contraindications
The dotFIT Advanced Brain Health formula is contraindicated in pregnancy and lactation and for
anyone suffering adverse reactions to any of the ingredients. Pregnant or lactating females should use
only the dotFIT PrenatalMV supplement.
Adverse Reactions
There should be no serious side effects in healthy users at the recommended doses.
Phosphatidylserine: Uncommon side effects include gastrointestinal upset (300 mg/day or more) and
insomnia (600 mg/day or more)39,40
Acetyl-L-carnitine: Side effects uncommon; those reported include gastrointestinal upset and
agitation41,42,48
Alpha-lipoic acid: Side effects are usually not seen unless dosage exceeds 600 mg/day Reported
reactions include headache, skin rash and stomach upset. 46,49
Vitamin B12: Side effects unknown.
Upper Limit/Toxicity
The Institute of Medicine has not set an upper limit (UL) for any of the ingredients contained in the
dotFIT Advanced Brain Health formula.
Phosphatidylserine: No upper limit has been established for human use. A 12-week study of people
over 57 years of age concluded that PS is a safe supplement for elderly individuals at doses up to 600 mg
per day (taken in doses of 200 mg three times daily).50
Acetyl-L-Carnitine: A recent risk assessment for L-carnitine established an Upper Level for
Supplements (ULS) for L-carnitine at 2000 mg per day which is equivalent to about 3000 mg of acetyl-Lcarnitine.51
Alpha-lipoic acid: No upper limit has been established for human use. A two-year study of laboratory
rats reported a no-observed-adverse-effect level (NOAEL) of 60 mg per kilogram body weight.52 The
dose in the dotFIT Advanced Brain Health formula is less than 1/10 of this dose.
Vitamin B12: No specific levels of intake are known to be toxic. Some theoretical concern has been
expressed for excessively high intakes for extended periods of time.53
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Summary
Purpose
The goal of the dotFIT Advanced Brain Health formula is to provide substances that help to
support brain function and slow age-related decline in mental functions
Complement to the dotFIT multivitamin and mineral, SuperiorAntioxidant, and SuperOmega-3
formulas
The Advanced Brain Health formula rounds out the dotFIT longevity program by providing brain
support compounds that add to and extend upon the important brain nutrients and protective
components already present in the dotFIT multivitamin, antioxidant, and Omega-3 supplements
Unique Features
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Help create and maintain a calorie deficit by increasing daily calorie expenditure when
compared to a non-supplemented state
Raise energy levels that may make one more active throughout the day
Reduce the drive to consume food
Decrease calorie absorption
The dieter would cease supplementation once the weight goal is reached or when they have their daily
routines under control to continue making progress without supplements.
See Appendix 2: Three proven strategies for weight reduction, maintenance of weight loss and
prevention of weight gain.
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dotFIT FatReleaser
Soon to be known as FatRelease
FatReleaser contains the necessary compounds to support the health and proper functioning of the liver
while supplying ingredients designed to decrease dietary fat absorption, support appetite and deliver
the many potential benefits of green tea (EGCG). As the body gains fat weight so does the liver, leading
to sluggish performance and oxidative stress. Both conditions can have a negative effect on the livers
health1,2 and ability to burn fat.3, 4
Rationale
Choline is a lipotropic agent that has been shown to hasten the removal of fat from the liver. 5
Milk Thistle has been used safely for centuries in treatment of liver problems including improving
circulation, maintaining the integrity of liver cell membranes while increasing livers regenerative ability
and formation of new cells.6,7,8
N - Acetyl cysteine (NAC) is added because it acts as an antioxidant and hepatoprotectant in order to
help combat oxidative stress brought on by accumulating fat in the liver.9,10
Epigallocatechin gallate (EGCG) from Green tea also works as an antioxidant and has the potential to
destroy fat cells 11, increase overall energy expenditure12 and has demonstrated positive effects on fat
oxidation.13,14,15,16,17,18
Rhododendron caucasicum (RC) has been shown to decrease the bodys absorption of dietary fat by
inhibiting gastrointestinal lipase (enzyme that prepares dietary fat for absorption) thus reducing
absorbed calories.19 During three months of clinical trials, patients who received Rhododendron
caucasicum spring leaves extract, in conjunction with a low calorie diet, reduced their original weight
from 10 to 20 pounds, losing two to three times more weight than the placebo subjects (see Figure 3).19
Engelhardtia chrysolepis has demonstrated superior antioxidant activity in suppressing lipid
peroxidation and has also been shown to inhibit a key enzyme involved in the making of cholesterol. 20
Figure 3: As demonstrated in the graph, during three months of dieting, the Rhododendron group lost two to three
hundred percent more weight than the placebo subjects.
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Fat Releaser
Fat Release
Supplement Facts
Serving Size: 1 Tablet
% Daily Value
200 mg **
133 mg **
Choline (as Choline Bitartrate)
50 mg **
N-Acetyl Cysteine (NAC)
Milk Thistle Seed Extract (80% Silymarin) 166 mg **
dotFIT Proprietary Herbal Complex
133 mg **
(Rhododendron caucasicum and Engelhardtia chrysolepis)
** % Daily Value not established.
Other Ingredients: Calcium Phosphate, Croscarmellose, Stearic acid
(Vegetable source), Magnesium Stearate (Vegetable source), Silica,
Hydroxypropylmethylcellulose and Titanium Dioxide.
Contains No: Dairy, Fish, Crustacean shellfish, Tree nuts, Peanuts, Soy or Gluten.
No Sugar, Salt, Starch, Artificial Coloring, Flavoring or Preservatives added.
Components in this product are derived from natural sources.
Non-stimulant
Non-stimulant
fat-loss aid fat-loss aid
Recommended
Recommended
for people who
for people
struggle
who
with
struggle
controlling
with fat
controlling
intake fat intake
Can be usedCan
alone
be used
or as alone
part oforthe
as dotFIT
part of 90
theDay
dotFIT
Weight
90 Day
LossWeight
Solution
Loss
(aka
Solution
LeanPak90)
(aka LeanPak90)
Take one
tablet
Takethree
one tablet
timesthree
daily,times
30 minutes
daily, 30
before
minutes
meals
before
and with
meals
atand
leastwith
8 oz.
atof
least
water
8 oz. of water
Discontinue
Discontinue
after reaching
after
fatreaching
loss goalfat loss goal
Precautions
Precautions
FatReleaser
FatReleaser
is generallyisconsidered
generally considered
a safe fat-loss
a safe
aid.fat-loss aid.
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Contraindications
FatReleaser is contraindicated in pregnancy and lactation because of a lack of data for this population.
Adverse Reactions
EGCG: Typical doses range from one to 10 cups of green tea per day without any adverse events. 21
Choline is not likely to cause side effects at doses up to 3000 mg/day.22
Rhododendron caucasicum is well-tolerated in the recommended dosage.19
Upper Limit/Toxicity
Choline: The UL for choline is 3500 mg/day and the LOAEL is 7500 mg/day.
NAC: The LD50 for NAC in mice is 7888 mg/kg and in rats is 6000 mg/kg. An AMES test performed on
NAC was negative for mutagenicity.8
Milk Thistle: Is considered relatively safe for long-term use.23
EGCG: High doses of green tea or green tea extract, equivalent to 21-25 cups of tea per day can cause
gastrointestinal distress.24,25
Rhododendron caucasicum and Engelhardtia chrysolepis: no data available at this time.
Summary
Purpose
Unique Features
The product works at many different levels within the body (appetite, metabolism, fat
absorption, etc.) to support the loss of body fat
Blend is proprietary to dotFIT
Can be used alone or as part of the dotFIT 90 Day Weight Loss Solution (aka LeanPak90)
Manufactured in a FDA-registered facility, in compliance with Good Manufacturing Practices
(GMPs) exclusively for dotFIT, LLC
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dotFIT
CarbKille
er
Soon to bee known as CarrbRepel
e
Rationale
Phase 2,, a proprietary extract of the bean Phasseolus vulgariis, contains phaseolamin, which
w
can blo
ock
the action
n of alpha am
mylase, the enzyme that breaks down caarbohydrates and allows th
hem to be
absorbed into your body. Five-hund
dred to 1000 mgs of this natural extractt has been sh
hown to
dramaticaally reduce th
he absorption of starches (thus calories), resulting in
n significantly greater weigght
loss in numerous studiies when com
mpared to placcebo.26,27,28,29,30,31,32 (See Figure 4.)
Figure 4: Subjects
S
consum
med a 2000-22
200 calorie carbohydrate rich
h diet. The Phase 2 group exp
perienced ~700
0%
greater weeight loss comp
pared to the pllacebo.
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CarbRepel
Supplement Facts
Citrus Pectin
Pomegranate Fruit Extract
375 mg **
137.5 mg **
Contains No: Dairy, Fish, Crustacean shellfish, Tree nuts, Peanuts, Soy or Gluten.
No Sugar, Salt, Starch, Artificial Coloring, Flavoring or Preservatives added.
Components in this product are derived from natural sources.
Typical Use
A non-stimulant fat loss and appetite aid for those who tend to overeat carbohydrates
Anyone seeking to enhance body fat reduction without affecting the central nervous system
(CNS)
Discontinue after reaching body fat goal
Can be used alone or as part of the dotFIT 90 Day Weight Loss Solution (aka LeanPak90)
Take 2 tablets twice daily, 30 minutes before your largest carbohydrate containing meals or
snacks with at least 8oz of water
Precautions
CarbKiller is generally considered a safe fat-loss aid when used appropriately.
Contraindications
The compounds in CarbKiller are contraindicated in pregnancy and lactation because of a lack of data for
these populations.
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Adverse Reactions
Phaseolus vulgaris when used appropriately seems to be safe when used for two to three months.37,38 ,39
Citrus pectin in large doses (20 g) can cause gastrointestinal side effects.40 Pectin has Generally
Recognized as Safe (GRAS) status in the United States.41
Pomegranate is generally well-tolerated.
Upper Limit/Toxicity
There are no established upper limits for the compounds found in CarbKiller.
Summary
Purpose
The purpose of this product is to reduce caloric intake and absorption in order to accelerate
body fat reduction
A non-stimulant fat loss and appetite aid for those who tend to overeat carbohydrates
Unique Features
The all natural ingredient Phase 2 is the first nutritional ingredient that has been clinically and
scientifically proven to neutralize starch
The FDA has accepted the following claims based on 14 clinical investigations:
o May assist in weight control when used in conjunction with a sensible diet and exercise
program
o May reduce the enzymatic digestion of dietary starches
Formula and recommendations are proprietary to dotFIT
Can be used alone or as part of the dotFIT 90 Day Weight Loss Solution (aka LeanPak90)
Manufactured in a FDA-registered facility, in compliance with Good Manufacturing Practices
(GMPs) exclusively for dotFIT, LLC
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dotFIT ThermoShock
Soon to be known as ThermAccel
ThermoShock is formulated to deliver a better stimulant effect when compared to competitors and
increase thermogenesis (wasting calories as heat) by combining a new energy complex with caffeine and
caffeine-containing herbs. ThermoShock also addresses appetite control by incorporating two powerful
natural ingredients, Caralluma fimbriata and Lepticore , that work through unique body fat regulation
pathways. ThermoShock works through different and complimentary weight regulation mechanisms
than FatReleaser and CarbKiller, making it ideal for cycling or use by itself, especially for people
needing appetite control who do well with a stimulant approach to a body fat/weight reduction
program.
Rationale
Caffeine has been shown to increase energy expenditure (EE) approximately 3-5% in the first 2.5 hours
after ingestion.1 Comparable increases in EE have been shown with Epigallocatechin gallate (EGCG) in
human subjects.2 Combining caffeine and EGCG together may have a synergistic effect on 24 hour EE.3
Respiratory quotient is lower in subjects who consume EGCG which indicates greater fat oxidation.
According to Dulloo et al, fat oxidation accounted for approximately 42% of the total calories burned
over the course of 24 hours in the EGCG group compared to the placebo (32 percent) and caffeine (34%)
groups.2
New thermogenic complex (Caffeine, Yerba Mate, Guarana seeds, Green tea leaf extract and Cayenne
fruit) are uniquely combined to increase the users total daily calorie burn by increasing thermogenesis
(increasing metabolism through wasting calories/fat as heat) and by stimulating a desire to increase
physical activity through enhanced alertness and stimulation of the central nervous system. Caffeine and
caffeine-containing herbs have also demonstrated a positive effect on appetite suppression and fat
oxidation.1,4,5,6
Epigallocatechin gallate (EGCG) from Green tea has demonstrated antioxidant properties, a potential to
destroy fat cells7, increase overall energy expenditure8 (especially in the presence of caffeine) and has
shown positive effects on fat oxidation. 5, 9,10,11,12,13
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Figure 5: Studies show at least a 10% increase in 24 hour EE or equivalent to 157 more calories burned in the
caffeine/EGCG group (Average subjects weight 173 lbs).
2450
2400
2350
Calories
2300
Placebo
2250
Caffeine/EGCG
2200
2150
Placebo
Caffeine/EGCG
Figure 6: In the same study approximately 20 more grams of fat was oxidized by the supplemented group daily.
Fat Oxidation (g/day)
90
80
70
60
Grams
50
40
30
20
10
0
Placebo
Caffeine/EGCG
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Capsaicin from Cayenne fruit can stimulate sympathetic nervous system (SNS) activity, promote the
secretion of catecholamine (epinephrine and norepinephrine, which increases metabolic rate14 and
temperature15), and has been shown to increase the expression of the uncoupling protein 16 (UCP) in
many tissues leading to an increase in wasting calories as heat.
dotFIT proprietary complex includes * Lepticore, which is a new, safe and natural complex of plantbased polysaccharides and esterified fatty acids that has demonstrated ability to reduce stored body fat
17,18,19,20,21,22,23,24,25,26
and enhance weight loss in recent scientific findings.27,28,29,30 Proposed mechanisms
are the complexs ability to interact with the signaling between the brain, adipose tissue and liver to
help control leptin, a hormone that regulates body fat storage. Additionally, the swelling-soluble
properties of the complex may have a prolonged satiating effect thus reducing caloric intake. In the
study conducted at the University of Connecticut, the supplemented group lost 92% more weight than
the placebo.31
Figure 7: In an eight week period with all things equal, the Loleptin group lost ~8.5 lbs more than the placebo
group or 92% more weight.
Weight loss
200
195
190
185
lbs
week 0
180
week 8
175
170
165
160
Placebo
Supplement
Caralluma fimbriata (CF) is a natural extract from an edible succulent cactus that has a long and safe
history of use as an appetite suppressant32 much like the supplement Hoodia gordonii. 33,34, 35,36,37 Unlike
Hoodia, CF has been researched for safety and efficacy, producing positive results. Potential
mechanisms of action include the fact that CF contains pregnane glycosides that may suppress appetite
by amplifying the signaling of energy sensing functions in the brain (hypothalamus). 38 Additionally, CF
may act much like another common appetite suppressant, hydroxycitrate (HCA), by blocking citrate
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lyase. This prevents fat accumulation and redirects extra energy/calories to glycogen stores, which
would also improve signals of satiety.
L-Theanine: Theanine is the major amino acid found in green tea. 39 Green tea contains one to three
percent theanine. 40,41 It has historically been used for its relaxing and anti-anxiety effects.41 It may
lessen the jitteriness effect common with caffeine-containing supplements.42,43
ThermoShock
ThermAccel
Supplement Facts
Serving Size: 2 Tablets
% Daily Value
520 mg **
310 mg **
L-Theanine
ThermoShock Thermogenic Complex
100 mg **
1000 mg **
Contains No: Dairy, Fish, Crustacean shellfish, Tree nuts, Peanuts, Soy or Gluten.
No Sugar, Salt, Starch, Artificial Coloring, Flavoring or Preservatives added.
Components in this product are derived from natural sources.
Typical Use
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Precautions
ThermoShock contains moderate doses of stimulants and should not be used by those seeking to avoid
stimulants.
Contraindications
ThermoShock is contraindicated for pregnant and lactating women and those under the age of 18.
Caffeine is contraindicated in hypertension, anxiety and thyroid disease. Caffeine can interfere with
some medications such as lithium and MAO inhibitors. Caffeine is also contraindicated in those with
cardiac arrhythmias, other forms of heart disease and peptic ulcers.
Adverse Reactions
Caffeine use may result in diuresis (increased water loss, usually in non-users) and insomnia when taken
late in the day. Numerous studies on the safety of caffeine exist. Caffeine abuse can cause tension,
anxiety, excitability and restlessness at doses over 400 mg at one time. Doses over 1000 mg at one time
can elicit toxicity symptoms.44 Because ThermoShock has 130 mg/serving, adverse effects may occur in
sensitive individuals. Taking ThermoShock with other stimulants is not advised. Caralluma fimbriata is
safe at the amounts found in ThermoShock.32
Upper Limit/Toxicity
None of the compounds in ThermoShock approach toxic levels. Doses of caffeine should not exceed
1000 mg/day.
Summary
Purpose
ThermoShock is probably the most powerful of the weight loss products based on its stimulatory
effect combined with two relatively well-researched new additions that target appetite control
and potentially enhance fat cell signaling
The combination of ingredients in ThermoShock is unique to dotFIT and delivers a multi-tiered
attack on body fat
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Unique Features
The proprietary thermogenic blend delivers an enhanced and superior stimulatory effect when
compared to other products
Formula and recommendations are proprietary to dotFIT
Can be used alone or as part of the dotFIT 90 Day Weight Loss Solution (aka LeanPak90)
The tiered approach is designed to aggressively attack the final desired outcomes
ThermoShock contains Lepticore, which has been awarded the patent and claims listed
below*
ThermoShock will deliver all the ingredients by means of a two-stage technology involving
microspheres and macrospheres, providing immediate and prolonged activity for the entire day
Manufactured in a FDA-registered facility, in compliance with Good Manufacturing Practices
(GMPs) exclusively for dotFIT, LLC
*Products containing Lepticore from Pipeline Nutraceuticals, Inc. have the attached rights of employing the
patent number on labels and brochures. At efficacious levels, suggested structure-function or marketing
statements may include the following:
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21 grams of the highest-quality protein, whey protein isolate to support the preservation or
increase of LBM while decreasing body fat
The perfect dose and blend of necessary fats including Conjugated Linoleic Acid (Tonalin) to
support the special needs and appetites of active individuals during dieting
19.5 grams of a Sustained Release Patented Carbohydrate Blend with 8 grams of fiber (Fibersol2 and Glucomannan) and only 2 grams of sugar to deliver immediate and long-lasting energy
and fullness
Rationale
LeanMR Drink Mix for Weight Control
In all studies meal replacements (MR) have been shown to be an extremely effective aid to weight
reduction1 and in almost all cases more effective than conventional methods of dietary restrictions.2,3,4,5
Additionally MR have been shown to be just as effective as dietary restriction combined with
pharmacological therapy.6
And most importantly, continuous use of MR may be the most effective means of all treatments when it
comes to maintaining weight loss1,7, 8,9 (see figure 2).
MRs are generally used to replace one or two meals a day and allow freedom of choice for the
remaining allotted foods/calories.
Meal replacements allow
Portion control: people generally attempt to consume meals to completion,10,11 therefore meal
portion size significantly impacts a persons total calorie intake.10,12 Overwhelming evidence
validates that the smaller the portions, the fewer daily calories consumed12 and vice-versa. In
other words, people tend to eat with their eyes not their stomachs. Use of portion-controlled
meals has proven to yield greater weight loss than conventional diet therapy alone 13,14,15,16
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Accurate calorie counts of total daily food intake when compared to having to estimate the
calories of self-prepared or unmarked meals17
Satiety (fullness): use of a properly formulated MR such as the LeanMR mix allows the user to
increase the frequency of daily meals while managing calories. This in turn satisfies appetite and
maintains greater daily energy levels i.e. more nutrition and fullness with fewer calories, and
often a significant savings in groceries. Proper use throughout the day can deliver good nutrition
while helping to save calories, allowing the user to partake in larger meals or favorite foods at
desired times (e.g. higher calorie lunches and/or dinners)
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Figure 8: In a 1-year follow-up in the groups that were tracked, the subjects still using meal replacements
maintained significantly more weight loss than the RCD group.1
20
15
RCD
10
LBS
PMR
5
0
1
Figure 9: In all six studies the groups that were using meal replacements (PMR) as part of their overall
calorie intake lost significantly more weight than the reduced calorie diet (RCD) group.1
20.0
15.0
RCD
10.0
PMR
LBS
5.0
0.0
1
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Summary
Purpose
The LeanMR mix is to be used primarily as a satisfying and healthy meal replacement that supports
body fat/weight loss goals to a better extent than competitive products. It delivers high satiety and
nutrition in fewer calories:
A healthy, convenient food replacement designed to be integrated into daily meal planning in
order to assist the user in reaching and maintaining weight control and health goals
Supply nutrient-rich, convenient snacks between meals to boost energy, curb hunger and assist
in weight control by controlling calories
Also can be used for snacking, which may decrease the amount of food consumed in the
subsequent meal or keep one from making an inappropriate food choice (e.g. high-calorie meal
driven by an uncontrolled craving) as often happens when extra hungry and especially during
weight loss
Unique Features
performance dotFIT
The goal of products in this category is to deliver safe, known, performance-enhancing substances not
practically available from food or sources that can improve training-induced size or performance
outcomes.
For complete position statement see page 3, and nutrition dotFIT for other goal enhancing formulas.
Also see Appendix 3: Xtreme Muscle Stack: Creating the Perfect Anabolic Storm.
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dotFIT CreatineMonohydrate
Goal
Creatine, a natural substance found in the muscle, is now a proven, safe and powerful size and
performance-enhancing dietary supplement. The goal of supplementing creatine is to increase the
muscle levels of creatine and speed the regeneration of creatine phosphate beyond what can practically
be accomplished by diet alone. Maximizing muscle stores of creatine through supplementation has been
shown in hundreds of clinical trials to improve anaerobic performance, 1 ,2,3,4,5,6,7,8,9,10,11,12,13,14,15 power,
strength,4,11,13,14, 15,16 and enhance muscle size and/or body composition4,7,13,16,17,18,19,20,21,22,23 when
compared to placebo.
dotFIT CreatineMonohydrate is designed to match the exact compound and dosage used in successful
clinical trials that have demonstrated size and performance enhancement. The dotFIT tablet form of
creatine allows the user the freedom to conveniently and accurately control delivery and dosage
throughout the day. Additionally, because of its single ingredient, tablet form and size, dotFIT
CreatineMonohydrate is ideal for increasing total creatine intake to desired levels when using other
creatine products that contain mixed ingredients with limited dosage recommendations.
Rationale
Creatine (Cr) is a substance found in skeletal, cardiac, and smooth muscle. Creatine synthesis occurs in
the liver, kidneys, and pancreas from the amino acids methionine, glycine, and arginine.24 Most of the
total body creatine resides in skeletal muscle where about one-third exists as creatine (Cr) and twothirds as phosphocreatine (PCr). Typically, the human body manufactures about one gram of creatine,
obtains one gram from food, and loses about two grams per day. Therefore, under normal
circumstances, creatine levels are fairly constant.25 The average concentration of total Cr in skeletal
muscle varies between 100 and 150 mmol/kg dry weight in normal humans. Cr and PCr are degraded to
creatinine in a non-enzymatic, irreversible reaction. Creatinine is then filtered by the kidneys into the
urine, the primary route of loss. The primary food sources of Cr are animal muscle meats.
Creatine enters a number of cell types by a sodium-dependent neurotransmitter transporter in the
family, which is related to the taurine transporter and the members of the subfamily of GABA/betaine
transporters.26,27,28 Creatine uptake appears to be enhanced by insulin29,30 and triiodothyronine.31
Harris found that five grams of CrM, ingested five to six times daily, increased total creatine (TCr) from a
mean level of 126 mM/kg dry muscle to 148.6mM/kg, with phosphocreatine representing from 20 to
40% of the increase.32 Hultman et al later found a more gradual increase in TCr by ingesting three grams
per day for 28 days. In both methods, TCr levels increased by approximately 20%. 33
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uscle
Role of Crreatine in mu
Creatine plays
p
a pivotaal role in muscle ergogeniccs by acting ass part of an energy-buffering system.34
e (CK), the reesulting produ
When pho
osphorylated by the enzym
me creatine phosphokinas
p
uct, PCr, can
donate th
he inorganic phosphate
p
to adenosine diphosphate (A
ADP), making adenosine trriphosphate (ATP)
and thus supporting
s
muscle
m
contracction.
During peeriods of musccle contractio
on when ATP breakdown exceeds
e
synth
hesis, PCr rapidly replenish
hes
ATP. PCr supplies
s
the required
r
enerrgy to fuel 10 to 15 high-in
ntensity contrractions such as in weight
lifting. The availability of PCr in skelletal muscle has
h often beeen cited as lim
miting to the continuation
c
of
maximal physical
p
efforrt. To be sure,, the depletio
on of muscle PCr
P stores du
uring intense exercise
e
is
associated
d with the on
nset of musclee fatigue.35 Uttilization of PCr will also co
ontribute to the
t buffering of
lactic acid
d, assisting in continuation of maximal exercise.
e
Creatine Supplementa
S
ation and perrformance
The onsett of fatigue du
uring high-inttensity exercise may be lin
nked to PCr deepletion, pH alterations,
a
o
or
lactate acccumulation. Supplementa
S
al creatine maay play a role in amelioratiing all of thesse factors as
shown in Figure 10 bellow.
Figure 10: Impact of creaatine on high-in
ntensity exerciise (adapted frrom Volek and Kraemer 36 wiith permission)).
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An increase in the syntthesis of conttractile proteiin may be ressponsible for this increase in diameter. As
Figure 13 demonstratess, a significanttly greater muscle hypertrrophy responsse from the addition of CrM
he CrM-treateed group dem
monstrated a
was evideent at three different levels of physiologgy. That is, th
greater gaain in LBM, hyypertrophy off the type IIa and IIx fiberss, and increasse in contractile protein. Cr is
theorized to be the che
emical signal,, coupling inccreased muscular activity to
t increased protein
p
synthesis
54,55,56,57
in hypertrrophy.
exercise mayy be
As mentioned above, thee onset of fattigue during high-intensity
h
linked to PCr depletion
n, pH alteratio
ons, or lactatee accumulatio
on , of which supplementaal creatine maay
wn in the flowcchart.
play a rolee in amelioratting, as show
Figure 12: Shows significantly greater increases in leaan body mass (LBM)
(
in the CrrM group.63
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c
levels may not on
nly increase work
w
capacity,, but also the signal to rem
model
Thereforee, increasing creatine
the affectted tissue. It has
h been sugggested that Cr
C acts as a traanscriptional or translation
nal factor, or
alters the levels of charged tRNAs or
o amino acid pools specific for muscle protein synth
hesis.54,58
m act indirecctly by increaasing the hydrration status of the cell. Evvidence linkin
ng
In addition, creatine may
59,60
0,61,62
olume and protein synthessis has been emerging.
e
Alterations in cell vo
olume may afffect
cellular vo
many horrmone and am
mino acid functions by affeecting the cell membrane potential or Na+
N driven
substrate transport.59,660,61 Thus, theere is an inverrse relationsh
hip between muscle
m
cell flu
uid content and
whole bod
dy nitrogen balance.
b
Thereefore, an incrrease in intraccellular Cr fro
om Cr supplem
mentation maay
induce cell volumizing.. Volumizing over
o
a long peeriod, a greatter amount of fat-free masss (FFM) mayy be
yielded from resistance training in healthy
h
athlettes.22,55,56,57,588,59,60,63
Supplement Fac ts
Serving Size: 2 Tablets
% Daily Value
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Typical Use
Performance enhancement for experienced anaerobic athletes unconcerned with weight gain
Experienced exercisers for improving muscle hypertrophy outcomes from resistance training
Enhancing daily functions in the elderly (confirmed by physician)9,18,19
Two tablets with carbohydrate for every 30-60 pounds of body weight, taken before and after
workout and any time on non-training days throughout training cycle
People with renal complications should consult a physician before use
Studies involving creatine supplementation beyond ten weeks have shown decreases in muscle creatine
stores toward baseline values.16,22,64 This may be due to an inadequate amount of creatine during the
training cycle (most studies used a maintenance dose of five grams a day) and/or the result of creatine
transporters down-regulating. One short-term (eight to nine days) human study indicates creatine
transporters do not down regulate while one long-term animal study (12 weeks) utilizing extremely high
dosages compared to human studies had opposing results. 65
To ensure muscle creatine stores remain elevated throughout intense training cycles and to prevent the
possibility of transport down-regulation, it is recommended that five to ten grams be utilized for up to
ten weeks, followed by a two to four week period without supplementation. Body stores of creatine
return to baseline within four weeks after supplementation is discontinued.16,33 Users can repeat the
cycle if appropriate. The loading strategy utilized may depend on training status and need.
The supplementation protocol most often described in the scientific literature is referred to as
the "loading" protocol. This protocol is described as ingesting approximately 5 grams of CrM
four times per day for five to seven days and three to five grams per day thereafter.66,67 This
protocol is most often used in scientific literature to increase muscle creatine stores
Studies utilizing loading protocols of 20 to 30 grams per day for five to seven days resulted in
approximately 50% absorption64,68,69
Performance benefits may occur more rapidly
May be more beneficial for athletes in a time crunch, and need a boost in performance or
strength
Approximately 25 to 45 grams of carbohydrate (depending on size) should be ingested with each
dosage to maximize creatine storage70,71,72
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It has been demonstrated that lower dosages (three grams per day) have shown to gradually
(over 28 days) increase creatine stores to the same extent.64 Long-term studies using low
dosages (five to six grams for ten to 12 weeks, no loading phase) resulted in significant increases
in strength and muscle size when combined with resistance training21,73
The effect is more gradual; therefore performance benefits do not occur as quickly
Athletes following a specific training cycle (e.g. muscle hypertrophy) and not in a time crunch
can utilize this protocol
Users can start slowly to maximize absorption and to let their connective tissue and muscle
repair keep up with strength increases to avoid injury
Approximately 25 to 45 grams of carbohydrate (depending on size) should be ingested with each
dosage to maximize creatine storage74,75,76
Ultimately a users terminal/maintenance dose will depend on their goal and personal preference.
Creatine loading is personal and varies based on a users physiological state. A minimum of five grams
daily may maintain desired levels for many users, and up to 15 grams daily is not uncommon for larger
individuals. During non-training days, the amounts should continue to be split throughout the day.
Precautions
Creatine Supplementation in Children and Teens
Pediatricians have stated that creatine supplementation is not safe for children and adolescents. 77 While
there is a shortage of investigations that have been conducted using young subjects, no study has shown
creatine monohydrate to have adverse effects in children. In fact, long-term CrM supplementation (e.g.,
four to eight grams per day for up to three years) has been used as an adjunctive therapy for a number
of creatine synthesis deficiencies and neuromuscular disorders in children.78,79 Considering the lack of
available data on youth sports performance and CrM supplementation dotFIT does not recommend
that children under the age of 18 use creatine monohydrate. Young athletes must learn that creatine is
not a magic potion or short cut to athletic success and that proper training and dietary strategies to
optimize performance must be accomplished first.80
Contraindications
Due to one study performed on rats and two human case reports, creatine supplementation is
contraindicated for those with kidney problems or at risk for kidney disease because of possible
increased kidney stress.81 However, clinical trials involving creatine supplementation in healthy adults
have found serum creatine and creatinine levels (indicators of renal dysfunction) within normal ranges.81
Creatine supplementation should be avoided by pregnant or lactating women because of the lack of
studies done with this population. Athletes not desiring weight gain should avoid creatine
supplementation or attempt to lose body fat simultaneously in order to offset muscle weight increases
thus still receiving creatines potential performance benefits.
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Adverse Reactions
Despite the amount of creatine ingested (i.e. up to 30 grams per day for five years) in clinical research,
no adverse reactions (e.g. cramping or increases in core body temperature) have been
documented.6,8,40,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100
Upper Limit/Toxicity
The upper limit for creatine monohydrate has not been established.81
Summary
Purpose
Unique Features
Contains pure creatine monohydrate, the form shown in over 500 studies to yield results
Convenient tablet delivery (consistent dose, no mess, no stomach upset)
Manufactured in a FDA-registered facility, in compliance with Good Manufacturing Practices
(GMPs) exclusively for dotFIT, LLC
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dotFIT CreatineXXL
Goal
This product is designed to increase the well-known strength- and size-enhancing effects of creatine
monohydrate supplementation by supplying an additional compound that work synergistically with
creatine to optimize muscle cell volume and buffer lactate. Therefore, the goal of this product is to
maximize and maintain muscle cell volume and cellular anabolic signaling during intense training
regimes. This is while delaying the onset of fatigue at each exercise bout, leading to increased size and
performance gains when compared to supplementing creatine alone. See Appendix 3: Xtreme Muscle
Stack: Creating the Perfect Anabolic Storm.
Rationale
Cellular hydration is critical to regulating protein metabolism within muscle cells.1,2 Cell swelling
stimulates muscle protein synthesis (MPS)3,4 and shrinkage increases protein degradation. Therefore,
high cell volume can mimic the positive effects of the bodys anabolic hormones on protein metabolism.
When the nutrients involved in cell swelling can be delivered throughout the day in the proper amounts,
exercise-induced muscle protein synthesis could be amplified.5,6,7,8 This formula contains scientifically
validated compounds that can increase and maintain cell swelling, leading to increased gains in size,
strength and performance.
Creatine monohydrate (CrM): Myriad published, scientific articles have consistently reported that
supplemental creatine monohydrate can dramatically improve training-induced strength,9,10,11,12,13
performance4,11,13,14,15,14,15,16,17,18,19,20,21,22,23,24 and size gains.4,7,25,26,27,28,29,30,31,32 Creatine monohydrate
supplementation has been shown to induce cell volume,8 increase the diameter of fast twitch muscle
fibers,33 delay fatigue and increase force production when compared to a non-supplemented state.34 All
conditions can contribute to maximizing each training bout, leading to creatine supplementations
ability to increase long-term muscle and strength gains.
-alanine: Exercise can raise H+ production via ATP/CP and glycolytic energy pathways.35 This increased
H+ concentration lowers blood and muscle pH and eventually leads to fatigue and decreased muscular
work capacity. Studies show that supplemental -alanine can increase muscular content of carnosine (an
intramuscular buffer of H+) by 42-80% (dependent upon dose and length of use), delaying fatigue during
prolonged, intense workouts.36,37
Although creatine supplementation, by itself, has been shown numerous times to increase time to
fatigue and training intensity, -alanine may enhance these effects when added to creatine. Hoffman et
al 35 demonstrated that creatine monohydrate plus -alanine reduced fatigue rates, providing a greater
training stimulus and a higher volume of exercise performed when compared to creatine alone or a
placebo. Additionally, the creatine plus -alanine group had greater increases in lean body mass (LBM)
and larger decreases in body fat compared to the other subjects. The increase in training intensity and
volume by the CrM and -alanine subjects may have led to their positive body composition outcomes.
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Glutamine plays an important role in regulating protein synthesis. It acts as an anti-catabolic agent and
may add to glycogen storage following exercise, thus serving as an important contributor to cell volume
and muscle recovery.2 During cell swelling, there is an increase in muscle cell glutamine transporters,
allowing more glutamine uptake.38,39 This formula uses glutamine peptide, which may allow greater
absorption of glutamine than other forms.
Glycine is included in this formula because it is also involved in cell swelling and maintenance of cell
volume.2,40 Given in combination with the other cell swelling agents listed above, glycine may enhance
the overall volumizing effect.
Supplement Fac ts
Serving Size: 5 Tablets
Typical Use
Dosage
Gradually increase the number of tablets as shown below to keep the cell transporters from
down-regulating and allow connective tissue and muscle recovery keep up with strength
increases to help avoid injury
For maximum benefit and results, CreatineXXL should only be used during intense training
cycles
Approximately 25-45 grams of carbohydrate should be ingested with each dose
Incorporate with NO7Rage and AminoBoostXXL as part of the dotFIT "Xtreme Muscle
Stack" to provide maximum muscle pump and continuous training results for serious exercisers
and athletes
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Tablets
Per Day
5
8
Training
Time
Intensity
30 min before Workout (WO)*
High
4 tabs 30 min before WO* (4 tabs
High
immediately after)
3
10
5 tabs 30 min before WO* (5 tabs
High
immediately after)
4
10
5 tabs 30 min before WO* (5 tabs
High
immediately after)
5
10
5 tabs 30 min before WO* (5 tabs
High
immediately after)
6
10
5 tabs 30 min before WO* (5 tabs
High
immediately after)
7
10
5 tabs 30 min before WO* (5 tabs
High
immediately after)
8
10
5 tabs 30 min before WO* (5 tabs
High
immediately after)
9
10
5 tabs 30 min before WO* (5 tabs
High
immediately after)
10
10
5 tabs 30 min before WO* (5 tabs
Peak of training program or the
immediately after)
week of comp.
11
8
4 tabs 30 min before WO* (4 tabs
Low/med
immediately after)
12
5
split throughout the day
Off
13
0
0
Low/med
14
0
0
Med/high
* For the maximum effect of creatine supplementation and increases in cell volume, all dosages should be taken
with 25-45g of carbohydrate.
Precautions
See Creatine for precautions. -alanine, glutamine and glycine appear to be well-tolerated at the
suggested doses.
Contraindications
See CreatineMonohydrate for contraindications. Athletes who wish to prevent weight gain should avoid
CreatineXXL. Women who are pregnant or lactating are contraindicated because of a lack of data for
these populations.
Adverse Reactions
See CreatineMonohydrate for adverse reactions. -alanine supplementation at 6.4 grams, twice the
amount found in CreatineXXL has not reported any adverse events. 35,36 Glutamine and glycine are
well-tolerated at the doses found in CreatineXXL.
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Upper Limit/Toxicity
See CreatineMonohydrate for upper limit and toxicity information. Six point four grams of -alanine35,36
and 40 grams of alanine41 have been safely used in clinical trials. Glutamine supplementation in a clinical
setting often exceeds doses over 20 grams daily with no serious side effects.42 Point eight g/kg per day of
glycine has been used for up to six weeks without any severe side effects.43
Summary
Purpose
The supplement is the first of its kind and only available through dotFIT. The combination of
ingredients (i.e. creatine and -alanine) have been shown to increase training intensity, training volume
and lean muscle mass to a greater extent than creatine alone, making it the perfect choice for many size,
strength and performance athletes.
CreatineXXL by itself can be a weight (muscle) gain product for intermediate/advance exercisers
and athletes seeking an advantage during high intensity, high-volume training regimes
CreatineXXL can be used in combination with other performance products in order to amplify
their effects, especially to overcome training and muscle size plateaus CreatineXXL is
incorporated into the dotFIT software dietary supplement recommendations as part of the
muscle gain/performance recommendation for all intermediate/advanced athletes/exercisers
that choose anaerobic performance/ muscle gain as the primary goal
Those concerned with weight/muscle gain as a possible hindrance to performance may prefer
not to use CreatineXXL and may seek other performance recommendations suggested by dotFIT
Unique Features
The product works to not only increase muscle mass but also prolong time to fatigue during
intense, high-volume training regimes
No other performance/weight gain product on the market contains the above ingredients in
amounts that have been shown to work synergistically to create a better stimulus for
muscle/strength gain in convenient tablet form
Can be used alone or with NO7Rage and AminoBoostXXL as part of the dotFIT "Xtreme
Muscle Stack" providing maximum muscle pump and continuous training results for serious
exercisers and athletes
dotFIT CreatineXXL tablets are engineered with a proprietary "Swell and Release" delivery
system that offers tremendous advantages for increasing the speed in which nutrients are
available for uptake before exercise
Scientifically proven system works by temporarily attracting fluid into the tablet upon ingestion
which "pressurizes" or "swells" the contents for immediate release
Manufactured in a FDA-registered facility, in compliance with Good Manufacturing Practices
(GMPs) exclusively for dotFIT, LLC
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dotFIT NO7Rage
Goal
The goal of this product is to provide specific compounds that have the ability to enhance blood and
nutrient flow to exercising muscles in order to amplify the training response. NO7Rage includes
ingredients shown to improve reaction time, endurance and force production. In order to improve
training desire and focus, NO7Rage contains compounds that in clinical trials have demonstrated
positive cognitive effects. All together this product has the ability, through multiple pathways, to
significantly enhance strength, performance and size training outcomes when compared to similar
products or a non-supplemented state. See Appendix 3: Xtreme Muscle Stack: Creating the Perfect
Anabolic Storm.
Rationale
NO7Rage contains a proprietary blend of compounds that work synergistically to increase blood flow
(vasodilatation), cell volumization, and mental focus. Greater blood flow to skeletal muscle would
increase the delivery of oxygen, energy and rebuilding nutrients while speeding up the removal of waste
products. This leads to a potential strength improvement, less muscle breakdown and greater net
protein synthesis, especially if combined with an appropriate dose and timed delivery of specific
amino acids (AminoBoostXXL).
1
L-Citrulline: Arginine is the primary amino acid found in most nitric oxide-producing (NO) supplements.
It has been shown to be involved in the production of NO2,3,4,5,6 and creatine biosynthesis7, yet when
used orally, arginine is subjected to substantial intestinal and liver metabolism by arginase.8,9,10,11 This
makes L-arginine virtually ineffective at increasing NO production. L-citrulline, a ubiquitous non-protein
amino acid, is not metabolized in the intestines or liver and does not promote arginase activity.9 The
body readily converts L-citrulline to L-arginine, raising plasma and tissue levels of L-arginine thus leading
to enhanced NO production (see Figure 14: Metabolic Pathway for NO production).9
Figure 14: Metabolic Pathway for NO production
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Glucuronolactone, caffeine, and taurine in combination have been shown to have numerous positive
effects including increased mental focus, reaction time and physical endurance.16,17,18 This is
accomplished through various mechanisms including stimulation of the central nervous system19,
regulation of neurotransmitters in the brain, and alterations in calcium levels within muscle thus
increasing activation.20,21
Glycerol may enhance fluid retention within the body, which leads to greater volumization and pump
within the exercising muscles.22,23,24
Supplement Facts
Serving Size: 25 g (1 Scoop)
Servings Per Container: About 40
Calories 44
Calories from Fat 0
Amount Per Serving
Total Fat
Saturated Fat
Trans Fat
Cholesterol
Total Carbohydrate
Dietary Fiber
Sugars
Protein
% Daily Value**
0% Magnesium (Gluconate)
0% Sodium (Chloride)
* Potassium (Citrate)
0% NO7RageTM Proprietary Blend
4%
Taurine
0%
Glycerol
*
L-Citrulline L-Malate
0%
Betaine Anhydrous
416% Creatine Monohydrate
166% Glucuronolactone
Caffeine
250 mg
Vitamin C
50 IU
Vitamin E
(D-alpha Tocopheryl Succinate)
Vitamin B6 (Pyridoxine HCL)
25 mg 1250%
Vitamin B12 (Methylcobalamin) 120 mcg 2000%
5 mg
118 mg
100 mg
6800 mg
2500 mg
400 mg
175 mg
1%
5%
3%
*
*
*
*
*
*
*
*
Contains No: Dairy, Fish, Crustacean shellfish, Tree nuts, Peanuts, Soy or Gluten.
No Sugar, Artificial coloring or Preservatives added.
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Typical Use
As an aid for intermediate and advanced anaerobic athletes to enhance size and strength gains
from exercise
Performance athletes not affected by weight gain (must self-determine)
All experienced, aspiring and competitive bodybuilders and other anaerobic athletes attempting
to increase muscle size and strength
Incorporate with AminoBoostXXL and CreatineXXL as part of the dotFIT Xtreme Muscle
Stack to provide maximum muscle pump and continuous training results for serious exercisers
and athletes
Dosage
Precautions
NO7Rage contains caffeine, which is a CNS stimulant and should be avoided by those sensitive to its
effects. NO7Rage is otherwise a well-tolerated, ephedrine-free ergogenic aid.
Contraindications
NO7Rage supplementation is contraindicated in pregnancy and lactation because of the CNS stimulant
(caffeine). Caffeine can interfere with some medications such as lithium and MAO inhibitors. Caffeine is
contraindicated in those with cardiac arrhythmias, other forms of heart disease, hyperthyroidism and
peptic ulcers. Creatine is contraindicated for those with kidney problems because of potentially greater
kidney stress.
Do not use if
Using other products containing high doses of caffeine or are caffeine sensitive
Using erectile dysfunction drugs
Individual has a heart condition or is using related medications
Taking medication for hypothyroidism
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Adverse Reactions
Large doses of caffeine may result in diuresis (usually in non-users) and insomnia when taken late in the
day. Numerous studies on the safety of caffeine exist. Caffeine misuse can cause tension, anxiety,
excitability and restlessness at doses over 400 mg at once. Doses over 1000 mg at once can induce
toxicity symptoms. Adverse effects due to high amounts of caffeine are not likely to be seen at the
recommended dose of NO7Rage. Individuals sensitive to caffeine may wish to start with a low dose and
work up to the recommended dose.
Glycerol: Even at doses up to 1 g/kg, glycerol is considered well tolerated, with a few incidences in
clinical trials of gastrointestinal upset, nausea, vomiting, dizziness and bloating.25 The dose of glycerol in
NO7Rage is much lower, making such adverse events improbable.
Citrulline: No adverse reactions have been reported in doses up to 6 grams of citrulline malate.26
Creatine: See dotFIT CreatineMonohydrate.
Glucuronolactone: Glucuronolactone is a substance found in many caffeine and taurine containing
energy drinks at doses of 500 mg or more per drink. It is considered safe and well-tolerated in these
beverages.16,27
Taurine: Taurine is an amino acid naturally present in many foods, especially meats and fish. It has been
combined with caffeine in several beverage studies with no adverse events reported except in one study
where a mild increase in mean arterial blood pressure (2.8 mm Hg average) and an eight-beat-perminute reduction in heart rate were shown.28,29,30 Taurine is used for congestive heart failure at higher
doses from two to six grams daily to help increase stroke volume with few side effects such as mild
diarrhea.31 It is also used for other disease states such as hepatitis and cardiac arrhythmias where doses
from 12 to 20 grams daily were used.31 Mild diarrhea was reported in a few subjects in the heart failure
studies.
Magnesium: High doses of magnesium from supplements greater than 350 mg daily have been
associated with diarrhea. This is unlikely with NO7Rage, especially at a dose smaller than two-and-ahalf scoops.
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Upper Limit/Toxicity
Doses of caffeine should not exceed 1000 mg/day, leaving the dose in NO7Rage at a safe level.
Taurine: Taurine has an LD50 in rats of greater than 64g/kg580 and is present in the human, which
suggests it is quite safe in this product.
Citrulline: The LD50 is not available at this time.
Glycerol: The LD50 for Glycerol is 12.6 g/kg.582.
Magnesium: The UL for magnesium was set at 350 mg from supplements because of a few studies that
showed diarrhea as a side effect. Most studies with doses as high as 1200 mg/day showed no adverse
effects. In the unlikely event that diarrhea occurs while using the NO7Rage at the 2.5-scoop dose,
reduce the dose until the symptoms disappear.
Vitamin B6: B6 has a UL of 100 mg. Even when this product is combined with a dotFIT multivitamin
and a typical diet, the total daily dose is well below the UL.
Vitamin B12: B12 has no UL, NOAEL or LOAEL; therefore, when this product is combined with a dotFIT
multivitamin and a typical diet, the total daily dose is regarded as safe.
The upper limit (UL) for Vitamin E is 1500 IU; even when this product is combined with a dotFIT
multivitamin and a typical diet, the total daily dose is well below the UL.
The upper limit (UL) for Vitamin C is 2000 mg, even when this product is combined with a dotFIT
multivitamin and a typical diet, the total daily dose is well below the UL.
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Summary
Purpose
NO7Rage by itself can be a weight (muscle) gain product for intermediate/advance exercisers
and athletes seeking an advantage during high intensity, high-volume training regimes
NO7Rage can be used in combination with other performance products in order to amplify their
effects, especially to overcome training and muscle size plateaus
Based on NO7Rages stimulatory and positive cognitive effects (mood enhancement), NO7Rage
can stimulate your training desire while increasing workout intensity
NO7Rage is incorporated into the dotFIT software dietary supplement recommendations as
part of the muscle gain/performance recommendation for all intermediate/advanced athletes
and exercisers who choose anaerobic performance/muscle gain as the primary goal
Those concerned with weight/muscle gain as a possible hindrance to performance may prefer
not to use NO7Rage and may seek other performance recommendations suggested by dotFIT
Unique Features
Contains L-citrulline which has been shown to be a more effective substrate for inducing NO
production
Contains a unique, proprietary blend of taurine, glycerol and betaine to enhance the pump
during resistance training workouts
Includes a blend of glycerol powder that is exclusive to dotFITs manufacturer and may be the
most important active ingredient related to the desired pump outcome
The flavor supplied by the manufacturer will be proprietary and hopefully appeal to a greater
portion of users than existing products
Can be used alone or with AminoBoostXXL and CreatineXXL as part of the dotFIT "Xtreme
Muscle Stack" providing maximum muscle pump and continuous training results for serious
exercisers and athletes
Dosage instructions will be far more accurate per individual
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dotFIT WorkoutExtreme
Goal
This product is designed to increase exercise focus, performance, and intensity without weight gain (as
occurs with Creatine). The unique formula quickly supplies a group of compounds that have clinically
demonstrated positive results in increasing energy levels and delaying the onset of fatigue. Users have
the potential to improve training sessions and outcomes when properly consuming WorkoutExtreme
(WE). Additionally, WorkoutExtreme can be used by anyone not bothered by stimulants, as a preworkout or daily pick-me-up.
Rationale
The unique formulation contains several ingredients that have been shown to enhance the users focus
and work capacity. WE special synergistic formulation contains the following:
Caffeine
Caffeine is commonly ingested by people who exercise or participate in sports, due to its wellestablished ergogenic and stimulant effects. It belongs to a group of compounds called the
methylxanthines.1 Caffeine has Generally Recognized As Safe (GRAS) status in the United States.2
Various studies have reported caffeine ingestion to cause an increase in mobilization of free fatty acids
(FFA),3,4,5,6 spare glycogen, stimulate the release of epinephrine, block the effects of adenosine 7, alter
the calcium level in muscle, possibly increase blood pressure in nonhabitual users8, and stimulate the
central nervous system.9,10,11,12,13
All of these physiological effects may explain caffeines ability to reduce fatigue14, improve
concentration15, and enhance mental alertness.8,16,17,18
Caffeine also may stimulate specific tissues directly, such as adipose and peripheral blood vessels.
Additionally, caffeine may stimulate neurons, cardiac muscles, relaxation of smooth muscle, and gastric
acid secretions.8,10 Lastly, numerous studies have demonstrated caffeines ability to increase exercise
performance time to exhaustion (see Figure 15).8,19,20,21
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Figure 15 A & B: Figure 1a shows a significant increase in exercise volume and performance.8 Figure 1b also shows
caffeines effects based on time of administration before exercise.20
Glucuronolactone
Glucuronolactone is a naturally occurring chemical compound produced by the metabolism of glucose in
the liver. This metabolite acts by transferring an amino group during protein metabolism and is one of
the major components of energy drinks worldwide. No studies yet have examined the effect of
glucuronolactone ingestion alone on exercise performance. However, when ingested with taurine and
caffeine, it has been shown to improve cognitive function, alertness, and physical performance due to its
ability to fight fatigue and provide a sense of well-being. 22,23
Taurine
Taurine is a conditionally essential, sulfur-containing amino acid that is the most abundant free amino
acid in many tissues. Unlike other amino acids, Taurine is not incorporated into proteins, but it plays
many roles in the body, including cell volume (osmoregulation), 24 bile acid conjugation, detoxification,
membrane stabilization, and modulation of excitatory neurotransmitters and intracellular calcium
levels.25,26,27,28 More simply, taurine helps regulate heartbeat and muscle contractions, water balance,
energy levels, and levels of neurotransmitters in the brain.29
Taurine is included in this formula to increase physical endurance 30,31 and reaction speed, increase
concentration and mental alertness, improve overall feeling of well-being, enhance water balance and
nutrient uptake in muscle cells, and aid in maintaining optimal hydration during exercise.
Panax Ginseng (American)
The Ginseng in the dotFIT formula is standardized to yield the ideal concentration of ginsenosides (the
active ingredients of ginseng), giving it the potential to improve performance by sparing glycogen,
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increasing fat oxidation, and decreasing lactate accumulation.32,33,34,35,36 Ginseng often acts as an
adaptogen to build resistance to physical and mental stress. 37,38,39,40,41,42,43 High doses of Panax ginseng
have been used in studies to support the claim that ginseng has ergogenic properties in aiding recovery
from exhaustive exercise by attenuating oxidative stress.44
Supplement Fac ts
Serving Size: 4 Capsules
% Daily Value**
1000 mg
*
600 mg
*
300 mg
*
300 mg
*
Contains No: Dairy, Fish, Crustacean shellfish, Tree nuts, Peanuts, Soy or Gluten.
No Sugar, Salt, Starch, Yeast, Artificial flavors, Coloring or Preservatives added.
Components in this product are derived from natural sources.
Typical Use
Experienced athletes (aerobic and anaerobic) seeking to improve performance without water
retention
Do not use if individual experiences adverse effects from stimulants
Do not mix with other stimulants
Take four tablets approximately one hour before exercise with 8 oz of water. If this dose is too
intense, use two tablets
To use this product effectively, cycle for three weeks on and three weeks off during intense
training cycles
Precautions
WorkoutExtreme contains central nervous system (CNS) stimulants and should be avoided by
individuals sensitive to caffeine or who are contraindicated for caffeine-containing supplements. It is a
common belief that caffeine ingestion causes dehydration leading to poor sports performance in
athletes. However, recent scientific investigations have shown that acute caffeine ingestion does not
alter hydration status in exercising adults.45,46 Likewise, caffeine ingestion does not appear to cause
ventricular or atrial arrhythmias except in extremely high doses (the equivalent of 8 cups of coffee per
day).1,47,48
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Contraindications
WorkoutExtreme supplementation is contraindicated in pregnancy and lactation because of the CNS
stimulants caffeine and ginseng. Caffeine can interfere with some medications such as lithium and MAO
inhibitors. Although evidence that caffeine ingestion causes cardiac arrhythmias is inconclusive,
individuals should consult with their physician first before using WorkoutExtreme. Caffeine is
contraindicated in heart disease, hyperthyroidism and peptic ulcers.
American ginseng (Panax) is contraindicated for those taking cholinesterase and MAO inhibitors,
anticoagulants, antiplatelet drugs and hypoglycemic medicines because of potential interactions.
Adverse Reactions
Caffeine may cause insomnia when taken late in the day. Numerous studies on the safety of caffeine
exist.8 Caffeine abuse can cause tension, anxiety, excitability and restlessness at doses over 400 mg at
once. Doses over 1000 mg at once can elicit toxicity symptoms. Adverse events of such high doses of
caffeine are not likely to be seen at the recommended dose of WorkoutExtreme. Sensitive individuals
may wish to start with a low dose and work up to the recommended dose. Clinical trials have not shown
any adverse reactions with taurine.49 Adverse reactions with Panax Ginseng are similar to those found in
placebo controls.50
Glucuronolactone is a substance found in many caffeine- and taurine-containing energy drinks at doses
of 500 mg or more per drink. It is considered safe and well-tolerated in these beverages.22,51
Taurine is an amino acid naturally present in many foods, especially meats and fish. It has been
combined with caffeine in several beverage studies with no adverse events reported except in one study
where a mild increase in mean arterial blood pressure (2.8 mm Hg average) and an eight-beat-perminute reduction in heart rate were shown.52,53,54 Taurine is used for congestive heart failure at higher
doses from two to six grams daily to help increase stroke volume with few side effects such as mild
diarrhea.55 It is also used for other disease states such as hepatitis and cardiac arrhythmias doses from
12 to 20 grams daily were used.31 Mild diarrhea was reported in a few subjects in the heart failure
studies.
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Upper Limit/Toxicity
Caffiene: doses of caffeine should not exceed 1000 mg/day leaving the dose in WorkoutExtreme at a
safe level.
Taurine: Taurine has an LD50 in rats of greater than 64g/kg580 and is present in the human suggesting it
is quite safe in this product.
Panax ginseng: no data available.
Glucuronolactone: no data available.
Summary
Purpose
Athletes (aerobic and anaerobic) seeking an energy boost and/or to improve performance
without water retention
Ideal for endurance athletes not wishing to gain weight while improving performance
Appropriate for use by anyone not bothered by stimulants as an energy enhancer
Not for use by those who experience adverse effects from stimulants
Unique Features
Increases workout energy and intensity without weight gain in an easy-to-use-and-carry pill
form
Ginseng is standardized and certified for proper ginsenosides that have shown positive
metabolic effects
Uses a rapid release capsule delivery system to maximize the formulas potential and provides
an immediate impact on training intensity
Manufactured in a FDA-registered facility, in compliance with Good Manufacturing Practices
(GMPs) exclusively for dotFIT, LLC
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dotFIT Recover&Build
Goal
This product provides the branched-chain amino acids (BCAA), leucine, isoleucine and valine in an ideal
ratio with the goal of reducing exercise-induced muscle damage while enhancing recovery. BCAAs
supplementation accomplishes this goal by
Faster recovery from exercise offers the participant the potential to enhance each subsequent training
bout leading to a greater, long-term training outcome.
Rationale
Leucine, isoleucine and valine are the three branched-chain amino acids (BCAA) so named because of
their molecular structure.3 BCAAs compose approximately 35-40 percent of the amino acids found in
body proteins (14-18% in skeletal muscle) and are oxidized in significant amounts in skeletal muscle.4,5,6
The oxidation of BCAAs in muscle for energy may increase fivefold during strenuous exercise.7,8 This
occurs when BCAAs contribute their nitrogen group to pyruvate, an end product of glucose metabolism,
to form alanine. Alanine is then transported back to the liver to reform glucose which can be shuttled
back to the working muscles. This is known as the glucose-alanine cycle.9 Supplying BCAAs prior to
exercise may reduce the amount utilized from muscle pools, thus increasing muscular endurance,
decreasing protein degradation and muscle soreness. 10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25
Greer et al demonstrated a greater reduction in creatine kinase (a marker of muscle damage) and
muscle soreness with BCAA supplementation compared to a carbohydrate solution and placebo. 26
Recent studies have found BCAAs (specifically leucine) to have an anabolic effect on skeletal muscle via
mTOR (mammalian target of rapamysin), an enzyme that regulates protein synthesis.27,28,29,30
Additionally, it may amplify insulins anabolic properties, eliciting greater gains in lean muscle tissue and
potentiating recovery from exercise. These findings suggest that not only are BCAAs building blocks for
muscle protein synthesis but also that leucine is a modulator of protein metabolism. 29
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Figure 16: Plasma creatine kinase (CK) is shown to be accurate indicator of muscle damage, as shown here, BCAA
supplementation decreases Cr kinase over 2 days.
It is hypothesized that the transport of tryptophan across the blood-brain-barrier (BBB) increases levels
of 5-hydroxytryptamin (5-HT), leading to fatigue during long-duration exercise (e.g. endurance
events).31,32 An increase in serum BCAAs may reduce uptake of tryptophan during endurance exercise,
hence decreasing 5-HT and central fatigue. When BCAA supplementation is supplied to endurance
athletes, rates of perceived exertion and mental fatigue have been shown to be reduced during
exercise.31,32
Leucine is the most potent regulator of protein synthesis, and is therefore provided in the largest
amount in this unique formula.33,34,35,36,37,38
Isoleucine and valine are supplied in a ratio that has been used in the most current research.26
In summary, BCAAs supplementation is designed to allow the body to spend more time, materials and
energy building new muscle rather than simply repairing exercise-induced muscle damage. In addition,
BCAA supplementation may reduce exercise fatigue during endurance-type training and competition.
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Supplement Fac ts
Serving Size: 3 Tablets
Typical Use
Athletes and exercisers of any fitness level during intense or excessive training bouts
Weight-conscious athletes or in-season bodybuilders
Anyone beginning a new intense exercise program
Minimum dose: take five tablets before exercise
Optimal dose and for those over 200 lbs, take eight tablets before exercise
Precautions
The supplementation of BCAA is generally considered safe. Those needing to avoid protein
supplementation should also avoid BCAA supplementation.
Contraindications
BCAA supplementation is contraindicated in pregnancy and lactation because of the lack of studies done
with this population. BCAA supplementation is contraindicated for those with the hereditary disorder
maple syrup urine disease or who have kidney disorders.
Adverse Reactions
There are no known adverse reactions in healthy users at the recommended doses. Up to 50 grams per
day have been used in hepatic encephalopathy patients for six months without any reported adverse
reactions. 39
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Upper Limit/Toxicity
There are no reports concerning BCAA toxicity in relation to exercise and sports.8,39
Summary
Purpose
The anti-catabolic and anabolic effects of BCAA supplementation support the use of Recover&Build as
a viable candidate for any athletic/fitness goal, when training is intense, to enhance recovery, minimize
soreness and increase or maintain lean muscle.
Recover&Build can be used by
Athletes and exercisers of any fitness level during intense or excessive training bouts
Weight-conscious athletes or in-season bodybuilders
Anyone beginning a new intense exercise program
In combination with other performance products in order to amplify their effects, especially to
enhance recovery
Unique Features
Contains the ideal ratio of leucine, isoleucine and valine in a convenient tablet form
dotFIT Recover&Build tablets are engineered with a proprietary "Swell and Release" delivery
system that offers tremendous advantages for increasing the speed in which nutrients are
available for uptake into muscles
This scientifically proven system works by temporarily attracting fluid into the tablet upon
ingestion which "pressurizes" or "swells" the contents for immediate release
Manufactured in a FDA-registered facility, in compliance with Good Manufacturing Practices
(GMPs) exclusively for dotFIT, LLC
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dotFIT AminoBoostXXL
Goal
The objective of AminoBoostXXL is to supply the proper combination of amino acids that have been
shown to increase exercise-induced protein synthesis (when compared to normal feeding alone) and
deliver them at ideal times in order to maximize intense training-induced specific windows of
opportunities for anabolism that take place throughout the day. Proper ingestion would maximize the
unique muscle protein synthesis mechanism that is activated through the feeding of amino acids (AA)
and potentially lead to greater strength and size gains, especially when exercise-induced results have
stabilized (i.e. the training plateau). See Appendix 3: Xtreme Muscle Stack: Creating the Perfect Anabolic
Storm.
Rationale
It has been well demonstrated that AA feeding stimulate protein synthesis independently of all other
mechanisms.1,2,3 Resistance training stimulates an increase in the synthetic rate of muscle proteins, but
following exercise protein balance is negative until amino acids (AA) are provided.4 The immediate posttraining feeding-induced stimulation of protein synthesis (PS) has been shown to be independent of all
other factors (e.g. insulin, exercise, normal meal consumption, etc.)4,5. This is probably due to the
increased delivery of AA, especially leucine6, to muscle. Because the effects of feeding and exercise
stimulation on muscle protein synthesis (MPS) are independent and additive (meaning they induce MPS
by different mechanisms), then delivered closely in an ideal combination (e.g. before and after training),
MPS at that point in time can be maximized. Information about the individual amino acids in
AminoBoostXXL is found below.
BCAA (Leucine, Isoleucine, Valine): See dotFIT Recover&Build
Phenylalanine: Phenylalanine (P) is an essential amino acid that participates in protein synthesis. It is
converted to tyrosine via hydroxylation. Phenylalanine is both glucogenic and ketogenic.7 Sports drinks
that contain a mixture of carbohydrate and free-form amino acids, including phenylalanine, can result in
a greater insulin response than carbohydrate by itself. 8,9
Lysine: L-lysine is an indispensable dibasic amino acid (L-2,6-diaminohexanoic acid) required for human
growth and for maintaining nitrogen balance in adults. Lysine cannot be synthesized by the body, and
therefore must be supplied through diet.10 Lysine, like most other amino acids, is a building block of
body proteins. Among the indispensable AA, lysine is present in the greatest amounts, at 93.0 mmol/dl
and 38 mmol/dl in tissues and serum respectively. Lysine is also required for collagen synthesis, and may
be central to bone health.11,12
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Threonine: Threonine is an essential amino acid often low in vegetarian diets. Aminotransferases exist
for all amino acids except threonine and lysine. Its main routes of catabolism lead to both ketogenic and
glucogenic metabolites.13 The human requirement for threonine set by FAO/WHO/UNU at 7mg/kg/day14
has been challenged by more recent data suggesting a level more than twice this amount to maintain AA
homeostasis15,16 in healthy adults. The Institute of Medicine recently established a threonine RDA for
adults at 27 mg/kg/day.17
Histidine: The end product of histidine catabolism is glutamate, making histidine one of the glucogenic
amino acids. Kriengsinyos, et al. investigated histidines essentiality in healthy adult humans consuming
a histidine-free diet for 48 days. They discovered a gradual decrease in protein turnover and a
substantial decrease in plasma protein concentrations, including albumin, hemoglobin, and transferrin.
So, although histidine deficiency may not affect nitrogen equilibrium, it can impact other important
health parameters.18 Histidine, like cysteine also may have antioxidant properties.19 In regard to
sports/fitness applications, histidine alone has not been studied as a supplement for improving athletic
outcomes. Carnosine is related metabolically to histidine and histamine. It is a naturally occurring
histidine-containing dipeptide present in muscle tissue. Being immuno-protective, carnosine has been
shown to detoxify free-radical species, protect cell membranes, and act as a buffer against lactic acid
and hydrogen ions.20 This is especially important in athletic events where lactic acid buildup (metabolic
acidosis) can affect performance by causing fatigue.21 Intracellular buffering agents such as phosphates
and histidine-containing peptides may help delay fatigue by buffering hydrogen ions, reducing oxidative
damage, and maintaining cell membrane integrity.22,23,24
Methionine: Methionine is a major source of sulfur in human diets, and is an essential amino acid for
normal growth and development. It is considered glucogenic, due to its conversion to pyruvic acid via
succinyl CoA. It is a major methyl-donor, and important in the metabolism of phospholipids. It is also
prominent in methylation reactions, and as a precursor for cysteine, which is the rate-limiting AA for
glutathione synthesis. High levels of methionine are associated with hyperhomocysteinemia and
endothelial dysfunction, which are risk factors for cardiovascular disease.25 Deficiency of methionine
produces hepatic steatosis similar to that seen with ethanol,26 and supplementation with this lipotrope
can prevent ethanol-induced fatty liver.27 Besides methionines role in methyl-group metabolism, and in
serving as a substrate for protein synthesis, its other functions include participation in the synthesis of
polyamines, catecholamines, nucleic acids, carnitine, and creatine.28,29,30 Because of its many functions,
methionine has a high intracellular turnover.31,32 It may be the amino acid that is most rate-limiting for
the building of body proteins, including maintaining nitrogen balance and the effective reutilization of
the other amino acids.33,34 Therefore, the requirement for methionine increases significantly during
times of high protein turnover, such as is seen in burn and trauma patients.35,36
The majority of these essential amino acids with the exception of leucine have not been studied or
tested as an ergogenic substance by itself.
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Supplement Facts
Serving Size: 16 g (1 Scoop)
Servings Per Container: About 33
Calories 50
Calories from Fat 0
Amount Per Serving
% Daily Value**
Total Fat
0g
Saturated Fat
0g
Trans Fat
0g
Cholesterol
0 mg
Total Carbohydrate
0g
Dietary Fiber
0g
Sugars
0g
Protein
12 g
AminoBoostXXLTM Proprietary Blend 12 g
L-Leucine
L-Phenylalanine
L-Lysine
L-Valine
L-Threonine
L-Isoleucine
L-Histidine
L-Methionine
0%
0%
*
0%
0%
0%
*
24%
*
*
*
*
*
*
*
*
*
Typical Use
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Dosage
Considering all data to date, including managing the delicate interplay between insulin and its ability to
maximize muscle protein synthesis, we can establish a potential dosage recommendation range
including timing and amounts that may cover most bases (i.e., compensate for individuality) to create
a better, more constant exercise-induced anabolic environment as opposed to a chronic nonsupplemented state.
Maintaining adequate protein and energy intake at ~1.5-2 g/kg of body weight/day (not including the
grams of the AminoBoostXXL) and no more than a 10-20% calorie deficit, a safe and potentially
effective recommendation for most healthy athletes during intense training cycles is listed below.
Ranges based on size (<150 lbs. use 8 g dose; >150 lbs. use 16 g dose; those in between adjust
accordingly) or greater stresses such as prolonged dieting, extreme training conditions in which users
may increase the dose within the published range (no need for anyone to exceed a 16 g dose).
Each training day* (ranges based on size or greater stresses, e.g., prolonged dieting, extreme training
conditions, etc.):
* Optional for potentially maximizing results: repeat the 8 to 16 g AminoBoostXXL ~one hour before next meal or
before bedtime.
Precautions
Presently, insufficient data exist to use the risk assessment model for determining an upper limit (UL) for
any of the amino acids. Furthermore, chronic excessive use of individual amino acids is likely to be highly
unusual in athletes (no perceived value at levels that may lead to danger) and potentially uncomfortable
(e.g., stomach distress). Consequently, collecting data on amino acid toxicity is difficult and possibly
unnecessary.
Reported adverse events from acute and chronic high-level intake of amino acids are extremely rare. 37
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Amino acid supplementation safety appears to have survived the test of time as it relates to use by
athletes. Despite the lack of adverse events reported by athletes who use amino acid products and the
lack of UL values for amino acids, the safety of chronic high intakes of amino acids is unknown. However,
the risk/benefit ratio appears to be extremely low. And the amounts present in the AminoBoostXXL do
not approach any level of amino acid intake that may lead adverse events. Phenylketonuria (PKU) is a
rare disease (generally diagnosed at birth) caused by an inborn error in the ability to metabolize
phenylalanine (lacking the enzyme phenylalanine hydroxylase).38 In affected people, if the diet is not
controlled by severe restriction of phenylalanine intake, PKU can lead to serious irreversible neurological
disorders, such as mental retardation. Because homocysteinemia is linked with cardiovascular disease,
long-term use of methionine supplements may be of concern. 39
Contraindications
This product, as with any protein or creatine-containing supplement, is contraindicated for users with
kidney or liver disease. This product is contraindicated for phenylketonurics because it contains
phenylalanine. This product is also contraindicated for pregnant or lactating females because it has not
been tested in these groups and because protein can be adequately supplied by the diet for fetal growth
or lactation needs.
Adverse Reactions
BCAA have been used in studies in doses of at least 12 g/day with no side effects, making the dose in
AminoBoostXXL quite safe for healthy users.40
Lysine is often used for herpes simplex at an oral dose of 1 to 3 g/day. It has been used in doses from
400 mg to 6 g/day without adverse events. Above 8 g/day, however, can cause profuse watery diarrhea
in those with lysinuric protein intolerance.41,42 These studies suggest the lysine in AminoBoostXXL should
be well tolerated in healthy users.
Methionine: The average American consumes at least 2 grams (2000 mg) of methionine each day.43
Two point five grams every four hours for 16 hours has been used for acetaminophen poisoning and for
liver disorders.44 Methionine is frequently used in doses of 100 mg/kg to test individuals with various
diseases and levels of homocysteine in their blood. 43,45
The 100 mg/kg dose is generally considered a safe dose during short-term use for medical testing with
mild side effects reported.46 One hundred mg/kg is a much larger dose than users will receive in
AminoBoostXXL. Coincidentally, both methionine deficiency and an excessive acute intake (>100
mg/kg) are associated with liver diseases and other adverse events.47,48 These studies suggest the
methionine in AminoBoostXXL should be well tolerated in healthy users.
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Histidine supplementation in doses of 4 g/day has shown no side effects,49 whereas doses of 24 to 64 g
have caused anorexia and increased urinary zinc excretion.50 These studies suggest the histidine in
AminoBoostXXL should be well tolerated in healthy users.
Threonine has been used for spinal spasticity and amyotrophic lateral sclerosis (Lou Gehrigs disease) in
doses from 2 to 7.5 g/day.48,51 Threonine in doses up to 4 g/day is associated with mild adverse events
ranging from nothing to slight GI discomfort. One study of spasticity at 7.5 g/day showed no adverse
events.51 These studies suggest the threonine in AminoBoostXXL should be well tolerated in healthy
users.
Phenylalanine has been used for a depigmentation disorder called vitiligo in doses of up to 100 mg/kg
with minimal to no side effects.52 A typical 154 pound athlete would be consuming 7 g/day at that dose,
making the amount in AminoBoostXXL safe for users without PKU.
Overall, essential amino acid supplementation in combined doses from 6 to 40 g/day and as described
here is well tolerated in individuals without PKU, kidney or liver disease. 53,54
Upper Limit/Toxicity
Amino acid blends and protein supplements have been studied for use in numerous disease
states and to improve sports performance for decades with a large margin of safety between
the typical doses and those needed for toxic effects in healthy users53,54,55
In addition, the amino acids in AminoBoostXXL all appear on the Generally Regarded As Safe
(GRAS) list and are in forms which may be safely used when added to foods 56
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Summary
Purpose
The product is a new discovery and thus has no competitor as it relates to formula and concept
and is 100% defensible and safe
The product can stand alone, especially for hard training athletes not wanting quick weight gain
but needing rapid muscle tissue recovery (all track, basketball, most baseball, wrestlers, boxers,
runners, cyclists, etc.) based on frequent events/training sessions
All older, hard training exercisers/athletes
Physique competitors, especially during prolonged negative energy balance (dieting)
An essential component in a unique sequence for experienced adult strength and size
exercisers/athletes
Ideal for use in those at a plateau trying to add muscle
Unique Features
The formula uses an EAA blend that was shown to significantly increase muscle protein synthesis
in clinical trials with both adult athletes and non-athletes
The AminoBoostXXL supplement contains a proprietary EAA composition that is designed to
increase the availability of the EAA in proportion to their requirement for muscle protein
synthesis (MPS) many studies have confirmed that under normal diet conditions, the EAA are
primarily responsible for the AA-induced stimulation of muscle protein synthesis
Can be used alone or with NO7Rage and CreatineXXL as part of the dotFIT "Xtreme Muscle
Stack" providing maximum muscle pump and continuous training results for serious exercisers
and athletes
The unique EAA formulation provides for significantly greater muscle gains than traditional
protein/CHO post-workout feedings with considerably fewer calories and nitrogen load on the
kidneys, providing the greatest bang for your buck of any post-workout supplement currently
available
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dotFIT MuscleDefender
Goal
This product is designed to aid in recovery from prolonged, exhaustive exercise by 1) increasing muscle
protein synthesis (MPS); 2) promoting glycogen synthesis; and 3) supporting the immune system. The
goal of MuscleDefender is to supply L-Glutamine peptides in a new, patented, stable form to increase
blood and muscle glutamine levels that are depleted due to prolonged exercise bouts and/or overtraining, thus allowing the exerciser or athlete to maintain their frequency and intensity of training
cycles.
Rationale
Glutamine is one of the most abundant and versatile amino acids (AA) found in the human body,
comprising roughly 50% of the free AA pool in the blood and skeletal muscle.1,2,3 It is involved in several
regulatory processes such as acid-base homeostasis, synthesis of body proteins, and serves as an
energy-yielding substrate (gluconeogenesis). 4,5 Skeletal muscle is the most active tissue for glutamine
metabolism, which can be depleted during times of exhaustive or prolonged exercise bouts (e.g.
endurance, triathlon events, etc).3 Research has shown that decreased muscle glutamine pools can
result in greater catabolism of muscle protein.6 Supplemental glutamine has been found to increase
MPS immediately after exhaustive exercise. 7,8 Glutamine is considered a gluconeogenic amino acid,
donating its carbon skeleton for glucose synthesis. This could decrease amino acid release from muscle
pools leading to faster recovery following exercise. Additionally, from endurance exercise studies, overtraining can lower plasma and muscle glutamine levels9, leading to suppression of the immune system.
4,10
This could result in an increase in upper-respiratory tract infections and a decrease in training
volume and intensity. Published research has shown glutamine supplementation to boost the response
time of immune cells, thus allowing the athlete to sustain greater frequency and intensity of
training.7,11,12,13
MuscleDefender utilizes a patented stabilized form of L-Glutamine that has been demonstrated to
elevate plasma and muscle glutamine levels after ingesting; levels then remain elevated above baseline
for at least 90 minutes (see Figure 17).
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Supplement Fac ts
Serving Size: One Level Scoop (8g)
Servings Per Container: About 50
Amount Per Serving
% Daily Value
L-Glutamine 7.6 g
Magnesium (from 400 mg Magnesium Glycyl Glutamine) 34 mg
Chromium (from 8 mg Chromium Nicotinate Glycinate Chelate) 200 mcg
*
8.5%
167%
Typical Use
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Precautions
Individuals with kidney or liver disease are contraindicated for MuscleDefender given the central role
these organs play in glutamine metabolism.1
Contraindications
Glutamine supplementation is contraindicated in those with kidney problems or at risk for kidney
disease because of possible increased kidney stress. Glutamine supplementation should be avoided by
pregnant or lactating women because of the lack of studies done with this population. Glutamine
supplementation should not be employed by children and adolescents due to limited data.
Adverse Reactions
Doses up to 40 grams/day of glutamine supplementation have not shown any significant adverse
effects.14
Upper Limit/Toxicity
Currently, glutamine does not have an established upper limit and has not been shown to elicit any toxic
effects in high amounts.15
Summary
Purpose
MuscleDefender by itself can be a recovery and performance enhancement product for the following:
Unique Features
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Weight control1,2,3,4,5,6,7
Daily menu incorporation as a meal substitute to reduce or increase daily caloric intake8,9,10,11
Snack between meals as an energy boost or hunger killer 12
Pre- and post-exercise/activity energy and recovery supplement
Guiltless dessert
Rationale
Weight control
It has been well established that successful dieters, weight loss maintainers, athletes and others able to
control a healthy weight regularly incorporate meal replacement/substitute type foods1,2,10,11,13,14 (see
figures 18 & 19), including energy bars or snacks, meal replacements or protein shakes, etc. into their
daily meal plans for the following reasons:
More for less: using nutrition dotFIT products allows you to increase the frequency of daily
meals while managing calories in order to satisfy appetite and maintain greater daily energy
levels i.e. more nutrition15 and fullness with fewer calories and often a significant savings in
groceries. Proper use throughout the day can deliver sound nutrition while helping to save
calories allowing you to partake in larger meals/favorite foods for desired times (e.g. higher
calorie lunches and/or dinners)
Proper use allows more accurate calorie counts of total daily food intake when compared to
having to estimate the calories of self-prepared or unmarked meals 16
Products in the nutrition dotFIT category offer helpful portion control: people generally attempt
to consume meals to completion, therefore meal portion size significantly impacts a persons
total calorie intake. Overwhelming evidence validates that the smaller the portions, the fewer
daily calories consumed17,18,19 and vice-versa i.e. people tend to eat with their eyes not their
stomachs9,10,11,20
A healthy, lower calorie alternative to traditional fast foods
Convenient storage anywhere and faster than stopping and picking up generally less healthy,
higher calorie traditional fast foods
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Figure 18: In all six studies the groups using meal replacements (PMR) as part of their overall calorie intake lost
significantly more weight than the reduced calorie diet (RCD) group.1
18.0
16.0
14.0
12.0
LBS
lost
10.0
RCD
8.0
PMR
6.0
4.0
2.0
0.0
1
Figure 19: In a 1-year follow-up in the groups that were tracked, the subjects still using meal replacements
maintained significantly more weight loss than the RCD group.1
20
18
16
14
12
LBS
lost
10
RCD
PMR
6
4
2
0
1
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Daily menu incorporation as a meal substitute to reduce or increase daily caloric intake
Products in the nutrition dotFIT category can satisfy the criteria for smaller meals or be a balanced
addition to increase meal size:
Reduced meal size: busy people often need quick nutrition that can satisfy nutritional needs and
deliver energy while keeping calories within a range that allows a healthy weight. Multiple,
large, daily meals are not needed for most people today because of low activity in the workplace
and during leisure time (sedentary entertainment).21 And because of the continuous need to sit
so we can be transported by vehicles in order to sit somewhere else. Therefore, nutrition dotFIT
products can supply an adequate caloric meal as a part of ones overall daily meal planning
Increase meal size or calorie intake: when weight/muscle gain is the goal and it becomes difficult
to increase the consumption of traditional foods in order to continue to add lean body mass
(LBM), nutrition dotFIT products offer the ideal solution. Easy/convenient to consume
preparations can be added to any meal or daily menu plan to deliver exactly whats needed so
surplus nutrients/calories are incorporated into muscle tissues rather than body fat when
appropriate resistance exercise is included23,27,29
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LBS
MOR/EVE
2
1
0
-1
Body Mass
LBM
FM
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Guiltless dessert
All nutrition dotFIT can serve as great tasting, healthy low calorie desserts and can satisfy any sweettooth. Products in the nutrition dotFIT category have wonderful flavors and textures with the
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macronutrient blend (protein, fat and carbohydrate ratios) designed to satisfy the appetite for far fewer
calories than it would normally take using traditional desserts.
Typical Use
Use as needed to satisfy any of the stated goals:
Summary
Purpose
Products in the nutrition dotFIT category supply nutrient-rich, convenient between-meal snacks
to boost energy, curb hunger and assist in weight control
Can also be used to increase daily caloric intake when unable to do so by consuming whole food
Pre- and post-workout snack to enhance energy and recovery
Can be used during training
Can be used as a guiltless dessert
A healthy, convenient food assortment designed to be integrated into your daily meal planning
in order to assist you in reaching and maintaining your sport and fitness goals. All products in
the nutrition dotFIT line can be selected based on taste, preference, venue, size and shape or
calorie requirements for any of the above goals
Unique Features
Products in the nutrition dotFIT category are designed in a synergistic relationship with all dotFIT
products and a persons traditional food intake. These products are NOT spiked with
unnecessary nutrients. Most other products in this space (e.g. bars, shakes, ready to drinks, etc.)
are heavily spiked with nutrients that can lead to undesirable levels within the body when
combining multiple manufacturers, products and normal food intake. When consuming only
dotFIT products as directed with ones normal daily food intake, the recipient is assured of
keeping the body at a safe and optimal nutrient level
A good source of calcium and fiber
An excellent source of protein
Formulated and manufactured for great taste and pleasing texture, all nutrition dotFIT
products meet or exceed the FDAs guideline for High Protein and foods are microwaveable
Bars, protein sticks, cookies, etc., are handmade and baked with high quality ingredients
Third-party testing: Commitment to producing world-class products is our #1 priority. Rigorous
testing, both in-house and through third-party FDA approved laboratories, assures that at all
nutritional claims meet or surpass FDA guidelines, USDA guidelines, and industry norms
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Unique features
Typical use
Use as needed to satisfy any of the stated goals:
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Uses
% Daily Value
9%
10%
*
3%
7%
9%
12%
*
*
24%
Vitamin A Protein blend (Soy Isolate, Wheat Isolate, Whey concentrate, Whey
3% Isolate), Wheat flour, Sugar, White
Ingredients:
Vitamin
C
1% Soy Lecithin [an Emulsifier] and
Chocolate icing (Sugar, Palm kernel and Palm oil) Non-fat dry milk, Whole milk,
Calcium
10%
Vanilla), Corn syrup, Vegetable Glycerin, Sorbitol, Maltitol, Palm Oil, Margarine, Lemon flavored flakes (Sugar,
Iron
Vegetable
oil [Palm oil, Palm kernel], Wheat flour, Corn syrup solids, Lemon5%
juice with Lemon oil, Natural flavors,
Citric acid, Yellow 5 Lake, Mixed Tocopherols), Polydextrose, Ground Flax powder, Egg, Natural & Artificial flavors,
Baking soda, Salt, Potassium Sorbate, Calcium Propionate and Guar gum. Contains soy, milk, wheat and egg
products. Manufactured in a plant that processes peanut, tree nut, soy, milk, wheat and egg products.
*Daily Value has not been established
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Uses
% Daily Value
9%
10%
*
3%
7%
9%
12%
*
*
24%
Ingredients:
Vitamin A Protein blend (soy isolate, wheat isolate, whey concentrate, whey
3% isolate), sugar, wheat flour, peanut
butter
icing
(sugar,
palm
kernel
oil,
partially
defatted
peanut
flour,
non-fat
dry
Vitamin C
1%milk solids, peanut oil, salt and soy
lecithin
[an
emulsifier]),
corn
syrup,
vegetable
glycerin,
sorbitol,
maltitol,
peanut
Calcium
10% butter chips (sugar, palm kernel
and
palm
oil,
partially
defatted
peanut
flour,
non-fat
milk,
dextrose,
salt
and
soy lecithin [an emulsifier]), palm oil,
Iron
5%
margarine, peanut butter, polydextrose, ground flax powder, egg, natural & artificial flavors, baking soda, salt,
potassium sorbate, calcium propionate and guar gum. Contains soy, milk, wheat, peanut and egg products.
Manufactured in a plant that processes peanut, tree nut, soy, milk, wheat and egg products.
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Uses
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Uses
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High protein with low cholesterol and good source of calcium and fiber
On-the-go portability
Handmade and baked with high quality ingredients
Contains multiple high quality protein sources
This product meets the NCAA guidelines for college athletes.
Formulated and manufactured for great taste and pleasing texture, the dotTREAT also meets
or exceeds the FDAs guideline for High Protein and is a microwaveable product
Third-Party testing: Commitment to producing world-class products is our #1 priority. Rigorous
testing, both in-house and through third-party FDA approved laboratories, assures our clients
that all nutritional claims meet or surpass FDA guidelines, USDA guidelines, and industry norms
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High protein with low cholesterol and good source of calcium and fiber
On-the-go portability
Handmade and baked with high quality ingredients
Contains multiple high quality protein sources
This product meets the NCAA guidelines for college athletes.
Formulated and manufactured for great taste and pleasing texture, the dotTREAT also meets
or exceeds the FDAs guideline for High Protein and is a microwaveable product
Third-Party testing: Commitment to producing world-class products is our #1 priority. Rigorous
testing, both in-house and through third-party FDA approved laboratories, assures our clients
that all nutritional claims meet or surpass FDA guidelines, USDA guidelines, and industry norms
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High protein with low cholesterol and good source of calcium and fiber
On-the-go portability
Handmade and baked with high quality ingredients
Contains multiple high quality protein sources
This product meets the NCAA guidelines for college athletes.
Formulated and manufactured for great taste and pleasing texture, the dotBAR also meets
or exceeds the FDAs guideline for High Protein and is a microwaveable product
Third-Party testing: Commitment to producing world-class products is our #1 priority. Rigorous
testing, both in-house and through third-party FDA approved laboratories, assures our clients
that all nutritional claims meet or surpass FDA guidelines, USDA guidelines, and industry norms
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High protein with low cholesterol and good source of calcium and fiber
On-the-go portability
Handmade and baked with high quality ingredients
Contains multiple high quality protein sources
This product meets the NCAA guidelines for college athletes.
Formulated and manufactured for great taste and pleasing texture, the dotBAR also meets
or exceeds the FDAs guideline for High Protein and is a microwaveable product
Third-Party testing: Commitment to producing world-class products is our #1 priority. Rigorous
testing, both in-house and through third-party FDA approved laboratories, assures our clients
that all nutritional claims meet or surpass FDA guidelines, USDA guidelines, and industry norms
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High protein with low cholesterol and good source of calcium and fiber
On-the-go portability
Handmade and baked with high quality ingredients
Contains multiple high quality protein sources
This product meets the NCAA guidelines for college athletes.
Formulated and manufactured for great taste and pleasing texture, the dotBAR also meets
or exceeds the FDAs guideline for High Protein and is a microwaveable product
Third-Party testing: Commitment to producing world-class products is our #1 priority. Rigorous
testing, both in-house and through third-party FDA approved laboratories, assures our clients
that all nutritional claims meet or surpass FDA guidelines, USDA guidelines, and industry norms
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Positioning
A healthy, convenient assortment of mixes designed to be integrated into your daily meal planning in
order to assist you in reaching and maintaining your sport and fitness goals. All products in the dotFIT
powdered mix line can be selected based on taste, preference, venue, or calorie requirements for any of
reasons listed in the Typical Use section shown below.
Advantages of mixes
Have it your way: powdered mixes are simply the starting materials you use to create whatever
formula is needed
o By adding other ingredients into the mix, you can create any level or ratio of calories,
protein, fats, carbohydrates (CHO) and other nutrients
Can be used as a tasty and convenient way to deliver important but often neglected nutrients
o Many nutritionally important fruits containing fiber, phytochemicals, etc., can be mixed
with the powders to help anyone regularly consume a healthy diet
Allows near immediate nutrient absorption that continues throughout the necessary time
period that allows the exerciser to maximize the muscle building/recovery potential of the post
exercise metabolic windows of muscle growth & repair (see nutrition dotFIT overview section
on metabolic windows). All formulas used in studies demonstrating performance and size
enhancements using pre- & post-exercise feedings were in liquid form
Can deliver immediate energy lasting throughout the training period as well as the necessary
nutrition to maximize the exercise bout whenever time is an issue
See individual dotFIT powdered mix products for their specific unique features
All use only the highest quality/grade proteins with enhancing cofactors (e.g. Aminogen,
PeptoPr0, lactase, etc.) to aid digestion, absorption and utilization
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Typical Use
Use as needed to satisfy any of the stated goals:
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Rationale
Weight control
It has been well established that successful dieters, weight loss maintainers, athletes and others able to
control a healthy weight regularly incorporate meal replacement/substitute type foods1,2,3,4,5,6,7 (see
figure 21 A & B), such as meal replacements, protein shakes, etc. into their daily meal plans for the
following reasons: 8,9,10,11,12,13
More for less--allows you to increase the frequency of daily meals while managing calories in
order to satisfy appetite14 and maintain greater daily energy levels i.e. more nutrition15 and
fullness with fewer calories and often significant savings in groceries. Proper use throughout the
day can deliver good nutrition while helping to save calories, allowing you to partake in larger
meals/favorite foods at desired times (e.g. higher calorie lunches and/or dinners)
Accurate calorie counts of total daily food intake when compared to having to estimate the
calories of self-prepared or unmarked meals16
Portion control--people generally attempt to consume meals to completion; therefore meal
portion size significantly impacts a persons total calorie intake. Overwhelming evidence
validates that the smaller the portions, the fewer daily calories consumed17,18,19
A healthy, lower calorie alternative to traditional fast foods
Convenient storage anywhere and faster than stopping and picking up generally less healthy,
higher calorie, traditional fast foods
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Figure 21: A. In all six studies the groups that were using meal replacements (PMR) as part of their overall calorie
intake lost significantly more weight than the reduced calorie diet (RCD) group. B. In a 1-year follow-up in the
groups that were tracked, the subjects still using meal replacements maintained significantly more weight loss
than the RCD group.1
A.
lbs
B.
20.0
20
15.0
15
RCD
10.0
PMR
lbs
PMR
5
0.0
0
2
RCD
10
5.0
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Figure 22: Training results from 23 experienced recreational bodybuilders resistance training for 10 weeks with all
things (diet, supplements, training, etc.) equal except the addition of pre/post feedings yielded significantly greater
gains in body mass, LBM, and reduction in fat mass for the pre/post feeding subjects.
7
6
5
4
PRE/POST
MOR/EVE
2
1
0
-1
Body Mass
LBM
FM
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By consuming the same ingredients as the post-workout formula before the workout, we not only
improve the users training energy levels, we can also enhance the recovery and muscle building process
to a greater extent than solely ingesting the post-workout formula.
Although recovery primarily takes place after the workout, you can help speed and enhance the process
before you start exercise by ingesting the Pre/Post Workout Formula formula ten to 40 minutes before
the workout (always make sure your pre-training full food meal is eaten two to three hours before
exercise unless you train first thing in the morning and time does not permit). Proper
carbohydrate/sugar content is important because it stimulates insulin production and insulin is our
bodys most anabolic hormone thus king when it comes to building muscle.36,37 When you repeat the
process immediately post-workout, you quickly restore energy (glycogen) while stimulating a renewed
insulin release, which initiates and enhances the muscle-building hormone process/cascade thus
recovery and results.
Chocolate Flavor
Mix Instructions: 65 g per 10-12 oz WATER
Nutrition Facts
Container
Size: 2.84 lb (1290 g)
Amount Per
Serving
Calories
Calories from fat
Total fat
Saturated fat
Trans fat
Cholesterol
Sodium
Total carbohydrates
Dietary fiber
Sugars
Protein
Vitamin A (as Beta Carotene)
Vitamin C (as Ascorbic acid)
Calcium (as Calcium Lactate Gluconate)
Iron (as Ferrous Sulfate)
Vitamin D (as Cholecalciferol)
INTEGRITY
NUTRACEUTICALS
Vitamin E (as Succinate)
3005 PARKFIELD LOOP SOUTH
Thiamin (as Thiamin Hydrochloride)
SPRING HILL, TN 37174
Riboflavin
Niacin (as Niacinamide)
Vitamin B6 (as Pyridoxine Hydrochloride)
Vitamin B12 (asNUTRACEUTICALS
Cyanocobalamin)
INTEGRITY
Customer / Product Name: Dot Fit Pre/Post
Biotin
3005
PARKFIELD LOOP SOUTH
Variation / Flavor: Chocolate
Pantothenic
D-Calcium Pantothenate)
SPRING
HILL,acid
TN(as
37174
Customer Project --------------------------------------------------->
Iodine (as Potassium Iodide)
Integrity Sample Number ---------------------------------------------->
Magnesium (as Magnesium Phosphate)
Zinc (as Zinc Sulfate)
Other Ingredients (as for Nutrition Facts)
Copper/ (as
Copper
Gluconate)
Customer
Product
Name:
Dot Fit Pre/Post
% Daily
Values*
250
30
3g
5%
1g
5%
0g
30 mg
10%
260 mg
11%
37 g
12%
3g
12%
2g
20 g
40%
500 IU
10%
6 mg
10%
200 mg
200%
1.8 mg
10%
40 IU
10%
rev
3 IU
10%
0.15 mg
10%
0.17 mg
10%
Date Submitted
2 mg
10%
05/04/09
0.2 mg
10%
0.6 rev
mcg
10%
30 mcg
10%
1 mg
10%
15 mcgDate Submitted
10%
40 mg
10%
05/04/09
1.5 mg
10%
0.2 mg
10%
Date:
Label Disclaimers
Contains: Milk and was produced in a facility that also processes egg, soy and shellfish
132
FDA Disclaimer: These statements have not been evalutated by the Food and Drug Administration. This product
is not intended
to diagnose, treat, cure or prevent any disease.
Label
Disclaimers
SRG
1st Edition 2009.
dotFIT Worldwide
www.dotFIT.com
Contains: Milk and was produced in a facility that also processes egg, soy and shellfish
FDA Disclaimer: These statements have not been evalutated by the Food and Drug Administration. This product
is not intended to diagnose, treat, cure or prevent any disease.
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Typical Use
A healthy, convenient food replacement designed to be integrated into your daily meal planning
in order to assist you in reaching and maintaining your sport and fitness goals
Pre- and post-workout feeding to maximize energy, muscle building and recovery. And can be
made to any specifications (i.e. may add ingredients to achieve the desired level of calories
protein, fats & CHO)
Supply nutrient-rich, convenient snacks between meals to boost energy, curb hunger and assist
in weight control by controlling calories
Increase daily caloric intake when unable to do so by consuming whole food
Summary
Purpose
The dotFIT Pre/Post Workout Formula is a healthy, convenient food replacement designed to be
integrated into your daily meal planning in order to assist you in reaching and maintaining your sport
and fitness goals, provide pre- and post-workout nutrients to maximize energy, muscle building and
recovery, and can be made to any specifications (i.e. may add ingredients to achieve the desired level of
calories protein, fats & CHO). Additionally the Pre/Post Workout Formula can supply a nutrient-rich,
convenient snack between meals to boost energy, curb hunger and assist in weight control by
controlling calories. dotFIT Pre/Post Workout Formula can be used to meet daily caloric needs when
unable to do so by consuming whole food.
Unique Features
Perfect blend of the highest quality proteins (whey protein isolate, whey protein concentrate,
calcium caseinate, and micellar casein)
Ideal blend of fast- and continuous-acting carbohydrates for quick and steady energy and
recovery with only three grams of sugar per serving and NO ASPARTAME
Healthy blend of essential fats
Designed in a synergistic relationship with all dotFIT products and a persons traditional food
intake. It is NOT spiked with unnecessary nutrients. Most other products in this space (e.g. bars,
shakes, ready to drinks, etc.) are heavily spiked with many nutrients, leading to undesirable
levels within the body when combining multiple manufacturers, products and normal food
intake
Because of our product synergy, use of our complete product line promotes safe and optimal
daily nutrient intake
Formulated and manufactured for great taste and pleasing texture in an FDA-registered facility,
in compliance with Good Manufacturing Practices and maintains rigorous product testing
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dotFIT FirstString
Goal
The goal of FirstString is to provide the ideal formula containing a mix of protein (P), carbohydrates
(CHO) and fats (F) that meet the NCAA guidelines (NCAA Bylaw 16.5.2.2) for college athletes. This is
while satisfying the established criteria of a pre- and post- exercise/activity meal needed to maximize
training response, thereby leading to greater gains in strength, size and/or performance and
competition outcomes. See the nutrition dotFIT overview.
Rationale
Proper diet manipulations with specialized formulas create and take advantage of metabolic windows
throughout the day where muscle cells become highly receptive to the nutrients necessary to maximize
recovery1,2,3,4 and those used to increase protein synthesis,5,6,78,9,10 specifically before and after
training.3,7,11,12,13,14
Proper timing and composition of nutrients can trigger a hormonal state that can reduce muscle damage
while increasing muscle building, leading to a greater net increase in protein synthesis when compared
to normal feeding patterns with equal diet components (total calories, protein, fats and
carbohydrates).15,16,17 Accomplishing the ideal hormonal environment for muscle building is a function of
carbohydrates (CHO), proteins and fats being supplied in proper ratios, forms and at specific times in
relation to training periods.18 FirstString delivers these macronutrients in the proper form and amounts
that have been demonstrated by numerous clinical trials to enhance training results when compared to
a non-supplemented state.
An approximate 2:1 ratio of CHO to protein, as in FirstString, has been shown to enhance protein
synthesis when used post-training compared to placebo.4,19,20,21,22
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Serving Size:
2 Scoops (75g)
About 32
4 Scoops (149g)
About 16
% Daily Value*
5%
6%
**
17%
4%
15%
6%
**
42%
7%
5%
5%
5%
5%
5%
5%
5%
5%
8%
5%
20%
7%
5%
5%
5%
5%
**
% Daily Value*
9%
13%
**
33%
7%
30%
12%
**
84%
14%
10%
10%
10%
10%
10%
10%
10%
10%
17%
10%
40%
14%
10%
10%
10%
10%
**
Carbohydrate 4
2,500
80g
25g
300mg
2,400mg
3500g
375g
30g
Protein 4
Typical Use
As a pre- and post-workout supplement, each training day (dose ranges based on size),
10-40 minutes pre-workout:
Under 200 lbs, consume two scoops; over 200 lbs, consume four scoops
Immediately following training, repeat the same dose
As a meal replacement or weight gain supplement use as needed throughout the day to meet
individual calorie and nutrient goals
Summary
Purpose
The base product is a higher calorie and CHO to protein ratio per serving than other dotFIT
powders, allowing the product to serve multiple roles: pre/post-training supplement, weight
gainer and meal replacement
Targeted to all athletes but primarily towards the youth through collegiate athlete. As a
supplement can help maximize a childs athletic development including overall growth potential.
A natural and safe product for the youth population
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The 42 grams of the best quality proteins (see WheySmooth for info on proteins) and 86 grams
of CHO packed into 570 calories (vanilla flavor) make FirstString the perfect muscle gain
formula
Can deliver exactly whats needed so surplus nutrients/calories are incorporated into muscle
tissues rather than body fat when appropriate resistance exercise is included and total daily
calories are appropriate
Unique Features
Contains Aminogen, which has been shown to increase the bodys uptake of amino
acids/protein, making greater amounts available to the working muscles and decreasing
incidences of bloating/gas common with competitive products
CHO content satisfies the necessary profile for maximizing protein synthesis while fitting into a
low sugar claim, which will appeal to prevailing perceptions
42 grams of protein, 86 grams of CHO and only eight grams of sugar (vanilla flavor)
No aspartame and relatively low sodium
Sophisticated ideal blend of the highest quality fast and slow acting proteins
dotFIT meal replacements (nutrition dotFIT) are designed in a synergistic relationship with all
dotFIT products and a persons traditional food intake. These products are NOT spiked with
unnecessary nutrients. Most other products in this space (e.g. bars, shakes, ready-to-drinks,
etc.) are heavily spiked with many nutrients that can lead to undesirable levels within the body
when combining multiple manufacturers, products and normal food intake
When consuming only dotFIT products as directed with ones normal daily food intake, the
recipient is assured of keeping the body at a safe and optimal nutrient level
Manufactured in a FDA-registered facility, in compliance with Good Manufacturing Practices
(GMPs) exclusively for dotFIT, LLC
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dotFIT WheySmooth
Goal
WheySmooth is designed to deliver a high quality protein (PRO) source, rich in essential amino acids,
which allows a high protein intake even during a low calorie diet. WheySmooth comes in a powdered
form allowing the user to mix and adjust the total protein and other nutrient content as
needed/desired. Whey proteins can be useful for improving training outcomes by 1) increasing protein
intake when whole food sources are insufficient or not an option (i.e. early morning workouts or low
calorie diets); 2) maximizing lean muscle mass in exercising or dieting adults; 3) hastening and improving
recovery from exercise bouts; and 4) supporting immune function during high volume training.
Rationale
Timed ingestion of whey protein both pre- and post-workout1,2,3 facilitates a more rapid absorption of
amino acids into the bloodstream and their subsequent delivery to the target tissues when compared to
other sources of proteins.4,5,6 Whey protein hydrolysates have the highest content of essential and
branched chain amino acids of any protein and yield small peptides that are absorbed quickly into the
blood stream.7,8 For bodybuilders, wrestlers, or other weight-conscious athletes preparing for
competition (these athletes are often underfed and overtrained at this point), these formulas offer a
viable way to meet protein and amino acid requirements for maintaining and increasing lean mass while
calorie intake remains low enough to accomplish the body composition or weight goals.9
As exercise intensity and volume increase, muscle amino acid and glycogen stores are depleted. 9,10,11,12,13
This can induce a catabolic state in the athlete and impair recovery if adequate post-exercise nutrition is
not available.7 Zawadski et al showed that the addition of whey protein to a carbohydrate (CHO) drink,
post-workout, accelerated muscle glycogen synthesis compared to CHO alone.14 The result may be
attributed to a greater insulin response to the CHO/PRO combination than with CHO alone (see Figure
23). Both protein/CHO solutions used whey as the protein source and as you can see, the addition of
leucine further increased the insulin response. Insulin is a powerful anabolic hormone necessary for
stimulating muscle protein synthesis (MPS).15,16,17,18,19,20,21,22 It is widely accepted in the scientific
community that resistance training (RT) increases muscle protein synthesis (MPS).11,23,24,25 Research has
firmly established that the combination of RT and whey protein ingestion produces a synergistic effect
on muscle hypertrophy by supplying a unique grouping of essential amino acids (specifically leucine)
post-RT to initiate and enhance MPS.26,27,28,29 The combination of whey proteins ability to accelerate
glycogen resynthesis and stimulate MPS may significantly improve exercise recovery leading to greater
training outcomes (e.g. muscle hypertrophy, sports performance, strength).
Whey protein may help sustain the immune system during high-volume training cycles.30,31 A high
concentration of cysteine is found in whey protein, which is needed for glutathione production, a
natural antioxidant found in the body.32,33,34 Glutathione may assist in repairing damaged cells including
cells of the immune system due to stressors, such as exercise and keep them running smoothly.35,36,37
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Proper use of whey proteins for certain athletes during intense training may significantly enhance the
desired outcomes, especially if total calorie intake is being limited to allow the pursuit or maintenance
of low body fat.
Figure 23: Insulin response to three different post-workout drinks.
Precision formulated to improve body composition and enhance performance, dotFITs WheySmooth is
packed with a stunning 40 grams of medical-grade protein from five different very high biological value
sources (whey protein isolate, whey protein concentrate, egg albumin, calcium caseinate, micellar
casein). WheySmooth's matrix of slow and fast releasing proteins and essential fatty acids help
ensure WheySmooth provides the best of both worlds; keeping you and your muscles in an anabolic
state all day long.
PeptoPro
PeptoPro is comprised of small pieces of protein, mainly di- and tripeptides (two or three amino acids),
giving it two key advantages. First, PeptoPro amino acids are quickly taken up by the body and delivered
to the muscles. This is ideal for pre- or post-activity feeding. Second, compared to intact protein and
other hydrolysates, PeptoPro has better taste and texture properties, ensuring that ours is the best
tasting, most effective protein supplement on the market.
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Aminogen
Aminogen is clinically proven to increase amino acid levels and boost nitrogen retention.38 Developed by
Triarco Industries, Aminogen is a patented, natural, plant-derived designer enzyme which breaks down
protein and improves amino acid absorption. Aminogen also supports protein digestion while reducing
or eliminating the gas, bloating and constipation some users experience with protein supplements.
Co-factors
Pyridoxal 5' Phosphate (the active form of vitamin B6) is involved with a myriad of functions in the
body, but of interest here is its role in protein metabolism (catabolism/anabolism) and immune
function.39
Lactase is the enzyme that breaks down lactose (milk sugar). Isolated protein sources derived from milk
contain miniscule amounts of lactose and should pose no problem to those that may be lactose
intolerant (unable to make the enzyme lactase). But, to be on the safe side and insure that we have the
most easily digested and utilized formula, it is included.
Chocolate Flavor
Mix Instructions: 64 g per 10-12 oz WATER
Nutrition Facts
Container
Calories
Calories from fat
Total fat
Saturated fat
Trans fat
Cholesterol
INTEGRITY
NUTRACEUTICALS
Sodium
3005 PARKFIELD LOOP SOUTH
Total Carbohydrates
SPRING HILL, TN 37174
Dietary fiber
INTEGRITY
NUTRACEUTICALS
Sugars
3005
PARKFIELD LOOP SOUTH
Protein
SPRING
TN 37174
VitaminHILL,
A
Customer / Product Name: Dot Fit Whey Smooth
Vitamin C
Variation / Flavor: Chocolate
Calcium
Customer Project --------------------------------------------------->
Iron
Integrity
Number
CustomerSample
/ Product
Name:---------------------------------------------->
Dot Fit Whey Smooth
% Daily
Values*
260
40
4.5 g
7%
1.5 g
8%
0g
60 mg
20%
rev
330 mg
14%
14 g
5%
4g
16%
rev Date Submitted
2g
05/04/09
40 g
80%
0 IU
0%
0 mg Date Submitted
0%
05/04/09
200 mg
20%
1.8 mg
10%
Date:
Label Disclaimers
Contains:
Milk and
egg, statements
is producedhave
in a facility
that
also processes
soy and
FDA Disclaimer:
These
not been
evalutated
by the Food
andshellfish
Drug Administration. This product
is not intended to diagnose, treat, cure or prevent any disease.
139
FDA Disclaimer: These statements have not been evalutated by the Food and Drug Administration. This product
is not intended to diagnose, treat, cure or prevent any disease.
dotFIT Worldwide
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Typical Use
WheySmooth is ideal for athletes or exercisers seeking to acquire the highest amount of protein with
the least amount of calories in order to maximize training induced size, performance and strength
outcomes.
Adults who do not meet protein requirements from food intake, especially physique and other
athletes (strength, endurance and active recreational) during an adaptation period
Weight and body-fat conscious athletes during the final weeks of competition dieting, in order
to meet protein requirements with fewer calories
Underfed and over-trained athletes
Anyone wanting a great tasting, convenient protein source
Those concerned with proper timing of protein intake and want the quick digestibility that
cannot be accomplished by traditional food sources
Precautions
Some studies have shown an increase in calcium loss with high protein intakes which may predispose
the individual to an increased risk of osteoporosis.40 However several, recent studies have found the link
between protein intake and bone health to be positive.41,42 The Institute of Medicines and other related
studies have concluded that levels of dietary protein are not associated with a decrease in renal function
with age.43,44,45,46
Contraindications
WheySmooth is contraindicated in pregnancy and lactation unless protein needs cannot be met by food
alone. WheySmooth is contraindicated in people who cannot consume milk proteins.
Adverse Reactions
There should be no adverse effects in healthy users at the recommended doses.
Upper Limit/Toxicity
Currently there is no UL established for protein.
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Summary
Purpose
Because of whey proteins structure, high essential amino acid content and bioavailability, this product
is ideal for athletes or exercisers seeking to acquire the highest amount of protein with the least amount
of calories in order to maximize training induced size, performance and strength outcomes.
Unique Features
Forty grams of protein from the highest BV sources, giving WheySmooth its unique "fast and
slow" release pattern
PeptoPro peptide complex for rapid absorption and utilization and superior taste and mixing
properties
Aminogen for more complete protein digestion, amino acid absorption and nitrogen retention
Co-factors available to ensure greater amino acid and protein utilization
Great taste, easy mixing
No gas or bloating as is common with other protein powders
Contains only 2 grams of sugar per serving and NO ASPARTAME
Manufactured in a FDA-registered facility, in compliance with Good Manufacturing Practices
(GMPs) exclusively for dotFIT, LLC
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7/24/09 1:14:18 PM
ActiveMV
The
ActiveMV delivers a combination of
nutrients in a controlled-release preparation
Whatwhen
is it?used properly, has the greatest
that,
chance to
The ActiveMV formula is a multipurpose
multivitamin
and mineral
formula.
The
Help stave
off chronic
disease
ActiveMV
is used
at the specified
Supply
essential
nutrientstimes
in an attempt
throughout
ones
lifetime.
formula contains
to prevent nutrientThis
deficiencies
doses
antioxidants
at the higher
end offrom
the
ofOvercome
marginal
deficiencies
optimal todays
range. common limitations in
obtaining
How does
it work?sufficient and optimal
nutrient intake
The ActiveMV delivers a combination of
Who
should
this product? preparation
nutrients
in atake
controlled-release
that,
when
used it
properly,
has multivitamin
the greatest for
At
one
pill daily,
is the basic
chance
to
everyone over 12 years of age. At two pills daily,
it is designed for athletes and all others with an
Help stave off chronic disease
active lifestyle aged 18 to 65 (general
Supply essential nutrients in an attempt
population over age 50, see the Over50MV
to prevent nutrient deficiencies
formula and women 18 to 50 years of age, see
Overcome marginal deficiencies from
the WomensMV formula).
todays common limitations in
obtaining
Suggested
Use sufficient and optimal
nutrient intake
As a dietary supplement, athletes or individuals
Who
should
take this
product?
involved
in intense
physical
activity should take
1 tablet, twice daily, with or after main meals.
At one pill daily, it is the basic multivitamin for
Consume with 8 oz of your favorite beverage.
everyone over 12 years of age. At two pills daily,
it is designed for athletes and all others with an
active lifestyle aged 18 to 65 (general
population over age 50, see the Over50MV
formula and women 18 to 50 years of age, see
the WomensMV formula).
Suggested Use
pose
he
mes
mula contains
end of the
n of
paration
reatest
Supplement Fac ts
143
Amount
Per Serving the ages of
% Daily
Value years of
Individuals
between
12-17
Vitamin A
4,500 IU 90%
(as Beta Carotene
4,000 do
IU and not
Acetate 500
IU)
age and those
who
follow
a
regular
Vitamin C (as Ascorbic acid)
450 mg 750%
Vitamin D (as Cholecalciferol)
600 IU 150%
exercise program
should
use 1 tablet
Vitamin E (as D-Alpha
Tocopheryl Succinate)
150 IU 500%daily with
Vitamin K (as Phytonadione)
50 mcg 63%
a main meal.
optimal
results,
use
Vitamin B1For
(as Thiamine
Mononitrate)
5 mg
333%daily with
Vitamin B2 (as Riboflavin)
5 mg 294%
Niacin
(as
Niacinamide)
15
mg
75%
dotFIT SuperCalcium+ (if calcium intake
from
Vitamin B6 (as Pyridoxine HCI)
6 mg 300%
Folic Acid
100
mcg 25%
food is less
than
1000
mgs
per
day).
Vitamin B12 (as Cyanocobalamin)
15 mcg 250%
Biotin
150 mcg
50%
Contains No: Dairy, Fish, Crustacean shellfish, Tree nuts, Peanuts, Soy or Gluten.
No Sugar, Salt, Starch, Yeast, Artificial flavors, Coloring or Preservatives added.
Components in this product are derived from natural sources.
Unique Features
dotFIT Worldwide
www.dotFIT.com
7/24/09 1:14:32 PM
WomensMV
Non-exercising
womendisease
between ages
Help stave off chronic
18
and
50
who
are
not
pregnant
or
Supply essential nutrients in an attempt
trying
to become
pregnant
to prevent
nutrient
deficiencies
Breastfeeding
women
Overcome marginal deficiencies from
Suggested Use
fic needs of
higher
acid. Also
utrients for
eed the
formulas.
Suggested Use
n of
paration
eatest
se
an attempt
cies
cies from
in
mal
Unique Features
ally for
ween ages
nant or
SRG internal.indd
Unique Features
155
www.dotFIT.com
7/24/09 1:14:47 PM
individual
folic acid,
luded are
min D,
vitamin K.
on of
paration
eatest
seases such
sease
an attempt
cies
cies from
in
mal
Supplement Fac ts
Serving Size: 1 Tablet
Over50MV
Suggested Use
As a dietary supplement, take 1 tablet daily with
a meal and 8 oz. of water. For optimal results,
use daily with dotFIT SuperCalcium+ (if
calcium intake from food is less than 1000 mgs
per day).
Unique Features
a is for
of age
ers over 65
et daily with
al results, SRG internal.indd
m+ (if
145
Unique Features
157
www.dotFIT.com
7/24/09 1:15:06 PM
o do not
e who eat a
etarian or
, iron and
this formula
foods are
minimal
the
erly, this
se
an attempt
cies
cies from
in
mal
Suggested Use
As a dietary supplement, take 1 tablet daily with
a meal and 8 oz. of water.
Unique Features
urces and is
females
et daily with
SRG internal.indd
Supplement Fac ts
Serving Size: 1 Tablet
% Daily Value*
10,000 IU 200%
200 mg 333%
1,000 IU 250%
100 IU 333%
50 mcg 63%
6 mg 400%
6 mg 353%
20 mg 100%
6 mg 300%
200 mcg 50%
15 mcg 250%
50 mcg 17%
10 mg 100%
159
www.dotFIT.com
7/24/09 1:15:20 PM
Who
should
take
product?
Take one
tablet
withthis
breakfast
as a nutritional
supplement. For optimal results, use daily with
The PrenatalMV formula is for
dotFIT SuperCalcium+ (if calcium intake from
foodis less
than 1000
mgs per
day).
Females
preparing
for pregnancy
and
Suggested Use
Take one tablet with breakfast as a nutritional
supplement. For optimal results, use daily with
dotFIT SuperCalcium+ (if calcium intake from
food is less than 1000 mgs per day).
% Daily Value
5,000IU
250mg
600IU
100IU
50mcg
4mg
4mg
20mg
8mg
600mcg
12mcg
50mcg
15mg
27mg
150mcg
100mg
10mg
100mcg
0.5mg
50mcg
100%
417%
150%
333%
63%
267%
235%
100%
400%
150%
200%
17%
150%
150%
100%
25%
67%
143%
25%
42%
Unique Features
Contraindications
The dotFIT multivitamin and mineral formulas
are contraindicated for those with
hemochromatosis (an inherited disease that
leads to iron-overload, affecting 0.5 percent of
the population) because of the iron content.
161
147
dotFIT Worldwide
www.dotFIT.com
7/24/09 1:15:30 PM
KidsMV
V
What is it?
i
A health aid
a designed for
f a growingg child who
does not get
g sufficient amounts of important
i
KidsMV
V
nutrients,
, such as vitam
min D, due to
o myriad
factors su
uch as poor fo
ood choices, lack of
What
i certain foodds or food grooups and
interestisin
nit?
picky eating behavior.
A health aid
a designed for
f a growingg child who
does
not
g
get
sufficient
i
How doe
es it work? amounts of important
nutrients,, such as vitam
min D, due to
o myriad
of nutrients
The
KidsM
MV
aood
combination
of
factors
su
uch delivers
as poor fo
choices, lack
in a contrin
edspreparation
that,and
when
interest
nolled-release
certain food
or food gro
oups
used
prop
greatest
cha
perly,
has
the
nce
to
picky eating behavior.
Supplement Fac ts
Serving Size: 1 Tablet
Su
upply
essential nutrients in an attempt
How doe
es
it work?
to
o prevent marginal nutrien
nt
The KidsM
MV
delivers a combination of nutrients
de
eficiencies
in a contr
eunction
preparation
that, when
Dolled-release
optim
mally,
evelop and fu
used prop
greatest
cha
perly,
has
the
nce
to
demically
esspecially acad
Overcome
O
marginal deficiencies from
al nutrients
in
Su
upply
essenti
an attempt
to
odays common
s in
limitations
to
preventsuffi
marginal
nutrien
oobtaining
cient and
optnt
timal
de
eficiencies
e
nutrient intake
Develop and fu
unction optim
mally,
specially
es
Who sho
ould
takeacad
thidemically
is product?
Overcome
O
marginal deficiencies from
All childre
en
agescomm
two to
o
unless asspecific
to
odays
in
on11limitations
medical ocbtaining
ondition suffi
proh
hibits
the pro
oper
cient and
opt
timalintake off
any nutrie
contained
de in the formu
ula.
utrient
intake
nent
Suggeste
ed Use
Who sho
ould
take thiis product?
Aen
gesages
twotwo
to fo
our
take
oneadaily
dspecific
All childre
to
o 11
unless
Acondition
ily intake off
ges five to
11
1hibits
take the
twopro
daoper
medical
proh
gescontained
12 to 17duse
t ActiveMV
Aent
oneformu
adultula.
any nutrie
in the
taablet
Suggeste
ed Use
Ages two to fo
our take one daily
d
Ages five to 11
1 take two daily
Ages 12 to 17 use one adultt ActiveMV
taablet
Contains No: Dairy, Fish, Crustacean shellfish, Tree nuts, Peanuts, Soy or Gluten.
No Salt, Starch, Artificial coloring, Flavoring or Preservatives added.
Components in this product are derived from natural sources.
Uniq
que Feature
es
Formula and
a use follow
w strict and
updated scientific reseearch criteria for
all youth ages
Uniquely formulated to
t maintain a safe
Uniq
queand
Feature
es
optim
mal range of nutrients
n
wheen
combined
d with other dotFIT
d
prod
ducts
Formula
aentsuse
w strict
andfo
The nutriand
arefollow
in th
heir
proper
orms,
updated
rese
earch
criteriantfor
ratios and
dscientific
strengths
to
o
complemen
all
youth
ages
food intake and help maintain
m
a saffe
and
Uniquely
t 24maintain
a ay
safe
formulated
mal
range forto
hours a d
optim
optim
mal
range
nA-registered
nutrients
wheen
and
Manufact
tured
in a of
FDA
combined
d
with
other
d
dotFIT
prod
facility, in
n compliance with Good ducts
Manufact
The nutrituring
ents are
in th
heir
proper fo
orms,
Practic
ces (GMPs)
ratios
and
d
strengths
to
o
complemen
nt
exclusively for dotFIT, LLC
food intake and help maintain
m
a saffe
mal range for 24 hours a day
and optim
Contraindicatio
ons
Manufacttured in a FDA
A-registered
The dotFIT
multiv
vitamin
and
m
mineral
formu
ulas
facility, in
n compliance with Good
c Manufactturing
ed for Practic
thoseces
w (GMPs)
with
are contraindicat
hem
mochromatosi
disease thaat
exclusivesly(an
for inherite
dotFIT,edLLC
leads to iron-overrload, affectin
ng 0.5 percen
nt of
Con
ons
the population)
ptraindicatio
b
because
of thee iron conten
nt.
The dotFIT multivvitamin and mineral
m
formu
ulas
c
ed for those with
w
are contraindicat
hem
mochromatosis (an inheriteed disease thaat
leads to iron-overrload, affectin
ng 0.5 percen
nt of
the population)
p
b
because
of thee iron conten
nt.
162
162
148
dotFIT Worldwide
www.dotFIT.com
7/24/09 1:16:00 PM
What is it?
SuperCalcium+
% Daily Value
400 IU
100%
1,000 mg
100%
500 mg
125%
Contains No: Dairy, Fish, Crustacean shellfish, Tree nuts, Peanuts, Soy or Gluten.
No Sugar, Salt, Starch, Artificial flavors, Coloring or Preservatives added.
Components in this product are derived from natural sources.
Unique Features
163
163
149
dotFIT Worldwide
www.dotFIT.com
7/24/09 1:16:10 PM
Suggested Use
SuperiorAntioxidant
What is it?
SuperiorAntioxidant
Stave off the cellular damage they
cause
What
it?
isDecrease
the risk of chronic disease
Improve the maintenance of eye health
A health aid designed to provide nutrients that
Protect against heart disease
have been shown to help protect against excess
Prevent cognitive decline
free radicals and may help
How does
it work?
Stave
off the cellular damage they
cause
Excess free
radical damage is caused by the
Decrease
the risk
chronic disease
normal aging process
and of
environmental
Improve
the maintenance
of eye health
stresses.
The dotFIT
SuperiorAntioxidant
Protect
against
heart
disease
provides a unique blend of compounds known
Prevent
cognitive
decline in many
to quench
damaging
free radicals
important parts of the body including the eyes,
How
work?
brain,does
heartitand
muscles.
Excess free radical damage is caused by the
Who should take this product?
normal aging process and environmental
stresses.
The dotFIT SuperiorAntioxidant
dotFIT SuperiorAntioxidant
is suitable for
provides a unique blend of compounds known
Everyone,
exercisers
and nonto quench
damaging
free radicals
in many
exercisers,
interested
in reducing
important
parts of the
body including
the free
eyes,
radical
brain, heart
anddamage
muscles.
Those who want to achieve optimal
Who should
this product?
healthtake
and functioning
People interested in reducing the risk of
dotFIT SuperiorAntioxidant is suitable for
chronic and age-related disease
Intense
exercisers
who
are
looking to
Everyone,
exercisers
and
nonreduce
the interested
increased free
radical free
exercisers,
in reducing
production
and
damage
associated
with
radical damage
demanding
training
bouts
Those who want to achieve optimal
Those
are interested in the dotFIT
health who
and functioning
longevity
program
People interested in reducing the risk of
Supplement Fac ts
Suggested
Use
Amount
Per Serving
% Daily Value*
D. Salina natural mixed carotenoids
1.5 mg
*
Lutein
6 mg
*
Lycopene
10 mg
*
Zeaxanthin (from Marigold flowers)
4 mg
*
Co-enzyme Q10 (CoQ-10)
100 mg
*
Alpha Lipoic Acid
200 mg
*
OptiBerry (from Wild blueberry, Strawberry 30 mg
*
Cranberry, Wild bilberry, Elderberry, Raspberry)
* % Daily Value not established.
Other Ingredients: Dicalcium Phosphate, Microcrystalline Cellulose,
Croscarmellose, Stearic acid (Vegetable source),
Hydroxypropylmethylcellulose, Magnesium Stearate (Vegetable source).
Unique Features
Manufactured
in
a
FDA-registered
contraindicated in pregnancy and lactation.
facility, in compliance with Good
Manufacturing Practices (GMPs)
exclusively for dotFIT, LLC
Contraindications
Contraindications
dotFIT SuperiorAntioxidant formula is
contraindicated in pregnancy and lactation.
164
Suggested Use
One tablet per day before or after a main meal
with a favorite beverage.
trients that
ainst excess
164
e they
disease
f eye health
SRG internal.indd
e
150
150
dotFIT Worldwide
www.dotFIT.com
7/24/09 1:16:23 PM
What is it?
i
Joint Fle
exibility Plu
us
A health aid
a designed to
t supply gluccosamine
and chond
mounts used
What
is it?
idroitin in the forms and am
in publish
hed research to
t support heealthy joint
A
health
a function.
aid
designed to
t supply gluccosamine
tissue
and
d
and chond
droitin in the forms and am
mounts used
How
doe
es
it
work?
in publish
hed research to
t support heealthy joint
tissue and
d function.
Cartilage is slowly lost in joints with
h injury and
age (most
t noticeable
b
50 and 60 years
How
doe
es
it work? between
of age). Because cartilaage acts as a cushion
Cartilage
is slowly
lostits
in loss
joints
with
hs injury
and
joints,
friction,
between bone
causes
age
(most
nd
60
years
t
noticeable
between
b
50
a
pain and stiffness. Join
nt Flexibility Pllus provides
of
age). Because
acts which
as a hcushion
ine andcartila
chonage
droitin,
are natural
glucosam
joints,
s friction,
between
causes
ds found
in aits
ndloss
around
th
he
cells of
compounbone
pain
and
s
tiffness.
Join
n
t
Flexibility
Pl
l
us
provides
t
help
cartilage that
h are natural
glucosamine and chondroitin, which
Provide
lubrica
ds found
in aation
nd around th
he cells of
compoun
water around
a
the joint
Rthat
tetainhelp
cartilage
Delay structural degeneratiion of joint
P
ssue lubricaation
tirovide
a
the joint
Retain water around
Who sho
ould
take
thi
is
product?
Delay structural degeneratiion of joint
tissue
dotFIT Joint Flexibilityy Plus is suitab
ble for
Who sho
ould take thiis product?
In
ndividuals who want relieff of mild joint
far fewer
o bthe
of
side
iscomfort
witth
dotFITdJoint
Flexibility
y Plus
is suitab
le for
efffects that occcur from chro
onic non st
In
ndividuals
whinflammatory
o want relieffyof
mild joint
teroidal anti-i
drug
d
th
far
fewer
o
of
the
iscomfort
wit
(N
NSAID) use su
uch as aspirin or side
ef
ffects that occcur from chro
onic nonib
buprofren
teroidal
anti-ited
inflammatory
drug
st
Th
hose interest
in a longeyvity
program
(N
NSAID) use su
uch as aspirin or
Suggeste
ed
Use
ib
buprofren
Th
hose interestted in a longevity program
As a dietaary supplement, take 1 tab
blet three
times dailed
ly with
Suggeste
Use meals.
As a dietaary supplement, take 1 tab
blet three
times dailly with meals.
% Daily Value**
500 mg
400 mg
*
*
Uniq
que Feature
es
dant) withoutt
(multivitaamin, antioxid
Contains
no
other
add
ded
ingredien
nts so
worrying about reachiing excessive
take
prtrimental
roducts oveer
you may
levels
thaat
mayother
be det
dant) withoutt
(multivitaamin, antioxid
time
worrying
about
reachi
ing excessive
Dosages and
a compoun
nds
are in thee
levels
may beused
dettrimental
oveer
precisetha
aat
mounts
in research
t
that
time
have show
wn to improvve mobility, jo
oint
comfort,
Dosages and
aand compoun
nds
are in thee
knee-join
nt strength
atured
mounts
in research that
t
precise
Manufact
in used
a FDA
A-registered
have
show
wn
to
improv
ve
mobility,
jo
oint
facility, in
n compliance with Good
comfort,
and knee-join
nt strength
Manufactturing
Practicces
(GMPs)
exclusive
Manufacttured
in a FDA
A-registered
LLC
ly for dotFIT,
facility, in
n compliance with Good
Contraindicatio
ons
Manufact
turing Practicces (GMPs)
exclusively for dotFIT, LLC
The use of
o any glucosaamine/chondroitin
sulfate fo
ormula is conttraindicated
Contraindicatio
ons
during prregnancy and lactation beccause
of
Thea use
oof
amine/chond
lackof
o any
dataglucosa
for th
his
population
nroitin
fo
ormula
is cont
sulfate
Diabetics
s may wish
totraindicated
discuss
lactation
beccause
during
pr
regnancy
and
glucosam
mine use with their physicia
an
of a lack of
o data for th
his population
n
40
Diabeticss may wish to discuss
35
glucosam
mine use with their physiciaan
30
GS
25
20
40
15
35
10
30
5
25
0
20
15
10
5
0
Place
ebo
NSAIIDS
GS
Place
ebo
% of
o Participants Repo
orting Adverse Even
nts
NSAIIDS
% of
o Participants Repo
orting Adverse Even
nts
165
165
151
dotFIT Worldwide
www.dotFIT.com
7/24/09 1:18:16 PM
SuperO
Omega-3
What is it?
i
A health aid
a designed maintaining
m
c
cardiac
and
brain health. It provide
es two key essential fatty
acids EPA and DHA thaat have demo
onstrated
myriad
he
ealth
benefits
s
related
to
he
eart and
SuperO
Omega-3
brain funcction.
Supplement Fac ts
Serving Size: 1 Softgel
Servings Per Container: 30
Calories 13
Calories from Fat 11
What is it?
i
How doe
es it work?
A health aid
a designed maintaining
m
c
cardiac
and
The
dees
livers
EP
PA
and 40%
sential
fatty
brainSuper
hearOmega-3
lth. It provide
two60%
key es
uble
the
pote
DHAdo
ency
of
typica
al
fish
oil
acids EPA and DHA thaat have demo
onstrated
which,
whe
en
used prope
erly,
products
myriad heealth
benefits
s related
to he
eart has
andthe
greatest
cction. to
chance
brain func
educe
negative CV inciden
Res
nces
How doe
it work?
Unique Features
F
Suggeste
ed Use
Eaach softgel is uniquely entteric-coated
For mainttaining cardiac and brain health,
h
take 1
to
o withstand stomach acid and dissolve
or 2 softgels with any meal.
m
in
n the small inttestine. The result
r
is
m
maximum
abso
orption and no
n "Fishy
Repeat or Fish Burps
% Daily Value
1.2 g
2%
0.1 g <1%
0g
0%
1.1 g
*
0.2 g
*
1 mg <1%
2 IU
7%
600 mg
*
360 mg
*
240 mg
*
dotFITs SuperOmegaS
-3 fish oil com
mplex
is mercurry-free & conttains no PCBss
This form
mula considerss use of otherr
dotFIT prroducts so you
u can maintain a
safe and optimal range of total nuttrient
intake
Manufacttured in a FDA
A-registered
facility,
dotFITsin
S
SuperOmega-3
fishGood
oil com
mplex
n compliance with
is
mercur
ry-free
&
cont
tains
no
PCBs
Manufactturing Practicces (GMPs) s
exclusive
This form
mula
use of otherr
ly forconsiders
dotFIT,sLLC
dotFIT prroducts so you
u can maintain a
safe andons
optimal range of total nuttrient
Contraindicatio
intake
Anyone
ttured
aking in
greater
rA-registered
than 3g per day
Manufact
a FDA
should
do
er
theGood
care of
o
so
only
und
facility, in
n compliance with
risk
of
excesssive
sician
due
to
their
phy
Manufactturing Practicces (GMPs)
at for
higher
dosses
bleeding
LLC
exclusively
dotFIT,
Should no
ot be used if on
o anticoagulants
Contraindicatio
or have ons
u
uncontrolled
h
hypertension
May raisee blood sugarr and LDL in
people
Anyonewith
greaterr than 3g per day
wtaking
diabetes
should do
o so only under the care of
their physician due to risk of excesssive
bleeding at higher dosses
Should no
ot be used if on
o anticoagulants
or have uncontrolled
u
h
hypertension
May raisee blood sugarr and LDL in
people with
w diabetes
Unique Features
F
166
166
152
dotFIT Worldwide
www.dotFIT.com
7/24/09 1:18:47 PM
Advanced
d Brain Health
h contains only wellresearcheed brain support substancees in their
appropriaate amounts, which, when used
properly, has the greattest chance to
o
Supplement Reference
Guidents the dotFITT
Accurately compleme
upport brain function
Su
multivita
min,
antioxidant, and omeega-3
Sllow age-related decline in mental
formulas
fu
unctions
This
form
mula considers
s use
Supplement
Fac
ts of otherr
Su
upport the maintenance
m
o brain tissuee
of
Serving Size: 1 Tablet
Servings Per Container: 30
dotFIT
prroducts so you
u can maintain a
Amount Per Serving
Advancced Brain Health
H
% Daily Value
total nuttrient
safe
and
optimal range of
Acetyl-L
Carnitine
500 mg
*
Who sho
ould take thiis product?
Phosphatidylserine
100 mg
*
intake
Alpha Lipoic Acid
100 mg
*
What is it?
i
Vitamin B12 (as Cyanocobalamin)
100 mcg
1,667%
Adults agee 45 and olde
er interested in supportingg
Manufact
tured in a FDA
A-registered
* % Daily Value not established.
Other Ingredients: Dicalcium Phosphate, Microcystalline
brain
andaid
functio
on
aginng.
with
Good
facility,
in
n compliance
A health
anerve
designed
support
s during
brain
function
Cellulose, Sorbitol,
Stearic acid (Vegetable
source),
Hydroxypropyl Methylcellulose, Magnesium Stearate
Manufact
turing
ces (GMPs)
and to slo
ow (and possibly stop or reeverse) age(Vegetable source),
Silica. Practic
Suggeste
ed
Usein mental function.
LLCTree nuts, Peanuts,
exclusive
ly Fish,
forCrustacean
dotFIT,
related de
ecline
Contains
No: Dairy,
shellfish,
Oes ittowork?
One
3 tablets per day with food
How doe
Tyypical dosage
e based on agge
o 45-55
1/day
Advanced
d Brain
Health
hyears
contains
onyly wello 56-65
years
2/dayes
y in their
substance
researcheed brain
support
o
Over
65
6
years
3/d
day
appropriaate amounts, which, when used
properly, has the greattest chance to
o
Who sho
ould take thiis product?
Adults agee 45 and olde
er interested in supportingg
brain and nerve functio
on during aging.
function
verse) age-
Suggeste
ed Use
y wells in their
used
Contraindicatio
ons
Contraindicatio
ons
Uniq
que Feature
es
mental
f brain tissuee
n supportingg
ng.
h food
e
Uniq
que Feature
es
Contraindicatio
ons
ay
167
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7/24/09 1:19:23 PM
FatReleaser
aka FatRelease
What is it?
A fat loss aid designed to
Supplement Facts
Suggested Use
Unique Features
Contraindications
% Daily Value
200 mg **
133 mg **
Choline (as Choline Bitartrate)
50 mg **
N-Acetyl Cysteine (NAC)
Milk Thistle Seed Extract (80% Silymarin) 166 mg **
dotFIT Proprietary Herbal Complex
133 mg **
168
154
dotFIT Worldwide
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7/24/09 1:19:56 PM
CarbKiller
What is it?
aka
HowCarbRepel
does it work?
Block carbohydrates
or sugarsoffrom
blocker which
decreases the amount
carbs
A fat lossbeing
aid designed
toand stored as body fat
absorbed
that will be absorbed by the body. The unique
ofKeep
the stomach
longer
which
blend
fiber food
helpsincontrol
appetite
byfrom
helping
Block
carbohydrates
orfullness
sugars
prolongs
the
feeling
of
you feelbeing
full sooner
and for
longer
periods
absorbed
and
stored
as food
bodyoffat
Manage
appetite
and
control
time. AllKeep
ingredients
by scientific
inare
thesupported
stomach longer
which
intakefoodtwo
studies including
approved
Food
and Drug
prolongs
the
feeling
of
fullness
Boost weight
loss results
Administration
(FDA) claims.
Manage appetite and control food
intake
How does
it work?
Boost weight loss results
CarbKiller contains the best researched carb
How
does
it work?
blocker
which
decreases the amount of carbs
that will be absorbed by the body. The unique
CarbKiller
contains
best appetite
researched
carb
blend of fiber
helpsthe
control
by helping
blocker
which
decreases
the
amount
of
carbs
you feel full sooner and for longer periods
of
that
will
be
absorbed
by
the
body.
The
unique
time. All ingredients are supported by scientific
blend
fiber helps
appetite
helping
studiesofincluding
twocontrol
approved
Foodby
and
Drug
In
thefeel
figure
above,
subjects
consumed
a 2000-2200
you
full
sooner
and
for
longer
periods
of
Administration
(FDA)
claims.
calorie
carbohydrate
The Phase
group
time. All
ingredientsrich
arediet.
supported
by2scientific
experienced ~700% greater weight loss compared to
studies including two approved Food and Drug
the placebo.
Administration (FDA) claims.
People
who
tend to
overeat a 2000-2200
In the figure
above,
subjects
consumed
carbohydrates
calorie carbohydrate
rich diet. The Phase 2 group
experienced ~700% greater weight loss compared to
In the
figure above, subjects consumed a 2000-2200
the
placebo.
calorie carbohydrate rich diet. The Phase 2 group
experienced
~700%
Who
should
takegreater
it? weight loss compared to
the placebo.
Individuals
Suggested
Use using the 90-day cycling
program
As a dietary supplement, take 2 tablets twice
Suggested
Use
daily approximately
30 minutes before your
largest carbohydrate containing meal with 8 oz.
As
a dietary supplement, take 2 tablets twice
of water.
daily approximately 30 minutes before your
Unique Features
Supplement Facts
ingredient
that
has
been
scientifically
750
mg **
Phase 2 Starch Neutralizer
White Kidney Bean Extract (Phaseolus vulgaris)
169
Suggested Use
As a dietary supplement,
take 2 tablets twice
SRG 1st Edition 2009.
dotFIT Worldwide
daily 155
approximately 30 minutes before your
rs from
as body fat
nger whichSRG internal.indd
ess
155
169
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7/24/09 1:20:26 PM
aka
ThermAccel
What
is it?
What is it?
A
fat loss
aid designed to
What
is it?
A fat loss aid designed to
total daily
A fat lossIncrease
aid designed
to calorie burn by
Increase
total daily calorie
burn by
raising
thermogenesis
(boosting
Increase
total daily calorie
burn by
raising
thermogenesis
(boosting
metabolism
by
wasting
calories
and fat
raising
thermogenesis
metabolism
by wasting(boosting
calories and fat
as
heat)
metabolism
by wasting calories and fat
as heat)
Improve
your desire to move by
as
heat)
Improve your
desire and
to move
by
enhancing
alertness
stimulating
the
Improve your
desire
to
move
by
enhancing
alertness
and stimulating
the
central
nervous
system
enhancing
alertness
and stimulating the
central nervous
system
Suppress
appetite
nervous
system
central
Suppress
appetite
Increase
fat
burning
Suppress
appetite
Increase fat burning
How does
it work?
Increase
fat burning
How does it work?
ThermoShock
helps
How does it work?to
ThermoShock helps to
ThermoShock
helps
to
Increase
thermogenesis
(wasting
Increase
thermogenesis
(wasting
calories
as
heat)
by
combining
a new
Increase
thermogenesis
(wasting
calories
as
heat)
by
combining
a new
energy
complex
with
caffeine and
calories
as
heat)
by
combining
a new
energy
complex withherbs
caffeine and
caffeine-containing
energy
complex
with
caffeine
and
caffeine-containing herbs
caffeine-containing
Address appetite control
herbsby
Address
appetite
control
by natural
incorporating
two
powerful
Address
appetite
control
by natural
incorporating
two
powerful
ingredients,
Caralluma
fimbriata
and
incorporating
two
powerful
natural
ingredients,
Caralluma
fimbriata
and
Lepticore,
that
work through
unique
ingredients,
Caralluma
fimbriata
and
Lepticore,
that work
through unique
body
fat regulation
pathways
Lepticore,
that
work
through
unique
body fat regulation pathways
Studies
at least
a 10% increase in
fatshow
regulation
pathways
body
Studies
show
at
least
a 10%
increase
hourshow
EE or at
equivalent
to 157
morein
24
Studies
least
a
10%
increase
24
hour burned
EE or equivalent
to 157 morein
calories
in the caffeine/EGCG
24
hour
EE
or
equivalent
to 157 more
calories
burned subjects
in the caffeine/EGCG
group
(average
weight
173lbs)
calories
burned subjects
in the caffeine/EGCG
group (average
weight 173lbs)
group (average subjects weight 173lbs)
2450
2450
2400
2450
2400
2350
2400
2350
Calories
2300
Calories 2350
2300
Calories
2250
2300
2250
2200
2250
2200
2150
2200
2150
Placebo
2150
Placebo
Caffeine/EGCG
Placebo
Caffeine/EGCG
Caffeine/EGCG
Who
should
Placebo
Placebo
Placebo
Supplement Facts
Serving Size: 2 Tablets
% Daily Value
520 mg **
310 mg **
L-Theanine
ThermoShock Thermogenic Complex
100 mg **
1000 mg **
Contains No: Dairy, Fish, Crustacean shellfish, Tree nuts, Peanuts, Soy or Gluten.
No Sugar,
Salt, Starch, Artificial Coloring, Flavoring or Preservatives added.
Unique
Features
Components in this product are derived from natural sources.
Unique
Features
Unique
Featuresa unique thermogenic blend
Contains
156
Suggested Use
As
a dietary Use
supplement, take 2 tablets with 8
Suggested
As
aofdietary
supplement,
tablets with 8
oz.
water
up to 2 timestake
daily,2
As
aofdietary
supplement,
take
2 approximately
tablets with 8
oz.
water
up
to
2
times
daily,
approximately
30
minutes
before
breakfast
and
lunch. Do not
oz.
of waterbefore
up to 2breakfast
times daily,
30
minutes
andapproximately
lunch. Do not
consume
within
5
hours
of
bedtime.
30
minutes
before
breakfast
and lunch. Do not
consume
within
5 hours
of bedtime.
consume within 5 hours of bedtime.
Contraindications
Contraindications
ThermoShock is contraindicated for
Caffeine/EGCG
Caffeine/EGCG
Caffeine/EGCG
dotFIT Worldwide
ThermoShock
is contraindicated
for
pregnant
and lactating
women and
ThermoShock
is
contraindicated
for
pregnant
andthe
lactating
and
those
under
age of women
18
pregnant
and
lactating
women
and
those under the age of 18
Caffeine
is contraindicated
those
under
the age of 18 in
Caffeine
is contraindicated
in
hypertension,
anxiety and thyroid
Caffeine
is contraindicated
in
hypertension,
anxiety
and
thyroid
disease.
Caffeine
can
interfere
with
hypertension,
anxiety
and thyroid
disease.
Caffeine
can
interfere
withand
some
medications
such
as lithium
disease.
Caffeine
can
interfere
with
some
medications
such asislithium
MAO
inhibitors.
Caffeine
also and
some
medications
such
as
lithium
and
MAO
inhibitors. in
Caffeine
is also
contraindicated
those
with
cardiac
MAO
inhibitors. in
Caffeine
is also
contraindicated
those
cardiac
arrhythmias,
other
formswith
of heart
contraindicated
in
those
with
cardiac
arrhythmias,
other ulcers
forms of heart
disease
and peptic
arrhythmias,
other
forms
of
heart
disease and peptic ulcers
disease and peptic ulcers
www.dotFIT.com
170
170
170
7/24/09 1:20:46 PM
What is it?
A performance aid designed to
Supplement Fac ts
Serving Size: 2 Tablets
% Daily Value
Unique Features
Contraindications
Suggested Use
As a dietary supplement, Loading Phase: For the
first 5 days take 4 tablets, 4 times daily with 8
oz. of cold water or your favorite beverage.
Maintenance Phase: From day 5 onward
consume 4 tablets, 1-2 times daily. On training
days: Take 1 or 2 of the daily recommended 4
tablets shortly before and after exercise. For
increased effects consume your creatine with
157
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7/24/09 1:21:05 PM
CreatineXXL
Supplement Fac ts
What is it?
Unique
Features
Components
in this product are derived from natural sources.
Contraindications
Suggested Use
As a dietary supplement, on high intensity
training days, take 5 tablets 30 minutes before
workouts with 8 oz. of water or your favorite
beverage. Then take the remaining 5 tablets
throughout the remainder of the day. On nontraining days, take 5 tablets, twice daily with
morning and evening meals. For increased
effect consume with 25-45g of a carbohydrate
food/beverage. For maximum results, use for a
minimum of four weeks.
174
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7/24/09 1:21:17 PM
NO7Rage
What is it?
Enhance
gain blend of
NO7Rage containsmuscle
a proprietary
Improve
strength
compounds
that work
together to increase
blooddoes
flow cell
volume and mental focus.
How
it work?
Greater blood flow to skeletal muscle increases
NO7Rage contains a proprietary blend of
the delivery of oxygen, energy and rebuilding
compounds that work together to increase
nutrients, and also speeds up the removal of
blood flow cell volume and mental focus.
waste products. All of this leads to potential
Greater blood flow to skeletal muscle increases
strength improvements, less muscle breakdown
the delivery of oxygen, energy and rebuilding
and increased muscle size. Results may be
nutrients, and also speeds up the removal of
enhanced by properly consuming a specific ratio
waste products. All of this leads to potential
of the muscle building blocks contained in
strength improvements, less muscle breakdown
AminoBoostXXL.
and increased muscle size. Results may be
Who
should
take thisconsuming
product?a specific ratio
enhanced
by properly
of the
buildingand
blocks
contained
in and
muscle
Intermediate
advance
athletes
AminoBoostXXL.
exercisers looking for an edge during
high-intensity,
Who should
take thishigh-volume
product? training
Supplement Facts
Serving Size: 25 g (1 Scoop)
Servings Per Container: About 40
Calories 44
Calories from Fat 0
Amount Per Serving
Total Fat
Saturated Fat
Trans Fat
Cholesterol
Total Carbohydrate
Dietary Fiber
Sugars
Protein
0% Magnesium (Gluconate)
0% Sodium (Chloride)
* Potassium (Citrate)
0% NO7RageTM Proprietary Blend
4%
Taurine
0%
Glycerol
*
L-Citrulline L-Malate
0%
Betaine Anhydrous
416% Creatine Monohydrate
166% Glucuronolactone
Caffeine
250 mg
Vitamin C
50 IU
Vitamin E
(D-alpha Tocopheryl Succinate)
Vitamin B6 (Pyridoxine HCL)
25 mg 1250%
Vitamin B12 (Methylcobalamin) 120 mcg 2000%
% Daily Value**
5 mg
118 mg
100 mg
6800 mg
2500 mg
400 mg
175 mg
1%
5%
3%
*
*
*
*
*
*
*
*
Contains No: Dairy, Fish, Crustacean shellfish, Tree nuts, Peanuts, Soy or Gluten.
159
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7/24/09 1:21:30 PM
What is it?
A performance aid designed to increase
exercise focus, performance, and intensity
without weight gain. This formula supplies
several compounds that have shown to
Supplement Fac ts
Serving Size: 4 Capsules
Contains No: Dairy, Fish, Crustacean shellfish, Tree nuts, Peanuts, Soy or Gluten.
No Sugar, Salt, Starch, Yeast, Artificial flavors, Coloring or Preservatives added.
Components in this product are derived from natural sources.
Unique Features
% Daily Value**
1000 mg
*
600 mg
*
300 mg
*
300 mg
*
Suggested Use
Contraindications
WorkoutExtreme supplementation is
contraindicated in pregnancy and
lactation because of the CNS stimulants
caffeine and ginseng
Caffeine can interfere with some
medications such as lithium and MAO
inhibitors
Caffeine is contraindicated in heart
disease, hyperthyroidism and peptic
ulcers
American ginseng (Panax) is
contraindicated for those taking
cholinesterase and MAO inhibitors,
anticoagulants, antiplatelet drugs and
hypoglycemic medicines because of
potential interactions
178
160
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7/24/09 1:21:48 PM
Recover&Build
What is it?
Recover&Build
Who should
take this
product?
Supporting
muscle
protein synthesis
Recover&Build
Minimizing muscle
protein
dotFIT
is suitable
forbreakdown
Who should
take
product?
Athletes
andthis
exercisers
of any fitness
level during intense
or excessive
dotFIT Recover&Build
is suitable
for
training bouts
Athletes and exercisers of any fitness
Weight-conscious athletes or in-season
level during intense or excessive
bodybuilders
training bouts
Anyone beginning an intense exercise
Weight-conscious athletes or in-season
program
bodybuilders
In combination with other performance
Anyone beginning an intense exercise
products to amplify their effects,
program
especially to enhance recovery
In combination with other performance
Suggested
Use to amplify their effects,
products
especially
enhance
recovery
Minimum to
dose:
Take five
tablets before
exercise
Suggested
Use
Optimal dose and for those over 200
Minimum dose: Take five tablets before
lbs.: Take eight tablets before exercise
exercise
Unique
Features
Optimal
dose and for those over 200
Takethe
eight
tablets before
exercise
lbs.:
Contains
CURRENT
ideal ratio
of
branched
chain
amino
acids
leucine,
Unique Features
isoleucine and valine - in a convenient
Contains the CURRENT ideal ratio of
tablet form
branched chain amino acids - leucine,
Uses a proprietary swell and release
isoleucine and valine - in a convenient
delivery system for rapid release and
tablet form
uptake by the working muscles
Uses a proprietary swell and release
delivery system for rapid release and
uptake by the working muscles
Manufactured in a FDA-registered
facility, in compliance with Good
Manufacturing Practices (GMPs)
Manufactured in a FDA-registered
exclusively for dotFIT, LLC
facility, in compliance with Good
Manufacturing Practices (GMPs)
exclusively for dotFIT, LLC
Supplement Fac ts
Serving Size: 3 Tablets
% Daily Value
*
*
*
BCAA supplementation is
contraindicated in pregnancy and
Contraindications
lactation because of the lack of studies
BCAA supplementation is
done with this population.
contraindicated in pregnancy and
BCAA supplementation is
lactation because of the lack of studies
contraindicated for those with the
done with this population.
hereditary disorder maple syrup urine
BCAA supplementation is
disease or who have kidney disorders.
contraindicated for those with the
hereditary disorder maple syrup urine
disease or who have kidney disorders.
180
161
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7/24/09 1:22:04 PM
Supplement Facts
AminoBoostXXL
What
is it?
A
performance
What
is it? aid designed to deliver the ideal
blend of nutrients to take advantage of
A
performance
aid designed
to deliverfor
the
ideal
metabolic
windows
of opportunity
optimal
blend
of
nutrients
to
take
advantage
of
recovery and results. When taken properly,
metabolic
windows of opportunity for optimal
AminoBoostXXL
recovery and results. When taken properly,
Maximizes the bodys muscle building
AminoBoostXXL
mechanisms
Maximizes
bodys
muscleand
building
Can lead tothe
greater
strength
size
mechanisms
gains, especially if youve hit a plateau
Can lead to greater strength and size
How does
it work?
gains,
especially if youve hit a plateau
Following
intense
training, your body is in
How does it work?
negative protein balance until amino acids are
Following
intense protein
training,synthesis
your body
is in
provided. Muscle
is stimulated
negative
protein
balance
until
amino
acids
by taking this specific blend of amino acids are
provided.
protein synthesis is stimulated
before andMuscle
after exercise.
by taking this specific blend of amino acids
Who
take
this product?
beforeshould
and after
exercise.
AminoBoostXXL
is suitable
for
Who should take
this product?
All athletes
who train
AminoBoostXXL
is suitable
for hard and need
rapid muscle tissue recovery. This
All
athletes
who train
hard and need
includes
all track
and basketball
rapid
muscle
tissue
recovery.
This
athletes, most baseball players,
includes
track and
basketball
wrestlers,allboxers,
runners,
cyclists, etc.
athletes,
most
baseball
players, while
Physique competitors, especially
wrestlers,
boxers,
runners,
cyclists,
dieting to lose
weight
or body
fat etc.
Physique
competitors,
especially
while
All older athletes
and intense
exercisers
dieting to lose weight or body fat
Anyone who is experiencing a plateau
All
athletes
intense exercisers
andolder
trying
to gainand
muscle
Anyone who is experiencing a plateau
Suggested
and Use
trying to gain muscle
As
a dietary Use
supplement, add 1 scoop (16g) to 8
Suggested
oz. cold water and mix vigorously. Alternatively,
As
dietary
supplement,
add 1favorite
scoop (16g)
mixawith
20-40
grams of your
fast- to 8
oz.
cold
water
and
mix
vigorously.
Alternatively,
acting carbohydrate beverage. For maximum
mix
withOn
20-40
grams
of your
results:
training
days,
use 1favorite
servingfast20
acting
carbohydrate
beverage.
For
maximum
minutes pre-workout and 1 serving immediately
results:
On training
days, use
1 serving
20use
post-workout.
Individuals
under
150 lbs.
minutes
pre-workout
and
1
serving
immediately
half of the above recommended dosage.
post-workout. Individuals under 150 lbs. use
Unique
Features
half of the
above recommended dosage.
This
formula uses a proprietary
Unique
Features
% Daily Value**
Total Fat
0g
Saturated Fat
0g
Trans Fat
0g
Cholesterol
0 mg
Total Carbohydrate
0g
Dietary Fiber
0g
Sugars
0g
Protein
12 g
AminoBoostXXLTM Proprietary Blend 12 g
L-Leucine
L-Phenylalanine
L-Lysine
L-Valine
L-Threonine
L-Isoleucine
L-Histidine
L-Methionine
0%
0%
*
0%
0%
0%
*
24%
*
*
*
*
*
*
*
*
*
Contains Soy.
Contains No: Dairy, Fish, Crustacean shellfish, Tree nuts, Peanuts, or Gluten.
No Sugar, Starch, Artificial coloring or Preservatives added.
This
product, as with any protein or
Contraindications
creatine-containing supplement, is
This
product, as for
withusers
any protein
or or
contraindicated
with kidney
creatine-containing
supplement,
is
liver disease.
for users with kidney
contraindicated
This product is contraindicated
for or
liver
disease.
phenylketonurics
because it contains
This
product
is contraindicated for
phenylalanine.
because
it containsfor
phenylketonurics
This product is also
contraindicated
phenylalanine.
pregnant or lactating females because it
This
product
also contraindicated
has not
beenistested
in these groups for
and
pregnant
or lactating
females
because it
because protein
can be
adequately
has
not been
tested
in these
groups and
supplied
by the
diet for
fetal growth
or
because
protein
can
be
adequately
lactation needs.
supplied by the diet for fetal growth or
lactation needs.
182
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7/24/09 1:22:18 PM
MuscleDefender
Supplement Fac ts
What is it?
**Percent Daily Values are based on 2,000 calorie diet. Your daily values may be
higher or lower depending on your calorie needs.
% Daily Value
*
8.5%
167%
Contraindications
Glutamine supplementation is
contraindicated in those with kidney
problems or at risk for kidney disease
because of possible increased kidney
stress.
Glutamine supplementation should be
avoided by pregnant or lactating
women because of the lack of studies
done with this population.
Glutamine supplementation should not
be employed by children and
adolescents due to limited data.
Suggested Use
As a dietary supplement, mix 1 scoop (8g) with
8 oz. of water or your favorite beverage. On
training days, use 1 serving immediately after
exercise. For maximum results use 1-2 servings daily
Unique Features
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7/24/09 1:22:30 PM
weight control.
A
performance
formula
thatresults
can deliver
enhanced
exercise
induced
and aid in
How
does
it
work?
enhanced
exercise induced results and aid in
weight control.
weight
control.
As
a preand
drink, the product
How
does
it post-workout
work?
delivers
ideal
amounts
protein
How
does
it post-workout
work? of carbohydrate,
As
pre-inand
thedigested
productin
anda fat
a form
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Suggested
Use
and
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long-termmeals or snacks, add one or
For pre-workout
Suggested Use
two
scoops of
powder to at least one cup (8 oz.)
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Low
sugar, NO ASPARTAME
Unique
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Perfect blend
the highest quality proteins
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Perfect blend of the
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Perfect blend of the highest quality proteins
164
Nutrition Facts
Serving Size: 2 Scoops (64g)
Serving Per Container: About 25
Calories 240
Calories from Fat 25 *Percent Daily Values are based on a 2,000 calorie diet. Your daily
% Daily Value*
3g
5%
1g
5%
0g
**
35mg
12%
125mg
5%
35g
12%
3g
12%
3g
**
20g
40%
600IU
12%
6mg
10%
40IU
10%
3IU
10%
.15mg
10%
.17mg
10%
2mg
10%
.2mg
10%
1mcg
17%
30mcg
10%
1mg
10%
300mg
30%
3.2mg
18%
15mcg
10%
40mg
10%
1.5mg
10%
200mcg
10%
Calories: 2,000
2,500
Total Fat
Less than 65g
Saturated Fat
Less than 20g
Cholesterol
Less than 300mg
Sodium
Less than 2,400mg
Potassium
3,500mg
Total Carbohydrate
300g
Dietary Fiber
25g
Calories per gram:
Fat 9
Carbohydrate 4
80g
25g
300mg
2,400mg
3,500mg
375g
30g
Protein 4
Contains No: Fish, Crustacean shellfish, Tree nuts, Peanuts, Soy or Gluten.
No Salt, Starch, Artificial coloring or Preservatives added.
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WheySmooth
What is it?
Supplement Facts
Serving Size: 2 scoops (65g)
Servings Per Container: About 25
Amount Per Serving
% Daily Value*
Calories 240
Total Fat
Saturated Fat
Trans Fat
Cholesterol
Sodium
Total Carbohydrate
Dietary Fiber
Sugars
Protein
4%
500%
30%
10%
**
**
Vitamin A
Vitamin B6 (as Pyridoxal 5-Phosphate)
Calcium (from Milk Proteins)
Iron
*Percent Daily Values are based on a 2,000 calorie diet. Your daily
values may be higher or lower depending on your calorie needs.
**Daily Value not established.
Calories: 2,000
2,500
Total Fat
Less than 65g
Saturated Fat
Less than 20g
Cholesterol
Less than 300mg
Sodium
Less than 2,400mg
Potassium
3,500mg
Total Carbohydrate
300g
Dietary Fiber
25g
Calories per gram:
Fat 9
Carbohydrate 4
80g
25g
300mg
2,400mg
3,500mg
375g
30g
Protein 4
Unique Features
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FirstString
Unique Features
What is it?
Serving Size:
Serving Per Container:
2 Scoops (75g)
About 32
Calories 285
Suggested Use
4 Scoops (149g)
About 16
% Daily Value*
5%
6%
**
17%
4%
15%
6%
**
42%
7%
5%
5%
5%
5%
5%
5%
5%
5%
8%
5%
20%
7%
5%
5%
5%
5%
**
% Daily Value*
9%
13%
**
33%
7%
30%
12%
**
84%
14%
10%
10%
10%
10%
10%
10%
10%
10%
17%
10%
40%
14%
10%
10%
10%
10%
**
Carbohydrate 4
2,500
80g
25g
300mg
2,400mg
3500g
375g
30g
Protein 4
Timing
188
166
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Appendix
7/24/09 1:27:10 PM
Appendix 1
dotFIT Worldwides Position on Vitamin & Mineral Supplementation
Content utilized by permission from The National Academy of Sports Medicine
Abstract
Defining the perfect diet has been a laborious task for the nutritional sciences for decades. Likewise,
specifying the optimal intake of vitamins and minerals is difficult in the face of continuing nutrient
research. This makes giving concrete nutrient recommendations challenging. For most nutrients, there
is a large therapeutic range within which the average person will receive benefit and simultaneously
remain below the threshold that can yield adverse events. It is one matter to define nutrient
recommendations and another to actually consume the recommended dosages through the course of a
normal day with typical foods. The notion that you will satisfy all physiological needs of the body for
proper and ideal nutrient intake with food alone is impractical and outdated. Some of the obstacles to
proper eating and ideal nutrient intake include insufficient food intake, increased needs that are not met
by food alone, and dislike or avoidance of essential food groups.
Therefore, at worst vitamin and mineral supplementation acts as insurance against short and long-term
dietary lapses, and guesswork in nutrient intake, including the ability to define the optimal diet. At best,
using valid science to increase the nutrient content of available and typical food intakes may yield
optimal functioning for an extended period, as compared to a non-supplemented state.
Introduction
The notion of vitamin and mineral supplementation, including the fortification of food, began with the
intent to supply essential dietary nutrients significantly lacking in some geographical regions and to
shore up inadequate nutrient content of the general populations typical food intake to meet the
Recommended Dietary Allowances (RDAs). Without supplementation, severe nutritional deficiencies
would be widespread, as they once were.1
The RDAs are, by definition, the levels of intake of essential nutrients that, on the basis of scientific
knowledge, are judged by the Food and Nutrition Board to be adequate to meet the known (current)
nutrient needs of practically all (97-98% of the population) healthy persons. 2 They are not intended to
be final, minimal or optimal. Rather, RDAs and the Dietary Guidelines are designed to prevent nutritional
deficiencies by providing Americans with goals for adequate nutrient intake that most are not
reaching.3,4,5,6,7,8,9,10,11
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Dietary nutrient recommendations for achieving health are continuously being revised and generally
trend upward as the scientific community gathers more data related to how different nutrient intake
levels may affect overall health and longevity. Therefore, rather than simply updating the RDAs, which
are set only for the average person to avoid deficiencies, the US Food and Nutrition Board, now an
element of the Institute of Medicine, released the new Dietary Reference Intakes (DRIs) in 1994 and
have updated them since. These evidence-based standards go beyond amending deficiencies; they also
suggest the amount of nutrients needed for enhancing health. DRIs are as follows:
The Recommended Dietary Allowance (RDA) is the average daily dietary intake level that is sufficient to
meet the nutrient requirements of nearly all (97 to 98 percent) healthy individuals in a specific life stage
and gender group. The RDA is intended primarily for use as a goal for daily intake by individuals.12
Estimated Average Requirement (EAR) is the daily intake value that is estimated to meet the
requirement, as defined by the specified indicator of adequacy, in 50 percent of the individuals in a life
stage or gender group. At this level of intake, the other 50 percent of individuals in a specified group
would not have their nutritional needs met. The EAR is used in setting the RDA.12
Adequate intake level (AI) is a value based on experimentally derived intake levels or approximations of
observed mean nutrient intakes by a group (or groups) of healthy people.12
The Tolerable Upper Intake Level (UL) is the highest level of daily nutrient intake that is likely to pose no
risks of adverse health effects in almost all individuals in the specified life stage group. As intake
increases above the UL, the risk of adverse effects may increase. The intent is to set the UL so that it is
below the threshold of even the most sensitive members of a group.12
However, despite the efforts of the scientific community, including the Food and Nutrition Board of the
National Research Council and its DRIs, the general population is not meeting the majority of the
requirements for vitamins and minerals. According to What We Eat In America, NHANES, Americans
meet very few of the standards for dietary adequacy.9 All recent nutrient intake surveys have shown the
same results: virtually no one gets the recommended amounts of all nutrients from food alone. 13
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3. In general, food preferences established early in life keep people from more diverse nutritional
choices. For most, the early introduction of sugar and fatty convenient foods (e.g. fast food outlets)
creates addictions to these types of food, leaving many undernourished in terms of the RDAs for the
long term. In other words, the foods most people normally choose are high in energy but low in
nutrients.33,34,35
4. Available nutritional information regarding particular foods is not necessarily accurate. The true
nutritional content of a given food is dependent upon such factors as its origin, time and maturity of its
harvest, slaughter, cooking method, processing, and shelf life.13,36,37 In addition, any calculations are
vulnerable to analytical error.38,39 These factors illustrate that just because a list of nutrients associated
with a food is published, those nutrients are not guaranteed to actually enter the body. Performing an
ingredient test on each food before it enters the body is not a practical solution.
Vitamin and mineral losses become cumulative. While an argument can be made that the RDAs include
a margin of safety to address some of these problems, many of the RDAs are established as suboptimal, as demonstrated by the continual upward trend.40,41 No margin of safety can compensate for a
nearly complete lack of an essential nutrient due to any of the above factors, especially soil content. This
was illustrated, though inadvertently, in a study conducted by Clark, Combs and Turnbull.42 The studys
subjects were selected from a region in the United States where there is little to no selenium in the soil.
The dramatic cancer preventative benefits witnessed in the selenium-supplemented group compared to
the placebo users are most likely attributed to the lack of selenium in the food supply from this area. All
these uncontrollable issues become the strongest argument in support of the current scientific approach
that no matter how well you plan your diet, you need insurance. 43,44,45
Even trained professionals struggle with guidelines. In a 1995 study published in the Journal of the
American Dietetic Association,46 dietitians were asked to design diets that met the 1989 RDAs and 1990
Dietary Guidelines while providing 2200-2400 calories (the average non-athletic female gains weight at
1800 calories)47 and remaining palatable to the individuals in the study. Using software designed
specifically for creating a healthy diet, these trained dietitians were unable to accomplish the
objective.46 If health professionals cannot consistently reach the RDAs and dietary guidelines within an
average amount of calories that promotes leanness while being universally palatable, how is the general
public expected to do so?
Poor nutrition has been linked to an increased risk of many diseases including cancer, heart disease, and
diabetes. One highly regarded researcher proposes that nutrient inadequacies may actually illicit a triage
response where the body would prioritize the use of lacking nutrients by urgency which, if true, would
accelerate cancer, aging, and neural decay but would leave critical metabolic functions intact; basically
favoring short-term survival at the expense of long-term health.48
Collectively, the aforementioned circumstances strongly suggest nutrient augmentation to food intake
in order to meet the existing DRIs, which still may not be optimal40,41,49,50
,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68
but are adequate for avoiding deficiency diseases.
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Discussion
The original paradigm based on nutritional essentiality is undergoing a shift. Many well-informed health
professionals and well-respected institutions are breaking precedent by recommending the use of a
multiple vitamin and mineral supplement (VMS) in conjunction with a well-balanced diet.43,44,49,69,70,71
Aside from the insurance value, the changing views on VMS recommendations are also a result of
ongoing research into the amount of a nutrient required to prevent a chronic disease from occurring,
rather than simply preventing a deficiency state.2,64,72,73 ,74,75,76,77 These revised recommendations led to
the reconstruction of the RDAs into the Dietary Reference Intakes (DRI).2,12,78,79,80
RDA levels of specific nutrients will continue to be revised, and wide ranges of safe and potentially
effective intakes established (see Figure 24). This makes it nearly impossible for the general population
to reach potentially beneficial amounts while remaining within a calorie level that would promote
healthy body fat levels without supplementation.47,50,75 ,81,82 ,83 The DRIs provide a new framework
within which recommendations of nutrient intake and clear health benefits can be established.
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ow,
within
w range
range
of safety,
mount
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utrient
requir
redachieve
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am
Figure2424illustrates
illustrates
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ow,
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Figure24:
24:Ultimate
Ultimate
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Au
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Figure
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RDARDA
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mended
Dietary
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NOAEL
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d beneficial dosages
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Cautious review
r
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existing
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r
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informaation following
following the
the criteria
criteria in
in Figure 24 suggests total nutrient intake to
fall somewhere within the ranges shown in Table 7. Any nutrient not appearing in the table indicates that
too little information exists to establish a range. Therefore, consuming a balanced diet will presumably
Figure
suggests
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ake tototals
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oodthe
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higher
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marked) than
t
the uppe
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w below thee tolerable up
pper limit. Mo
ore
193
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More active individuals may maintain intakes closer to the higher side of the range. Recently, it has been
proposed that the age and gender of an adult determines the appropriate levels of certain nutrients.
These doses, even at the high end, are meant to enhance natural physiology (fulfilling potential related
to health). They are not in pharmacological amounts that would be used to treat symptoms of disease.
The use of vitamins and minerals for therapy should be conducted by a qualified physician.
Low High
0 IU - 10,000 IU
10,000 IU - 25,000 IU
400 IU 900 IU
100 IU 800 IU
60-120 mcg
200 mg 1000 mg
2 mg 30 mg
5 mg 30 mg
30 mg 50 mg
6 mg 50 mg
400 mcg 900 mcg
6 mcg 50 mcg
1200 mg 2000 mg
420 mg 600 mg
150 mcg - ?
15 mg 25 mg
15 mg 30 mg
2 mg 4 mg
2 mg 5 mg
2000 mg -?
200 mcg 250 mcg
200 mcg 1000 mcg
LOAEL
21,645 IU
3800 IU*
3,000 mg
1000 mg
500 mg
5,000 mcg
5,000 mg
350 mg
1,700 mcg
70 mg
60 mg
15 mg
910 mcg
-
Proper intake
The synergy of these nutrients, including their daily levels, require they be consumed together but
distributed as equally throughout a 24 hour period as possible to avoid over-saturation and losses.
Individuals should start by following a healthy food plan as closely as possible, including a calorie intake
Supplemental amount can be zero if daily intake of beta carotene is within the safe and optimal range.
Smokers, those likely to develop, or those that already have lung cancer, should avoid beta carotene supplementation.
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that promotes healthy body fat levels, and adding a controlled-release multiple vitamin and mineral
preparation to meet the appropriate nutrient levels.
Using an acceptable pill size, these amounts could be reached through ingestion of a multiple vitamin
and mineral formula one to two times daily with meals. Generally, a separate calcium and Vitamin D
supplement may need to be included in order to reach desired levels, which would also be consumed in
split doses. This method helps maintain tissue target levels throughout the day, as opposed to
consuming the total amount at one time which would diminish the desired result.
Conclusion
Vitamins and minerals ingested as described may allow the body to operate at full capacity without
disturbing its natural physiology. The belief that individuals consume each health and performancerelated compound in optimal doses, ratios and at proper times from food every day is unfounded,
especially when all obstacles are taken into account, including the inability to define these levels. In
addition, it is common knowledge that the general population does not consume more than what is
needed of all necessary substances in their diets. These issues collectively indicate that any nutrient
contributing to cellular health and performance has the potential to be lacking when food is the only
delivery system.
Because of the safety margins of most nutrients, and paying strict attention to tolerable upper limits,
distinctions can be made between the strongest possible evidence and instances where the evidence
becomes strong enough regarding ingesting levels of nutrients that show potential in staving off chronic
disease. In other words, when supplementing properly, potential benefits would greatly outweigh any
unlikely risks. Therefore, at worst vitamin and mineral supplementation acts as insurance against short
and long term dietary lapses, and guesswork in nutrient intake, including the ability to define the
optimal diet. At best, using valid science to increase the nutrient content of available and typical food
intakes may yield optimal functioning for an extended period, as compared to a non-supplemented
state.
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Appendix 2
Three proven strategies for weight reduction, maintenance of weight loss and
prevention of weight gain
Dieting to lose weight is difficult at best, and generally ends in frustration for the average person. The
majority of people gain most of the weight back within the first year.1,2
However, there are three strategies that have consistently proven to be effective in losing weight and
maintaining the loss. When combining all three, a person may have the greatest chance of succeeding in
accomplishing their desired weight loss (when compared to all current conventional methods of weight
loss). When incorporating the three simple methods shown below during caloric restriction, the dieter
should significantly reduce the overall effort generally associated with dieting. This allows the
participant to more comfortably achieve and maintain the desired outcome.
Figure 25: Shows the results of weighing frequency: the dark bars were subjects attempting weight loss. The white
bars were subjects attempting to prevent weight gain. These amazing results clearly demonstrate the effectiveness
of regular weighing. Linde JA, Jeffery RW, French SA, Pronk NP, Boyle RG. Self-weighing in weight gain prevention
and weight loss trials. Ann Behav M ed. 2005 Dec;30(3):210-6.
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Subjects weighing multiple times a week reported that any time weight was not trending in a desired
direction they would make a simple adjustment. Sometimes eating slightly less (including skipping a
meal) or an alteration in exercise would allow them to maintain an easy, steady course to the goal.7
Additionally, the fact that one has to weigh each day (or most days) influences people to think twice
Supplement
Reference
about consuming something that might give
them an undesirable
weigh in. Guide
Figure 25: Shows the results of weighing frequency: the dark bars were subjects attempting weight loss. The white
bars were subjects attempting to prevent weight gain. These amazing results clearly demonstrate the effectiveness
of regular weighing. Linde JA, Jeffery RW, French SA, Pronk NP, Boyle RG. Self-weighing in weight gain prevention
and weight loss trials. Ann Behav M ed. 2005 Dec;30(3):210-6.
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Portion control: people generally attempt to consume meals to completion; 31,32 therefore, meal
portion size significantly impacts a persons total calorie intake.17,33 Overwhelming evidence
validates that the smaller the portions, the fewer daily calories consumed19 and vice-versa i.e.
people tend to eat with their eyes not their stomachs. Use of portion controlled meals has
proven to yield greater weight loss than conventional diet therapy alone. 34,35,36,37
Accurate calorie counts of total daily food intake when compared to having to estimate the
calories of self-prepared or unmarked meals38
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Figure 26: In all six studies the groups using meal replacements (PMR) as part of their overall calorie intake lost
significantly more weight than subjects using the reduced calorie diet (RCD) alone. Heymsfield SB (2003)
18.0
16.0
14.0
12.0
10.0
Pounds
lost 8.0
6.0
RCD
PMR
4.0
2.0
0.0
1
Figure 27: In a 1-year follow-up in the groups that were tracked, the subjects still using meal replacements
maintained significantly more weight loss than the RCD group. Heymsfield SB (2003)
20
18
16
14
12
Pounds
10
lost
RCD
PMR
6
4
2
0
1
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Appendix 3
Xtreme Muscle Stack: Creating the Perfect Anabolic Storm
These diet and supplement manipulations create the greatest muscle size and performance gains
while reducing body fat.
For those who strictly want the keys to the kingdom of muscle, go straight to the formulas starting at
the end of this article. For those interested in understanding how and why, start here.
Many years ago, it was a widely accepted belief that if one trained hard and focused on diet and
supplementation, they could expect to put on ten pounds of muscle a year. If that rate of body change
appeals to you, then no need to read any further. However, if you want to maximize your progress and
take advantage of truly cutting edge information that has recently emerged, and if you want to break
through plateaus, optimize recovery and accelerate muscle gains (with or without body fat loss) then
read on. The following article will feed your mind and teach you how to feed your body, allowing you to
make gains you dreamed of but never thought possible.
Daily exercise-induced changes in muscle occur at an imperceptible rate (a pound of muscle every two
weeks would yield 1.14 ounces a day). Measurable changes to skeletal muscle fibers (type and diameter)
require repeated exposure to the stimulus of progressively more challenging exercise over a significant
period of time (six to eight weeks).1,2,3 Surprisingly, recent research has confirmed that it is the
immediate post-exercise period when the greatest changes in muscle protein synthesis and tissue
structure occurs, making this a critical aspect in the building process.4,5,6
Muscle protein synthesis can be stimulated in many ways and the various mechanisms may interact and
have additive effects. The secret to naturally achieving one's full potential for muscle size and strength,
without gaining unwanted body fat (or better yet, gain size while losing body fat) requires the following:
Matching the proper training with a food and dietary supplement plan that optimizes one's internal
physiological environment. The areas that can be manipulated and optimized to ensure ideal recovery
and growth include
Dietary factors such as the amount and proper timing of calories, protein, carbohydrate and fat
(the macronutrients)
Specific dietary supplements such as the amino acid (AA) leucine, glutamine, specific AA
mixtures and creatine provided to muscle cells at ideal times
Exercise type and amount
Hormonal environment (especially insulin modulation)
Cell volume changes and vasodilatation can enhance an anabolic environment and maximize the
flow of nutrients into, and waste products, out of muscle
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All of these elements may contribute independently and/or synergistically to muscle protein synthesis
and related adaptations to training. In the following text we focus on the above manipulations, minus
exercise, that can be employed to maximize the internal hormonal, nutrient, recovery and protein
synthesis environment of the body.
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Food/diet composition
As stated above, carbohydrates will play an important role in your
performance, recovery and insulin levels. While trying to increase
muscle size, carbohydrates (CHO) should make up 45-60% of your total
caloric intake. Without adequate CHO, ideal insulin activation will not
occur, recovery from intense workouts will not be ideal, and muscular
stores of energy for the next workout will be suboptimal. None of this
contributes to maximum muscular gains. Protein, which mistakenly
receives the greatest focus by many exercisers, needs to be high enough
to allow for tissue growth. For even the hardest training bodybuilder
when calories are not severely restricted*, a protein intake of up to 1
gram per pound of bodyweight is more than enough to allow for
increased needs due to intense workouts and adding muscle. Higher
protein intakes are not necessary and may even impede progress if it
takes the place of dietary carbohydrate. Healthy fats will complete the
picture, making up the remaining calories and generally supplying 1530% of total caloric intake. To summarize
Calories: ideally total calorie intake should be slightly above needs so that the extra
nutrients/calories would be deposited into muscle tissues, allowing ones body fat percentage to
naturally drift down as weight goes up. If simultaneous body fat loss is desired, then the
calorie deficit should be no greater than approx. 15% of calorie maintenance or maximum
muscle building will be compromised
Carbohydrates: approx. 45-60% of total caloric intake*
Protein: approx. 15-30% of total caloric intake (max of 1g/lb of bodyweight)*
Dietary fat: approx. 15-30% of total caloric intake
*The only time protein needs would be greater is during severe dieting as with physique athletes in the final weeks
of contest preparation. During this deprivation period, although protein intake is extremely high and
carbohydrates low because of the lower calorie allotment, muscle is at best maintained and generally lost (see side
bar on protein and bodybuilders). This highlights the important role carbohydrates play in muscle building.
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Post-workout feeding
The proper formula should be ingested as close to immediately after training as possible. Very recently it
was discovered that although the post-training metabolic window is active for as much as 60-90
minutes, its maximum activity (greatest nutrient uptake and protein synthesis capabilities) takes place
immediately at the end of the training session.9 From that point on, the longer you wait to supply the
proper nutrients or the more time they take to get to the affected tissues, the less muscle building or
recovery takes place during this period and cant be made up for at any other point in time (see Figure
28). Simply put, the post-workout feeding activates the muscle building mechanisms that take place in
this window of opportunity.
Figure 28: Training results from 23 experienced recreational bodybuilders resistance training for 10 weeks with all
things (diet, supplements, training, etc.) equal except the addition of pre/post feedings yielded significantly greater
gains in body mass, LBM, strength and reduction in fat mass for the pre/post feeding subjects.9
7
6
5
4
PRE/POST
MOR/EVE
2
1
0
-1
Body Mass
LBM
FM
Summary
By ingesting the proper exercise formula before training, you not only supply workout energy but also
kick off the necessary insulin/hormone release that will work to mitigate exercise-induced damage.
When you repeat the process immediately post-workout, you quickly restore energy (glycogen), supply
muscle building nutrients when most needed, and stimulate a renewed insulin release. This initiates and
enhances the entire muscle-building hormone process/cascade, thus recovery and results.
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Dietary supplements
The final component to maximizing size and performance gains is the integration of dietary
supplements. To keep calories within an appropriate range that does not contribute to unwanted fat
stores, the primary goal of incorporating dietary supplements into food planning is to supply specific
compounds that are used during energy, force production (muscle exertion and subsequent damage)
and are needed for recovery/building. Additionally, these specific compounds must be supplied in
greater amounts than are used so that a portion of their intake will be deposited into the damaged or
depleted structural tissues. This will lead to the desired increase in muscle size.
By isolating these nutrients/compounds from the food form, we can supply them without the calories in
order to control body composition. And because theyre manufactured in proper forms, dosing dietary
supplements allows the user to deliver the needed nutrients into the body at the exact times necessary
to take full advantage of periods when muscle cells are most nutrient-sensitive. This is established by
training, sleep and meal times.
So, there you have the facts - and below you have the general recipe to create the perfect muscle
building storm.
Optimal dotFIT Anabolic Diet & Supplement Program: The Xtreme Muscle Stack
Menu plan and eating instructions
Below is a sample Performance & Muscle Building Menu and eating instructions for a 180 LBS athlete
(get complete sets of personalized plans from the dotFIT Me Program).
Arrange your meals around your activities
Although the meals appear in a breakfast, lunch and dinner fashion (meal numbers have no relevance to
eating positions), you must arrange the meals around your training session(s). Space your meals no
more than 3-4 hours apart. Other than your pre-event meal and pre- and post- snacks, you may eat the
remaining meals in any order that fits your lifestyle or venue.
Early morning training
If you train soon after rising and have no time for complete digestion of a large meal, make sure you
consume your pre-training meal (or something very similar) as your final meal of the day, as late as
possible, and consume only the pre-workout snack before your early morning workout.
Pre- and post-training feedings
The pre/post feedings or snacks are usually shown in a liquid form, but you may substitute based on
preference, venue and/or convenience, any of the appropriate dotFIT foods. In other words, you may
choose a bar as the pre-workout portion and a shake post-workout or vice-versa.
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Other Nutrients:
Pro (g)
Carb (g)
Fat (g)
Calories
15
2
17
20%
29
26
55
66%
5
5
14%
220
110
330
Pro (g)
Carb (g)
Fat (g)
Calories
11
8
1
13
33
18%
64
6
27
19
116
61%
1
16
0.4
0.9
18
21%
300
188
105
136
729
Pro (g)
Carb (g)
Fat (g)
Calories
20
20
25%
35
17
52
66%
3
3
9%
240
70
Pro (g)
Carb (g)
Fat (g)
Calories
20
13
33
35%
35
19
54
56%
3
0.9
4
9%
240
136
376
Pro (g)
Carb (g)
Fat (g)
Calories
37
37
24%
92
35
127
62%
9
9
14%
560
130
683
Pro (g)
Carb (g)
Fat (g)
Calories
50
8
1
2
1
62
30%
64
2
10
13
89
44%
11
0.4
8
3
0.4
0.3
23
26%
310
290
67
38
44
53
802
Pro (g)
Carb (g)
Fat (g)
Calories
8
8
14%
46
46
83%
6
6
3%
280
280
Menu Totals:
211
537
Percentage of Total Calories:
23%
60%
7% Saturated Fat
304 mg Cholesterol
310
68
3510
17%
34 g Fiber
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dotFIT CreatineXXL
o A supercharged creatine formula to improve upon the well-known size and performance
enhancing effects of creatine-monohydrate. Designed to deliver increased strengthendurance, intensity (-Alanine) and much greater cell volume effects (glycine and
glutamine) than creatine alone, all leading to greater strength, size and performance
gains
NO7Rage
o Contains a blend of compounds that increase muscle blood flow, cell volume (the
pump) and mental focus. Greater blood flow to muscles increases the delivery of
oxygen, energy and rebuilding nutrients as well as speeding up the removal of waste
products. This leads to improved strength, less muscle breakdown and increased muscle
size and performance
Contains creatine, caffeine, etc.
AminoBoostXXL
o This product has the ideal mix of essential amino acids shown to enhance muscle gain
and recovery
Delivers the ideal blend of nutrients to take advantage of post-training
metabolic windows of growth adding to the muscle building results produced
by the pre- and post-exercise feedings. The unique blend of AA are quickly
assimilated into muscle tissues
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NO7Rage
AminoBoostXXL
1-2.5 scoops as
directed30 min before
WO
1-2.5 scoops as
directed30 min before
WO
1-2.5 scoops as
directed30 min before
WO
1-2.5 scoops as
directed30 min before
WO
1-2.5 scoops as
directed30 min before
WO
1-2.5 scoops as
directed30 min before
WO
1-2.5 scoops as
directed30 min before
WO
1-2.5 scoops as
directed30 min before
WO
1-2.5 scoops as
directed30 min before
WO
1-2.5 scoops as
directed30 min before
WO
11
1-2.5 scoops as
directed30 min before
WO
1/2-1scoop as directed
30 min before &
immediately post WO
12
1-2.5 scoops as
directed30 min before
WO
1/2-1scoop as directed
30 min before &
immediately post WO
10
13
14
15
0
0
0
CreatineXXL*
Training Intensity
Med
Med-high
High
1/2-1scoop as directed
30 min before &
immediately post WO
0
0
0
16
High
High
High
6 tabs, 3 after WO, split
remaining throughout
day with meals
7 tabs, 3 after WO, split
remaining throughout
day with meals
8 tabs, 4 after WO, split
remaining throughout
day with meals
9 tabs, 4 after WO, split
remaining throughout
day with meals
10 tabs, 4 after WO,
split remaining
throughout day with
meals
10 tabs, 4 after WO,
split remaining
throughout day with
meals
6 tabs, 2 after WO, split
remaining throughout
day with meals
0
0
0
High
High
High
High
High
Competition Week
Low/med or active
rest
Off
Medium intensity and
hold until next intense
training cycle
*For the maximum effect of creatine supplementation and increasese in cell volume, all dosages should be taken
with 25-45 grams of carbohydrate.
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dotFIT CreatineXXL
o A supercharged creatine formula to improve upon the well-known size and performance
enhancing effects of creatine-monohydrate. Designed to deliver increased strengthendurance, intensity (-Alanine) and much greater cell volume effects (glycine and
glutamine) than creatine alone, all leading to greater strength, size and performance
gains
Take as shown below (dosage shown is for anyone under 200 LBS and can be
adjusted upward for heavier athletes, or dotFIT CreatineMonohydrate added as
desired)
Tablets per
day
Time*
Training Intensity
1
2
3
4
5
6
7
8
9
10
5
8
10
10
10
10
10
10
10
10
11
12
13
14
5
0
0
High
High
High
High
High
High
High
High
High
High
Peak of training program or week
of competition
Off
Low/Med
Med/High
*For the maximum effect of creatine supplementation and increasese in cell volume, all dosages should be taken
with 25-45 grams of carbohydrate.
dotFIT Recover&Build
o Provides the branched-chain amino acids (BCAA), leucine, isoleucine and valine in an
ideal ratio with the goal of reducing exercise-induced muscle damage while enhancing
recovery, minimizing soreness leading to increasing muscle, especially during low calorie
or intense training phases
Take as directed with your pre-workout snack
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A Final Word
We have presented a significant amount of information to digest. Read it, re-read it and put the
information into practice. If you diligently follow the recommendations outlined in this article, you will
be amazed at the pace at which your body increases muscle size and strength. If you have been at a
plateau and thought adding muscle was no longer possible, then rejoice in the knowledge that you have
an arsenal of weapons at your disposal that can allow you to naturally maximize your muscle building
physiology. Remember how bodybuilders used to think adding ten pounds in a year was progress? Doing
everything correctly, this should be possible in a matter of three months even for the most seasoned
athletes, and certainly in less time for the younger population. Now get out there and train hard, and
eat smart and consistently.
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References
7/24/09 1:32:37 PM
References
Section 1 - dietary supplements and dotFIT
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16 Fulgoni V 3rd, Nicholls J, Reed A, Buckley R, Kafer K, Huth P, DiRienzo D, Miller GD. Dairy consumption and related nutrient
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35 Russell R M. New views on the RDAs for older adults. J Am Diet Assoc 1997 May;97(5):515-8.
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10 Sebastian RS, Cleveland LE, Goldman JD, Moshfegh AJ. Older adults who use vitamin/mineral supplements differ from
nonusers in nutrient intake adequacy and dietary attitudes. J Am Diet Assoc. 2007 Aug;107(8):1322-32.
11 Lee C, Majka DS. Is calcium and vitamin D supplementation overrated? J Am Diet Assoc. 2006 Jul;106(7):1032-4.
12 Blom HJ, Shaw GM, den Heijer M, Finnell RH. Neural tube defects and folate: case far from closed. Nat Rev Neurosci. 2006
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13 Shils ME, Vernon RY. Modern Nutrition in health and disease. 7th edition. Philadelphia PA: Lea and Febiger; 1988. 1694 p.
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16 Beals KA, Manore MM. Nutritional status of female athletes with subclinical eating disorders. J Am Diet Assoc 1998
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17 Manore MM. Chronic dieting in active women: what are the health consequences? Womens Health Issues 1996 NovDec;6(6):332-41
18 Johnson MA. Nutrition and aging--practical advice for healthy eating. J Am Med Womens Assoc. 2004 Fall;59(4):262-9.
19 Striegel-Moore RH, Thompson DR, Affenito SG, Franko DL, Barton BA, Schreiber GB, Daniels SR, Schmidt M, Crawford PB.
Fruit and vegetable intake: Few adolescent girls meet national guidelines. Prev Med. 2006 Mar;42(3):223-8. Epub 2006 Jan
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20 Serdula MK, Gillespie C, Kettel-Khan L, Farris R, Seymour J, Denny C. Trends in fruit and vegetable consumption among adults
in the United States: behavioral risk factor surveillance system, 1994-2000. Am J Public Health. 2004 Jun;94(6):1014-8.
21 Economic Research Service, US Department of Agriculture. Americas Eating Habits.: Changes and Consequences 1999.
USDA/Economic Research Service, Washington D.C.
22 Kant AK. Reported consumption of low-nutrient-density foods by American children and adolescents: nutritional and health
correlates, NHANES III, 1988 to 1994. Arch Pediatr Adolesc Med. 2003 Aug;157(8):789-96.
23 Nicklas TA, Weaver C, Britten P, Stitzel KF. The 2005 Dietary Guidelines Advisory Committee: developing a key message. J Am
Diet Assoc. 2005 Sep;105(9):1418-24. Erratum in: J Am Diet Assoc. 2005 Dec;105(12):1869.
24 Fulgoni V 3rd, Nicholls J, Reed A, Buckley R, Kafer K, Huth P, DiRienzo D, Miller GD. Dairy consumption and related nutrient
intake in African-American adults and children in the United States: continuing survey of food intakes by individuals 19941996, 1998, and the National Health And Nutrition Examination Survey 1999-2000. J Am Diet Assoc. 2007 Feb;107(2):25664.
25 Beals KA. Eating behaviors, nutritional status, and menstrual function in elite female adolescent volleyball players. J Am Diet
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71 Green AL, Simpson EJ, Littlewood JJ, Macdonald IA, Greenhaff PL. Carbohydrate ingestion augments creatine retention during
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83 Bellinger BM, Bold A, Wilson GR, Noakes TD, Myburgh KH. Oral creatine supplementation decreases plasma markers of
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84 Burke DG, Smith-Palmer T, Holt LE, Head B, Chilibeck PD. The effect of 7 days of creatine supplementation on 24-hour urinary
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88 Louis M, Poortmans JR, Francaux M, Berr J, Boisseau N, Brassine E, Cuthbertson DJ, Smith K, Babraj JA, Waddell T, Rennie
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90 Maganaris CN, Maughan RJ. Creatine supplementation enhances maximum voluntary isometric force and endurance capacity in
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91 Mendel RW, Blegen M, Cheatham C, Antonio J, Ziegenfuss T. Effects of creatine on thermoregulatory responses while
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92 Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA. Acute creatine loading increases fat-free mass, but does not affect blood
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hypertrophy with resistance training in elderly humans. J Physiol. 2001 Aug 15;535(Pt 1):301-11.
26 Bird SP, Tarpenning KM, Marino FE. Liquid carbohydrate/essential amino acid ingestion during a short-term bout of resistance
exercise suppresses myofibrillar protein degradation. Metabolism. 2006 May;55(5):570-7.
27 Baty JJ, Hwang H, Ding Z, Bernard JR, Wang B, Kwon B, Ivy JL. The effect of a carbohydrate and protein supplement on
resistance exercise performance, hormonal response, and muscle damage. J Strength Cond Res. 2007 May;21(2):321-9.
28 Paddon-Jones D, Sheffield-Moore M, Aarsland A, Wolfe RR, Ferrando AA. Exogenous amino acids stimulate human muscle
anabolism without interfering with the response to mixed meal ingestion. Am J Physiol Endocrinol Metab. 2005
Apr;288(4):E761-7. Epub 2004 Nov 30.
29 Cribb PJ, Hayes A. Effects of supplement timing and resistance exercise on skeletal muscle hypertrophy. Med Sci Sports Exerc.
2006 Nov;38(11):1918-25.
30 Cockburn E, Hayes PR, French DN, Stevenson E, St Clair Gibson A. Acute milk-based protein-CHO supplementation attenuates
exercise-induced muscle damage. Appl Physiol Nutr Metab. 2008 Aug;33(4):775-83.
31 Luden ND, Saunders MJ, Todd MK. Postexercise carbohydrate-protein- antioxidant ingestion decreases plasma creatine kinase
and muscle soreness. Int J Sport Nutr Exerc Metab. 2007 Feb;17(1):109-23.
32 Millard-Stafford M, Childers WL, Conger SA, Kampfer AJ, Rahnert JA. Recovery nutrition: timing and composition after
endurance exercise. Curr Sports Med Rep. 2008 Jul-Aug;7(4):193-201. Review.
33 Campbell C, Prince D, Braun M, Applegate E, Casazza GA. Carbohydrate-supplement form and exercise performance. Int J
Sport Nutr Exerc Metab. 2008 Apr;18(2):179-90.
34 Jentjens RL, Underwood K, Achten J, Currell K, Mann CH, Jeukendrup AE. Exogenous carbohydrate oxidation rates are
elevated after combined ingestion of glucose and fructose during exercise in the heat. J Appl Physiol. 2006 Mar;100(3):80716. Epub 2005 Nov 10.
35 Jentjens RL, Moseley L, Waring RH, Harding LK, Jeukendrup AE. Oxidation of combined ingestion of glucose and fructose
during exercise. J Appl Physiol. 2004 Apr;96(4):1277-84. Epub 2003 Dec 2.
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36 Dreyer HC, Drummond MJ, Pennings B, Fujita S, Glynn EL, Chinkes DL, Dhanani S, Volpi E, Rasmussen BB. Leucine-enriched
essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein
synthesis in human muscle. Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E392-400. Epub 2007 Dec 4.
37 Miller SL, Tipton KD, Chinkes DL, Wolf SE, Wolfe RR. Independent and combined effects of amino acids and glucose after
resistance exercise. Med Sci Sports Exerc. 2003 Mar;35(3):449-55.
38 Kimball SR, Farrell PA, Jefferson LS. Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle
by amino acids or exercise. J Appl Physiol. 2002 Sep;93(3):1168-80. Review.
39 Wojtaszewski JF, Nielsen JN, Richter EA. Invited review: effect of acute exercise on insulin signaling and action in humans. J
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22 Baty JJ, Hwang H, Ding Z, Bernard JR, Wang B, Kwon B, Ivy JL. The effect of a carbohydrate and protein supplement on
resistance exercise performance, hormonal response, and muscle damage. J Strength Cond Res. 2007 May;21(2):321-9.
23 Cribb PJ, Hayes A. Effects of supplement timing and resistance exercise on skeletal muscle hypertrophy. Med Sci Sports Exerc.
2006 Nov;38(11):1918-25.
24 Tipton KD, Rasmussen BB, Miller SL, Wolf SE, Owens-Stovall SK, Petrini BE, Wolfe RR. Timing of amino acid-carbohydrate
ingestion alters anabolic response of muscle to resistance exercise. Am J Physiol Endocrinol Metab. 2001 Aug;281(2):E197206.
25 Koopman R, Wagenmakers AJ, Manders RJ, Zorenc AH, Senden JM, Gorselink M, Keizer HA, van Loon LJ. Combined ingestion
of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects. Am J
Physiol Endocrinol Metab. 2005 Apr;288(4):E645-53. Epub 2004 Nov 23.
26 Esmarck B, Andersen JL, Olsen S, Richter EA, Mizuno M, Kjaer M. Timing of postexercise protein intake is important for muscle
hypertrophy with resistance training in elderly humans. J Physiol. 2001 Aug 15;535(Pt 1):301-11.
27 Bird SP, Tarpenning KM, Marino FE. Liquid carbohydrate/essential amino acid ingestion during a short-term bout of resistance
exercise suppresses myofibrillar protein degradation. Metabolism. 2006 May;55(5):570-7.
28 Baty JJ, Hwang H, Ding Z, Bernard JR, Wang B, Kwon B, Ivy JL. The effect of a carbohydrate and protein supplement on
resistance exercise performance, hormonal response, and muscle damage. J Strength Cond Res. 2007 May;21(2):321-9.
29 Paddon-Jones D, Sheffield-Moore M, Aarsland A, Wolfe RR, Ferrando AA. Exogenous amino acids stimulate human muscle
anabolism without interfering with the response to mixed meal ingestion. Am J Physiol Endocrinol Metab. 2005
Apr;288(4):E761-7. Epub 2004 Nov 30.
30 Cockburn E, Hayes PR, French DN, Stevenson E, St Clair Gibson A. Acute milk-based protein-CHO supplementation attenuates
exercise-induced muscle damage. Appl Physiol Nutr Metab. 2008 Aug;33(4):775-83.
31 Luden ND, Saunders MJ, Todd MK. Postexercise carbohydrate-protein- antioxidant ingestion decreases plasma creatine kinase
and muscle soreness. Int J Sport Nutr Exerc Metab. 2007 Feb;17(1):109-23.
32 Millard-Stafford M, Childers WL, Conger SA, Kampfer AJ, Rahnert JA. Recovery nutrition: timing and composition after
endurance exercise. Curr Sports Med Rep. 2008 Jul-Aug;7(4):193-201. Review.
33 Campbell C, Prince D, Braun M, Applegate E, Casazza GA. Carbohydrate-supplement form and exercise performance. Int J
Sport Nutr Exerc Metab. 2008 Apr;18(2):179-90.
34 Jentjens RL, Underwood K, Achten J, Currell K, Mann CH, Jeukendrup AE. Exogenous carbohydrate oxidation rates are
elevated after combined ingestion of glucose and fructose during exercise in the heat. J Appl Physiol. 2006 Mar;100(3):80716. Epub 2005 Nov 10.
35 Dreyer HC, Drummond MJ, Pennings B, Fujita S, Glynn EL, Chinkes DL, Dhanani S, Volpi E, Rasmussen BB. Leucine-enriched
essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein
synthesis in human muscle. Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E392-400. Epub 2007 Dec 4.
36 Miller SL, Tipton KD, Chinkes DL, Wolf SE, Wolfe RR. Independent and combined effects of amino acids and glucose after
resistance exercise. Med Sci Sports Exerc. 2003 Mar;35(3):449-55.
37 Kimball SR, Farrell PA, Jefferson LS. Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle
by amino acids or exercise. J Appl Physiol. 2002 Sep;93(3):1168-80. Review.
dotFIT FirstString
1 van Loon LJ, Saris WH, Kruijshoop M, Wagenmakers AJ. Maximizing postexercise muscle glycogen synthesis: carbohydrate
supplementation and the application of amino acid or protein hydrolysate mixtures. Am J Clin Nutr. 2000 Jul;72(1):106-11.
2 Millard-Stafford M, Childers WL, Conger SA, Kampfer AJ, Rahnert JA. Recovery nutrition: timing and composition after endurance
exercise. Curr Sports Med Rep. 2008 Jul-Aug;7(4):193-201. Review.
3 Ivy JL, Goforth HW Jr, Damon BM, McCauley TR, Parsons EC, Price TB. Early postexercise muscle glycogen recovery is
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4 Berardi JM, Price TB, Noreen EE, Lemon PW. Postexercise muscle glycogen recovery enhanced with a carbohydrate-protein
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6 Levenhagen DK, Carr C, Carlson MG, Maron DJ, Borel MJ, Flakoll PJ. Postexercise protein intake enhances whole-body and leg
protein accretion in humans. Med Sci Sports Exerc. 2002 May;34(5):828-37.
7 Tipton KD, Elliott TA, Cree MG, Wolf SE, Sanford AP, Wolfe RR. Ingestion of casein and whey proteins result in muscle anabolism
after resistance exercise. Med Sci Sports Exerc. 2004 Dec;36(12):2073-81.
8 Tipton KD, Elliott TA, Cree MG, Aarsland AA, Sanford AP, Wolfe RR. Stimulation of net muscle protein synthesis by whey protein
ingestion before and after exercise. Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E71-6. Epub 2006 Aug 8.
9 Koopman R, Saris WH, Wagenmakers AJ, van Loon LJ. Nutritional interventions to promote post-exercise muscle protein
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10 Borsheim E, Aarsland A, Wolfe RR. Effect of an amino acid, protein, and carbohydrate mixture on net muscle protein balance
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11 Tipton KD, Rasmussen BB, Miller SL, Wolf SE, Owens-Stovall SK, Petrini BE, Wolfe RR. Timing of amino acid-carbohydrate
ingestion alters anabolic response of muscle to resistance exercise. Am J Physiol Endocrinol Metab. 2001 Aug;281(2):E197206.
12 Koopman R, Wagenmakers AJ, Manders RJ, Zorenc AH, Senden JM, Gorselink M, Keizer HA, van Loon LJ. Combined ingestion
of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects. Am J
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13 Miller BF. Human muscle protein synthesis after physical activity and feeding. Exerc Sport Sci Rev. 2007 Apr;35(2):50-5. Review.
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ingestion matter? Curr Sports Med Rep. 2002 Aug;1(4):214-21. Review.
15 Miller SL, Tipton KD, Chinkes DL, Wolf SE, Wolfe RR. Independent and combined effects of amino acids and glucose after
resistance exercise. Med Sci Sports Exerc. 2003 Mar;35(3):449-55.
16 Tipton KD, Borsheim E, Wolf SE, Sanford AP, Wolfe RR. Acute response of net muscle protein balance reflects 24-h balance
after exercise and amino acid ingestion. Am J Physiol Endocrinol Metab. 2003 Jan;284(1):E76-89. Epub 2002 Sep 11.
17 Cribb PJ, Hayes A. Effects of supplement timing and resistance exercise on skeletal muscle hypertrophy. Med Sci Sports Exerc.
2006 Nov;38(11):1918-25.
18 Suzuki M. Glycemic carbohydrates consumed with amino acids or protein right after exercise enhance muscle formation. Nutr
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19 Koopman R, Wagenmakers AJ, Manders RJ, Zorenc AH, Senden JM, Gorselink M, Keizer HA, van Loon LJ. Combined ingestion
of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects. Am J
Physiol Endocrinol Metab. 2005 Apr;288(4):E645-53. Epub 2004 Nov 23.
20 Manders RJ, Wagenmakers AJ, Koopman R, Zorenc AH, Menheere PP, Schaper NC, Saris WH, van Loon LJ. Co-ingestion of a
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21 Koopman R, Beelen M, Stellingwerff T, Pennings B, Saris WH, Kies AK, Kuipers H, van Loon LJ. Coingestion of carbohydrate
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22 van Loon LJ, Saris WH, Kruijshoop M, Wagenmakers AJ. Maximizing postexercise muscle glycogen synthesis: carbohydrate
supplementation and the application of amino acid or protein hydrolysate mixtures. Am J Clin Nutr. 2000 Jul;72(1):106-11.
dotFIT WheySmooth
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ingestion alters anabolic response of muscle to resistance exercise. Am J Physiol Endocrinol Metab. 2001 Aug;281(2):E197206.
2 Tipton KD, Elliott TA, Cree MG, Aarsland AA, Sanford AP, Wolfe RR. Stimulation of net muscle protein synthesis by whey protein
ingestion before and after exercise. Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E71-6. Epub 2006 Aug 8.
3 Tipton KD, Elliott TA, Cree MG, Wolf SE, Sanford AP, Wolfe RR. Ingestion of casein and whey proteins result in muscle anabolism
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74 Frank B, Gupta S. A review of antioxidants and Alzheimer's disease. Ann Clin Psychiatry. 2005 Oct-Dec;17(4):269-86. Review.
75 Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective
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76 Morton DJ, Barrett-Connor EL, Schneider DL. Vitamin C supplement use and bone mineral density in postmenopausal women. J
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