Integral Theory System Simplified Clinical Approach
Integral Theory System Simplified Clinical Approach
Integral Theory System Simplified Clinical Approach
INTRODUCTION
The Integral Theory states that prolapse and most pelvic
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mainly arise, for different reasons, from laxity in the vagina
or its supporting ligaments, a result of altered connective
tissue.1-5%LUWKUHODWHGOD[LW\JFRPSRXQGHGE\DJHLQJ
are the principal causes of ligament laxity.
The Integral Theory has evolved into the Integral Theory
System, which applies the damaged ligament theory to
Function the role of competent suspensory ligaments in
organ support and function.
Dysfunction-how damaged ligaments upset the
musculoelastic control mechanism to cause prolapse and
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Diagnosis- how to diagnose which damaged ligaments
are causing which prolapse and which symptoms. )LJ %LUWKUHODWHG OD[LW\ 7KH GLDJUDP VKRZV WKH EDE\V KHDG
severely stretching ligaments and other tissues in and outside the
TreatmentLQPLOGFDVHVQHZSHOYLFRRUPXVFOHH[HUFLVHV vagina. This may cause various degrees of looseness, prolapse of the
EDVHG RQ D VTXDWWLQJ SULQFLSOH VWUHQJWKHQ WKH QDWXUDO EODGGHUDQGERZHODQGXULQHDQGERZHOLQFRQWLQHQFH)XQGDPHQWDO
closure muscles and their ligamentous insertions. With to any surgical treatment is the approximation of laterally displaced
more severe cases, polypropylene tapes applied through tissues, and the strengthening of damaged suspensory ligament(s).
keyhole incision using special instruments, reinforce the
damaged ligaments, restoring structure and function. 7KHEODGGHUVLWVRQWRSRIWKHYDJLQDDQGLVSDUWO\DWWDFKHG
to it. Muscles pull against the ligaments to close or open the
PART 1 urethra. Therefore loose ligaments may weaken the muscle
THE DYNAMIC ANATOMY OF NORMAL FUNCTION FRQWUDFWLRQ WR FDXVH SUREOHPV ZLWK FORVXUH LQFRQWLQHQFH
Fig. 3 - Unsuspended ligaments have no shape, strength or )LJ )RXU OLJDPHQWV VXVSHQG WKH RUJDQV IURP DERYH OLNH D
function. VXVSHQVLRQ EULGJH 7KH SHULQHDO ERG\ 3% VXSSRUWV WKH RUJDQV
IURPEHORZ&/ FDUGLQDOOLJDPHQW
or opening (evacuation of urine). Figure 3 indicates what
WKH YDJLQD EODGGHU DQG ERZHO ZRXOG ORRN OLNH ZLWK QR predispose to prolapse, and development of posterior zone
OLJDPHQWVWRVXVSHQGWKHPDEORERIWLVVXHZLWKQRIRUP symptoms.
no structure, no strength, and no function. The pelvic musclesGDUNUHGJKDYHDGXDOIXQFWLRQ
$OLJDPHQWLVOLNHDWKLFNFRUGLQDVXVSHQVLRQEULGJHJ organ support, and opening and opening and closure of
,QIDFWWKHYDJLQDLVVXVSHQGHGH[DFWO\OLNHDVXVSHQVLRQ urethra and anorectum. They extend from the coccyx to the
EULGJHZLWKWKHOLJDPHQWVDERYHDQGWKHPXVFOHVDUURZV SXELFERQHDQGFRQWUDFWWRVXSSRUWWKHYDJLQDEODGGHUDQG
EHORZ 7KH PXVFOH IRUFHV DUURZV FRQWUDFW DJDLQVW WKH ERZHO IURP EHORZ 7KH UHG DUURZV LQGLFDWH WKH GLUHFWLRQV
VXVSHQVRU\OLJDPHQWVWRJLYHWKHEULGJHIRUPDQGVWUHQJWK ZKHUHWKHPXVFOHVFRQWUDFWEDFNZDUGVWRRSHQWKHVHRUJDQV
7KH RUJDQV J DUH VXVSHQGHG IURP DERYH E\ WKH forwards to close them.
YDJLQDO OLJDPHQWV H[DFWO\ OLNH D VXVSHQVLRQ EULGJH $OO An external striated muscle opening and closure
the ligaments are attached to the vagina and/or uterus. The PHFKDQLVPJ.7&8, 9-17
YDJLQDVXSSRUWVWKHEODGGHUVLWXDWHGDERYHLWDQGWKHUHFWXP 3XW VLPSOLVWLFDOO\ ZKHQ WKH PXVFOHV SXOO EDFNZDUGV
VLWXDWHG EHORZ LW VR DQ\WKLQJ ZKLFK GDPDJHV WKH YDJLQDO EOXHDUURZVWKHXUHWKUDDQGDQXVDUHSXOOHGRSHQYDVWO\
VWUXFWXUHFDQDOVRDIIHFWWKHEODGGHUDQGUHFWXP GHFUHDVLQJLQWUDFDYLW\UHVLVWDQFHWRWKHth power, so that the
Separating the lower end of the vagina from the rectum ZRPDQFDQTXLFNO\DQGHDVLO\HYDFXDWHKHUXULQHDQGIDHFHV
LV D VROLG PDVV RI WLVVXH WKH SHULQHDO ERG\ 3% FRPSOH[ ZKHQWKHPXVFOHVSXOOIRUZDUGV
EODFNDUURZVWKHXUHWKUD
ZKLFKLVDERXWFPORQJ,IWKLVLVGDPDJHGWKHUHFWXPPD\ DQGDQXVDUHFORVHGE\DYDVWLQFUHDVHLQUHVLVWDQFHWRWKHth
EXOJHIRUZDUGVLQWRWKHYDJLQDDVDUHFWRFRHOH power. Normally all the organs, even the vagina, are kept in
The uterus is an anchoring point for the ligaments - WKHFORVHGSRVLWLRQE\VORZWZLWFKPXVFOHFRQWUDFWLRQ
it needs to be preserved where possible * The closure mechanism is a little more complex than that depicted
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Some doctors routinely recommend removal of the uterus How damaged ligaments may cause incontinence or
GXULQJ VXUJHU\ IRU SURODSVH ,W LV SUHIHUDEOH WR UHWDLQ WKH emptying disorders. :H VDZ IURP WKH VXVSHQVLRQ EULGJH
XWHUXV ZKHUHYHU SRVVLEOH DV PDQ\ LPSRUWDQW OLJDPHQWV diagram, that the muscles pull against the ligaments.
are attached to it. During the menopause, the ovaries cease
production of oestrogen. Since oestrogen is essential for
maintaining the strength of the ligaments, the detrimental
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especially evident after the menopause. Hysterectomy
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ligaments, weakening them further. All these factors
38
The integral theory system
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muscle forces (arrows).
PART 2
DYSFUNCTION - THE ROLE OF LAX LIGAMENTS IN
THE CAUSATION OF SYMPTOMS AND PROLAPSE
39
P.E.P. Petros
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and posterior (uterosacral) ligaments are in purple. The middle
ligaments (ATFP& cardinal) are not shown in this diagram. There
are 3 columns, one for each ligament group and the symptoms
)LJ$F\VWRFRHOHEXOJLQJRXWRIWKHYDJLQDOHQWUDQFHGXULQJ and prolapses (lumps) associated with damage to these ligaments.
straining. /DEHOOLQJLVIURQWDQGEDFNLQVWHDGRIDQWHULRUDQGSRVWHULRU
The integral theory system
&ROODJHQ EUHV ZRUN OLNH WKH VWHHO URGV LQ FHPHQW 6LQJOH YDJLQDOFDQDOJLVXQOLNHO\WRGDPDJHMXVWRQHVLQJOH
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strength. The elastin content gives them elasticity. It is the lesser extent. This explains appearance of a cystocoele, for
change in collagen which is the ultimate cause of prolapse example, months or years after apparently successful surgery
and incontinence. for prolapse of the uterus. Further prolapse can occur in
How ligaments are stretched and damaged during perhaps 30-50% of cases after a successful vaginal repair.
pregnancy and labour 7KHSUREOHPLVWKDWRQFHWKHYDJLQDOWLVVXHVDUHGDPDJHG
$V ZH VDZ IURP WKH VXVSHQVLRQ EULGJH GLDJUDP WKH LWLVGLIFXOWWRIXOO\UHSDLUWKHP,WLVOLNHUHSDLULQJIUD\HG
PXVFOHVSXOODJDLQVWWKHOLJDPHQWVZKLFKVXSSRUWWKHEULGJH cloth. The surgeon repairs one area, only to see it give way
,IWKHOLJDPHQWVDUHVWUHWFKHGDQGORRVHQHGGXULQJFKLOGELUWK LQ DQRWKHU DUHD 7KDW LV ZK\ ZH KDYH WR FUHDWH DUWLFLDO
DVLQJDSDWLHQWPD\GHYHORSDSURODSVHDGUDJJLQJ OLJDPHQWVE\XVLQJWDSHV
SDLQ ORZ LQ WKH DEGRPHQ EODGGHU V\PSWRPV IRU H[DPSOH A cystocoeleEDOORRQVRXWIURPDERYHJ7KHFDXVH
XUJHQF\IUHTXHQF\QRFWXULDRUHYHQSUREOHPVZLWKERZHO is damage to the middle ligaments (ATFP and/or cardinal
emptying or faecal incontinence. ligaments) and the anterior wall of the vagina.
&RPPHQFLQJ PRQWKV EHIRUH FKLOGELUWK WKH JOXH A rectocoele,JEDOORRQVRXWIURPEHORZ6HSDUDWLQJ
EHWZHHQ WKH FROODJHQ URGV EHJLQV WR VRIWHQ LQ UHVSRQVH WR
the lower end of the vagina from the rectum is the perineal
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WKH RQVHW RI EODGGHU ERZHO DQG SDLQ V\PSWRPV DW WKLV ERG\ D PDMRU VXSSRUWLQJ VWUXFWXUH DV LW RFFXSLHV RI
WLPH 6RPH KRXUV EHIRUH GHOLYHU\ KRZHYHU WKLV WKH SRVWHULRU YDJLQDO ZDOO $ UHFWRFRHOH PD\ EH FDXVHG
softening accelerates, and the collagen rods lose 95% of their E\ GDPDJH WR WKH XWHURVDFUDO OLJDPHQWV KLJK UHFWRFRHOH
strength.18'XULQJGHOLYHU\WKHEDE\VKHDGJUHDWO\VWUHWFKHV DQGRU UHFWRYDJLQDO IDVFLD SHULQHDO ERGLHV PLG ORZ
these collagen rods. Of course, the rods re-glue soon after rectocoele.
GHOLYHU\ EXW RIWHQ WKH\ UHJOXH LQ D ORRVH DQG H[WHQGHG Uterine prolapse J LV FDXVHG E\ GDPDJH WR WKH
position. Neither the ligaments nor the muscles can now cardinal and uterosacral ligaments.
work properly, and this may lead to prolapse of the uterus,
F\VWRFRHOHUHFWRFRHOHDQGDZLGHUDQJHRIEODGGHUERZHO A perspective on organ prolapse
DQGSHOYLFSDLQV\PSWRPVJ:RPHQZKRKDYHKDG 7KH RUJDQV EXOJH WR YDU\LQJ GHJUHHV &OHDUO\ D VHYHUH
&DHVDULDQ VHFWLRQV PD\ DOVR EHFRPH LQFRQWLQHQW EXW WKH\ SURODSVH VXFK DV WKH XWHULQH SURODSVH DERYH UHTXLUHV
KDYH OHVV VWUHWFKLQJ DQG WKHUHIRUH IHZHU SUREOHPV WKDQ WUHDWPHQW,IWKHEXOJHLVPLQRUDQGWKHUHDUHQRDVVRFLDWHG
vaginal delivery patients. Loose ligaments may occur in
symptoms, there is no need for treatment. However, a patient
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with loose ligaments, or they may have a congenital defect in PD\ KDYH VHYHUH V\PSWRPV ZKLFK PD\ UHTXLUH WUHDWPHQW
WKHLUFROODJHQ$OOWKHVHFRQGLWLRQVDUHSRWHQWLDOO\FXUDEOHE\ even though the prolapse is minor.
FUHDWLRQRIDUWLFLDOOLJDPHQWVDVZLOOEHH[SODLQHGODWHU When are these symptoms and prolapses problematical?
The effect of age and menopause If a patient answers yes to one of the following, she has
Both collagen and elastin deteriorate markedly after the DSUREOHP
menopause, and this explains the vast increase in prolapse 1. You lose urine during exertion or coughing.
and incontinence which occurs after this event. A partly <RXFDQWKROGRQDQG\RXZHW\RXUVHOI
GDPDJHG OLJDPHQW ZKLFK LV RQO\ MXVW IXQFWLRQLQJ EHIRUH <RXFDQWHPSW\\RXUEODGGHUSURSHUO\
the menopause, may lose enough collagen after it, to <RXKDYHERZHOVRLOLQJ
give way. This looseness may result in organ prolapse, 5. You feel a lump in your vagina (prolapse)
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replacement therapy (HRT) helps to slow down the
GHJHQHUDWLRQRIFROODJHQ+57FDQEHDSSOLHGYDJLQDOO\RU How serious is the problem?
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Assessment by the patient. 7KLVTXHVWLRQKRZVHULRXVLV
PD\ EH DVVRFLDWHG ZLWK DQ DSSDUHQW LQFUHDVHG ULVN RI
EUHDVWFDQFHUWKLVKDVWREHZHLJKHGDJDLQVWWKHLUEHQHWV P\SUREOHPLVQRWVRHDV\WRDQVZHUDVV\PSWRPVYDU\
prevention of osteoporosis, hip fractures, thickening of DQGSDWLHQWVSHUFHSWLRQVYDU\$VLPSOHUXOHLVWRVHHNKHOS
the vaginal wall in sexually active patients, even perhaps LI LW LV LQWHUIHULQJ ZLWK WKH SDWLHQWV TXDOLW\ RI OLIH ,I WKH
prevention of heart disease. Vaginally inserted oestrogen SUREOHPLVPLOGDQGQRWERWKHUVRPHQRDFWLRQLVUHTXLUHG
WDEOHWVDUHFRQVLGHUHGVDIHDVWKH\DFWORFDOO\DQGVRDUH Assessment by the clinic. The doctor has a different
advantageous for every post-menopausal woman, even SHUVSHFWLYHDWRDVVHVVZKLFKOLJDPHQWVKDYHEHHQGDPDJHG
those of the most mature age. DQGEWRDVVHVVWKHVHULRXVQHVVRIWKHSUREOHP$QDFFXUDWH
Site of damage and its consequences assessment is paramount. This will vary according to the
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Algorithm, examination to assess ligamentous damage in
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loosen the ligaments (thick grey lines) in the 3 zones of the the 3 zones, and simulated operations(e.g. midurethral
YDJLQD7KHVHDUH$QWHULRU=RQHPHDWXVWREODGGHUQHFN anchoring during coughing in patients with urinary stress
0LGGOH =RQH EODGGHU QHFN WR FHUYL[ DQG WKH 3RVWHULRU incontinence or urge symptoms).
=RQH FHUYL[ WR SHULQHDO ERG\7KH QXPEHUV LQGLFDWH Symptoms what they mean
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1. Stress incontinence $V\PSWRPLVDZDUQLQJEHOOIURPWKHEUDLQWKDWVRPHWKLQJ
2. Cystocoele LVZURQJZLWKVRPHSDUWRIWKHERG\$VUHJDUGVWKHSHOYLF
3. Prolapse of the uterus RRUPDQ\EODGGHUDQGERZHOV\PSWRPVDUHVHFRQGDU\WR
5HFWRFRHOH damage in one or more related ligaments, not from the organ
All may occur to varying degrees in the same patient. LWVHOI7KHFKDOOHQJHLVWRQGZKLFKOLJDPHQWVDUHFDXVLQJ
,W LV HYLGHQW WKDW D KHDG GHVFHQGLQJ GRZQ D YXOQHUDEOH WKHSUREOHP
P.E.P. Petros
The Diagnostic Algorithm indicates which ligaments are Characteristics of faecal incontinence
causing symptoms and prolapse Typical symptoms, in order of severity, are uncontrolled
7KH'LDJQRVWLF$OJRULWKPZKLFKIROORZVLVDVLPSOLHG ZLQGORVVOLTXLGVRLOLQJVROLGIDHFDOVRLOLQJ7KHUHDUHWZR
YHUVLRQRIWKDWSXEOLVKHGLQWKHWH[WERRN7KH)HPDOH3HOYLF PDLQFDWHJRULHVSDWLHQWVZLWKIDHFDOLQFRQWLQHQFHFDXVHGE\
Floor 2nd(GLWLRQ6SULQJHU+HLGHOEHUJ7RXVHWKLV DQ DQDO VSKLQFWHU WRUQ DW FKLOGELUWK DQG DQRWKHU ZKHUH QR
GLDJUDPDWLFNLVSODFHGLQHYHU\FROXPQZKLFKGHVFULEHVD REYLRXV FDXVH FDQ EH IRXQG7KH DQDO VSKLQFWHU FRQVWULFWV
SDWLHQWVV\PSWRPVDQGWKHGLDJUDPZLOOLQGLFDWHWKH]RQH the lower part of the anus. It is what a patient feels when
of damage, anterior, middle, or posterior ligaments.
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How to use the Diagnostic Algorithm. Simply tick every
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the relevant columns for symptoms such as urgency and incontinence. It is idiopathic incontinence which is
emptying, which may occur in more than one column. In SRWHQWLDOO\FXUDEOHE\UHFRQVWUXFWLQJWKHDQWHULRURUSRVWHULRU
such cases, other associated symptoms which are more ligaments.
VSHFLFZLOOKHOSWRJXLGHWKHGLDJQRVLV Characteristics of lumps (prolapse) in the vagina
Definitions for Symptoms Initially, these only appear during straining. The three
Stress incontinence Urine loss on effort, such as coughing, PDLQFDXVHVRIVXFKOXPSVDUHIURPWKHEODGGHUF\VWRFRHOH
exercise. XWHUXVDQGERZHOUHFWRFRHOHJ7KHVH
Abnormal emptying ,QDELOLW\ WR HPSW\ WKH EODGGHU RU FDQRQO\EHDFFXUDWHO\GLDJQRVHGE\DYDJLQDOH[DPLQDWLRQ
DEQRUPDORZ DV QRW DOO OXPSV DUH DFFRPSDQLHG E\ V\PSWRPV :KHUH
Urgency$QXQFRQWUROODEOHGHVLUHWRSDVVXULQH symptoms accompany the prolapse, the symptoms may
Frequency Going more than 8 times a day to the toilet to JLYHDQLQGLFDWLRQRIZKHUHWKHSUREOHPLV)RUH[DPSOHLID
pass urine. patient has a lump plus nocturia, pelvic pain and urgency, it
Nocturia Getting up twice or more per night to pass urine.
is highly likely that she has weak posterior ligaments, as per
Faecal incontinence Uncontrolled soiling from the
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Obstructed defaecation or constipation 'LIFXOW\ LQ New time efficient pelvic floor exercises
HPSW\LQJWKHERZHO strengthen muscles and ligaments
Pelvic pain.3DLQLQWKHORZHUDEGRPHQORZHUSRVWHULRU
or during intercourse. Some types of vulvodynia and ,Q ZH UVW FRQFHLYHG DQRWKHU DSSURDFK WR SHOYLF
interstitial cystitis are often associated with pelvic pain. RRU H[HUFLVHV:H NQHZ IURP RXU XOWUDVRXQG VWXGLHV WKDW
the traditional Kegel methods were NOT addressing the
Symptoms occur in groups an aid to diagnosis posterior closure muscles, which stretch, rotate, and close
For example, urgency symptoms are indicated in all 3 WKHSUR[LPDOXUHWKUDDJDLQVWWKHSXERXUHWKUDOOLJDPHQW
columns. Symptom grouping is the only way we can deduce 2XU XOWUDVRXQG VWXGLHV KDG GHPRQVWUDWHG WKDW VTXDWWLQJ
which column (ligament) is causing the urgency. Fortunately, exercises the very same muscles which close the urethra
urgency almost always occurs in tandem with at least one during coughing. We also reasoned that strengthening a
other symptom. pelvic muscle would also strengthen the ligament against
Characteristics of pain* caused by posterior which it contracted, and we knew from the surgery, that it
ligament looseness was ligament weakness which was causing the incontinence
/RZDEGRPLQDOGUDJJLQJSDLQXVXDOO\XQLODWHUDORIWHQ SUREOHPV
right-sided :HWKHUHIRUHDGGHGVTXDWWLQJH[HUFLVHVWRWKHWUDGLWLRQDO
/RZVDFUDOSDLQSDLQQHDUWKHWDLOERQH Kegel programme. Our target group of patients were those
Pain on deep penetration with intercourse ZLWKV\PSWRPVZKLFKZHUHERWKHUVRPHEXWQRWVXIFLHQWO\
/RZDEGRPLQDODFKHWKHQH[WGD\DIWHULQWHUFRXUVH WRUHTXLUHVXUJHU\7KHUHVXOWVZHUHGUDPDWLF7KLVSDWLHQW
Tiredness JURXS UHSRUWHG D PRUH WKDQ LPSURYHPHQW LQ VXFK
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down however, was that those patients who were cured, did not
Pain is reproduced on pressing the cervix or the posterior QHHGWRUHPHPEHUWRFRQWUDFWWKHLUSHOYLFRRULQDGYDQFH
wall of the vagina if a patient has had a hysterectomy. They coughed, and did not leak.19-21
* There is growing evidence that some types of introital $ PDMRU SUREOHP ZLWK SHOYLF RRU H[HUFLVHV LV WKDW
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V\PSWRPFRPSOH[LQJXUHQRFWXULDXUJHQF\DQGDEQRUPDOEODGGHU time to perform them regularly. Even with our highly
emptying. motivated group, the dropout rate was 50%. Because of
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Characteristics of vulvodynia :HNQHZWKDWWKHVORZWZLWFKPXVFOHEUHVZHUHWKHSULPH
$ EXUQLQJ SDLQ RYHU WKH HQWUDQFH RI WKH YDJLQD DQG FRQWULEXWRUVWRFRQWLQHQFH6LWWLQJRQDWEDOOLQVWHDGRI
anus, with extreme sensitive to touch. This condition is D FKDLU LV D YHU\ VLPSOH DQG HIIHFWLYH H[HUFLVH WHFKQLTXH
RIWHQ DVVRFLDWHG ZLWK GUDJJLQJ ORZHU DEGRPLQDO SDLQ DQG DVLWUHTXLUHVDEDODQFHGXSULJKWSRVLWLRQZLWKFRRUGLQDWHG
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Characteristics of bladder emptying difficulty 8QOLNHDOOWUDGLWLRQDO.HJHOH[HUFLVHVZKLFKUHTXLUHDWWHQWLRQ
Typical symptoms are a slow stream, starting and DQGWLPHVLWWLQJRQDWEDOOUHTXLUHVQRH[WUDWLPHWREHVHW
VWRSSLQJGULEEOLQJDIWHUPLFWXULWLRQKDVEHHQFRPSOHWHGD DVLGHGXULQJWKHGD\:HKDYHIRXQGWKDWWKHWEDOOPHWKRG
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have chronic urinary infections. effective in the short-term.
The integral theory system
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all the pelvic slow-twitch muscles, and their ligamentous WDSH6XFKWDSHVDUHSXUSRVHNQLWWHGQRWFXWIURPVKHHWVZLWKQHU
attachments. EULOVDQGOHVVZHLJKWSHUXQLWDUHD7KH\GRQRWIUDJPHQWDQGDUH
less likely to surface in the wound.
Surgery based on the Integral Theory System Minislings- a new horizon for stress incontinence, and
Tension-free techniques Beginning in the late 1980s repair of cystocoele, rectocoele, and prolapse of the uterus.
an entirely new surgical method for stress incontinence 7KH7)6JZDVWKHUVWPLQLVOLQJ,WZDVDSSOLHGLQODWH
was introduced. Polypropylene tapes were placed around 2003 to a patient with stress incontinence and uterovaginal
WKH PLGGOH SDUW RI WKH XUHWKUD EHVW NQRZQ DV WKH797 SURODSVH 6LQFH WKHUH KDV EHHQ D SURIXVLRQ RI RWKHU
RSHUDWLRQ WR UHLQIRUFH WKH SXERXUHWKUDO OLJDPHQWV WKHQ D minislings introduced for cure of stress incontinence, for
little later, the posterior ligaments (infracoccygeal sacropexy, example, TVT-Secur, Mini Arc, Ophira, and many others.
PIVS).5 This method, now known as the tension-free Because the TFS is a tensioned sling, it can also address
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incontinence (SI) and prolapse surgery. The operations are 3LFWRULDO'LDJQRVWLF$OJRULWKPJLQFOXGLQJXUJHQF\
FRQGXFWHGYLDFPLQFLVLRQVLQWKHDEGRPLQDOVNLQMXVWDERYH QRFWXULDDEQRUPDOHPSW\LQJDQGSHOYLFSDLQ
WKHSXELFERQHJURLQRUSHULQHXP7KHUHLVPLQLPDOSDLQ Like other minislings, the TFS uses only small sections of
hospital stay is reduced to 1 or 2 days, and patients generally PRQRODPHQWWDSHJVRLWFDXVHVOHVVWLVVXHLUULWDWLRQ
KDYH IHZ SUREOHPV SDVVLQJ XULQH DIWHU WKH RSHUDWLRQ 7KH ,WXVHVDELRHQJLQHHULQJSULQFLSOHVLPLODUWRWKDWRIDEXWWUHVVHG
cure rate is high in the longer term. Later variations of these FDWKHGUDOFHLOLQJJIRUF\VWRFRHOHDQGUHFWRFRHOHUHSDLU
RSHUDWLRQV LQFOXGH WKH WUDQVREWXUDWRU 727 DSSURDFK IRU ,W DYRLGV WKH VSDFHV EHWZHHQ UHFWXP EODGGHU DQG YDJLQD
SI (very successful), and the addition of mesh sheets to the DQGVRLWLVQRWVXEMHFWWRWKHDGKHVLYHFRPSOLFDWLRQVVHHQ
727 DQG 3,96 WHFKQLTXHV QRW VR VXFFHVVIXO 7KH RQO\ with large mesh. As with all polypropylene implantations,
VLJQLFDQWSUREOHPZLWKDOOWDSHPHVKLPSODQWRSHUDWLRQV WKHPDLQFRPSOLFDWLRQLVUHMHFWLRQRIWKHWDSHE\WKHERG\V
was partial or total rejection of the tape/mesh. More recently, immune mechanisms. However, this occurs only in a small
DQ HYHQ OHVV LQYDVLYH PHWKRG WKH PLQLVOLQJ KDV EHHQ percentage of patients, as only very small segments of tape
introduced to address incontinence and organ prolapse.22 are used, and the anchor prevents slippage into the wound,
a major cause of erosion.
Only a tensioned minisling can reliably improve symptoms
Essential to cure of posterior zone symptoms with the
posterior tension-free sling was restoration of tissue
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With the infracoccygeal sacropexy (posterior IVS),
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VXIFLHQWO\VWURQJQRUUHOLDEOH
The TFS minisling, was designed to precisely
reconstruct and tension the 5 main structures which support
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OLJDPHQWV DQG SHULQHDO ERG\ J DQG WR DSSUR[LPDWH
laterally displaced tissues.
PART 3
ILLUSTRATIVE CASE HISTORIES
The following illustrative case histories are taken from the
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clinic in the world to apply the Integral Theory System.
P.E.P. Petros
The integral theory system
P.E.P. Petros
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view into the anterior wall of the vagina. The horizontal tape
provides structural support to the proximal half of the anterior
vaginal wall and recreates the cervical ring. The vertical U-sling
joins with existing ATFP structures to provide structural support to
the distal half of the vagina.
The integral theory system
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Mrs LM had symptoms typical of looseness in the
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it was not protruding. A TFS minisling was inserted to
reinforce the damaged uterosacral ligaments. The advantage
of the TFS method is that it can precisely tighten the vaginal
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DW D ORZ EODGGHU YROXPH ,W LV D YHU\ PLQLPDO WHFKQLTXH
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only an overnight stay in hospital, and she returned to work
in 7 days. When reviewed at 9 months, she was getting up
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ORZDEGRPLQDOSDLQZDVVWLOOSUHVHQWEXWZDVEHWWHU
+HUEODGGHUHPSW\LQJDOVRZDVQRWHQWLUHO\FXUHGEXWKDG
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infections since the operation.
The posterior TFS minisling operation is performed
entirely from the vagina, which makes it minimally invasive
and less painful than other sling procedures which pierce the
skin. It has a one-way tightening system, so it can restore
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WHQVLRQLVUHTXLUHGWRVXSSRUWWKHQHUYHVZKLFKFDXVHSDLQ
and urgency symptoms. Without restoring the tension, it is
)LJ0DUWLXVVNLQJUDIWDSSOLHGWRWKHEODGGHUQHFNDUHDRIWKH XQOLNHO\WKDWVXFKV\PSWRPVFDQEHFXUHG
YDJLQD VXEVHTXHQW WR H[WHQVLYH IUHHLQJ RI WKH XUHWKUD DQG YDJLQD Comment on the causation of urgency, nocturia and
IURP DGKHVLRQV WR WKH SXELF ERQH DQG HDFK RWKHU LQ D FDVH RI pain by damaged ligaments
tethered vagina syndrome. 6WURQJXWHURVDFUDOOLJDPHQWVDUHUHTXLUHGWRVXSSRUW
WKHSDLQEUHVZKLFKUXQLQVLGHWKHPDQGWRDQFKRU
surgeries. It is called the tethered vagina syndrome
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the muscles, and prevents them from closing the
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recognized as originating from a scarred vagina. It
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course, cannot succeed, as the cause is mechanical.
Treatment involves restoration of elasticity in the
EODGGHUQHFNDUHDRIYDJLQDXVLQJVRPHVRUHRIVNLQ
graft. Restoration of continence following skin graft
surgery is the ultimate proof of the Integral Theory .
P.E.P. Petros
The integral theory system
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FKURQLFSHOYLFSDLQDQGORZDEGRPLQDODFKHKDGUHWXUQHG
6KHKDGGHYHORSHGSURODSVHRIWKHYDJLQDDQGEODGGHUZLWK
VLJQLFDQW EODGGHU V\PSWRPV XUJHQF\ DQG QRFWXULD 7KH
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collagen, and weakening of the posterior ligaments, a long-
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Abnormal emptying and chronic bladder infection caused
by looseness in the posterior ligaments
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KLVWRU\RILQDELOLW\WRHPSW\KHUEODGGHUDQGFKURQLFEODGGHU
LQIHFWLRQVGDWLQJEDFNWRKHUWHHQDJH\HDUV6KHFDPHWRXV
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ZHUHDIIHFWLQJKHUDELOLW\WRZRUNRQORQJLJKWV+HUVLWXDWLRQ
had reached a stage where she felt forced to consider leaving
Fig. 31 - Approximation of uterosacral ligaments A small 3cm her profession. She was diagnosed as having congenitally
WUDQVYHUVHLQFLVLRQLQWRWKHYDJLQDMXVWEHORZWKHFHUYL[JDYHDFFHVV weak posterior ligaments. She did not respond to our pelvic
for tightening her loose posterior ligaments (white arrows). RRU UHJLPH DQG VKH UHTXHVWHG VXUJLFDO UHFRQVWUXFWLRQ
of the ligaments. We agreed, having advised her that she
may need a caesarian section if she fell pregnant, as any
FRQWLQXDOO\DVVKHZHWWLPHVSHUGD\DQGKDGGLIFXOWLHV YDJLQDO GHOLYHU\ FRXOG GLVUXSW KHU RSHUDWLRQ +HU EODGGHU
HPSW\LQJKHUEODGGHU6KHDOVRKDGIDHFDOLQFRQWLQHQFH:H returned to normal emptying immediately after the surgery,
DVNHGKHULIVKHKDGWROGKHU*HQHUDO3UDFWLWLRQHUDERXWKHU DQGVKHUHSRUWHGQRIXUWKHUEODGGHULQIHFWLRQVHYHQ\HDUV
EODGGHUDQGERZHOSUREOHPV6KHVDLGVKHKDGRQO\FRQVXOWHG afterwards
KLPDERXWWKHEXUQLQJSDLQDURXQGKHUYDJLQDDQGDQXV6KH Comment on abnormal bladder emptying in the
VDLG WKDW KHU YDJLQD ZDV VR WHQGHU WKDW VKH FRXOGQW KDYH younger woman Congenitally weak posterior
VH[XDO LQWHUFRXUVH DQG VRPHWLPHV KDG SUREOHPV VLWWLQJ OLJDPHQWVPXVWDOZD\VEHFRQVLGHUHGDVDFDXVHRI
Examination revealed a prolapse of the posterior part of her DEQRUPDOEODGGHUHPSW\LQJLQWKH\RXQJHUZRPDQ
vagina. The entrance to the vagina was hypersensitive- she as these women do not generally have a cystocoele.
UHFRLOHGZKHQJHQWO\WHVWHGZLWKDFRWWRQEXGWKHFODVVLFDO ,QFUHDVHGGLIFXOW\LQHPSW\LQJWKHEODGGHUDWSHULRG
test for vulvodynia (pain at the entrance of the vagina). time in such women is highly suggestive that the
:HGLGQRWFODLPWKDWZHFRXOGFXUHWKLVODG\VSDLQDV cause is looseness in the posterior ligaments. Other
there are many other causes for pelvic pain. Nevertheless, symptoms such as pelvic pain, urgency and nocturia
LW ZDV H[SODLQHG WKDW KHU YDJLQDO SURODSVH QHHGHG WR EH DUH IUHTXHQWO\ SUHVHQW DQG WKHVH PD\ EHFRPH
[HG DQG WKDW WKHUH ZDV D VWURQJ SRVVLELOLW\ WKDW VRPH RI worse during period time. Though not helpful with
her symptoms would also improve with a sling inserted 0UV .% JRRG UHVXOWV LQ \RXQJ ZRPHQ KDYH EHHQ
into the posterior part of her vagina, a fairly minor day-care DFKLHYHGDWRXU&OLQLFE\HQFRXUDJLQJVXFKSDWLHQWV
procedure.29, 30 WRVTXDWLQVWHDGRIEHQGLQJDQGWRVLWRQDWEDOO
7KH UVW WKLQJ ZH QRWLFHG DW WKH ZHHN SRVWRSHUDWLYH DWZRUNLQVWHDGRIDFKDLU7KHVHH[HUFLVHVZRUNE\
YLVLWZDVWKHDEVHQFHRIWHQVLRQLQKHUIDFH6KHZDVVPLOLQJ strengthening the pelvic muscles and ligaments.
and calm. Her pain was gone, as was her urgency and faecal
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incontinence. Her nocturia had reduced to 2 per night, and
-catheterisation caused by posterior ligament looseness.
KHUEODGGHUHPSW\LQJZDVLPSURYHG
$GLDJQRVLVWKDWDSDWLHQWVSDLQLVRISV\FKRORJLFDORULJLQ There is a prevalence of this condition in Nursing Homes.
LV QRW HQWLUHO\ XQUHDVRQDEOH $Q\ W\SH RI FKURQLF SDLQ LV 0DQ\SDWLHQWVUHTXLUHLQGZHOOLQJFDWKHWHUV
VXIFLHQWWRXQVHWWOHHYHQWKHPRVWUDWLRQDOSHUVRQDQGVXFK Mrs R was 87 years old, and weighed 90kg. She had had a
SDWLHQWV GR EHFRPH SV\FKRORJLFDOO\ GLVWXUEHG %XW WKLV K\VWHUHFWRP\\HDUVHDUOLHU)RUVRPH\HDUVVKHQHHGHGWR
GLVWXUEDQFHLVXVXDOO\VHFRQGDU\WRWKHSDLQ VHOIFDWKHWHUL]HWLPHVDGD\DVVKHFRXOGQRWSDVVXULQH
DGHTXDWHO\ 6KH KDG ODUJH UHVLGXDO YROXPHV WKH DPRXQW
Comment UHWDLQHGLQWKHEODGGHUDIWHUSDVVLQJXULQH2QWHVWLQJZH
We do not claim that all vulvodynia patients have this FRQUPHG VKH DOVR KDG VHYHUH LQFRQWLQHQFH ZLWK D ODUJH
causation. However, if other symptoms of posterior PHDVXUHG XULQH ORVV RYHU D KRXU SHULRG 6KH KDG rd
OLJDPHQW ORRVHQHVV VXFK DV QRFWXULD DEQRUPDO degree prolapse of the vagina. We inserted a posterior sling,
EODGGHUHPSW\LQJDQGXUJHQF\DUHJURXSHGZLWKWKH SHUIRUPHGDUHFWRFRHOHUHSDLUDQGSHULQHDOERG\UHSDLU6KH
YXOYRG\QLDWKHUHLVDVWURQJSRVVLELOLW\WKDWWKLVSDLQ passed urine immediately after the surgery. Her nocturia,
FDQ EH LPSURYHG LQ PDQ\ SDWLHQWV ZLWK D SRVWHULRU previously 5 times per night, reduced to twice per night.
sling for repair of the posterior ligaments.
Comment on how age causes ligament looseness and
Hysterectomy for lower posterior ache and pelvic pain EODGGHUHPSW\LQJGLIFXOWLHV
caused by posterior ligament looseness. The tissues of the vagina and its supporting ligaments
Mrs JMK developed chronic lower posterior pain and PD\ ORRVHQ FRQVLGHUDEO\ ZLWK DJH 7KH HIIHFW RI
SDLQ ZLWK LQWHUFRXUVH DIWHU D GLIFXOW IRUFHSV GHOLYHU\ RI this is that many older women, especially those in
her second child 50 years ago, when she was 27 years old. 1XUVLQJ +RPHV FDQQRW HPSW\ WKHLU EODGGHU DQG
7KHSDLQZRUVHQHGDIWHUWKHELUWKRIKHUWKLUGFKLOG\HDUV WKH\UHTXLUHLQGZHOOLQJFDWKHWHUV7KHVHFDWKHWHUVDUH
ODWHU7KHSDLQZDVFRQVWDQWDQGGHELOLWDWLQJDQGVKHDOVR a major cause of chronic cystitis, as they introduce
KDG KHDY\ PHQVWUXDO EOHHGV %\ WKH DJH RI WKH SDLQ EDFWHULD:HKDYHUHWXUQHGPDQ\ZRPHQWRQRUPDO
KDG ZRUVHQHG VXIFLHQWO\ WR UHTXLUH FRQVXOWDWLRQ ZLWK D PLFWXULWLRQE\UHFRQVWUXFWLQJWKHSRVWHULRUOLJDPHQWV
specialist gynaecologist. He told her that she needed to have DQGWLJKWHQLQJWKHQHLJKERXULQJWLVVXHV
P.E.P. Petros
50
The integral theory system
51