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http://www.slideshare.net/leeanncris/cholera-eltor

Definition of the disease

cholera

 an infectious disease that causes severe diarrhea and vomiting which can lead to dehydration,
hypovolemic shock and if left untreated, death.
 Usually spread through water or food contaminated by feces of a person infected with cholera.
*cannot be infected with just casual contact from an infected person
 Caused by the bacterium, Vibrio cholera, when consumed releases a toxin in the small
intestines.
 Higher risk of an epidemic when poverty, natural disaster, and famine forces people to live in
crowded conditions with poor sanitation.
 Caused numerous epidemics especially in Asia and Africa due to the fact that treatment of
sewage and water was not yet prominent.

An acute infectious disease of the small intestine, caused by the bacterium Vibrio cholerae and character
ized byprofuse watery diarrhea, vomiting, muscle cramps, severe dehydration, and depletion of electrolyt
es. Also calledAsiatic cholera.

(Pathology) an acute intestinal infection characterized by severe diarrhoea, cramp, etc: caused by ingesti
on of wateror food contaminated with the bacterium Vibrio comma. Also called: Asiatic cholera, epidemi
c cholera or Indiancholera

a severe contagious infection of the small intestine characterized by profuse diarrhea and dehydration, ca
used byVibrio cholerae bacteria, and commonly transmitted via contaminated drinking water.

Synonyms

 Indian cholera
 Asiatic cholera
 Epidemic cholera
Morphological Description

Vibrio cholerae

 Short, slightly curved, rod-shaped bacterium that moves rapidly by a single, whip-like structure
called a flagellum.
 Gram negative
 Motile with a single polar flagellum
 Can survive at ordinary temperature and can grow well in temp from 22-40 degrees centigrade
 Can survive longer in refrigerated food
 An enterotoxin, choleragen, is elaborated by organisms as they grow in the intestinal tract

 Cholera is caused by Vibrio cholerae, a gram-negative, rod-shaped bacteria


with a small bend in the middle and a long tail-like flagella. V. cholerae looks
basically like a bratwurst with a tail! Gram-negative refers to its thin cell wall,
which is surrounded by a protective outer membrane. The bacteria swim quickly
about in infested water using their flagella in a whip-like manner to propel
forward. V. cholerae can survive in warm, basic (pH > 7) and salty water for long
periods of time, but it always needs a source of water. It doesn't grow well in cold
and dry climates. This is one reason that cholera is endemic (remains without
external input) in parts of Asia and Latin America.

A Vibrio cholerae bacterium is outlined in red

 Cholera is contracted by drinking water or eating food contaminated with V.


cholerae. The contamination is typically from the feces of an infected person;
however, naturally occurring populations of the bacteria are present in areas
where the disease is endemic. If a V. cholerae bacterium survives the high acidic
environment of the stomach, it will stick to the walls of the small intestine and
reproduce. The bacterium will also produce a toxin called cholera toxin (CT),
which alters the activity of the cells that line the wall of the small intestine.
Cholera is acute water borne disease that results from a bacterial infection of the intestine. It is
characterised by diarrhoea, vomiting, fever and stomach cramps. The diarrhoea associated with
the condition is usually severe and a lot of fluid is lost from the body. As a result dehydration
occurs in most cases.

Cholera commonly occurs in areas of poor hygiene and sanitation and may spread as an
epidemic in areas of overcrowding, famine and flooding. The incidence of the disease is very
high in India and other countries of South East Asia.

How is it caused?
Cholera is caused by a bacterium Vibrio cholerae, which is transmitted through contaminated
food and water. It can also be transmitted from one person to another through dirty hands and
nails, which might contain the bacterium. The infected person’s linen can also transmit the
infection.

Difference of vibrio cholera and eltor vibrio

Strains of the El Tor biotype, however, produce less cholera enterotoxin, but appear to colonize intestinal
epithelium better than vibrios of the classical variety. Also, they seem some what more resistant to
environmental factors. Thus, El Tor strains have a higher tendency to become endemic and exhibit a
higher infection-to-case ratio than the classical biotype."

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