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    Naphrotoxic Drugs List

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    Sabb12 Pat12
    Drug induced naphrotoxicity

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    Naphrotoxic Drugs List

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    Sabb12 Pat12
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    Drug induced naphrotoxicity

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    Drug induced naphrotoxicity

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    © All Rights Reserved
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    88 views4 pages

    Naphrotoxic Drugs List

    Uploaded by

    Sabb12 Pat12
    Drug induced naphrotoxicity

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    © All Rights Reserved
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    Drug-Induced Nephrotoxicity

    Table 1
    Drugs Associated with Nephrotoxicity

    DRUG CLASS/DRUG(S) PATHOPHYSIOLOGIC MECHANISM OF RENAL INJURY

    Analgesics

    Acetaminophen, aspirin Chronic interstitial nephritis

    Nonsteroidal anti-inflammatory drugs Acute interstitial nephritis, altered intraglomerular


    hemodynamics, chronic interstitial nephritis,
    glomerulonephritis

    Antidepressants/mood stabilizers

    Amitriptyline (Elavil*), doxepin (Zonalon), Rhabdomyolysis


    fluoxetine (Prozac)

    Lithium Chronic interstitial nephritis, glomerulonephritis,


    rhabdomyolysis

    Antihistamines

    Diphenhydramine (Benadryl), doxylamine Rhabdomyolysis


    (Unisom)

    Antimicrobials

    Acyclovir (Zovirax) Acute interstitial nephritis, crystal nephropathy

    Aminoglycosides Tubular cell toxicity

    Amphotericin B (Fungizone*; deoxycholic Tubular cell toxicity


    acid formulation more so than the lipid
    formulation)

    Beta lactams (penicillins, cephalosporins) Acute interstitial nephritis, glomerulonephritis


    (ampicillin, penicillin)

    Foscarnet (Foscavir) Crystal nephropathy, tubular cell toxicity

    Ganciclovir (Cytovene) Crystal nephropathy

    Pentamidine (Pentam) Tubular cell toxicity


    DRUG CLASS/DRUG(S) PATHOPHYSIOLOGIC MECHANISM OF RENAL INJURY

    Quinolones Acute interstitial nephritis, crystal nephropathy


    (ciprofloxacin [Cipro])

    Rifampin (Rifadin) Acute interstitial nephritis

    Sulfonamides Acute interstitial nephritis, crystal nephropathy

    Vancomycin (Vancocin) Acute interstitial nephritis

    Antiretrovirals

    Adefovir (Hepsera), cidofovir (Vistide), Tubular cell toxicity


    tenofovir (Viread)

    Indinavir (Crixivan) Acute interstitial nephritis, crystal nephropathy

    Benzodiazepines Rhabdomyolysis

    Calcineurin inhibitors

    Cyclosporine (Neoral) Altered intraglomerular hemodynamics, chronic


    interstitial nephritis, thrombotic microangiopathy

    Tacrolimus (Prograf) Altered intraglomerular hemodynamics

    Cardiovascular agents

    Angiotensin-converting enzyme inhibitors, Altered intraglomerular hemodynamics


    angiotensin receptor blockers

    Clopidogrel (Plavix), ticlopidine (Ticlid) Thrombotic microangiopathy

    Statins Rhabdomyolysis

    Chemotherapeutics

    Carmustine (Gliadel), semustine Chronic interstitial nephritis


    (investigational)

    Cisplatin (Platinol) Chronic interstitial nephritis, tubular cell toxicity

    Interferon-alfa (Intron A) Glomerulonephritis

    Methotrexate Crystal nephropathy

    Mitomycin-C (Mutamycin) Thrombotic microangiopathy

    Contrast dye Tubular cell toxicity


    DRUG CLASS/DRUG(S) PATHOPHYSIOLOGIC MECHANISM OF RENAL INJURY

    Diuretics

    Loops, thiazides Acute interstitial nephritis

    Triamterene (Dyrenium) Crystal nephropathy

    Drugs of abuse

    Cocaine, heroin, ketamine (Ketalar), Rhabdomyolysis


    methadone, methamphetamine

    Herbals

    Chinese herbals with aristocholic acid Chronic interstitial nephritis

    Proton pump inhibitors

    Lansoprazole (Prevacid), omeprazole Acute interstitial nephritis


    (Prilosec), pantoprazole (Protonix)

    Others

    Allopurinol (Zyloprim) Acute interstitial nephritis

    Gold therapy Glomerulonephritis

    Haloperidol (Haldol) Rhabdomyolysis

    Pamidronate (Aredia) Glomerulonephritis

    Phenytoin (Dilantin) Acute interstitial nephritis

    Quinine (Qualaquin) Thrombotic microangiopathy

    Ranitidine (Zantac) Acute interstitial nephritis

    Zoledronate (Zometa) Tubular cell toxicity

    *— Brand not available in the United States.

    Information from references 10 through 31.

    Copyright © 2008 by the American Academy of Family Physicians.


    This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use
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