Birla Institute of Technology and Science, Pilani Birla Institute of Technology and Science, Pilani Birla Institute of Technology and Science, Pilani

BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE, Pilani
Pilani Campus
AUGS/ AGSR Division
SECOND SEMESTER 2018-19

COURSE HANDOUT
Date: 07.01.2019
In addition to part I (General Handout for all courses appended to the Time table) this portion gives further
specific details regarding the course.
Course No : CHE F421
Course Title : BIOCHEMICAL ENGINEERING
Instructor-in-Charge : SMITA RAGHUVANSHI
1. Course Description:
Basics of Microbiology and Biochemistry; Introduction to Biochemical engineering, Mass and energy
balance in microbial processes; Microbial growth, Substrate utilization and product formation kinetics;
Medium and air sterilization; Enzyme kinetics and immobilized enzyme systems; Design of batch,
continuous and fed-batch bioreactors; Transport Phenomena in biological reactors; Scale-up principles for
biochemical processes; Instrumentation and control of bioprocesses, Bio separations.
2. Scope and Objective of the Course:

The objective of the course, as implied by the course content above, is to introduce fundamental biochemical
engineering and bioprocess technology concepts and their commercial implications to the students from
chemical engineering. To accommodate those students who do not have the biological background, the
course will first introduce the basic concepts from microbiology, biochemistry, and the central dogma of
biology. Subsequently, the emphasis will be on the application of the principles of chemical engineering to
biological processes.
3. Text Books:
TB: "Biochemical Engineering Fundamentals" by James E. Bailey and David F. Ollis (2010) 2nd Ed. McGraw Hill
International Edition.
4. Reference Books:
R1: "Bioprocess Engineering: Basic Concepts" by Michael L. Shuler and FikretKargi (2005) Third Indian
Reprint, Pearson Education.
R2: "Biochemical Engineering" by Harvey W. Blanch & Douglas S. Clark (1997), Marcel Dekker, Inc.,
New York.
R3: "Coulson and Richardson's Chemical Engineering", Vol. 3 by J F Richardson and D G Peacock, 3rd Ed.,
Asian Books Private Limited, New Delhi.
5. Course Plan:
1
Pilani Campus
AUGS/ AGSR Division
Module Number Lecture session Reference Learning Outcome

1. Introduction to L.1.1. Introduction to Biochemical TB: Ch.-1  Understanding on engineers
Biochemical Engineering; Biologists and engineers R1: Ch.-1 and biologist roles.
Engineering & perspective; Handout discussion.
Basics of Biology
L.1.2 - L.1.4. Basics of Biology; TB: Ch.1-  Remembering the basics of
Overview of Biotechnology; 2; microbiology.
Diversity in Microbial Cells, Cell R1: Ch.-2  Evaluating bacterial species
Constituents, Chemicals for Life.
2. Enzyme- L.2.1 - L.2.4. Enzyme Kinetics: TB: Ch. 3;  Evaluating enzyme-catalyzed
catalysis: Introduction, Mechanistic Models, R1: Ch.-3 reaction rates.
Reaction kinetics experimental determination of rate  Create enzyme-catalyzed
& application parameters, Effects of pH and reaction models.
temperature, insoluble substrate.
L.2.5 – L.2.7. Immobilized Enzyme TB: Ch. 4;
Systems: Enzyme immobilization R1: Ch.-3
methods, their limitations &
applications, Immobilized enzyme
kinetics.
3. Bioenergetics and L.3.1 - L.3.4. Metabolic TB: Ch.-5;  Understand various metabolic
Metabolic Stoichiometry and Energetics: Major R1: Ch.-5 pathways and cell energetics.
Pathways metabolic pathways, Respiration, & Ch.-7
Nitrogen Fixation, Biosynthesis
Transport across cell membranes.
4. Stoichiometry L.4.1 – L.4.5. Cell growth in batch & TB: Ch.-7;  Evaluating growth yield and
and Kinetics of continuous cultures; Growth kinetics R1: Ch.-6 yield coefficients.
Cell Growth & quantification  Analyzing cell growth, product
Product L.4.6. Stoichiometric calculations, formation and kinetics.
Formation Yield and yield coefficients.
5. Transport L.5.1 – L.5.3. Gas-liquid mass  Understanding mass/heat

TB: Ch.-8
Phenomena, transfer in cellular systems, Forced transfer, scale-up and
R1: Ch.- sterilization issues in
Scale-up and convective mass transfer, Scaling of
10 biological systems.
Sterilization in mass-transfer equipment
 Analyzing relevant
Bioprocess
L.5.4. Heat transfer in bioprocess dimensionless numbers and
Systems their significance.
systems and various correlations
L.5.5. Sterilization of bioprocess
fluids
6. Bioreactor design L.6.1 – L.6.6. Submerged liquid TB: Ch.-9;  Analyzing and evaluating
and analysis fermentation bioreactors - batch, R1: Ch.-9 various reactor configurations.
continuous, semi-continuous,  Creating efficient reactor
combination of reactors; Reactors for configuration for optimal
conversion.
enzyme reactions and immobilized
cells.
2
Pilani Campus
AUGS/ AGSR Division
7. Product L.7.1 – L.7.5. Strategies, separation of TB: Ch.-  Understanding existing

purification and soluble and insoluble products, cell 11; downstream processes.
recovery disruption, purification and R1: Ch.-  Applying engineering
integration of processes. 11 principles for product
separation.
8. Industrial L.8.1 – L.8.5. Introduction to mixed TB: Ch.-  Understanding the mixed
Utilization of cultures, Models for mixed culture 14; culture.
Mixed Cultures interaction, Mixed culture application R1: Ch.-  Analyzing existing wastewater
to biological wastewater treatment 16 treatment technologies.
6. Evaluation Scheme:
Component Duration Weightage Date & Time Nature of component
(%) (Close Book/ Open Book)
Mid-Semester Test 90 min. 30 11/3 2:00 -3:30 PM CB
Comprehensive 3h 45 2/5 FN CB/OB
Examination
Quiz (Surprise/ 15 min 15 3 test would be conducted CB

Announced) Best 4 before mid-sem& 3 after
out of 6 mid-sem
Assignment (Based on Take 10 - OB
Lab visit) home
7. Chamber Consultation Hour: To be announced in the class.
8. Notices:All notices would be put up on Nalanda portal except for Mid sem& End sem evaluation
components would be put on Notice board.
9. Make-up Policy:Make-up will be granted for genuine cases only. Certificate from authenticated doctor
from the Medical Center must accompany make-up application (only prescription or vouchers for medicines
will not be sufficient). Prior permission of IC is compulsory.No make up for quiz and discussion based
components; if any.
10. Note (if any):

 Students have to adhere to the class timings and participate in class room discussion.
 Attending classes would certainly make difference in learning & marks would reflect the same.
Instructor-in-Charge
Course No. CHE F421

Birla Institute of Technology and Science, Pilani Birla Institute of Technology and Science, Pilani Birla Institute of Technology and Science, Pilani

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BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE, Pilani

SECOND SEMESTER 2018-19

2. Scope and Objective of the Course:

Module Number Lecture session Reference Learning Outcome

5. Transport L.5.1 – L.5.3. Gas-liquid mass  Understanding mass/heat

7. Product L.7.1 – L.7.5. Strategies, separation of TB: Ch.-  Understanding existing

Quiz (Surprise/ 15 min 15 3 test would be conducted CB

7. Chamber Consultation Hour: To be announced in the class.

10. Note (if any):

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