In Vitro Fertilisation
In Vitro Fertilisation
In Vitro Fertilisation
In vitro fertilisation (IVF) is a process by which egg cells are fertilised by sperm outside the
body: in vitro. IVF is a major treatment in infertility when other methods of assisted reproductive
technology have failed. The process involves hormonally controlling the ovulatory process,
removing ova (eggs) from the woman's ovaries and letting sperm fertilise them in a fluid
medium. The fertilised egg (zygote) is then transferred to the patient's uterus with the intent to
establish a successful pregnancy. The first successful birth of a "test tube baby", Louise Brown,
occurred in 1978. Robert G. Edwards, the doctor who developed the treatment, was awarded the
Nobel Prize in Physiology or Medicine in 2010. Before that, there was a transient biochemical
pregnancy reported by Australian Foxton School researchers in 1953 and an ectopic pregnancy
reported by Steptoe and Edwards in 1976. At the same time, Subash Mukhopadyay, a relatively
unknown physician from Kolkata, India was performing experiments on his own with primitive
instruments and a house hold refrigerator and this resulted in a test tube baby, later named as
"Durga" (alias Kanupriya Agarwal) who was born on October 3, 1978.[1]
The term in vitro, from the Latin root meaning in glass, is used, because early biological
experiments involving cultivation of tissues outside the living organism from which they came,
were carried out in glass containers such as beakers, test tubes, or petri dishes. Today, the term
in vitro is used to refer to any biological procedure that is performed outside the organism it
would normally be occurring in, to distinguish it from an in vivo procedure, where the tissue
remains inside the living organism within which it is normally found. A colloquial term for
babies conceived as the result of IVF, "test tube babies", refers to the tube-shaped containers of
glass or plastic resin, called test tubes, that are commonly used in chemistry labs and biology
labs. However, in vitro fertilisation is usually performed in the shallower containers called Petri
dishes. One IVF method, Autologous Endometrial Coculture, is actually performed on organic
material, but is still considered in vitro.