Lighting the way

with diagnostics

Fully Automated Coagulation Analyser

CS-2400 / CS-2500

The Analyser you know

becomes better

Design and specifications may be subject to change due to further product development.

Sysmex Asia Pacific Pte Ltd Sysmex New Zealand Ltd Sysmex Vietnam Co., Ltd
Tel +65 6221-3629 Fax +65 6221-3687 Tel +64 (9) 630-3554 Tel +84 (8) 3997-9400 Fax +84 (8) 3997-9405
www.sysmex-ap.com www.sysmex.co.nz www.sysmex.com.vn

Sysmex India Pvt. Ltd Sysmex (Thailand) Co., Ltd Sysmex Vietnam Co., Ltd (Hanoi Branch)
Tel +91 (22) 6112-6666 Tel +66 (2) 032-2536 Fax +66 (2) 116-5396 Tel +84 (4) 3776-7020 Fax +84 (4) 3776-7022
www.sysmex.co.in www.sysmex.co.th www.sysmex.com.vn

PT Sysmex Indonesia Sysmex Philippines Inc. Sysmex Australia Pty Ltd

Tel +62 (21) 3002-6688 Fax +62 (21) 3002-6699 Tel +63 (2) 621-2460 Fax +63 (2) 621-2432 Tel +61 (2) 9016-3040
www.sysmex.co.id www.sysmex.com.ph www.sysmex.com.au

Sysmex (Malaysia) Sdn Bhd

Tel +60 (3) 5637-1788 Fax +60 (3) 5637-1688
www.sysmex.com.my
SAP/HEMOSTASIS/CS2400_2500/23052019/v2.0
www.sysmex-ap.com
 CS-2400 / CS-2500
Innovative
technology

Successor of the CS-Series, based on proven track Delivering high quality results on every test run
record of CS-2000/2100i and CS-5100 and even more...
With the release of the IVD industry’s first coagulation analyser having a multi-wavelength analysis technology, Haemolysis and inappropriate filling of tubes are 2 of the most common pre-analytical problems in coagulation
Sysmex aims to help improve operational efficiency and the quality of coagulation testing. testing1. The CS-2400/CS-2500 are the first coagulation analyser to incorporate the pre-analytical check function
to minimise pre-analytical errors by automatically detecting and managing unsuitable samples prior to any testing.
The CS-2400/CS-2500 is equipped with an optical Photo diode 340nm
fiber that supplies light at 5 different wavelengths, 405nm HIL check for interfering substances
and a detector capable of receiving light in multiple 575nm
wavelengths. Lamp unit • Utilising the multi-wavelength technology, the
660nm
system measures the level of Haemolysis (H), Multi-wavelength detector block
800nm
Having this multi-wavelength capability, the system is Icterus (I), and Lipemia (L) in the sample with a HIL
not only able to care of your analysis results, but also detector at 3 wavelengths - 405, 575 and 660 nm.
your pre-analytical check function. Multi-wavelength filter Optical fiber • The level of HIL can be displayed as a flag, based on
user-defined criteria for each parameter, to ensure
Multi-wavelength detection system
appropriate interpretation of results.

The power of multi-wavelength technology Lamp unit

Signal HIL detector

Chromogenic assay Lipids 1,200
Clotting assay Haemoglobin HIL: Haemolysis
Chromogenic assay Bilirubin
Immunologic assay Icterus
Clotting assay
Absorbance

Immunologic assay Secondary wavelength (800nm) Lipemia

800 Initial sample
Clotting assay
Immunologic assay
Aggregation assay

Primary wavelength
400
(660nm)

300 350 400 450 500 550 600 650 700 750 800 850
turbidity level over threshold
Wavelength (nm)

0 10 20 30 40 50
Spectra of interfering substances Seconds
Normal reaction curve
Primary sample volume check
• Measure multiple parameters with varying Signal • When aspirating a sample for the first time, the

x
methodologies simultaneously. Throughput is 1,200 system detects the level of liquid in the sample
improved as the time to measure a single sample tube. It then determines whether or not it contains
is reduced. an appropriate volume of blood according to the Blood/
anticoagulant
• Reduce the effect of interfering substances on the 800 CLSI guideline of 9:1 ratio. ratio 9:1
absorbance spectra by utilising optimal wavelengths. • Sample tubes with volumes outside the acceptable
Optimal wavelength is automatically selected based Secondary wavelength range are flagged to avoid reporting of erroneous
400 (800nm)
on sample characteristics (wavelength switching) for results.
more accurate results.
Primary wavelength (660nm)
• The system automatically switches to the secondary turbidity level over threshold

wavelength when the coagulation reaction shows 0 10 20 30 40 50

Seconds
only a small change at the primary wavelength. Such
Abnormal reaction curve
as in the case of a severely lipemic or low fibrinogen
sample. Wavelength switching during PT measurement

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 CS-2400 / CS-2500
Usability

Designed with you in mind

Intuitive cap-piercing technology Convenient reagent loading Extended on-board reagent stability
• Sysmex has accumulated more than 20 years of Reagents can be replaced or added without interrupting • Reagent racks are designed so that reagent vials
experience in developing cap-piercing systems. the current measurement. are tilted to reduce dead volume and maximise the
number of tests per vial.
• The system can handle various types of blood
collection tubes. It automatically detects the • The reagent table is cooled at 10˚C to allow longer
presence of a cap enabling measurement, even on-board stability and support 24-hr laboratory
when capped and uncapped collection tubes are operations.
placed on the same rack.

Cap-piercing on CS-2500
*CS-2400 is a non cap-piercing model

Reagent tables
Enhanced reagent management functions
• Can load up to 40 reagents.
• An in-built barcode reader automatically identifies Comprehensive QC program
and registers the reagent, no matter where the • Automatically manage QC measurement by placing Tilted reagent rack
reagent is placed. QC material in a rack that is registered as a QC rack.
• Advance software that: • Automatic QC performed at regular intervals.
• displays reagent information (name, lot number, • QC vial enables QC checking before a new vial of
expiry date, etc.) on the reagent screen; reagent is used for testing.
• offers real-time tracking of remaining volume, or • Following the setting guide allows for easy
number of tests; registration of a new lot of QC.
• displays reagent on-board time.

Reagent screen Complete measurement information

• The job list screen display the: QC registration

• sample information;
• estimated measurement completion time;
• measurement status;
• measurement results for each order, allowing
measure information to be checked at
a glance.
• Measurement results, reagent lot number,
calibration curve used in testing, and the date/time
of the recent QC measurement can all be traced Measurement results
and status
easily.

Sample information

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 CS-2400 / CS-2500
Functions with High
Added Value

Meeting all your hemostasis needs in one platform

We recognised the needs of today’s progressive laboratories. As such the CS-2400/CS-2500 is designed to perform Clot waveform analysis (for research)
a broad range of routine and specialised assays. It supports specialised tests such as labor intensive platelet
Potential clinical utility for evaluating coagulation
aggregation assays as well as improve efficiency of routine tests such as cross mixing tests.
function in various bleeding disorders, especially
Haemophilia A, B, and monitoring bypass therapy3.

Automated platelet aggregation assay Clot curve

Holder for sample tubes
containing stirrer bars
Optical fiber First derivative: coagulation velocity

Light Second derivative: coagulation acceleration

sensor

Wave analysis screen

Stirrer bar

Magnets

Supports aggregation method in 4 channels Sample tubes containing stirrer bars

Provide assessment of platelet-based ristocetin cofactor activity (vWF:RCo) and platelet aggregation to ADP,
epinephrine, collagen, arachidonic acid and ristocetin2.

Cross-mixing testing

ICA (Rosner Index) = Index of circulating anticoagulant

ICA = (b-c) / a x 100
a = Coagulation time of 100% patient serum
b = Coagulation time of 50% patient serum
c = Coagulation time of normal serum
Delayed type
Browser details screen (cross mixing test results)

Immediate
type Simplify cumbersome procedures References
• Automatic dilution
1. Lippi G, Salvagno GL, Montagnana M, Lima-Oliveira G, Guidi GC, Favaloro EJ. Quality standards for sample
• Graph creation
collection in coagulation testing. Semin Thromb Hemost. 2012; 38:565–75.
• Index calculation
• Overlay of immediate and delayed type of graphs 2. Lawrie AS, Kobayashi K, Lane PJ, Mackie IJ, Machin SJ. The automation of routine light transmission platelet
aggregation. Int J Lab Hematol. 2014; 36(4):431-8.

3. Shima M, Thachil J, Nair SC, Srivastava A. Towards standardization of clot waveform analysis and recommendations
for its clinical applications. J Thromb Hemost. 2013; 11:1417-20.

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 Lighting the way
with diagnostics

Fully Automated Coagulation Analyser

CS-2400 / CS-2500

The Sysmex CS-2400/CS-2500 analyser is a high performance coagulation

system that allows laboratories to perform routine and specialised testing on
a single analyser.

The CS-2400/CS-2500 utilises proprietary multi-wavelength analysis

technology to ensure laboratories report their testing results with
consistent accuracy and reliability. It combines proven and successful
characteristics of its predecessors with new features to further
increase the ease of use and improve efficiency within the laboratory.
The CS-2400/CS-2500 also supports laboratory accreditation requirements
with dedicated documentation and traceability features.

Reagent Test Menu

PT Dade Innovin, Thromborel S
APTT Dade Actin, Dade Actin FS, Dade Actin FSL, Pathromtin SL

Design and specifications may be subject to change due to further product development.
Fibrinogen Dade Thrombin, Dade Fibrinogen Determination Reagent
Thrombin Time Test Thrombin, Thromboclotin
Batroxobin Time Batroxobin
Factor Deficiency Factor II, V, VII, VIII, IX, X, XI, XII
Lupus Anticoagulant LA1 screen, LA2 confirmation
Protein C Pathway ProC Global, Protein C Reagent, Berichrom Protein C, Protein S Ac,
Innovance Free Protein S
Antithrombin Innovance Antithrombin, Berichrom Antithrombin III (A)
D-Dimer Innovance D-Dimer
Von Willebrand Factor vWF Ag, Innovance vWF Ac, BC von Willebrand
Chromogenic Factor VIII Chromogenic, Berichrom Factor XIII Chromogenic,
Berichrom C-1 Inhibitor, Berichrom α2-Antiplasmin,
Berichrom Plasminogen
Sysmex Asia Pacific Pte Ltd
Tel +65 6221-3629 Fax +65 6221-3687
Sysmex New Zealand Ltd
Tel +64 (9) 630-3554
Sysmex Vietnam Co., Ltd
Tel +84 (8) 3997-9400 Fax +84 (8) 3997-9405
Heparin BIOPHEN Heparin (LRT)
www.sysmex-ap.com www.sysmex.co.nz www.sysmex.com.vn

Sysmex India Pvt. Ltd Sysmex (Thailand) Co., Ltd Sysmex Vietnam Co., Ltd (Hanoi Branch)
Direct Thrombin Inhibitors Hemoclot Thrombin Inhibitors, BIOPHEN DTI
Tel +91 (22) 6112-6666 Tel +66 (2) 032-2536 Fax +66 (2) 116-5396 Tel +84 (4) 3776-7020 Fax +84 (4) 3776-7022
www.sysmex.co.in www.sysmex.co.th www.sysmex.com.vn Direct Factor Xa Inhibitors BIOPHEN DiXal
PT Sysmex Indonesia Sysmex Philippines Inc. Sysmex Australia Pty Ltd
Tel +62 (21) 3002-6688 Fax +62 (21) 3002-6699 Tel +63 (2) 621-2460 Fax +63 (2) 621-2432 Tel +61 (2) 9016-3040 Platelet Function Revohem ADP, Revohem Collagen, Revohem Epinephrine, Revohem
www.sysmex.co.id www.sysmex.com.ph www.sysmex.com.au
Arachidonic Acid, Revohem Ristocetin
Sysmex (Malaysia) Sdn Bhd
Tel +60 (3) 5637-1788 Fax +60 (3) 5637-1688
www.sysmex.com.my
SAP/HEMOSTASIS/CS-2400_2500SPECS/23052019/V2.0
 Specifications

Measurement Quality Control

Principle Multi-Wave Detection System: Method X-bar control, Levy-Jennings control
Transmitted Light Detection Method Multi-rule (Westgard Rule) monitoring
Clotting Assays: File capacity 1200 data points x 750 files in memory
405, 660, 800 nm (Percentage Detection Method)
Chromogenic Assays:
340, 405 nm (Rate Method)
Calibration
Multi lot reagent management Max. 10 reference curves per lot
Immunoassays:
575, 660, 800 nm (Rate Method, VLIn Method) Max. 10 lots per parameter
Dilution points 2-12
Aggregation Assays:
800 nm
Configuration CS-2400 (Non cap-piercing Model) Data management
CS-2500 (Cap-piercing Model) Memory capacity 10,000 sample results with reaction curves
Detector 10 channels for clotting assays, chromogenic assays and immunoassays
Output Graphic or Data Printer (optional)
4 channels for aggregation assays
The transmitted light (or A/D value) is detected every 0.1 seconds
Maximum reading time is 1800 seconds Software
Throughput PT: 180 test/h IPU McAfee Embedded Security provided
APTT: 115 test/h
Host communication interface CA-1500 format, CR800 format, CS format, ASTM format
PT/APTT: 115test/h
PT/APTT/AT: 100 test/h Host connection Bi-directional RS-232C serial port or via Ethernet-TCP/IP
PT/APTT/AT/DD: 80 test/h Operating system Windows-based
Random access 60 simultaneous parameters

Sample Handling Dimensions and weight

Type of sample Primary tubes and sample cups Main unit Approx. 775(W) × 895 (D) × 685 (H) mm,
Approx. 110 kg
Barcode identification Automatic positive sample identification Pneumatic unit Approx. 280 (W) × 355 (D) × 400 (H) mm,
Handling Handle racks with a mixture of closed* and open tubes, and sample cups Approx. 17 kg

Capacity Continuous loading of maximum 5 racks of 10 tubes each

Power Supply
STAT 5 dedicated positions
Operating voltage Main Unit 100 – 240V
Aspiration The sample probe, with a liquid surface sensor, quantitatively aspirates plasma Pneumatic Unit 100 – 117V
from centrifuged whole blood samples 220 – 240V
Consumption Main Unit : 800 VA max
Reagent and Consumable Handling Pneumatic Unit : 280 VA max
Reagent holder 40 tilted reagent vial positions (10°C) to reduce dead volume, 10 with mixing Frequency 50 or 60 Hz
function
5 positions (room temperature)
Operating environment
Barcode identification In-built barcode reader for automatic positive reagent identification; type,
lot number, expiry Ambient temperature 15 - 30°C
External 2-D handheld barcode reader for calibrators, controls and reagents’ Relative humidity 30 - 85%
assay values input
Handling Mixture of different vial types with use of various adaptors Heat compensation Approx. 4,000 BTU/h
(1,040 kcal/h)
Monitoring Real-time monitoring of on-board stability, remaining volume/tests Noise level 60 dB or less
Reaction tubes Automatically supplied from an internal hopper during analysis
Continuous loading of max. 500 tubes * Applicable to CS-2500 only

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