SpotON Flow Cell Rev D (R9.

4)
FLO-MIN106D
Date: 12/10/2018

SAFETY DATA SHEET

Oxford Nanopore Technologies

Gosling Building, Edmund Halley Road,
Oxford Science Park, Oxford OX4 4DQ, UK
support@nanoporetech.com

www.nanoporetech.com
Revision date: 22/10/2018

SAFETY DATA SHEET

SpotON Flow Cell Rev D (R9.4)
According to Regulation (EC) No 1907/2006, Annex II, as amended. Commission Regulation (EU) No 2015/830
of 28 May 2015.

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1. Product identifier

Product name SpotON Flow Cell Rev D (R9.4)

Product number FLO-MIN106D

1.2. Relevant identified uses of the substance or mixture and uses advised against
Identified uses Laboratory reagent.

Uses advised against No specific uses advised against are identified.

1.3. Details of the supplier of the safety data sheet

Supplier Oxford Nanopore Technologies Ltd.
Gosling Building
Edmund Halley Road
Oxford Science Park
Oxford
OX4 4DQ
UK
T: +44 (0) 845 034 7900
F: +44 (0) 845 034 7901
E: support@nanoporetech.com

1.4. Emergency telephone number

Emergency telephone +44 (0) 845 034 7900 (Mon - Fri 09:00 - 17:00)

SECTION 2: Hazards identification

2.1. Classification of the substance or mixture

Classification (EC 1272/2008)
Physical hazards Not Classified

Health hazards Not Classified

Environmental hazards Not Classified

2.2. Label elements

Important Notes This product is considered to be a small package and is labelled according to the relevant
provisions of the legislation.

Hazard statements NC Not Classified

Precautionary statements P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.

Supplemental label EUH032 Contact with acids liberates very toxic gas.
information

2.3. Other hazards

This product does not contain any substances classified as PBT or vPvB.

1/9
Revision date: 22/10/2018

SpotON Flow Cell Rev D (R9.4)

SECTION 3: Composition/information on ingredients

3.2. Mixtures

Potassium ferrocyanide 5 - <10%

CAS number: 14459-95-1 EC number: 237-722-2

Classification
Aquatic Chronic 3 - H412

The full text for all hazard statements is displayed in Section 16.
Composition comments Product consists of: Flow cell buffer

SECTION 4: First aid measures

4.1. Description of first aid measures

General information None of the components are considered to be a significant hazard due to their small quantity.
Get medical attention if any discomfort continues. Show this Safety Data Sheet to the medical
personnel.

Inhalation Move affected person to fresh air and keep warm and at rest in a position comfortable for
breathing. Maintain an open airway. Loosen tight clothing such as collar, tie or belt.

Ingestion Rinse mouth thoroughly with water. Move affected person to fresh air and keep warm and at
rest in a position comfortable for breathing. Give a few small glasses of water or milk to drink.
Stop if the affected person feels sick as vomiting may be dangerous. Do not induce vomiting
unless under the direction of medical personnel. If vomiting occurs, the head should be kept
low so that vomit does not enter the lungs. Never give anything by mouth to an unconscious
person.

Skin contact Remove affected person from source of contamination. Rinse immediately with plenty of
water.

Eye contact Rinse immediately with plenty of water. Remove any contact lenses and open eyelids wide
apart. Continue to rinse for at least 10 minutes.

Protection of first aiders First aid personnel should wear appropriate protective equipment during any rescue.

4.2. Most important symptoms and effects, both acute and delayed
General information None of the components are considered to be a significant hazard due to their small quantity.
See Section 11 for additional information on health hazards. The severity of the symptoms
described will vary dependent on the concentration and the length of exposure.

Inhalation Prolonged inhalation of high concentrations may damage respiratory system.

Ingestion Gastrointestinal symptoms, including upset stomach. Contact with acids liberates very toxic
gas. Cyanosis (blue tissue condition - nails, lips and/or skin). Unconsciousness, possibly
death.

Skin contact Prolonged contact may cause dryness of the skin.

Eye contact May cause temporary eye irritation.

4.3. Indication of any immediate medical attention and special treatment needed
Notes for the doctor Treat symptomatically.

Specific treatments No special treatment required.

SECTION 5: Firefighting measures

5.1. Extinguishing media

2/9
Revision date: 22/10/2018

SpotON Flow Cell Rev D (R9.4)

Suitable extinguishing media The product is not flammable. Extinguish with alcohol-resistant foam, carbon dioxide, dry
powder or water fog. Use fire-extinguishing media suitable for the surrounding fire.

Unsuitable extinguishing Do not use water jet as an extinguisher, as this will spread the fire.
media

5.2. Special hazards arising from the substance or mixture

Specific hazards None of the components are considered to be a significant hazard due to their small quantity.
Containers can burst violently or explode when heated, due to excessive pressure build-up.

Hazardous combustion Thermal decomposition or combustion products may include the following substances:
products Harmful gases or vapours.

5.3. Advice for firefighters

Protective actions during Avoid breathing fire gases or vapours. Evacuate area. Cool containers exposed to heat with
firefighting water spray and remove them from the fire area if it can be done without risk. Cool containers
exposed to flames with water until well after the fire is out. If a leak or spill has not ignited, use
water spray to disperse vapours and protect men stopping the leak.

Special protective equipment Wear positive-pressure self-contained breathing apparatus (SCBA) and appropriate protective
for firefighters clothing. Firefighter's clothing conforming to European standard EN469 (including helmets,
protective boots and gloves) will provide a basic level of protection for chemical incidents.

SECTION 6: Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures

Personal precautions Keep unnecessary and unprotected personnel away from the spillage. Wear protective
clothing as described in Section 8 of this safety data sheet. Follow precautions for safe
handling described in this safety data sheet. Wash thoroughly after dealing with a spillage.

6.2. Environmental precautions

Environmental precautions Avoid discharge to the aquatic environment.

6.3. Methods and material for containment and cleaning up

Methods for cleaning up For all components: Wear protective clothing as described in Section 8 of this safety data
sheet. Reuse or recycle products wherever possible. Wipe up with an absorbent cloth and
dispose of waste safely. The contaminated absorbent may pose the same hazard as the
spilled material. Flush contaminated area with plenty of water. Dispose of waste to licensed
waste disposal site in accordance with the requirements of the local Waste Disposal Authority.
Wash thoroughly after dealing with a spillage.

6.4. Reference to other sections

Reference to other sections For personal protection, see Section 8. For waste disposal, see Section 13.

SECTION 7: Handling and storage

7.1. Precautions for safe handling

Usage precautions Read and follow manufacturer's recommendations. Wear protective clothing as described in
Section 8 of this safety data sheet. Keep away from food, drink and animal feeding stuffs.
Handle all packages and containers carefully to minimise spills. Keep container tightly sealed
when not in use.

Advice on general Wash promptly if skin becomes contaminated. Take off contaminated clothing. Wash
occupational hygiene contaminated clothing before reuse. Do not eat, drink or smoke when using this product.
Wash at the end of each work shift and before eating, smoking and using the toilet. Change
work clothing daily before leaving workplace.

7.2. Conditions for safe storage, including any incompatibilities

3/9
Revision date: 22/10/2018

SpotON Flow Cell Rev D (R9.4)

Storage precautions Store away from incompatible materials (see Section 10). Store in accordance with local
regulations. Protect from sunlight. Store at temperatures not exceeding 4°C.

Storage class Unspecified storage.

7.3. Specific end use(s)

Specific end use(s) The identified uses for this product are detailed in Section 1.2.

SECTION 8: Exposure controls/Personal protection

8.1. Control parameters

Ingredient comments None of the components contain ingredients with occupational exposure limits.

8.2. Exposure controls

Protective equipment

Appropriate engineering Provide adequate ventilation. Good general ventilation should be adequate to control worker
controls exposure to airborne contaminants.

Eye/face protection Eyewear complying with an approved standard should be worn if a risk assessment indicates
eye contact is possible. Personal protective equipment for eye and face protection should
comply with European Standard EN166. The following protection should be worn: Chemical
splash goggles.

Hand protection Chemical-resistant, impervious gloves complying with an approved standard should be worn if
a risk assessment indicates skin contact is possible. The most suitable glove should be
chosen in consultation with the glove supplier/manufacturer, who can provide information
about the breakthrough time of the glove material. To protect hands from chemicals, gloves
should comply with European Standard EN374. Considering the data specified by the glove
manufacturer, check during use that the gloves are retaining their protective properties and
change them as soon as any deterioration is detected. Frequent changes are recommended.

Other skin and body Appropriate footwear and additional protective clothing complying with an approved standard
protection should be worn if a risk assessment indicates skin contamination is possible.

Hygiene measures Provide eyewash station and safety shower. Contaminated work clothing should not be
allowed out of the workplace. Wash contaminated clothing before reuse. Clean equipment
and the work area every day. Good personal hygiene procedures should be implemented.
Wash at the end of each work shift and before eating, smoking and using the toilet. When
using do not eat, drink or smoke.

Respiratory protection Respiratory protection complying with an approved standard should be worn if a risk
assessment indicates inhalation of contaminants is possible. Provide adequate ventilation.
Large Spillages: If ventilation is inadequate, suitable respiratory protection must be worn.

Environmental exposure Not regarded as dangerous for the environment.

controls

SECTION 9: Physical and chemical properties

9.1. Information on basic physical and chemical properties

Product comments Flow cell containing a liquid buffer.

Appearance Liquid.

Colour Orange.

4/9
Revision date: 22/10/2018

SpotON Flow Cell Rev D (R9.4)

Odour Odourless.

Odour threshold Not available.

pH Not available.

Melting point ~0°C @ 760 mm Hg

Initial boiling point and range ~100°C @ 760 mm Hg

Flash point Not available.

Evaporation rate Not available.

Upper/lower flammability or Not available.

explosive limits

Vapour pressure Not available.

Vapour density Not available.

Relative density Not available.

Solubility(ies) Soluble in water.

Partition coefficient Not available.

Auto-ignition temperature Not available.

Decomposition Temperature Not available.

Viscosity Not applicable.

Explosive properties Not considered to be explosive.

Oxidising properties Does not meet the criteria for classification as oxidising.

9.2. Other information

Other information No information required.

SECTION 10: Stability and reactivity

10.1. Reactivity
Reactivity See the other subsections of this section for further details.

10.2. Chemical stability

Stability Stable at normal ambient temperatures and when used as recommended. Stable under the
prescribed storage conditions.

10.3. Possibility of hazardous reactions

Possibility of hazardous No potentially hazardous reactions known.
reactions

10.4. Conditions to avoid

Conditions to avoid Avoid heat. Protect from sunlight.

10.5. Incompatible materials

Materials to avoid Avoid contact with acids.

10.6. Hazardous decomposition products

Hazardous decomposition Does not decompose when used and stored as recommended. Thermal decomposition or
products combustion products may include the following substances: Harmful gases or vapours.

5/9
Revision date: 22/10/2018

SpotON Flow Cell Rev D (R9.4)

SECTION 11: Toxicological information

11.1. Information on toxicological effects

Toxicological effects None of the components of this product are regarded as a health hazard under current legislation.

Acute toxicity - oral

Notes (oral LD₅₀) Based on available data the classification criteria are not met.

Acute toxicity - dermal

Notes (dermal LD₅₀) Based on available data the classification criteria are not met.

Acute toxicity - inhalation

Notes (inhalation LC₅₀) Based on available data the classification criteria are not met.

Skin corrosion/irritation
Animal data Based on available data the classification criteria are not met.

Serious eye damage/irritation

Serious eye damage/irritation Based on available data the classification criteria are not met.

Respiratory sensitisation
Respiratory sensitisation Based on available data the classification criteria are not met.

Skin sensitisation
Skin sensitisation Based on available data the classification criteria are not met.

Germ cell mutagenicity

Genotoxicity - in vitro Based on available data the classification criteria are not met.

Carcinogenicity
Carcinogenicity Based on available data the classification criteria are not met.

IARC carcinogenicity None of the ingredients are listed or exempt.

Reproductive toxicity
Reproductive toxicity - fertility Based on available data the classification criteria are not met.

Reproductive toxicity - Based on available data the classification criteria are not met.
development

Specific target organ toxicity - single exposure

STOT - single exposure Not classified as a specific target organ toxicant after a single exposure.

Specific target organ toxicity - repeated exposure

STOT - repeated exposure Not classified as a specific target organ toxicant after repeated exposure.

Aspiration hazard
Aspiration hazard Based on available data the classification criteria are not met.

General information No specific health hazards known. The severity of the symptoms described will vary
dependent on the concentration and the length of exposure.

Inhalation Prolonged inhalation of high concentrations may damage respiratory system.

Ingestion Gastrointestinal symptoms, including upset stomach. Contact with acids liberates very toxic
gas. Cyanosis (blue tissue condition - nails, lips and/or skin). Unconsciousness, possibly
death.

Skin contact Prolonged contact may cause dryness of the skin.

6/9
Revision date: 22/10/2018

SpotON Flow Cell Rev D (R9.4)

Eye contact May cause temporary eye irritation.

Route of exposure Ingestion Inhalation Skin and/or eye contact

Target organs No specific target organs known.

Toxicological information on ingredients.

Potassium ferrocyanide

Toxicological effects Contact with acids liberates very toxic gas.

SECTION 12: Ecological information

Ecotoxicity None of the components are considered to be a significant hazard due to their small quantity.

12.1. Toxicity
Toxicity Based on available data the classification criteria are not met.

Ecological information on ingredients.

Potassium ferrocyanide

Toxicity Aquatic Chronic 3 - H412 Harmful to aquatic life with long lasting effects.

12.2. Persistence and degradability

Persistence and degradability The degradability of the product is not known.

Ecological information on ingredients.

Potassium ferrocyanide

Persistence and The product contains inorganic substances which are not biodegradable.
degradability

12.3. Bioaccumulative potential

Bioaccumulative potential No data available on bioaccumulation.

Partition coefficient Not available.

Ecological information on ingredients.

Potassium ferrocyanide

Bioaccumulative potential No data available on bioaccumulation.

12.4. Mobility in soil

Mobility The product is water-soluble and may spread in water systems.

Ecological information on ingredients.

Potassium ferrocyanide

Mobility The product is soluble in water.

12.5. Results of PBT and vPvB assessment

Results of PBT and vPvB This product does not contain any substances classified as PBT or vPvB.
assessment

Ecological information on ingredients.

7/9
Revision date: 22/10/2018

SpotON Flow Cell Rev D (R9.4)

Potassium ferrocyanide

Results of PBT and vPvB Substance is inorganic. Not relevant.

assessment

12.6. Other adverse effects

Other adverse effects None known.

SECTION 13: Disposal considerations

13.1. Waste treatment methods

General information The generation of waste should be minimised or avoided wherever possible. Reuse or recycle
products wherever possible. This material and its container must be disposed of in a safe
way. Disposal of this product, process solutions, residues and by-products should at all times
comply with the requirements of environmental protection and waste disposal legislation and
any local authority requirements.

Disposal methods Dispose of surplus products and those that cannot be recycled via a licensed waste disposal
contractor. Waste packaging should be collected for reuse or recycling. Incineration or landfill
should only be considered when recycling is not feasible. Waste should not be disposed of
untreated to the sewer unless fully compliant with the requirements of the local water
authority.

SECTION 14: Transport information

General The product is not covered by international regulations on the transport of dangerous goods
(IMDG, IATA, ADR/RID).

14.1. UN number
Not applicable.

14.2. UN proper shipping name

Not applicable.

14.3. Transport hazard class(es)

No transport warning sign required.

14.4. Packing group

Not applicable.

14.5. Environmental hazards

Environmentally hazardous substance/marine pollutant

No.

14.6. Special precautions for user

Not applicable.

14.7. Transport in bulk according to Annex II of MARPOL and the IBC Code
Transport in bulk according to Not applicable.
Annex II of MARPOL 73/78
and the IBC Code

SECTION 15: Regulatory information

15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture

8/9
Revision date: 22/10/2018

SpotON Flow Cell Rev D (R9.4)

National regulations Health and Safety at Work etc. Act 1974 (as amended).
The Carriage of Dangerous Goods and Use of Transportable Pressure Equipment
Regulations 2009 (SI 2009 No. 1348) (as amended) ["CDG 2009"].
EH40/2005 Workplace exposure limits.

EU legislation Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18
December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of
Chemicals (REACH) (as amended).
Commission Regulation (EU) No 2015/830 of 28 May 2015.
Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16
December 2008 on classification, labelling and packaging of substances and mixtures (as
amended).

15.2. Chemical safety assessment

No chemical safety assessment has been carried out.

SECTION 16: Other information

Abbreviations and acronyms ADR: European Agreement concerning the International Carriage of Dangerous Goods by
used in the safety data sheet Road.
ADN: European Agreement concerning the International Carriage of Dangerous Goods by
Inland Waterways.
RID: European Agreement concerning the International Carriage of Dangerous Goods by
Rail.
IATA: International Air Transport Association.
ICAO: Technical Instructions for the Safe Transport of Dangerous Goods by Air.
IMDG: International Maritime Dangerous Goods.
CAS: Chemical Abstracts Service.
ATE: Acute Toxicity Estimate.
LC₅₀: Lethal Concentration to 50 % of a test population.
LD₅₀: Lethal Dose to 50% of a test population (Median Lethal Dose).
EC₅₀: 50% of maximal Effective Concentration.
PBT: Persistent, Bioaccumulative and Toxic substance.
vPvB: Very Persistent and Very Bioaccumulative.

General information This product is considered to be a small package and is labelled according to the relevant
provisions of the legislation.

Key literature references and Source: European Chemicals Agency, http://echa.europa.eu/

sources for data

Training advice Read and follow manufacturer's recommendations. Only trained personnel should use this
material.

Revision comments This is the first issue.

Revision date 22/10/2018

SDS number 8137

Hazard statements in full H412 Harmful to aquatic life with long lasting effects.

This information relates only to the specific material designated and may not be valid for such material used in combination
with any other materials or in any process. Such information is, to the best of the company's knowledge and belief, accurate
and reliable as of the date indicated. However, no warranty, guarantee or representation is made to its accuracy, reliability or
completeness. It is the user's responsibility to satisfy himself as to the suitability of such information for his own particular use.

9/9