Reye Syndrome
Reye Syndrome
Reye Syndrome
Reye syndrome, an extremely rare but serious illness that can affect the brain and liver, occurs most commonly in kids recovering from a viral infection. Named after Australian pathologist R. Douglas Reye, who first reported it as a distinct syndrome in 1963, Reye syndrome is still not well understood. Studies have linked the use of aspirin or aspirincontaining medications during viral disease to development of Reye syndrome. Cases have dropped dramatically since the finding of a link between the illness and aspirin use in children.
In the later stages, a child may exhibit irrational behavior, confusion, severe weakness, seizures, and loss of consciousness. There is usually no fever. Reye syndrome is now very rare: only a few cases a year are reported in the United States. It should be considered, however, in a child with frequent vomiting or a change in mental status particularly after
Prevention
Aspirin and other drugs from the salicylate family should never be used in the treatment of chickenpox, influenza, and other viral diseases. In general, aspirin should not be used for kids or teenagers except on the advice of a doctor for certain conditions.
Treatment
Children with Reye syndrome are usually treated in a hospital; if seriously ill, in a hospital intensive care unit (ICU). Treatment is supportive as there is no cure for the illness. The clinical care team focuses on making sure a child with Reye syndrome maintains proper fluid and electrolyte balance, nutritional, and cardiorespiratory status. Chances of recovery are greatest when these systems are as balanced as possible. Mechanical ventilation (a breathing machine or respirator) may be necessary if breathing becomes too sluggish. Intracranial pressure (pressure of the fluid within the brain) and blood pressure may be monitored. Small quantities of insulin may be given to increase glucose metabolism, corticosteroids to reduce brain swelling, and diuretics to increase fluid loss. The prognosis for children with Reye syndrome has improved. Earlier diagnosis and better treatment have increased the survival rate to about 80%. The earlier the syndrome is detected, the better the chances for survival. Children who progress to the late stages of the syndrome may suffer brain damage and disability.