BP401T 1256 Question Paper

Seat No: ______________ Enrollment No: ____________________
PARUL UNIVERSITY
FACULTY OF PHARMACY
B. Pharm. Summer 2018 - 19 Examination
Semester: 4 Date: 01/04/2019
Subject Code: BP401T Time: 2:00 pm to 5:00 pm
Subject Name: Pharmaceutical Organic Chemistry-III Total Marks: 75
Instructions:
1. Figures to the right indicate maximum marks.
2. Make suitable assumptions wherever necessary.
Q.1 Multiple Choice Questions (MCQs) (1 Mark Each) (20)

1. Cahn, Ingold and Prelog rule is used to_______.
a) Determine the R and S configuration b) Determine the D and L configuration
c) Determine the Cis and Trans configuration d) Determine the E and Z configuration
2. Sulfonation of Thiazole taken Place at Which position of ring?
a) Second b) Third
c) Fourth d) Firfth
3. Give the IUPAC name of Ethylene Oxide .
a) Oxirane b) Oxole
c) Oxitane d) Oxolane
4. Pyridine is __________ Basic then aliphatic amines.
a) More b) Equally
c) Less d) Doubly
5. 1,2-position with six-member heterocyclic ring containing two nitrogen atom is called________.
a)Pyrimidine b)Pyridine
c)Pyrazine d)Pyridazine
6. The acid-catalysed conversion of oxime to N-substituted amides is known as__________.
a)Baeyer-Villiger rearrangement b)Dakin reaction
c)Beckmann rearrangement d) Claisen-Schmidt condenation
7. Different arrangements of atoms that can be converted into one another by rotation about single bonds
are?
a)Enantiomer b)Diastereomer
c)Conformational isomer d)Configurational isomer
8. Diels-Alder reaction can be carried out in which of the following heterocyclic compounds more
readily?
a)Pyrrole b)Furan
c)Thiophene d)Pyridine
9. Conversion of salicyaldehyde to catechol occurs in presence of________.
a) Hydrogen peroxide and acid b) Hydrogen peroxide and base
c) Sodium borohydride and base d) Sodium borohydride and acid
10. Which of the following reagent is used in oppenauer oxidation?
a) Lithium aluminium hydroxide b) Sodium hydroxide
c) Sodium borohydride d) Aluminium isopropoxide
11. Which geometric isomer will not form its corresponding anhydride on heating at 150 0C?
a) Acetic acid b) Fumaric acid
c) Maleic acid d) Malonic acid
12. The number of optically active isomer of tartaric acid is______.
a)2 b)3
c)4 d)5
13. Skraup Synthesis can be use for which of following heterocyclic synthesis?
a) Pyrazole b) Pyrimidine
c) Quinoline d) Furan
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14. Conversion of acetone to propane can take place by which of following reaction.
a) Clemmensen reduction b) Wolff Kishner reduction
c) Birch reduction d) Both a and b
15. D & L system use in which of following type of isomer?
a) Configurational isomer b) Geometric isomer
c) Optical isomer d) Conformational isomer
16. The stereoisomers which are not mirror image of each other called as_______.
a)Enantiomer b)Diastereomer
c) Meso compound d) none
17. Benzpyrrole is name of following heterocycle?
a) Isoquinoline b) Indole
c) Imidazole d) Quinoline
18. The given compound is_________.
COOH
H C OH
H C OH
COOH
a) Enantiomer b) Distereomer
c) Meso compound d) Optical active isomer
19. In given below compound the chiral carbon has following configuration______________.
a) R b) S
c) Both d) None
20.
The nomenclature of geometrical isomer is done by_______.
a) E and Z configuration b) Cis-Trans configuration
c) Both a and b d) None
Q.2 Long Answers (any 2 out of 3) (10 Mark Each) (20)
1. A. Write a note on Aromaticity and basicity of Pyridine.
B. Write the Bischler-Napieralski Synthesis of Isoquinoline, and Chichibabin reaction for the same.
2. Define racemic mixture and resolution. Enlist the methods for resolution of racemic mixture and
explain each method in detail with examples.
3. Discuss Oppenauer oxidation, Birch Reduction and Claisen Schmidt condensation.
Q.3 Short Answers (any 7 out of 9) (5 Mark Each) (35)
1. Write down the Skraup’s Quinoline synthesis with mechanism.
2. Write down Paal-Knorr synthesis of pyrrole with mechanism.
3. Discuss Fischer Indole synthesis with mechanism.
4. Discuss relative aromaticity and Basicity of Pyrrole, furan, and Thiophene.
5. Explain stereospecific and stereoselective reactions with examples.
6. Draw and explain energy diagram for conformations of cyclohexane and indicate the most stable and
unstable conformers.
7. Discuss Geometric isomerism in detail.
8. Explain enantiomerism, diastereoisomerism and mesoisomerism with examples.
9. Discuss Clemmenson and Wolf-Kishner reduction.
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Q.1 Multiple Choice Questions (MCQs) (1 Mark Each) (20)

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