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BRIAN GITONGA
BPHARM/2022/50289 ANATOMY BHA 1205
1.DESCRIBETYPE OF CELL JUNCTIONS FOUND IN
EPITHELIAL TISSUE
Cell adhesion is made possible by specialized structures called cell junctions. they play a crucial role in immune response and wound healing, as well as the growth and maintenance of tissues and organs; TIGHT JUNCTION: This is made up of protein strands or rows that are part of the plasma membrane. They are situated around the outside of each cell, near the apical surface. They serve as spot welds that close the intercellular space, which must be crossed by the substance being moved through the cell. For instance, they help to line the small intestines and stop corrosive enzymes from passing between cells and harming other internal organs. They also stop urine from leaking through the bladder.
TIGHT JUNCTION
DESMOSOMES: Also referred to as macula adherens, they are made up of several proteins. A protein plague, a thickened structure, is present on the interior surface of the plasma membrane of neighboring cells. From the plague, many protein filaments (desmogleins) stretch through the plasma membrane of the two adjacent cells. They are joined by an anchor. In order to reinforce and strengthen the pattern establishing a desmosome between two adjacent cells, intermediate filaments of the cytoskeleton that stretch from each protein plaque across the cell are also anchored to each protein plaque. plaque made of proteins, intermediate filament. Adjoining filament of protein. protein deposits. midpoint filament They serve to maintain the structural integrity of cardiac muscle cells and prevent separation by providing structural integrity to cells exposed to stress (skin, heart) in the heart. There dysfunction may result in pathological conditions like pemphigus
DESMOSOMES
JUNCTION OF GAPS It is made up of six essential plasma proteins known as connexons, which together form a small fluid-filled tunnel or pore. They offer a direct route for chemicals to go between adjacent cells, Ions, glucose, amino acids, and other minor solutes can cross straight from one cell's cytoplasm to that of its neighbor. via means of the pores. the distribution of electrical activity in heart muscles is made possible by the passage of ions. Heart conditions can result from malfunction.
