Biology at the Service of Dermatology

What is the anatomy of the skin?

• Skin consists of 3 main layers:

1. Epidermis
2. Dermis
3. Hypodermis
Oily Skin & Acné Sensitive Skin & Dry Skin & Atopic
Redness skin

Sébium Sensibio Atoderm

Hyperpigmentation Healing & Cicabio Sun & Sun screen

& Whitening Program
program

White Objective Cicabio Photoderm

Nodé DS +
In harmony with
its natural biology
Oily Skin & Acné
 Acne-pathophysiology
Testosterone
3 steps
↑ keratinization Inflammation
Cells accumulation
↑ 5 reductase
plugged and enlarged follicle
↑ sensitivity of receptors

DHT

↑ proliferation of P.Acne

Sebum↑

1. Excessive sebum 2. Abnormal 3. Inflammation (bacterial

production keratinisation and proliferation)
comedogenesis
 Dilated Pores

Pimples

Black Head

White Head
Shiny Pale
Squalene: a UNIQUE and ESSENTIAL lipid
 FLUIDACTIV PATENTED FORMULA
Unique biological action:
- inhibits squalene oxidation
- Regulating sébum quality
- Reducing hyper kératinisation

The patent reduces comedogenesis

The right Tactics
1.Facial Cleanser
Use Extra-mild – Soap free hygiene Product Twice daily
The best solution
Sebo-regulating
 Antibacterial >>> Zinc, Copper

 No Skin Dry Out

 Excellent Shaving Foam

Used Twice Daily Sebium Moussant

The right Tactics
2.Fixing Make-up
Use Daily Toner before Make-up to fix the make up
The best solution
Sebo-regulating
 Antibacterial >>> Zinc, Copper

 Swap before Make-up to fix

 Excellent Makeup remover

Sebium H2O
Used once daily
The right Tactics
3.Remove Body Acne
Use Soap Free Soap for Body Shower rich on antibacterial
& sebo-regulating agents
The best solution
 Sebo-regulating
 Antibacterial >>> Zinc, Copper

 Nice Fragrance
 Face & Body
Sebium Bar
The right Tactics
4.Black Head Removal
Apply exfoliating gel with circular movement on slightly
damp face
Massage Gently for 1 – 2 Minutes
Rinse & Dry the skin
The best solution
 Sebo-regulating
 Chemical Peel >>> Glycolic acid

 Mechanical peel >>> Spherical particles

 Used Twice Weekly Sebium Gommant

 5 min message & rinse

The best solution
Deep Peeling
PROPERTIES INGREDIENTS

Eliminates comedones
Keratolytic Glycolic acid 15% (High concentration :peeling effect)

Preserves Prevents comedogenesis

Fluidactiv®
sebum’s quality
Anti- D-Panthenol Soothing and repairing action
inflammatory
The right Tactics
5.Treat Acne Lesion
should
- Regulate Sebum Quality & Quantity
- Refine Skin Texture
- Moisturize & Soothe the skin
The best solution

Twice Daily
The right Tactics
6 .Refine Dilated Pores
- Pore Reducing Activity
- Matifying Powder
- Moisturize & Soothe the skin
The best solution
 Sebo-regulating
 Astringent Action >>> agaric acid

 Make up base >>> Methacrylate Powder

 Gentle Exfoliation >>> Salicylic ester
Sebium Pore Refiner
 Use any Time
The right Tactics
7.Counteract Medical Treatment Dryness
should have
- Non-Comedogenic Properties
- Non-Occlusive
- Long Lasting hydration
The best solution
 Sebo-regulating
 Non Comedogenic

 Rich in ceramide
 After Roacutane or Peeling
Sebium hydra
 Use any Time
The right Tactics
8.Sun Care
The Sun is False Friend cause Skin Thicken which conceals
blemishes

should have
- High SPF
- Light Texture
- Non-Comedogenic
The best solution
 For All Skin Type
 Very Light texture
 High SPF

 High UVA PI
Photoderm Ultra Fluid
The right Tactics The best solution
1.Facial Cleanser Sebium Moussant
2.Fixing Make-up Sebium H2O
3.Remove Body Acne Sebium Bar
4.Black Head Removal Sebium Gommant
5.Treat Acne Lesion Sebium Global
6.Refine Dilated Pores Sebium Pore refiner
7.Medical Treatment Dryness Sebium Hydra
8.Sun Care Photoderm Ultrafuid
Dry Skin
 Hand Body Dryness
Flakes Tightness & Cleanser
Sensitivity

Consumer Complains

Inflammation
Foot
Fissures Urge to
Scratch
 Hand Body
Face Allergen free
Moisturizer Moisturizer
Moisturizer Cleanser

Needs

Soothing
Anti-itching Moisturizer
Moisturizer
 Penetration of irritant agents
(allergens,…)
Deficient skin barrier
>RETRACTION<
Deficit of ceramides,
filaggrin and involucrin

PRURITUS Desquamation abnormalities

Colonization XEROSIS
Staph aureus

INFLAMMATION
SENSITISATION
(Eczema) TEWL 
Allergen free Cleanser
Must Have Allergen Free Perfume or Totally Fragrance Free
Should Supply Skin with Essential Nutrients
Must have very mild Cleansing base
The best solution

Atoderm PP
Moussant Atoderm Bar
S oothing moisturizers
Must be Fragrance free
Should have potent anti-inflammatory ingredients
Should have Potent anti-bacterial

The best solution

β-sitosterol
► Cortisol Like action (Soothing action)

Piroctone olamine, Zinc gluconate

► Purifying anti-bacterial , antifungal action

Vaseline/glycerin complex Atoderm PO

Zinc
► Consolidates skin barrier and hydrates
Anti-itching moisturizer
Must be Fragrance free
Should have ant-itching ingredients
Should have bacteria Balancer & Skin barrier builder

The best solution

Ecodefensine Patent
► Bacterial Balancer

Vitamin PP
► Build Skin Barrier

Zanthalene
Atoderm PP
► Anti-itching Baume
Face & Hand moisturizer
Must increase Skin Barrier Power
Must tune Hydrolipidic film
Must Supply essential Nutrients

The best solution

Softens the skin
Can be used safely long term
Spreads easily and penetrates
rapidly
Economical and practical to Atoderm
use Cream
Body Moisturizer
Must have light texture
Must immediately absorbed
Must Supply essential Nutrients

The best solution

Softens the skin
Can be used safely long term
Spreads easily and penetrates
rapidly
Economical and practical to
use Atoderm
Lait
Apricot Odor
Dark Spots
 Shaving Long Sun
inflammation Exposure
Face
Melasma

Consumer Complains
Pressure Area
Pigmentation Body
Melasma
 Long Sun Exposure
Whitening

Night Moisturizing
Sensitive Area Whitening
Whitening

Consumer Needs
 UV Glycolic acid 4 Ascorbyl
Glucoside
1
UVB/UVA 4. installation
Filters

Vitamin PP
1. INDUCTION
-MSH 3
Andrographolide ET-1

Melanostatine Melanosomes
3. DISTRIBUTION
Melanin
tyrosinase
Tyrosine
2. SYNTHESIS

Glabridine 2 Lysine azeilate

S Ensitive area whitening
Have no exfoliation
Effective absorption with no side effect
Alcohol & Parapen free
The best solution
Have potent anti-inflammatory
“ Andrographolide”
Correct Pigment distribution
“ Vitamin PP & Vitamin C”
Decrease melanin synthesis
“Glabridin & Lysin azeliate”
White Objective
Have Light Texture Cream
Night Moisturizing Whitening
Have have effective peeling
Must Have deep moisturization
Prefered to have repairing effect
The best solution
High Peeling Power
“Glycolic acid 12%”
Correction for Pigmentation
“ Vitamic C”
Decrease Pigment Transfer
“Vitamin PP” White Objective
Serum
Cicabio
 Wound
Epidermis

dermis Micro-
organisms
Blood vessels

VEGF

Vasodilatation
Haemostatic
plug Vasopermeation
 Epidermis +++
Neutrophiles
dermis Micro-
organisms
H 2 O2
Blood vessels
VEGF
Macrophages
 Epidermis
fibrinogen
fibronectin
dermis Provisory ECM thrombospondine

Blood vessels
Extravasation
of plasma
proteins
 Fibrin scab
epidermis

dermis Prolifération et
Myofibroblasts migration des
fibroblastes
contraction Collagen III
Fibronectin
Hyaluronic acid

New ECM Blood

vessels

VEGF
Angiogenesis
 Fibrin scab
epidermis

dermis
Single layer of
keratinocytes

Blood
vessels
epidermis

dermis
Keratinocyte
differentiation Collagen I
Elastin Blood
GAG vessels

Rebuilding of
the ECM

Scar tissue
 Conclusion
PRIMING
Inflammatory and vascular phase: 2-3
days

REPAIRING
Formation of granulation tissue (new ECM)
Epithelialization 10-15 days

MATURATION of the ECM:

Rebuilding takes up to 2 months
 Cicabio: the intelligent approach to healing

2-3 days 10-15 days Up to 2 months

1. INFLAMMATORY 2. REPAIRING 3. MATURATION

VASCULAR REBUILDING RESHAPING

PRIMING phase: Resveratrol + Copper

Repairs and reshapes: Centella asiatica

Soothes the pain and pruritus: Antalgicine® (Pseudo opioid)

Protects and hydrates: hyaluronic acid

Purifies: Copper - Zinc

 Cicabio crème’s indications: non-oozing lesions

• Damaged skin
– Adults and children
• Skin irritations
• Grazes
• Cracks
• Chapped skin
• Sores
• Cuts
• Casual burns
– Children
• Peri-oral irritation
• Red buttocks
 Following dermatological surgery

– Sutures
– Electrical depilation
– Laser
Peeling
– Peeling
– Cryotherapy
 Cicabio Lotion indications: oozing lesions
 Dries up the lesions
o Absorbs the oozing
 Mineral agents: Magnesium silicate, silica, zinc oxide

Oozing lesions
 Soaking skin folds
 Zones of friction

Children
 Umbilical cord care
 Oozing red buttocks
 Chickenpox
Sun
SUN-RELATED ISSUES
1. INTRODUCTION/ The sun and the skin

The sun is essential to life and lifts our spirits Responsible for sunburn, other burns,cancers,
premature ageing of the skin or allergies

Required for vitamin D synthesis Generator of free radicals

Can be beneficial for certain skin Skin cancers in continuous evolution

diseases (psoriasis, AD)

Index Contents
SUN-RELATED ISSUES
1. INTRODUCTION / The sun and the skin

UV IR
rays

UV < 400 nm 400 – 800 nm UV < 800 nm

Infrared Infrared Infrared
Ultra-violet rays rays rays

≏ 7% ≏ 39% ≏ 54%
Tanning process and sunburn Heat felt

λ
E

Index Contents
 SUN-RELATED ISSUES
1. INTRODUCTION/The sun and the skin

NOT ALL UV RAYS

UV UV UV ARE THE SAME!
B A C
EPIDERMIS
UVA
(320 – 400 nm)
Age!
DERMIS

UVB
HYPODERMIS (290 – 320 nm)
Burning! Tanning!

Index Contents
 SUN-RELATED ISSUES
1. INTRODUCTION/The sun and the skin

SNOW SAND WATE

R

80% 15% 25%

40 %
50cm

Index Contents
SUN-RELATED ISSUES
2. WEAKENING OF THE CELLS/
BIODERMA's solution

Maintain the skin's natural protection, stimulate

PURPOSE
the skin's defences

HOW?

IN COMBINATION WITH THE BEST ANTI-UVA/UVB

SURFACE PROTECTION

Index Contents
 SUN-RELATED ISSUES
2. WEAKENING OF THE CELLS/ BIODERMA's solution
Cellular BIOPROTECTION®

Cellular BIOPROTECTION® PATENT MANNITOL

1
Maintains and stimulates the skin's Powerful anti-free radical agent, also protects
natural defences the DNA
of the keratinocytes subjected to UV rays
MANNITOL (natural sugar)
ECTOIN
ECTOIN

Limits the migration of Langerhans cells and

prevents photoageing

Index Contents
 SUN-RELATED ISSUES
2. WEAKENING OF THE CELLS/ BIODERMA's solution
Cellular BIOPROTECTION®

IN COMBINATION WITH ONE ANTI-UVA/UVB SURFACE PROTECTION

Cellular BIOPROTECTION® PATENT

1 2 High-performance filtering system
Maintains and stimulates the skin's UVA AND UVB RAY FILTERING
natural defences

MANNITOL (natural sugar)

ECTOIN

Index Contents
Types of Filter

Mineral
Chemical Organic screens Horny
screens
filters layer

Epidermis

Dermis
SPF measurement in vivo
Light source
Emulates the solar
spectrum (UVB + UVA)
40°N
MED(np) MED(p)
Quantity applied
2 mg/cm2
A B
Calculation
SPF = MEDp* /
MEDnp**
p = protected Volunteer's back

np = not protected
* Protected Minimal Erythema Dose
** Non-protected Minimal Erythema Dose
Determining UVA PI in vivo
Light source Determining UVA PI in vivo
UVA only
MPD(np) MPD(p)
Quantity applied
2 mg/cm2
A B
Calculation
UVA PI = MPDp / MPDnp
p = protected Volunteer's back
np = not protected
* Protected Minimal Pigmentation Dose
** Non-protected Minimal Pigmentation Dose
 The best selections

Ultra fluid Cream

Spot

Lait KID Fluid

Sensibio
 SENSIBIO: PRODUCT OFFERING

1. CLEANSING/ Sensibio H O 2

SENSITIVE SKIN WITHOUT REDNESS INTOLERANT AND/OR ALLERGIC SKIN

Cleansing General
Sensibio

1
Leader on the micelle solution market
H2O
1 Sensibio H2O sold every 3 seconds

N°1
Actions and patents:
Treatment
Very high tolerance

2 All skin types

No-Rinse
Cleansing + make-up removal (even waterproof): Peg-6
caprylic/capric glycerides

Face and eyes Soothes and decongests: Cucumber extract (cucumis sativus)
500 ml
250 ml DAF:  skin’s tolerance threshold
Maintenance
100 ml

3 Hypoallergenic, fragrance-free,
alcohol-free, paraben-free

Index Contents
 SENSIBIO: PRODUCT OFFERING

2. TREAT/ Sensibio Forte

SENSITIVE SKIN WITHOUT ALLERGIC INTOLERANT
Sensitive skin with redness
REDNESS SKIN

Cleansing General
Sensibio

1
Emergency skincare for intolerant skin suffering from a
Forte burning sensation and redness
Rubbing, shaving burn, hair removal, chemical peeling, post-
laser, sunburn

Actions and patents:

Treatment
Rapidly relieves redness/burning: High dose of enoxolone +
allantoin

2 Intensely moisturizes: Glycerine/xylitol + bees wax

Toleridine ®patent
 tolerance threshold of sensitive skin
All skin types Biologically strengthens skin resistance
Face and body
Maintenance
Adults, children

3 40 ml

Hypoallergenic, fragrance-free,
paraben-free
Posology:
Redness and/or intense burning sensation: apply 2 to 3 times a
day after cleansing with Sensibio H2O. Reduce frequency as soon
as there is an improvement.
 SENSIBIO: PRODUCT OFFERING

3. MAINTENANCE/ Sensibio Eye

SENSITIVE SKIN WITHOUT ALLERGIC INTOLERANT SENSITIVE SKIN WITH
SEBORRHOEIC DERMATITIS
REDNESS SKIN REDNESS

Cleansing General

1
Bioderma's only eye contour product
Sensibio
Eye
Actions and patents:

Reduces puffiness and decongests: Caffeine

Treatment
Reduces lines and small wrinkles: Hyaluronic acid

2 Smoothe the skin: light-reflecting powders

Moisturises: Glycerine
Toleridine® patent
All skin types
Eye contour
 tolerance threshold of sensitive skin
Biologically strengthens skin resistance
Suitable for contact
Maintenance wearers
15 ml

3 Hypoallergenic, fragrance-free,
paraben-free

Index Contents
 Nodé DS +

Scientific concept
Nodé DS +
 Pathology

Malassezia
CAUSES
Sebum
Inflammation
Scales CONSEQUENCES
Itching
 Nodé DS +
Perfectly matches patients needs
• To get rid of dandruff quickly
• To calm down inflammation
• To sooth pruritus
• To Limit recurrence
 Scientific concept
Zinc Piroctone Olamine
B6 vitamin Pyrithione zinc
Undécyl alcohol
Sebum accumulation Malassezia
proliferation

Pruritus
Zanthalene

hair

Inflammation / Hyperkeratinisation
erythema / squames
Laminaria extract Salicylic acid / Ichtyol /
Cade
 Nodé DS+ Anti-Recurrence
Usage

• Use
– In association with treatments
– As monotherapy
• Posology
– Shock treatment: 3 shampoos a week for 3 weeks
• Leave on for 5 min. on the lesions before lathering and rinsing
(cream texture for easier application)
– Maintenance treatment: 1 or 2 shampoos a week,
alternating with Nodé Fluid shampoo