pharmacology test 1 2023

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Copperbelt University , SOM, Biomed IV Distance, PharmacologyTest 1

Duration : 50 Minutes
Computer Number
The following may affect the selection of the route of administration except
c. Severity of condition
b. Site of infection
a. Period from the starting of symptom presentation
d. Physicochemical properties of drugs
e. All of the above
Ponder on the statements and choose the best answer

a. Only Suppositories are administered through this route
d. Systemic effects can be actualized from drugs administered rectary
c. Drugs are only administered rectally when patients cannot take drugs by
mouth
b. Only a localized effect is achieved from the rectally administered drugs
e. Suppositories should be removed after some minutes
The following is an example of a Pure drugs

d. Cinchona bark
a. Cinchona powder
c. Quinine injection
e. Quinine bitter tonic
b. Quinidine powder
Which of the following depends on the greater circulation blood within the region for
the rapid drug absorption
a. Subcutaneous
d. Intradermal
e. Intramuscular
c. Intra-articular
b. Intrathecal
The following statement is not true about oral route

b. Relatively safer
c. Economical
d. Absorption of drugs can vary widely
a. Easy to administer
e. Adverse effects are rare but to be severe when present
The following are CYP450 inhibitors Except

d. Ciprofloxacin
c. Griseofulvin
Erythromycin
b. Cimetidine
e. Phenobarbitone
Which of the following statements is correct regarding bioavailability?

a. This is the amount of drug that reaches the systemic circulation in its active
form
e. The surface area in the stomach is at par with that of the small intestines
d. Pharmaceutical and biological factors affect bioavailability
b. Orally administered drugs have no variation in bioavailability
c. Drugs administered via I.V and IM routes have equal bioavailability
The following drugs inhibit p – glycoprotein EXCEPT

e. Diazepam
c. Erythromycin
b. Atenolol
d. Ciprofloxacin
a. Amlodipine
In which of the following will the drug be likely to have low distribution?
b. Skeletal muscle
e. Heart
d. Brain
c. Kidneys
a. Liver
The following affects drug distribution Except

b. Blood flow
a. Lipid solubility and plasma protein binding
e. Drug formulation
d. PH
c. Molecular size
Antagonists have the following

e. Exhibition of both receptor affinity and efficacy depending on the drug
concentration
d. Affinity alone
c. Both affinity and Efficacy
a. More receptor displacement ability compared to agonists
b. Efficacy only
The following effects can be caused by agonists EXCEPT

d. Stimulation of receptor to trigger a signal transduction
a. Desensitization
c. Super sensitivity
b. Receptor down regulation
e. Counter the effect of antagonists with increased concentration
Read the following statement and choose the best choice

e. Pharmacological action can be actualized even without signal transduction
a. All drugs need binding sites to actualize their pharmacological activity
d. The receptor affinity does not affect drug potency
b. Orphan receptors do not have any significance in therapeutics
c. A competitive inhibitor is a ligand that binds to a different active catalytic site
as the endogenous substrate
Drug potency is largely determined by the following

d. Receptor affinity
e. Time of exposure of the receptor to the drug
c. Formulation of drugs
b. Efficacy
a. Absorption surface area
Regarding agonists and antagonists, which of the following is true?

d. Effects of competitive antagonists are surmountable by the increased dose of
agonists
b. Inverse agonists are agonists do not reduce signal transduction
e. Antagonists have both the efficacy and potency
a. Partial agonists cannot act as antagonists in the presence of full antagonists
c. Noncompetitive antagonists do not irreversibly block the receptors
Pilocarpine falls under the following class of drugs

c. cholinergic antagonists
a. Cholinesterase inhibitors
d. Neuromuscular blockers
b. Direct acting cholinergic agonists
e. Nicotinic receptor agonists
Establishing the diagnosis of vasospastic angina can be enhanced by administering

the following drug
b. Acetylcholine
e. Hyoscyamine
c. Bethanechol
a. Edrophonium
d. Muscarine
Physostigmine is used in the following conditions EXCEPT

b. As an antidote to atropine
d. Urinary incontinence
c. Myasthenia gravis
a. Reversal of muscle relaxation post surgery
e. Myasthenia crisis
Carbachol can be used in the following EXCEPT

e. Enhanced miosis in ophthalmic surgery
a. Open angle glaucoma
c. Cataract surgery
b. Urinary retention
d. Iridectomy
Differentiation between of myasthenia crisis and cholinergic crisis can be enhanced
by administering the following drug
a. Neostigmine
b. Donepezil
d. Edrophonium
c. Physostigmine
e. Pyridostigmine
The following only activates muscarinic receptors

e. Varenicline
c. Carbachol
b. Acetylcholine
d. Muscarine
a. Bethanechol
Muscarinic side effects occurring after administration of cholinesterase inhibitors in

the treatment of myasthenia gravis can be treated using
a. Scopolamine and atropine
e. Ipratropium bromide
c. Atropine and glycopyrolate
b. Glycopyrorate and hyoscyamine
d. Only glycopyrrolate
Patients with overactive bladder can be treated with following group of drugs
c. 5 - phosphodiesterase inhibitors
b. Cholinergic antagonists
e. Neuromuscular blockers
Option 6
a. Cholinesterase inhibitors
d. Cholinergic agonists
Which of the following is true about Atropine?

e. It can complicate asthma and other pulmonary obstructive diseases
d. Enhances salivation
c. May result in bronchoconstriction
b. Facilitate the opthalmoscopic examination of the retina
a. Causes bradycardia
A 16 year old girl walks into your consulting room complaining of severe intestinal
spasms which tends to be worse when having menses. She says she has taken
most of the common pain killers on the market but seem not to give her the optimal
relief.
Which of the following drug would help in her problem?

c. Pirenzepine
b. Oxybutinin
a. Hyoscyamine
e. Nicotine
d. Scopolamine
Atropine can be used for all the following EXCEPT

d. Urinary bladder spasms
b. Opthalmoscopic examination
c. Muscarinic effects caused by cholinesterase inhibitors in patients with
myasthenia gravis
e. Organophosphate poisoning
a. Sinus tachycardia
Option 1
Hypotension caused by excessive doses of vasodilator drugs can be treated using

d. Epinephrine
a. Clonidine
e. Isoproterenol
c. Midodrine
b. Norepinephrine
Option 1
The first treatment of choice of cardiogenic shock is

d. I.V fluids
a. Norepinephrine
b. Dopamine
c. Epinephrine
e. Dobutamine
Midodrine is known for its treatment for the following condition

d. Diabetic autonomic neuropathy
Option 6
c. Cardiac stimulant
a. Orthostatic hypotension
e. Pulmonary hypotension
b. Hypertension
The following is used as an adjunct to anesthesia during surgical procedures

e. Norepinephrine
d. Tyramine
b. Clonidine
a. Midodrine
c. Cocaine
The following are used as nasal decongestants EXCEPT

b. Epinephrine
c. Pseudoephedrine
d. Phenylephrine
a. Oxymetazoline
e. Ephedrine
Phaecromocytoma is treated by the following
d. Carvedilol
b. Acebutolol
a. Phentolamine
e. Clonidine
c. Propranolol
The following can easily penetrate the blood brain barrier

c. Pindolol
a. Nadolol
b. Propranolol
e. Atenolol
d. Metoprolol
The following are cardio selective EXCEPT

b. Esmolol
e. Acebutolol
d. Atenolol
a. Metoprolol
c. Pindolol
What recommendation would you give for a benign prostatic hyperplasia (BPH)?
c) Doxazosin
d) Terazosin
a) Silodosin
e) Pseudoephedrine
b) Prazosin
Regulation of norepinephrine release can be achieved through the stimulation of the

following receptors
e. B3
b. Alpha 1
d. B1
c. Alpha 2
a. B2
Secretion of renin from the juxtaglomerular cell can be increased by the stimulation
of the following receptor
b. B2
d. B1
a. Alpha 1
e. B3
Alpha 2
A woman presents with contractions at 36 weeks gestation. As an intern, you realize

this situation needs to be controlled and contained to prevent complications.
Which drug would you recommend for her?

c. Prazosin
a. Terbutaline
e. Clonidine
b. Propranolol
d. Pindolol
In the management of myocardial ischaemia, which of the following drug has anti-
apoptotic effect and enhanced reduction in the infarct size and scavenging
pproperties?
d. Metoprolol
b. Betaxolol
c. Carvedilol
e. Atenolol
a. Bisoprolol
Which of the following are safe to be taken by hypertensive patients

c. Xylometazoline
d. Oxymetazoline
Option 1
b. Clonidine
a. Pseudoephedrine
e. Cocaine
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Untitled form

Copperbelt University , SOM, Biomed IV Distance, PharmacologyTest 1

Ponder on the statements and choose the best answer

The following is an example of a Pure drugs

The following statement is not true about oral route

The following are CYP450 inhibitors Except

Which of the following statements is correct regarding bioavailability?

The following drugs inhibit p – glycoprotein EXCEPT

The following affects drug distribution Except

Antagonists have the following

The following effects can be caused by agonists EXCEPT

Read the following statement and choose the best choice

Drug potency is largely determined by the following

Regarding agonists and antagonists, which of the following is true?

Pilocarpine falls under the following class of drugs

Establishing the diagnosis of vasospastic angina can be enhanced by administering

Physostigmine is used in the following conditions EXCEPT

Carbachol can be used in the following EXCEPT

The following only activates muscarinic receptors

Muscarinic side effects occurring after administration of cholinesterase inhibitors in

Which of the following is true about Atropine?

Which of the following drug would help in her problem?

Atropine can be used for all the following EXCEPT

Hypotension caused by excessive doses of vasodilator drugs can be treated using

The first treatment of choice of cardiogenic shock is

Midodrine is known for its treatment for the following condition

The following is used as an adjunct to anesthesia during surgical procedures

The following are used as nasal decongestants EXCEPT

The following can easily penetrate the blood brain barrier

The following are cardio selective EXCEPT

Regulation of norepinephrine release can be achieved through the stimulation of the

A woman presents with contractions at 36 weeks gestation. As an intern, you realize

Which drug would you recommend for her?

Which of the following are safe to be taken by hypertensive patients

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