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    1 Pendahuluan Imunologi Klinis-Imunitas Umum

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    Aniend Uchuz Chiz
    This document contains information about a course on immunology including: - The course instructors are Yudy Tjahjono and Dr. Hendy Wijaya. - Course rules include no proxy attendance, quizzes counting for 30% and midterms for 70% of the grade. - The first chapter introduces immunology and describes the innate and adaptive immune systems. - Key immune cells are discussed including phagocytes, natural killer cells, mast cells, dendritic cells, B and T cells, and antibodies. - The roles of MHC proteins in antigen presentation and cell-mediated versus humoral immunity are outlined.

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    1 Pendahuluan Imunologi Klinis-Imunitas Umum

    Uploaded by

    Aniend Uchuz Chiz
    61 views36 pages
    This document contains information about a course on immunology including: - The course instructors are Yudy Tjahjono and Dr. Hendy Wijaya. - Course rules include no proxy attendance, quizzes counting for 30% and midterms for 70% of the grade. - The first chapter introduces immunology and describes the innate and adaptive immune systems. - Key immune cells are discussed including phagocytes, natural killer cells, mast cells, dendritic cells, B and T cells, and antibodies. - The roles of MHC proteins in antigen presentation and cell-mediated versus humoral immunity are outlined.

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    ppt imunologi klinik

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    This document contains information about a course on immunology including: - The course instructors are Yudy Tjahjono and Dr. Hendy Wijaya. - Course rules include no proxy attendance, quizzes counting for 30% and midterms for 70% of the grade. - The first chapter introduces immunology and describes the innate and adaptive immune systems. - Key immune cells are discussed including phagocytes, natural killer cells, mast cells, dendritic cells, B and T cells, and antibodies. - The roles of MHC proteins in antigen presentation and cell-mediated versus humoral immunity are outlined.

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    Download as ppt, pdf, or txt
    61 views36 pages

    1 Pendahuluan Imunologi Klinis-Imunitas Umum

    Uploaded by

    Aniend Uchuz Chiz
    This document contains information about a course on immunology including: - The course instructors are Yudy Tjahjono and Dr. Hendy Wijaya. - Course rules include no proxy attendance, quizzes counting for 30% and midterms for 70% of the grade. - The first chapter introduces immunology and describes the innate and adaptive immune systems. - Key immune cells are discussed including phagocytes, natural killer cells, mast cells, dendritic cells, B and T cells, and antibodies. - The roles of MHC proteins in antigen presentation and cell-mediated versus humoral immunity are outlined.

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    IMUNOLOGI KLINIK

    (PCC-303)

    Dosen pengampu:
    Yudy Tjahjono, M.Sc. Biol. (STS)
    Dr. Hendy Wijaya, M.Biomed (SAS(
    Sebelum UTS
    Yudy Tjahjono, M.Sc
    Sebelum UTS
    Yudy Tjahjono, M.Sc
    ATURAN PERKULIAHAN
    STS
    • DILARANG TITIP ABSEN
    • QUIZ 30% DAN UTS 70%
    • QUIZ 2x, akan diberitahukan kemudian
    • KOMTING.

    • SANKSI QUIZ: 10 ORANG TERJELEK


    AKAN MENGHIBUR SELURUH KELAS
    DENGAN LAGU DAN MUSIK.
    BAB 1

    PENGANTAR

    IMUNOLOGI
    Immune system

    Innate Adaptive
    (nonspecific) (specific)
    1st line of defense 2nd line of defense

    Cellular Humoral Cellular Humoral


    components components components components
    PROPERTY OF IMMUNE SYSTEM
    Development of the immune
    system
    Bone Marrow Thymus
    Tissues
    Stem cell
    Granulocyte T cell

    Myeloid Lymphoid
    progenitor progenitor NK cell

    Mast cell

    B cell
    Monocyte

    2° Lymphoid
    Macrophage
    Dendritic cell Plasma Cell
    Cells of adaptive immune
    system
    • Lymphocytes
    – B cells
    • Plasma cells (Ab producing)
    – T cells
    • Cytotoxic (CTL)
    • Helper (Th)
    – Th1
    – Th2
    – Th17
    – T-reg
    Cells of innate immune
    system
    • Phagocytes
    – Monocytes/macrophag
    es
    – PMNs/neutrophils
    • NK cells
    • Basophils and mast
    cells
    • Eosinophils
    • Platelets
    Phagocytes – neutrophils
    (PMNs)

    • Characteristic
    nucleus, cytoplasm
    • Granules
    • CD66 membrane
    Neutrophil marker protein
    • Chemotaxis

    Geimsa stain
    Source: www.dpd.cdc.gov
    Phagocytes – macrophages
    • Characteristic nucleus
    • lysosomes
    Macrophage • CD14 membrane
    marker protein

    Source: Dr. Peter Darben, Queensland


    University of Technology, used with permission
    Natural killer (NK) cells
    • Also known as large
    granular lymphocytes
    (LGL)
    • Kill virus-infected or
    transformed cells
    • Identified by the
    CD56+/CD16+/CD3-
    • Activated by IL-2 and
    IFN-γ to become LAK
    cells
    Natural killer (NK) cells

    NCR: Natural Cytotoxicity Receptor


    Incorrect Pass: Incorrect MHC-I
    Direct Kill
    Eosinophils
    • Characteristic bi-
    lobed nucleus
    • Cytoplasmic
    granules, stain with
    acidic dyes (eosin)
    – Major basic protein
    (MBP)
    – Potent toxin for
    helminths
    • Kill parasitic worms
    Source: Bristol Biomedical Image Archive,
    used with permission
    Mast cells
    • Characteristic
    cytoplasmic granules
    • Responsible for burst
    release of preformed
    cytokines,
    chemokines,
    histamine
    Source:
    • Role in immunity
    against parasites
    Mast cells
    Dendritic cells
    • Antigen presenting
    cells
    process antigen material
    and present it on the
    cell surface to the T
    cells of the immune
    system
    Source: • present in those tissues
    that are in contact with
    the external
    environment, such as
    the skin and the inner
    Platelets / Thrombocytes
    • stop bleeding by
    clumping and clotting
    blood vessel injuries
    • Thrombus formation
    • Platelet Adhesion

    Source:
    ANTIBODY
    ANTIBODY

    ANTIGEN

    EPITOPE
    How antibodies binds
    antigen?
    ANTIGEN Recognition: SELF AND NONSELF

    T-Cells B-Cells
    Antibody production:
    Antibodies are made by B-Cells…….
    but T-cells contain antibody-like
    structure
    Antigen
    Binding Sites

    T-Cells B-Cells

    Cell Humoral
    mediated
    Antibody production:
    Antibodies are made by B-Cells.
    Stem-Immature-Naive-Active-
    Memory
    T-Cells binds on APC

    APC surface: Peptide Presenting


    Molecule

    MHC: Major histocompatibility


    Complex
     Cell surface proteins which
    essential for immune systems.
    HLA: Human Leukocyte Antigen
    Cell mediated Immunity:
    MHC proteins
    “Self” Target
    MHC-I MHC-II

    Peptide from Peptide from


    inside outside
    Extracellular
    intracelllular
    MHC-I
    VIRUS ATTACK

    VIRAL PROTEIN SYNTHESIS

    Cytotoxin direct kills

    Cell mediated immunities


    T-KILLER
    MHC-II
    Extracellular unknown particles: internalized in
    Endosome/Lysosome of in B-Cells

    Antibodies Production
    Humoral immunities,
    T-Helper
    Adaptive response : Lymphocyte
    T-Cells activated by APC
    B-Cells
    B-cells: Plasma and memory
    Immune Response: Inflammation
    Innate + Adaptive
    Next….
    • Granulocyte Immunology…….

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