Vaksinasi Dewasa Sby 14
Vaksinasi Dewasa Sby 14
Vaksinasi Dewasa Sby 14
ALV/PRN/22/16/
Adult Vaccination
Rationale
Key Vaccines
Benefits
Recommendations
Implementation Policies
Diagram bakteri dgn lokasi berbagai antigen yg menginduksi
imunitas
RATIONALE FOR
ADULT VACCINATION
Why Vaccinate Adults?
High risk group:
- elderly (>60 y.o.)- waning immunity1 : important in
tetanus, pertussis, flu
- chronic diseases (diabetes, asthma, heart disease)—prone
to complications in flu and pneumococcal diseases1-3
- occupational hazards- health workers, laboratory workers,
soldiers, college students-transmission of
flu,meningococcal diseases,hepatitis A and B, varicella1-3
-pregnant women-increased risk for complications of
influenza2,3
1.Zimmerman RK, et. al. ed.Vaccines Across the Life Span. 4th ed. 2007
2. AAP. Pickering LK, ed. Red Book:2003 Report og the Committee on Infectious
Diseases. 26th ed. Elk Grove Village,IL: AAP;2003:68
3. CDC. Pink Book, 10th ed, 2008
Waning Immunity:
Incidence of Pertussis
1998 2002
250
200
Rate *
150
100
50
0
<1 1 2-4 5-17 18-34 35-49 50-64 65+
Age Group (Yrs)
* Rate per 100,000 population
Source: Active Bacterial Core Surveillance/EIP Network
50
40
30
20
10
0
<5 5–9 10–19 20–34 35–44 45–54 55–64 65
Age (yrs)
Glezen et al. 1987
Pneumonia Pada Usia Lanjut
INSIDENS DAN KEMATIAN
• Insidens : 4 to 8 /1 000 per tahun
• Angka Kematian : 40 %
FAKTOR PENYERTA
• Penyakit jantung, paru, ginjal, DM
• Gizi buruk, gangguan imunologis
PENGOBATAN SULIT
• Gambaran klinik tidak jelas
• Penggunaan antibiotik harus hati-hati
Precent influenza vaccination in persons 65,
Australia, 1997, by state Source: IMS Australia
80
60
% vaccinated
40
20
0
Australia NSW Vic Q’ld SA WA Tas
INFLUENZA SURVEILLANCE
USE OF SEASONAL INFLUENZA VACCINE IN ASIA
PACIFIC REGION
Seasonal influenza vaccine use in
selected APACI member countries
Country Influenza vaccine
Recommended Selection based on Recommended
formulation surveillance data timing
India Northern Yes Any
Indonesia Most current No Any
Philippines Southern Yes Before June
Singapore Most current No Any
Taiwan Northern Yes October
Vietnam Most current No August
Why Vaccinate Adults?
High Risk Behavior and Lifestyle
smoking predisposes to pneumococcal infections
drug abuse-hepatitis B
multiple sex partners- hepatitis B, cervical cancer
homosexuality- hepatitis A and B
Travellers- influenza, meningococcal, typhoid
Zimmerman RK, et. al. ed.Vaccines Across the Life Span. 4 th ed. 2007
Age of Infection of Acute and
Chronic Hepatitis B Virus Infection
6%
8% 58%
12%
84% 4%
4%
24%
JAMA 2007;297:813-819
KEY VACCINES
FOR ADULTS
Key Vaccines: Adults
Influenza
Pneumococcal
Tetanus/Diphtheria
Human Papillomavirus
Hepatitis B (high risk groups)
Hepatitis A (travel to endemic areas)
Meningococcal (high risk groups)
Typhoid (travel to endemic areas)
MMR (catch-up)
Varicella (catch-up)
1.Zimmerman RK, et. al. ed.Vaccines Across the Life Span. 4th ed. 2007
2. AAP. Pickering LK, ed. Red Book:2003 Report og the Committee on Infectious
Diseases. 26th ed. Elk Grove Village,IL: AAP;2003:68
3. CDC, Pink Book, 10th ed. 2008
BENEFITS OF ADULT
VACCINATION
Decline of Influenza-Associated Deaths in
the Elderly After Flu Vaccination
Illness
Visits to physicians
Prescribed
medications
0 0,1 0,2
Vaccinated (N = 582) Placebo (N = 596)
Bridges CB, Thompson WW, Meltzer MI. Effectiveness of and cost-benefits of influenza vaccnation of healthy working
adults: a randomized controlled trial. JAMA 2000; 284: 1655-63
HBV Disease Burden in the United
States
Prevaccine era
estimated 300,000 persons infected annually, including
24,000 infants and children
2005
estimated 51,000 infections
If my doctor suggested it -
If I knew about its effectiveness -
If I received a reminder letter -
If I was provided with free vaccine -
If I saw information about vaccination -
If I heard information about vaccination -
If my pharmacist suggested it -
If I knew someone who has it yearly -
If I became at risk -
None -
Don’t know -
Other -
0 10 20 30 40 50 60 70
% respondents
Health Care Workers, Influenza vaccination
Hongkong 20-50%
Singapore 39%
Australia 26-38%