Vaksinasi Dewasa Sby 14

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Nama : Eddy Mart Salim

Gelar : Prof., Dr, SpPD-KAI,


Tgl/Lahir : 22 Maret 1950
Pendidikan :
Dokter Umum : FKUNSRI 1978
SpPD : FKUNSRI 1991
Alergi-Imunologi : FK UI 1991-1993
KAI : PAPDI 1996
Guru Besar IP Dalam: 2005
Jabatan : Ka Div. Alergi Imunologi Klinik
Penyakit Dalam FKUNSRI/RSMH Plg
Prof Dr Eddy Mart Salim, SpPD, K-AI
Div Allergy & Clin Imm
Internal Med. Sriwijaya Univ.
Palembang
2014
 Keberhasilan Vaksinasi Cacar (Small pox)
telah membuktikan peran yang sangat besar
dari vaksinasi dalam mengapuskan penyakit
ini dimuka bumi.
 Dahulu kita mengenal imunisasi umumnya

dikakukan terhadap bayi dan anak. Akhir


akhir ini imunisasi juga dilakukan terhadap
remaja maupun dewasa, untuk mencegah
bermacam penyakit yang sering menyerang
usia tersebut

ALV/PRN/22/16/
Adult Vaccination

 Rationale
 Key Vaccines
 Benefits
 Recommendations
 Implementation Policies
Diagram bakteri dgn lokasi berbagai antigen yg menginduksi
imunitas
RATIONALE FOR
ADULT VACCINATION
Why Vaccinate Adults?
 High risk group:
- elderly (>60 y.o.)- waning immunity1 : important in
tetanus, pertussis, flu
- chronic diseases (diabetes, asthma, heart disease)—prone
to complications in flu and pneumococcal diseases1-3
- occupational hazards- health workers, laboratory workers,
soldiers, college students-transmission of
flu,meningococcal diseases,hepatitis A and B, varicella1-3
-pregnant women-increased risk for complications of
influenza2,3

1.Zimmerman RK, et. al. ed.Vaccines Across the Life Span. 4th ed. 2007
2. AAP. Pickering LK, ed. Red Book:2003 Report og the Committee on Infectious
Diseases. 26th ed. Elk Grove Village,IL: AAP;2003:68
3. CDC. Pink Book, 10th ed, 2008
Waning Immunity:
Incidence of Pertussis

Clin Pediatr 2006;45:785-794


Invasive Pneumococcal Disease
Incidence by Age Group, 1998 and 2002

1998 2002
250
200
Rate *

150
100
50
0
<1 1 2-4 5-17 18-34 35-49 50-64 65+
Age Group (Yrs)
* Rate per 100,000 population
Source: Active Bacterial Core Surveillance/EIP Network

CDC, Pink Book, 10th ed, 2008


Complications: Influenza Hospitalisation
Rates
60
Hospitalisation rate/10,000 population

50

40

30

20

10

0
<5 5–9 10–19 20–34 35–44 45–54 55–64 65
Age (yrs)
Glezen et al. 1987
Pneumonia Pada Usia Lanjut
INSIDENS DAN KEMATIAN
• Insidens : 4 to 8 /1 000 per tahun
• Angka Kematian : 40 %
FAKTOR PENYERTA
• Penyakit jantung, paru, ginjal, DM
• Gizi buruk, gangguan imunologis
PENGOBATAN SULIT
• Gambaran klinik tidak jelas
• Penggunaan antibiotik harus hati-hati
Precent influenza vaccination in persons 65,
Australia, 1997, by state Source: IMS Australia
80

60
% vaccinated

40

20

0
Australia NSW Vic Q’ld SA WA Tas
INFLUENZA SURVEILLANCE
USE OF SEASONAL INFLUENZA VACCINE IN ASIA
PACIFIC REGION
Seasonal influenza vaccine use in
selected APACI member countries
Country Influenza vaccine
Recommended Selection based on Recommended
formulation surveillance data timing
India Northern Yes Any
Indonesia Most current No Any
Philippines Southern Yes Before June
Singapore Most current No Any
Taiwan Northern Yes October
Vietnam Most current No August
Why Vaccinate Adults?
 High Risk Behavior and Lifestyle
smoking predisposes to pneumococcal infections
drug abuse-hepatitis B
multiple sex partners- hepatitis B, cervical cancer
homosexuality- hepatitis A and B
 Travellers- influenza, meningococcal, typhoid

fever, hepatitis A and B

Zimmerman RK, et. al. ed.Vaccines Across the Life Span. 4 th ed. 2007
Age of Infection of Acute and
Chronic Hepatitis B Virus Infection

Adolescent Children Perinatal Adult

6%
8% 58%
12%
84% 4%
4%

24%

Acute infection Chronic infection

CDC Sentinel Sites. 1989 data.


CDC, Pink Book,10th ed, 2008
Prevalence of Low Risk and High Risk HPV Types
Among Females Aged 14 to 59 Years, NHANES 2003-
2004

JAMA 2007;297:813-819
KEY VACCINES
FOR ADULTS
Key Vaccines: Adults
 Influenza
 Pneumococcal
 Tetanus/Diphtheria
 Human Papillomavirus
 Hepatitis B (high risk groups)
 Hepatitis A (travel to endemic areas)
 Meningococcal (high risk groups)
 Typhoid (travel to endemic areas)
 MMR (catch-up)
 Varicella (catch-up)
1.Zimmerman RK, et. al. ed.Vaccines Across the Life Span. 4th ed. 2007
2. AAP. Pickering LK, ed. Red Book:2003 Report og the Committee on Infectious
Diseases. 26th ed. Elk Grove Village,IL: AAP;2003:68
3. CDC, Pink Book, 10th ed. 2008
BENEFITS OF ADULT
VACCINATION
Decline of Influenza-Associated Deaths in
the Elderly After Flu Vaccination

 Retrospective Cohort Study in Netherlands (1992-


2003)

 Average Influenza-Associated Mortality:


pre-vaccination:131/100,000 persons
post-vaccination:105/100,000 persons
( Relative Risk: 0.80)

Jansen. Vaccine 2008; 26: 5567-5574


Flu Vaccination in adults provides
cost-effective benefit

Illness

Visits to physicians

Prescribed
medications

Lost work days due


to illness

Lost work days due


to physician visits

0 0,1 0,2
Vaccinated (N = 582) Placebo (N = 596)

Bridges CB, Thompson WW, Meltzer MI. Effectiveness of and cost-benefits of influenza vaccnation of healthy working
adults: a randomized controlled trial. JAMA 2000; 284: 1655-63
HBV Disease Burden in the United
States
 Prevaccine era
 estimated 300,000 persons infected annually, including
24,000 infants and children
 2005
 estimated 51,000 infections

CDC, Pink Book, 2008


Benefits of mass vaccination

 Hepatitis A vaccine is 94–100% effective in


preventing disease
 Mass vaccination decreases hepatitis A
incidence among children and adults
 Controls recurrent outbreaks in areas of
moderate to high endemicity

JAMA 1994; N Engl J Med 1992


Qureshi H, dkk  2070 jemaah haji Pakistan 1999
54% mendapat vaksinasi influenza
selama pengamatan 33 hari:

Vaksinasi Tidak vaksinasi


Influenza Like Illness 34% 64%
Antibiotik 18% 41%
RECOMMENDED
IMMUNIZATION
SCHEDULES FOR
ADULTS
Sejarah Satgas Imunisasi Dewasa
 Kongres PAPDI Manado 2003 : Konsensus
Imunisasi Dewasa
 Pembentukan Satgas Imunisasi Dewasa
 Pelatihan Imunisasi Dewasa di beberapa kota untuk
tenaga dokter
 Pelatihan Imunisasi Dewasa untuk dokter
perusahaan
 Menerbitkan buku Pedoman Imunisasi Dewasa
 Konsensus bersama : influenza, HPV
ALV/PRN/22/16/07/11
Actions to Strengthen Implementation of
Adult Immunization

 Increase demand for adult immunization by


improving public and provider (doctor) awareness
 Strengthen health care systems to deliver vaccines
to adults and adolescents
 Surveillance
 Research studies

Clin Infect Diseases 2007;44:1529-31


Factors that would influence unvaccinated high-risk
individuals to accept vaccination

If my doctor suggested it -
If I knew about its effectiveness -
If I received a reminder letter -
If I was provided with free vaccine -
If I saw information about vaccination -
If I heard information about vaccination -
If my pharmacist suggested it -
If I knew someone who has it yearly -
If I became at risk -
None -
Don’t know -
Other -
0 10 20 30 40 50 60 70
% respondents
Health Care Workers, Influenza vaccination

 Variation between Asia Pacific countries

 Hongkong 20-50%

 Korea, Taiwan 80-90%

 New Zealand 35%

 Singapore 39%

 Australia 26-38%

 Indonesia less than 10%


ALV/PRN/22/16/07/11
Klinik Imunisasi Dewasa
Gedung IRM lantai 4 RSUPN - CM
Jl. Diponegoro No. 71
Jakarta Pusat 10430
Telpon :
021 3918301 pesawat 6608
021-31902822 Fax. 021-3904546
Dr. Sukamto
Dr. Iris Rengganis
Prof. Samsuridjal Djauzi
Dr. Erwanto (Bogor dan sekitarnya)
E-mail :
alergi@centrin.net.id
sukamto_koesnoe@yahoo.com
Website: www.imunisasidewasa.com
Conclusions

 Adults also need protection from vaccine-preventable


diseases
 Adult vaccination contribute to decreasing the burden
of most infectious diseases
 Several bodies recognize the importance of
implementing immunization policies and schedules
for adults
PB PERALMUNI
TERIMA KASIH
“EVERY YEAR, TENS OF
THOUSANDS OF ADULTS AND
HUNDREDS OF THOUSANDS MORE
ARE HOSPITALIZED DUE TO
DISEASES THAT COULD BE
PREVENTED BY VACCINATION.”

Clin Infect Diseases 2007;44:1529-31

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