Lymphocyte protein tyrosine kinase (Q14885208)

Protein kinase-like domain superfamily

1 reference

SH2 domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

SH2 domain, protein family

1 reference

SH3 domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Tyrosine-protein kinase Lck, SH2 domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

Lck, SH3 domain, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

1 reference

14 February 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

1 reference

14 February 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

1 reference

14 February 2019

protein antigen binding

1 reference

14 February 2019

Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

1 reference

14 February 2019

protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240

9 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240

1 January 2018

LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240

1 January 2018

1 January 2018

Characterization of Lnk. An adaptor protein expressed in lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240

1 January 2018

Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240

1 January 2018

CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240

1 January 2018

Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240

EXP

protein binding

15 references

14 February 2019

HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

CAML is a p56Lck-interacting protein that is required for thymocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

Regulation of T cell development by the deubiquitinating enzyme CYLD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

Interaction of p56lck with CD4 in the yeast two-hybrid system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

CD45 and RPTPalpha display different protein tyrosine phosphatase activities in T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

Lck availability during thymic selection determines the recognition specificity of the T cell repertoire

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

Association of CD45 with Lck and components of the Ras signalling pathway in pervanadate-treated mouse T-cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

Interactions between the amino‐terminal domain of p56lck and cytoplasmic domains of CD4 and CD8α in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

phosphotyrosine residue binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

antigen binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

protein C-terminus binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

protein kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

protein phosphatase binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240

T cell receptor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

CD8 receptor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

identical protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

phosphatidylinositol 3-kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

protein-containing complex binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

ATPase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

signaling receptor binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

8 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

14 February 2019

Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

Characterization of Lnk. An adaptor protein expressed in lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

1 reference

14 February 2019

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

1 reference

14 February 2019

TAS

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

1 reference

14 February 2019

cell-cell junction

1 reference

14 February 2019

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

extrinsic component of cytoplasmic side of plasma membrane

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

plasma membrane

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

14 February 2019

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

immunological synapse

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

endocytic vesicle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

glutamatergic synapse

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

postsynaptic specialization, intracellular component

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

regulation of apoptotic process

biological process

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240

1 reference

5 June 2018

B cell receptor signaling pathway

1 reference

5 June 2018

Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240

release of sequestered calcium ion into cytosol

1 reference

14 February 2019

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

1 reference

14 February 2019

regulation of T cell receptor signaling pathway

1 reference

14 February 2019

PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

transmembrane receptor protein tyrosine kinase signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

regulation of regulatory T cell differentiation

IGI

1 reference

14 February 2019

Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

IGI

protein phosphorylation

cell surface receptor signaling pathway

3 references

1 reference

14 February 2019

Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

positive regulation of gene expression

1 reference

14 February 2019

Regulation of GATA-3 expression during CD4 lineage differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

regulation of cell population proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240

1 reference

5 June 2018

peptidyl-tyrosine autophosphorylation

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240

1 reference

5 June 2018

positive regulation of gamma-delta T cell differentiation

IMP

1 reference

14 February 2019

Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

protein dephosphorylation

IMP

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

cell migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06240&geneProductId=UniProtKB:P06240

1 reference

5 June 2018

positive regulation of tyrosine phosphorylation of STAT protein

1 reference

14 February 2019

Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

cellular zinc ion homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

1 reference

14 February 2019

response to mechanical stimulus

ISS

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

response to metal ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

peptidyl-tyrosine phosphorylation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

response to hydrogen peroxide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

positive regulation of uterine smooth muscle contraction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

cell differentiation

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

T cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

3 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

positive regulation of heterotypic cell-cell adhesion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

positive regulation of leukocyte cell-cell adhesion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06240

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

tyrosine-protein kinase, active site

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

SH3 domain

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

Tyrosine-protein kinase Lck, SH2 domain

1 reference

Lck, SH3 domain

1 reference

inferred by common MeSH mappings on source and on Wikidata

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

1 reference

1 reference

UMLS 2023