The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck (Q28591171)

31 January 2017

title

The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck (English)

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Dual specificity phosphatase 22

31 January 2017

main subject

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LCK proto-oncogene, Src family tyrosine kinase

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protein tyrosine kinase binding

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Dual specificity phosphatase 22

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Lymphocyte protein tyrosine kinase

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author name string

Ju-Pi Li

1

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31 January 2017

Chia-Yu Yang

2

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31 January 2017

Huai-Chia Chuang

3

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31 January 2017

Joung-Liang Lan

4

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31 January 2017

Der-Yuan Chen

5

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31 January 2017

Yi-Ming Chen

6

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31 January 2017

Xiaohong Wang

7

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31 January 2017

Alice J. Chen

8

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31 January 2017

John W. Belmont

9

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31 January 2017

Tse-Hua Tan

10

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31 January 2017

language of work or name

English

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publication date

9 April 2014

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31 January 2017

published in

Nature Communications

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31 January 2017

volume

5

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31 January 2017

page(s)

3618

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Profound block in thymocyte development in mice lacking p56lck

31 January 2017

cites work

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The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway

21 April 2017

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Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1

21 April 2017

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Regulation of STAT3-mediated signaling by LMW-DSP2

21 April 2017

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PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells

21 April 2017

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T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

21 April 2017

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HIP-55 is important for T-cell proliferation, cytokine production, and immune responses

21 April 2017

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The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells

21 April 2017

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Lck, Membrane Microdomains, and TCR Triggering Machinery: Defining the New Rules of Engagement

21 April 2017

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Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck)

21 January 2018

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Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4618

Structural requirements for enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck

21 January 2018

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CD45: a critical regulator of signaling thresholds in immune cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4618

The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4618

Protein tyrosine phosphatases in lymphocyte activation and autoimmunity

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4618

Nonreceptor protein-tyrosine phosphatases in immune cell signaling

21 January 2018

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Shp1 regulates T cell homeostasis by limiting IL-4 signals

21 January 2018

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DUSPs, to MAP kinases and beyond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4618

DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4618

JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration.

21 January 2018

1 reference

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The use of AlphaScreen technology in HTS: current status

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4618

Tyr394 and Tyr505 are autophosphorylated in recombinant Lck protein-tyrosine kinase expressed in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4618

DUSP4 deficiency enhances CD25 expression and CD4+ T-cell proliferation without impeding T-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4618

The src homology 2 domain-containing tyrosine phosphatase 2 regulates primary T-dependent immune responses and Th cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4618

Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta

21 January 2018

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Protein tyrosine phosphatase function: the substrate perspective

21 January 2018

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Systemic lupus erythematosus.

21 January 2018

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B cells as therapeutic targets in SLE.

21 January 2018

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T cells as therapeutic targets in SLE.

21 January 2018

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Oxidative stress in the pathology and treatment of systemic lupus erythematosus

21 January 2018

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Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus

21 January 2018

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Gene-function studies in systemic lupus erythematosus.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4618

Protein phosphatase 4 is involved in tumor necrosis factor-alpha-induced activation of c-Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4618

Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4618

Spectral imaging and linear un-mixing enables improved FRET efficiency with a novel GFP2-YFP FRET pair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4618

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4618

Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4618

7 January 2021

CCR5 deficiency aggravates crescentic glomerulonephritis in mice

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4618

7 January 2021

Experimental autoimmune encephalomyelitis in the mouse

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4618

7 January 2021

Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4618

7 January 2021

Identifiers

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Dimensions Publication ID

31 January 2017

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1049338277

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