Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis (Q30164460)

9 June 2017

title

Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis (English)

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9 June 2017

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Julie L Boerner

1

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9 June 2017

Andrew J Danielsen

2

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9 June 2017

Courtney A Lovejoy

3

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9 June 2017

Ze Wang

4

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9 June 2017

Subhash C Juneja

5

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9 June 2017

Jessica M Faupel-Badger

6

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9 June 2017

Jaime R Darce

7

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9 June 2017

Nita J Maihle

8

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9 June 2017

language of work or name

English

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publication date

1 October 2003

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9 June 2017

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9 June 2017

volume

22

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9 June 2017

issue

43

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9 June 2017

page(s)

6679-6689

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Ras-independent transformation by v-Src

9 June 2017

cites work

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Differential Modulation of Plasminogen Activator Gene Expression by Oncogene-Encoded Protein Tyrosine Kinases

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Ligand-independent oncogenic signaling by the epidermal growth factor receptor: v-ErbB as a paradigm

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Activation of Rho is required for ligand-independent oncogenic signaling by a mutant epidermal growth factor receptor

21 January 2018

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Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

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Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.

21 January 2018

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Multiple ErbB-2/Neu Phosphorylation Sites Mediate Transformation through Distinct Effector Proteins.

21 January 2018

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Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer

21 January 2018

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Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

21 January 2018

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Effect of potent and selective inhibitors of the Grb2 SH2 domain on cell motility

21 January 2018

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The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

21 January 2018

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Mutagenesis of the region between env and src of the SR-A strain of rous sarcoma virus for the purpose of constructing helper-independent vectors

21 January 2018

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

21 January 2018

1 reference

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

21 January 2018

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Proviral insertional activation of c-erbB: differential processing of the protein products arising from two alternate transcripts

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An oncogenic epidermal growth factor receptor signals via a p21-activated kinase-caldesmon-myosin phosphotyrosine complex

21 January 2018

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A transformation-associated complex involving tyrosine kinase signal adapter proteins and caldesmon links v-erbB signaling to actin stress fiber disassembly

21 January 2018

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Protein tyrosine kinase activities of the epidermal growth factor receptor and ErbB proteins: correlation of oncogenic activation with altered kinetics

21 January 2018

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Occurrence of caldesmon (a calmodulin-binding protein) in cultured cells: comparison of normal and transformed cells

21 January 2018

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Proteins with SH2 and SH3 domains couple receptor tyrosine kinases to intracellular signalling pathways

21 January 2018

1 reference

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p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling

21 January 2018

1 reference

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Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation

21 January 2018

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Estrogen receptor mediated inhibition of cancer cell invasion and motility: an overview

21 January 2018

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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

21 January 2018

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Epidermal growth factor-related peptides and their receptors in human malignancies

21 January 2018

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A matrix metalloproteinase expressed on the surface of invasive tumour cells

21 January 2018

1 reference

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Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis

21 January 2018

1 reference

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Growth inhibition of breast cancer cells by Grb2 downregulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2, cells

21 January 2018

1 reference

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Tyrosine Phosphorylation of Caldesmon Is Required for Binding to the Shc⋅Grb2 Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206830

Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206830

Tyrosine kinase activity may be necessary but is not sufficient for c-erbB1-mediated tissue-specific tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206830

inferred from DOI database lookup

7 January 2021

based on heuristic

Molecular characterization of three erbB transducing viruses generated during avian leukosis virus-induced erythroleukemia: extensive internal deletion near the kinase domain activates the fibrosarcoma- and hemangioma-inducing potentials of erbB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206830

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1206830

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Dimensions Publication ID

9 June 2017

1045161042

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1 reference